Shakeel-u-Rehman published the artcileClick chemistry inspired facile synthesis and bio-evaluation of novel triazolyl analogs of D-(+)-pinitol, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is structure activity enzyme inhibiting antitumor inositol triazole preparation human; click cycloaddition alkyne azide glucosidase inhibitory triazole inositol preparation; glucosidase inhibitory alkyne azide cycloaddition triazole cyclitol antitumor preparation.
Cu(I)-catalyzed alkyne-azide cycloaddition was carried out for the preparation of novel 1,4-disubstituted 1,2,3-triazoles of D-(+)-pinitol. All the analogs were screened for cytotoxicity against promyelocytic leukemia (HL-60), colorectal carcinoma (HCT 116) and pancreatic carcinoma (Mia-Paca-2) cancer cell lines using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) cytotoxicity assay. Compounds, e.g. I, showed the best activity with IC50 of 19.2, 17.5 and 16.4μM against leukemia (HL-60), colorectal carcinoma (HCT 116) and pancreatic carcinoma (Mia-Paca-2) cell lines resp. All the triazolyl analogs were further evaluated for β-glucosidase inhibitory activity, wherein, the deprotected derivatives, e.g. II, showed better activity with IC50 of 148.5, 139.2 and 142.4μM resp. The structure activity relationship (SAR) studies revealed that the analogs with bromo, nitro or Me groups (substituted Ph moiety attached to 1,2,3-triazole) moiety exhibited better cytotoxicity, while as, the analogs with N-substituted long chain aliphatic hydrocarbon R moieties displayed effective β-glucosidase inhibition.
Arabian Journal of Chemistry published new progress about 1,3-Dipolar cycloaddition reaction. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks).
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts