Yamamoto, Keizou published the artcileProduction of R-(-)-ketoprofen from an amide compound by Comamonas acidovorans KPO-2771-4, Synthetic Route of 42872-30-0, the main research area is ketoprofen isomer manufacture Comamonas; amidase ketoprofen forming stereospecificity Comamonas.
R-(-)-ketoprofen (I) was produced from racemic 2-(3′-benzoylphenyl)propionamide (keto-amide) by the isolated bacterial strain C. acidovorans KPO-2771-4. Sodium fumarate as the C source and 2-azacyclononanone or isobutyronitrile as the enhancer in the culture medium were effective for bacterial growth and the enhancement of I-producing activity. I produced from the keto-amide by resting cells was present in 99% enantiomeric excess. C. acidovorans KPO-2771-4 has an R-enantioselective amidase for keto-amide because the purified amidase from the bacterium hydrolyzed keto-amide, producing optically pure I and NH3.
Applied and Environmental Microbiology published new progress about Comamonas acidovorans. 42872-30-0 belongs to class nitriles-buliding-blocks, name is 2-(3-Benzoylphenyl)propanenitrile, and the molecular formula is C16H13NO, Synthetic Route of 42872-30-0.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts