Meerovich, G. A. published the artcileNovel Polycationic Photosensitizers for Antibacterial Photodynamic Therapy, Name: Phthalonitrile, the main research area is polycationic photosensitizer antibacterial photodynamic therapy; Aggregation; Antibacterial photodynamic therapy; cationic photosensitizer; Bacterial biofilms; Bacteriochlorins; Luminescence.
Antibacterial photodynamic therapy (APDT) is a promising method of treating local infected foci, in particular, surgical and burn wounds, trophic and diabetic ulcers. Photodynamic inactivation (PDI) is able to effectively destroy bacterial cells without them developing resistance in response to treatment. This work was dedicated to the study of photophys. and antibacterial properties of new photosensitizers (PS) based on polycationic phthalocyanines and synthetic bacteriochlorins for photodynamic inactivation of P. aeruginosa bacteria and their biofilms. Gram-neg. bacteria P. aeruginosa are often found in infected wounds, presumably in biofilm state and are characterized by rather low susceptibility to APDT, which is a problem. PS were studied for possible aggregation at various concentrations by means of absorption and fluorescence spectroscopy. The results of studies of the ZnPcChol8, (3-PyHp)4BCBr4 and (3-PyEBr)4BCBr4 in water and serum confirm the assumption of a low degree of their aggregation at high concentrations Consequently, their photodynamic efficiency is high enabling to use these PS at high concentrations to sensitize pathol. foci for APDT. It was shown that all the investigated PS had a high efficiency of photodynamic inactivation of Gram-neg. bacteria P. aeruginosa, as well as their biofilms. Tetracationic hydrophilic near-IR photosensitizer (3-PyEBr)4BCBr4 with reduced mol. size had significantly higher efficacy of photodynamic inactivation of P. aeruginosa biofilms compared with other studied photosensitizers.
Advances in Experimental Medicine and Biology published new progress about Absorption spectra. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Name: Phthalonitrile.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts