Barnes, David M. published the artcileDiscovery and Development of Metal-Catalyzed Coupling Reactions in the Synthesis of Dasabuvir, an HCV-Polymerase Inhibitor, Quality Control of 1885-29-6, the main research area is synthesis optimization dasabuvir chemoselective regioselective coupling sulfonamidation catalyst; dasabuvir synthesis optimization mutagenic impurity removal.
Dasabuvir is an HCV polymerase inhibitor which has been developed as a part of a three-component direct-acting antiviral combination therapy. During the course of the development of the synthetic route, two novel coupling reactions were developed. First, the copper-catalyzed coupling of uracil with aryl iodides, employing picolinamide derivative I, as the ligand, was discovered. Later, the palladium-catalyzed sulfonamidation of aryl nonaflate II, was developed, promoted by electron-rich palladium complexes, including the novel phosphine ligand, VincePhos III. This made possible a convergent, highly efficient synthesis of dasabuvir that significantly reduced the mutagenic impurity burden of the process.
Journal of Organic Chemistry published new progress about Cross-coupling reaction (chemoselective). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Quality Control of 1885-29-6.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts