Month: November 2022

On October 31, 2003, Elinson, M. N.; Fedukovich, S. K.; Zaimovskaya, T. A.; Vereshchagin, A. N.; Nikishin, G. I. published an article.Name: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile The title of the article was Electrocatalytic transformation of malononitrile and cycloalkylidenemalononitriles into spirotricyclic and spirotetracyclic compounds containing cyclopropane and pyrroline fragments. And the article contained the following:

Electrolysis of cycloalkylidenemalononitriles and malononitrile in MeOH in an undivided cell in the presence of the NaBr-NaOMe mediator system gives spirotricyclic compounds containing cyclopropane and pyrroline fragments in 50-77% yields. Spirobicyclic and spirotricyclic tetracyanocyclopropanes undergo electrolysis in alcs. to afford spirotricyclic and spirotetracyclic products containing cyclopropane and pyrroline fragments in 50-93% yields. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Name: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

The Article related to electrocatalytic spirocyclization malononitrile cycloalkylidenemalononitrile spirotricyclic spirotetracyclic cyclopropane pyrroline, Physical Organic Chemistry: Oxidation-Reduction, Including Dehydrogenation and Hydrogenolysis and other aspects.Name: 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

Referemce:
Nitrile – Wikipedia,
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On January 17, 2020, Feng, Jiaxu; Chen, Yingying; Qin, Wenhui; Huang, You published an article.Application In Synthesis of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile The title of the article was Phosphine-Catalyzed (3 + 2)/(3 + 2) Sequential Annulation of γ-Vinyl Allenoates: Access to Fused Carbocycles. And the article contained the following:

The first (3 + 2)/(3 + 2) sequential annulation of γ-vinyl allenoates with alkylidenemalononitriles enabled by phosphine catalysis has been reported. A broad range of structurally dense tetra- and penta-substituted bicyclic[3,3,0]octene derivatives, containing a quaternary center and three sequential stereogenic center, were synthesized in good to excellent yields. In this approach, three new C-C bonds are formed in one pot, and εC and αC of γ-vinyl allenoate are two electrophilic centers, whereas its γC exhibits nucleophilic reactivity. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Application In Synthesis of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

The Article related to alkylidenemalononitrile vinyl allenoate phosphine catalyst sequential diastereoselective annulation, fused carbocycle one pot preparation, Alicyclic Compounds: Tricyclic Compounds and Higher Analogs, Including Adamantanes, Fullerenes and other aspects.Application In Synthesis of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

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Nitrile – Wikipedia,
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On July 31, 2009, Li, Xiaochuan; Kim, Sung-Hoon; Kun, Jun; Son, Young-A. published an article.Electric Literature of 2510-01-2 The title of the article was Synthesis and Optical Properties of (A)n-π-(Ph)3N Type Dyes. And the article contained the following:

Two new (A)n-π-(Ph)3N type dyes were designed, synthesized and characterized. The optical properties and structures of them were studied, including UV-visible spectroscopy, photo-luminescence spectroscopy. The geometric structures of them were calculated theor. based on the DFT level using BLYP/GGA basis set, the HOMO/LOMO levels were also measured and calculated The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Electric Literature of 2510-01-2

The Article related to dye synthesis optical property, Optical, Electron, and Mass Spectroscopy and Other Related Properties: Optical Properties (Linear) and other aspects.Electric Literature of 2510-01-2

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Nitrile – Wikipedia,
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On December 27, 2018, Du-Cuny, Lei; Xiao, Qitao; Xun, Guoliang; Zheng, Qiangang published a patent.Product Details of 1036991-35-1 The title of the patent was Preparation of substituted 5-cyanoindole compounds for the treatment of lysine (K)-specific demethylase 1A mediated diseases. And the patent contained the following:

A compound of formula I, or a pharmaceutically acceptable salt thereof, is provided that has been shown to be useful for the treatment of lysine (K)-specific demethylase 1A (LSD1) – mediated diseases or disorders. Compounds of formula I wherein R1 is substituted C1-6 alkyl, substituted C3-6 cycloalkyl, substituted 7- to 11-membered spirocyclyl, etc.; R2 is H, halo, C1-4 alkyl, C1-4 haloalkyl, etc.; R3 is (un)substituted aminophenyl, (un)substituted aminopyridinyl, (un)substituted indolinyl, etc.; R4 is H, halo and C1-4 alkyl; R5 is H, halo, C1-4 alkyl, C1-4 haloalkyl, etc.; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their LSD1 modulatory activity. From the assay, it was determined that compound II exhibited IC50 value of 0.010 μM. The experimental process involved the reaction of 3-Amino-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile(cas: 1036991-35-1).Product Details of 1036991-35-1

The Article related to cyanoindole preparation lsd1 modulator, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Product Details of 1036991-35-1

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On December 4, 1997, Mitchell, Glynn; Smith, Stephen Christopher published a patent.Application of 13544-06-4 The title of the patent was Preparation of 1-aminoacetylindolines and analogs as herbicides. And the patent contained the following:

RC(:W1)CR1R2YC(:W2)ZR3 [I; R = (un)substituted indolino; R1,R2 = H or alkyl; R3 = H or (halo)aliphatyl, etc.; W1,W2 = O or S; Y = O or NR4; R4 = H, alkoxy, aliphatyl; Z = NR5 or CR6R7; R5-R7 = H or aliphatyl; R4R5 = CH2CH2, CH:CH, COCO, CH2CO; R6R7 = atoms to complete a carbocyclic ring] were prepared Thus, (EtO2CCH2)2NH was N-acylated by Me3CNCO and the product cyclized to give, after saponification, 2,4-dioxo-3-tert-butylimidazolidine-1-acetic acid which was chloridnated and the product amidated by 6-chloroindoline to give title compound II. Data for biol. activity of I were given. The experimental process involved the reaction of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile(cas: 13544-06-4).Application of 13544-06-4

The Article related to aminoacetylindoline preparation herbicide, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Application of 13544-06-4

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On December 31, 2018, Dyachenko, V. D.; Matusov, I. O.; Dyachenko, I. V.; Nenajdenko, V. G. published an article.Reference of 2-((1H-Indol-3-yl)methylene)malononitrile The title of the article was Knoevenagel Reactions of Indole-3-carbaldehyde. Synthesis of 3-Substituted Indole Derivatives. And the article contained the following:

The Knoevenagel condensations of 1H-indole-3-carbaldehyde with various CH acids gave a number of substituted 3-(1H-indol-3-yl)acrylonitriles and acrylamides which were alkylated to afford the corresponding N-alkyl derivatives I [R = CN, CO2(CH2)6CH3, C(O)NHc-Pr; R1 = Me, allyl, Bn, etc.]. The latter were used as Michael acceptors in the synthesis of 4H-pyran, pyridine, 5,6,7,8-tetrahydroquinoline and [1,3]thiazolo[3,2-a]pyridine derivatives containing an indole fragment. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Reference of 2-((1H-Indol-3-yl)methylene)malononitrile

The Article related to indole preparation, nitrile indole knoevenagel condensation, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Reference of 2-((1H-Indol-3-yl)methylene)malononitrile

Referemce:
Nitrile – Wikipedia,
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On December 25, 2018, Cao, Dongdong; Yang, Jianguo; Ying, Anguo; Mo, Hanjie; Chen, Dingben; Chen, Gang published a patent.Category: nitriles-buliding-blocks The title of the patent was Method for preparing trisubstituted 4-aminocarbazole and disubstituted 1-aminodibenzo[b,d]thiophene compound from 3-nitroindole compound or 3-nitrobenzothiophene and 2-(1-arylethylidene)malononitrile. And the patent contained the following:

The title method for preparing trisubstituted 4-aminocarbazole and disubstituted 1-aminodibenzo[b,d]thiophene compound includes adopting 3-nitroindole compound or 3-nitrobenzothiophene and 2-(1-arylethylidene)malononitrile as raw materials, reacting at 50°C for 6-24 h in solvent acetonitrile under the catalysis of triethylamine under the protection of nitrogen gas to obtain the final product. For instance, 1-amino-3-phenyl-2-dibenzothiophenecarbonitrile was prepared from 3-nitro-benzo[b]thiophene and 2-(1-phenylethylidene)-propanedinitrile in 52% yield. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Category: nitriles-buliding-blocks

The Article related to aminocarbazole aminodibenzothiophene preparation cyclization, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Category: nitriles-buliding-blocks

Referemce:
Nitrile – Wikipedia,
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On July 31, 2018, Honarmand, M.; Givzad, M. published an article.Recommanded Product: 75629-62-8 The title of the article was An efficient and eco-friendly process for the Knoevenagel reaction using nano organosalt catalyst. And the article contained the following:

A novel nano organosalt was synthesized easily by the reaction of sulfuric acid with 1,3-diaminopropane in water. The morphol. and structure of the synthesized organosalt were determined by various techniques. The catalytic application of organosalt was investigated in the Knoevenagel reaction of aryl/heteroaryl/alkyl aldehydes with activated methylene compounds under solvent-free conditions. The Knoevenagel products were obtained in high to excellent yields in the short reaction times. No toxic solvents and byproducts were involved, and in most cases no tedious purifications were needed. The catalyst was also recovered and reused after the five reaction cycles without a significant decrease in catalytic activity. The TEM image and elemental anal. of the recovered catalyst were confirmed the high stability and durability of nano organosalt under the applied reaction conditions. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Recommanded Product: 75629-62-8

The Article related to knoevenagel reaction nano organosalt catalyst eco friendly process, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Recommanded Product: 75629-62-8

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On February 28, 2001, Belley, Michel; Scheigetz, John; Dube, Pascal; Dolman, Sarah published an article.Quality Control of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile The title of the article was Synthesis of N-aminoindole ureas from ethyl 1-amino-6-(trifluoromethyl)-1H-indole-3-carboxylate. And the article contained the following:

Two routes to the synthesis of Et 6-(trifluoromethyl)-1H-indole-3-carboxylate are described. N-Amination of this key intermediate with O-(diphenylphosphinyl)hydroxylamine and subsequent reactions with aryl isocyanates, using pyridine as solvent, gave 1-indolylureas in good yields. The experimental process involved the reaction of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile(cas: 13544-06-4).Quality Control of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile

The Article related to indolylurea preparation, indolecarboxylate preparation isocyanate addition, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Quality Control of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile

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On February 23, 2006, Clayton, Joshua; Ma, Fupeng; Van Wagenen, Bradford; Ukkiramapandian, Radhakrishnan; Egle, Ian; Empfield, James; Isaac, Methvin; Slassi, Abdelmalik; Steelman, Gary; Urbanek, Rebecca; Walsh, Sally published a patent.COA of Formula: C10H8FNO2 The title of the patent was Preparation of isoindolones as metabotropic glutamate receptor potentiators. And the patent contained the following:

The title compounds I [R1 = (un)substituted 3-7 membered ring that may contain one or more heteroatoms selected from N, O and S; R2, R3 = H, alkyl, aryl, etc.; R4, R6 = H, OH, halo, etc.; R5 = H, halo, NO2, etc.; R7 = H, halo, NO2, etc.; R8, R9 = H, halo, NO2, etc.; or, where n is greater than 1, two or more R8 and/or R9 on adjacent carbons may be absent to form an alkenyl or alkynyl moiety], useful as metabotropic glutamate receptor modulators, particularly in neurol. and psychiatric disorders, were prepared E.g., a multi-step synthesis of II, was given. Generally, compounds I were active in assays described (e.g., mGluR2 assay) at concentrations (or with EC50 values) less than 10 μM. The pharmaceutical composition comprising the compound I is disclosed. The experimental process involved the reaction of Methyl 2-cyano-4-fluoro-6-methylbenzoate(cas: 877151-43-4).COA of Formula: C10H8FNO2

The Article related to isoindolone preparation metabotropic glutamate receptor potentiator mglur2, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.COA of Formula: C10H8FNO2

Referemce:
Nitrile – Wikipedia,
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