Pd(PPh3)4-Catalyzed Buchwald-Hartwig Amination of Aryl Fluorosulfonates with Aryl Amines was written by Lim, Taehyun;Byun, Sangmoon;Kim, B. Moon. And the article was included in Asian Journal of Organic Chemistry in 2017.Name: 4-((4-Methoxyphenyl)amino)benzonitrile The following contents are mentioned in the article:
Novel Buchwald-Hartwig aminations of aryl fluorosulfonates using a catalytic amount of Pd(PPh3)4 in the presence of Cs2CO3 were described. From these reactions, a variety of biaryl amines were obtained in moderate to good yields. This system allowed for the efficient amination of aromatic groups containing electron-rich as well as electron-poor functional groups. Aryl fluorosulfonates could be applied as alternative cross-coupling partners to aryl halides in palladium-catalyzed aminations. This study involved multiple reactions and reactants, such as 4-((4-Methoxyphenyl)amino)benzonitrile (cas: 319016-04-1Name: 4-((4-Methoxyphenyl)amino)benzonitrile).
4-((4-Methoxyphenyl)amino)benzonitrile (cas: 319016-04-1) belongs to nitriles. The electronic structure of nitriles is very similar to that of an alkyne with the main difference being the presence of a set of lone pair electrons on the nitrogen. Alkyl nitriles are sufficiently acidic to undergo deprotonation of the C-H bond adjacent to the CN group.Strong bases are required, such as lithium diisopropylamide and butyl lithium. The product is referred to as a nitrile anion. Name: 4-((4-Methoxyphenyl)amino)benzonitrile
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts