Walker, Benjamin R. published the artcileMediator-Enabled Electrocatalysis with Ligandless Copper for Anaerobic Chan-Lam Coupling Reactions, Product Details of C7H6N2, the main research area is mediator electrocatalysis copper anaerobic Chan Lam coupling reaction.
Simple Cu salts serve as catalysts to effect C-X bond-forming reactions in some of the most used transformations in synthesis, including the oxidative coupling of aryl boronic acids and amines. However, these Chan-Lam coupling reactions have historically relied on chem. oxidants that limit their applicability beyond small-scale synthesis. Despite the success of replacing strong chem. oxidants with electrochem. for a variety of metal-catalyzed processes, electrooxidative reactions with ligandless Cu catalysts are plagued by slow electron-transfer kinetics, irreversible Cu plating, and competitive substrate oxidation Herein, the authors report the implementation of substoichiometric quantities of redox mediators to address limitations to Cu-catalyzed electrosynthesis. Mechanistic studies reveal that mediators serve multiple roles by (i) rapidly oxidizing low-valent Cu intermediates, (ii) stripping Cu metal from the cathode to regenerate the catalyst and reveal the active Pt surface for proton reduction, and (iii) providing anodic overcharge protection to prevent substrate oxidation This strategy is applied to Chan-Lam coupling of aryl-, heteroaryl-, and alkylamines with arylboronic acids in the absence of chem. oxidants. Couplings under these electrochem. conditions occur with higher yields and shorter reaction times than conventional reactions in air and provide complementary substrate reactivity.
Journal of the American Chemical Society published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Product Details of C7H6N2.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts