Zhang, Yi published the artcile2-((1-Phenyl-1H-1,2,3-triazol-4-yl)methyl)-2-azabicyclo[3.2.1]octan-3-one derivatives: Simplification and modification of aconitine scaffold for the discovery of novel anticancer agents, Application In Synthesis of 1885-29-6, the main research area is phenyl triazolyl methylazabicyclooctanone preparation antitumor agent SAR mol docking; Aconitine; Antiproliferative activity; Hsp90 inhibitors; Structural simplification.
In this study, we designed and synthesized a series of I [R = H, 2-OH, 3-OH, 4-OH,..etc]. as potent Hsp90 inhibitors by simplifying and modifying the aconitine scaffold. Among these compounds, I [R = 3-Br] exhibited an excellent antiproliferative activity against LoVo cells with an IC50 value of 0.02μM and a significant Hsp90α inhibitory activity with an IC50 value of 0.71 nM. Mol. docking studies provided a rational binding model of I [R = 3-Br] in complex with Hsp90α. The following cell cycle and apoptosis assays revealed that compound I [R = 3-Br] could arrest cell cycle at G1/S phase and induce cell apoptosis via up-regulation of bax and cleaved-caspase 3 protein expressions while inhibiting the expressions of bcl-2. Moreover, I [R = 3-Br] could inhibit cell migration in LoVo and SW620 cell lines. Consistent with in vitro results, I [R = 3-Br] significantly repressed tumor growth in the SW620 xenograft mouse model.
European Journal of Medicinal Chemistry published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application In Synthesis of 1885-29-6.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts