Wei, Xiangyang published the artcileDecyanative Cross-Coupling of Cyanopyrimidines with O-, S-, and N-Nucleophiles: A Route to Alkoxylpyrimidines, Aminopyrimidines and Alkylthiopyrimidines, Formula: C6H4N2, the main research area is decyanative cross coupling cyanopyrimidine alc thiol amine; preparation alkoxylpyrimidine aminopyrimidine alkylthiopyrimidine.
The transition metal-free cross-coupling reactions of cyanopyrimidines with aliphatic alcs., thiols (or S-alkylisothiourea salts) and amines, giving the corresponding alkoxylpyrimidines, aminopyrimidines, and alkylthiopyrimidines, are reported. Preliminary mechanistic studies reveal that it probably involves a sequential nucleophilic addition-intramol. rearrangement process, which is promoted by an intramol. N-H···N five-membered hydrogen bonding interaction. The presence of a nitrogen atom next to the cyano group is indispensable. The wide substrate scope with excellent yields makes cyanopyrimidines a promising alternative substrate class to the frequently used pyrimidines halides for the formation of C-O, C-S, and C-N bonds through the decyanative cross-coupling reaction.
European Journal of Organic Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Formula: C6H4N2.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts