Girgis, Nabih S. published the artcilePhosphorus pentoxide in organic synthesis. VII. Synthesis of 3-aryl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-imines, Application of 2-Amino-4-methyl-1H-pyrrole-3-carbonitrile, the main research area is pyrrolopyrimidinimine aryl preparation antineoplastic; phosphorus pentoxide cyclization acetylaminopyrrolecarbonitrile; pyrrolecarbonitrile acetylamino phosphorus pentoxide cyclization; arylpyrrolopyrimidinimine preparation antineoplastic; fungicide arylpyrrolopyrimidinimine preparation; insecticide arylpyrrolopyrimidinimine preparation; plant regulator arylpyrrolopyrimidinimine preparation; pyrimidinimine arylpyrrolo antineoplastic preparation.
Anhydrous RR1C6H3NH2.HCl (R = H, R1 = H, 4-Cl, 2-F, 4-F, 3-Me, 4-Me, 4-Et, 4-Bu; R = 2-Cl, R1 = 4-Cl; R = 2-Me, R1 = 4-Me) reacted with pyrroles I [R2 = H, CHMeEt, CH2Ph; R3 = Me, Ph), P2O5, and N,N-dimethylcyclohexylamine at 150-180° to give the title compounds II, which were inactive against P388 lymphocytic leukemia. However, II (R = R1 = R2 = H, R3 = Me) was active against the plant louse, II (R = R2 = H, R1 = 4-F, R3 = Ph) was a plant regulator, and II (R = H, R1 = F, R2 = CHMeEt, R3 = Me) was a fungicide against Cercospora on peanut at 200 ppm.
Liebigs Annalen der Chemie published new progress about Antitumor agents. 59146-60-0 belongs to class nitriles-buliding-blocks, name is 2-Amino-4-methyl-1H-pyrrole-3-carbonitrile, and the molecular formula is C6H7N3, Application of 2-Amino-4-methyl-1H-pyrrole-3-carbonitrile.
Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts