Hamsath, Akil published the artcileIntramolecular tetrazine-acryloyl cycloaddition: chemistry and applications, Application of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is coumarin dihydropyridazine preparation; acryloyl ester amide tetrazine intramol cycloaddition.
An unprecedented intramol. [4 + 2] tetrazine-olefin cycloaddition with α,β-unsaturated substrates was discovered. The reaction produces unique coumarin-dihydropyridazine heterocycles that exhibited strong fluorescence with large Stokes shifts and excellent photo- and pH-stability. This property can be used for reaction anal. The rate of cycloaddition was found to be solvent dependent and was determined using exptl. data with a kinetic modeling software (COPASI) as well as DFT calculations (k1 = 0.64 ± 0.019 s-1 and 4.1 s-1, resp.). The effects of steric and electronic properties of both the tetrazine and α,β-unsaturated carbonyl on the reaction were studied and followed the known trends characteristic of the intermol. reaction. Based on these results, authors developed a “”release-then-click”” strategy for the ROS triggered release of methylselenenic acid (MeSeOH) and a fluorescent tracer. This strategy was demonstrated in HeLa cells via fluorescence imaging.
Chemical Science published new progress about [4+2] Cycloaddition reaction. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application of 2-Aminobenzonitrile(Flakes or Chunks).
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts