Potassium 2,2,5,7,8-Pentamethylchroman-6-oxide: A Rationally Designed Base for Pd-Catalysed Amination was written by Hoi, Ka Hou;Organ, Michael G.. And the article was included in Chemistry – A European Journal in 2012.Synthetic Route of C14H12N2O The following contents are mentioned in the article:
The authors have used a base, potassium 2,2,5,7,8-pentamethylchroman-6-hydroxide, for palladium-catalyzed amination. It has the necessary basicity to facilitate the efficient deprotonation of the corresponding aryl palladium ammonium complexes to give desirable kinetics, while having diminished nucleophilicity to mitigate undesired side reactions with base-sensitive functional groups. The base has shown excellent reactivity and selectivity with both highly reactive phosphine- and NHC-based Pd catalysts indicating it will have high compatibility, thus good generality and broad uptake in metal-catalyzed amination reactions. This study involved multiple reactions and reactants, such as 4-((4-Methoxyphenyl)amino)benzonitrile (cas: 319016-04-1Synthetic Route of C14H12N2O).
4-((4-Methoxyphenyl)amino)benzonitrile (cas: 319016-04-1) belongs to nitriles. There has been no report on the microbial biosynthesis of nitriles and the physiological function of such enzymes, nor was it not even known whether aliphatic and aromatic nitriles are biological compounds or just petrochemicals. Some nitriles are manufactured by heating carboxylic acids with ammonia in the presence of catalysts. This process is used to make nitriles from natural fats and oils, the products being used as softening agents in synthetic rubbers, plastics, and textiles and for making amines.Synthetic Route of C14H12N2O
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts