Feng, Guang-Shou published the artcileIridium-catalyzed asymmetric hydrogenation of quinazolinones, Category: nitriles-buliding-blocks, the main research area is dihydroquinazolinone preparation enantioselective; quinazolinone asym hydrogenation iridium diphosphine complex catalyst.
Enantioselective hydrogenation of quinazolinones was successfully realized by employing a chiral iridium/diphosphine complex as catalyst, furnishing the chiral dihydroquinazolinones I [R = i-Pr, Ph, 4-ClC6H4, etc.] with excellent yield and up to 98% enantioselectivity. Asym. hydrogenation at the gram scale was also conducted smoothly without loss of reactivity and enantioselectivity. Using the above methodol. as the key step, the enantiopure bioactive Eg5 inhibitor and (-)-SDZ 267-489 could also be conveniently synthesized.
Organic Chemistry Frontiers published new progress about Enantioselective synthesis. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Category: nitriles-buliding-blocks.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts