Ma, Chun-Hua published the artcileTransition-metal-free three-component acetalation-pyridylation of alkenes via photoredox catalysis, HPLC of Formula: 100-70-9, the main research area is aryl pyridinyl propanal preparation antitumor human; alkene diethoxyacetic acid cyanopyridine acetalation pyridylation photoredox catalysis.
A general transition-metal-free photoinduced acetalation-pyridylation of alkenes using diethoxyacetic acid and cyanopyridine was developed under mild conditions. By employing 4CzIPN as the photocatalyst and Cs2CO3 as the base, a diverse range of styrene derivatives and cyanopyridines worked well to give the desired products I (R1 = H, 3-OMe, 2-Cl, etc.; R2 = H, 2-F, 4-OMe, etc.; R3 = H, Me, CH2CH2Ph). The versatility of this method is highlighted by its application in the construction of various functional groups and the late-stage modification of drugs. Importantly, some of the synthesized compounds showed good in vitro antitumor activity, indicating that this protocol is of significance and potential for antitumor drug development.
Chinese Journal of Catalysis published new progress about Acetalization (photochem.). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, HPLC of Formula: 100-70-9.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts