Month: November 2022

On December 23, 2013, Ranise, Angelo; Lucchesini, Francesco; Caviglia, Matteo; Alfei, Silvana; Spallarossa, Andrea; Caneva, Chiara published an article.Recommanded Product: 2-((1H-Indol-3-yl)methylene)malononitrile The title of the article was Unconventional stereoselective one-pot synthesis of Knoevenagel-type indoles via in situ condensation of iminium salts with active methylene reagents. And the article contained the following:

A simple one-pot procedure for the stereoselective synthesis of Knoevenagel-type indoles is described. The method is based on the in situ reaction of indole iminium salts (four of them are fully characterized) with acyclic sym. and unsym. active methylene reagents in the presence of triethylamine. In general, the overall yields are moderate to good. Some of relevant reaction parameters and steric effects affecting stereoselectivity are discussed. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Recommanded Product: 2-((1H-Indol-3-yl)methylene)malononitrile

The Article related to stereoselective knoevenagel condensation iminium methylene, indole preparation, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Recommanded Product: 2-((1H-Indol-3-yl)methylene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On March 16, 2021, Levkov, Igor V.; Kysil, Andrii I.; Biitseva, Angelina V.; Shilin, Sergey V.; Saffon-Merceron, Nathalie; Yegorova, Tatyana V.; Voitenko, Zoia V. published an article.COA of Formula: C8H5BrFN The title of the article was Synthesis of 2-(methoxymethyl)isoindolin-1-imine derivatives via an unusual Delepine reaction. And the article contained the following:

The synthesis of 2-(methoxymethyl)isoindolin-1-imine derivatives via an unusual Delepine reaction was reported. The substrate substituents’ influence on the reaction course was studied, and a possible reaction mechanism proposed. The structure of 2-(methoxymethyl)isoindolin-1-imine was confirmed by X-ray diffraction anal. The experimental process involved the reaction of 2-(Bromomethyl)-6-fluorobenzonitrile(cas: 1261686-95-6).COA of Formula: C8H5BrFN

The Article related to methoxymethylisoindolinimine preparation, bromomethylbenzonitrile methanol delepine reaction, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.COA of Formula: C8H5BrFN

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On November 4, 2016, Choi, Isaac; Chung, Hyunho; Park, Jang Won; Chung, Young Keun published an article.SDS of cas: 13544-06-4 The title of the article was Active and Recyclable Catalytic Synthesis of Indoles by Reductive Cyclization of 2-(2-Nitroaryl)acetonitriles in the Presence of Co-Rh Heterobimetallic Nanoparticles with Atmospheric Hydrogen under Mild Conditions. And the article contained the following:

A cobalt-rhodium heterobimetallic nanoparticle-catalyzed reductive cyclization of 2-(2-nitroaryl)acetonitriles to indoles has been achieved. The tandem reaction proceeds without any additives under the mild conditions (1 atm H2 and 25 °C). This procedure could be scaled up to the gram scale. The catalytic system is significantly stable under these reaction conditions and could be reused more than ten times without loss of catalytic activity. The experimental process involved the reaction of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile(cas: 13544-06-4).SDS of cas: 13544-06-4

The Article related to indole synthesis reductive cyclization nitroarylacetonitrile cobalt rhodium nanoparticle catalyst, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.SDS of cas: 13544-06-4

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On May 1, 2014, Papeo, Gianluca Mariano Enrico; Krasavin, Mikhail Yurievitch; Orsini, Paolo; Scolaro, Alessandra published a patent.Recommanded Product: 877151-43-4 The title of the patent was Preparation of carboxamido-isoindolinone derivatives as selective PARP-1 inhibitors. And the patent contained the following:

Provided are substituted 4-carboxamido-isoindolinone derivatives of formula I which selectively inhibit the activity of poly (ADP-ribose) polymerase (PARP-1) useful in the treatment of cancer, cardiovascular disease, central nervous system injury, and inflammation. I [wherein R is H or fluorine, when (a) n is 0 and m is 0, 1, 2, or 3 then R1 is 3- to 6-membered cycloalkyl or 4- to 6-membered heterocyclyl; and R2 is 3-, 5-, or 6-membered cycloalkyl, 4- to 6-membered heterocyclyl, or (hetero)aryl; (b) n is 1 and m is 0 then R1 is 3- to 6-membered cycloalkyl or aryl each which is optionally substituted; and R2 is null, 3- to 6-membered cycloalkyl, 4- to 6-membered heterocyclyl, (hetero)aryl, each which is optionally substituted; (c) n is 2 or 3 and m is 0 then R1 is 3- to 6-membered cycloalkyl, 4-to 6-membered heterocyclyl, or (hetero)aryl, each which is optionally substituted; and R2 is null, 3- to 6-membered cycloalkyl, 4- to 6-membered heterocyclyl, (hetero)aryl, each which is optionally substituted; (d) n and m are each independently 1, 2, or 3; R1 and R2 are independently 3- to 6-membered cycloalkyl, 4- to 6-membered heterocyclyl, or (hetero)aryl] or pharmaceutically acceptable salts thereof are claimed and exemplified. II was prepared in a multistep procedure (preparation given). I were assayed for antitumor activity in Capan-1 BRCA-2 mutated mouse model from which it was determined III exhibited tumor growth inhibition of 54% with no evidence of toxicity. The present invention also provides processes for preparing I and pharmaceutical compositions comprising I. The experimental process involved the reaction of Methyl 2-cyano-4-fluoro-6-methylbenzoate(cas: 877151-43-4).Recommanded Product: 877151-43-4

The Article related to carboxamidoisoindolinone derivative preparation parp inhibitor cancer inflammation cardiovascular disease, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Recommanded Product: 877151-43-4

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On August 6, 2021, Liu, Lu; Li, Lei; Wang, Xin; Sun, Ran; Zhou, Ming-Dong; Wang, He published an article.Reference of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile The title of the article was Mn(III)-Mediated Radical Cyclization of o-Alkenyl Aromatic Isocyanides with Boronic Acids: Access to N-Unprotected 2-Aryl-3-cyanoindoles. And the article contained the following:

The synthesis of N-unprotected 2-aryl-3-cyanoindoles was realized via the Mn(III)-mediated radical cascade cyclization of o-alkenyl aromatic isocyanides with boronic acids. A possible mechanism involving a sequential intermol. radical addition, intramol. cyclization, and cleavage of the C-C bond under mild reaction conditions is proposed. Mechanism studies show that H2O or O2 might provide the oxygen source for the elimination of benzaldehyde. The experimental process involved the reaction of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile(cas: 13544-06-4).Reference of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile

The Article related to aryl cyanoindole preparation regioselective, alkenyl aromatic isocyanide boronic acid radical addition cyclization, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Reference of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On June 30, 1994, Mahboobi, Siavosh; Grothus, Goetz published an article.Category: nitriles-buliding-blocks The title of the article was 1,3-Dinitropropanes: intermediates to 1,3-diaminopropanes. And the article contained the following:

Reduction of malodinitriles RCH(CN)2 (R = di-p-anisylmethyl, 3-indolylmethyl) to the corresponding diamines does not work. Reduction of dinitro-2-(indol-3-yl)propanes and subsequent reaction with K2PtCl4 afforded dichloroplatinum(II) complexes I [R1 = H, Me, Et; R2 = H, Me, Ph; R3 = H (17); R1 = Et, R2 = 4-HOC6H4, R3 = 5- or 6-HOC6H4]. Complexes 17 show weak binding affinities to the estrogen receptor and no antitumor activity towards MCF-7- and MDA-MB-2231-cell lines. Two-fold addition of nitromethane to the aldehyde function is possible. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Category: nitriles-buliding-blocks

The Article related to indolylpropanediamine preparation reaction, propanediamine indolyl, platinum indolylpropanediamine preparation antitumor, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Category: nitriles-buliding-blocks

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Belley, Michel; Sauer, Effiette; Beaudoin, Daniel; Duspara, Petar; Trimble, Laird A.; Dube, Pascal published an article in 2006, the title of the article was Synthesis and reactivity of N-hydroxy-2-aminoindoles.Reference of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile And the article contains the following content:

Catalytic hydrogenation of (2-nitrophenyl)acetonitriles I (R1 = H, Cl, F, F3C, MeO, MeSO2, MeCONH; R2 = EtO2C, CN, MeSO2, PhSO2) bearing an electron-withdrawing substituent α to the nitrile, using Pd/C and (Ph3P)4Pd, affords N-hydroxy-2-aminoindoles II in good to excellent yields. (Ph3P)4Pd decreases the reduction rate of the intermediate hydroxylamine and acts as a catalyst during the cyclization onto the nitrile. The experimental process involved the reaction of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile(cas: 13544-06-4).Reference of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile

The Article related to acetonitrile nitrophenyl hydrogenation palladium catalyst, indole hydroxy amino preparation alkylation reduction acylation, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Reference of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On June 30, 1980, Moriya, Tamon; Hagio, Katsuaki; Yoneda, Naoto published an article.Application of 75629-62-8 The title of the article was Preparation and reactions of 3-(aminomethylene)-3H-indoles. And the article contained the following:

3-(Aminomethylene)-3H-indoles I (R = H, 5-OMe, 6-Me, 6-Cl; NR1R2 = pyrrolidino, piperidino, morpholino, NEt2, NBu2, NMe2) were prepared by the condensation of 3-indolecarboxaldehydes with secondary amines. Some were obtained as stable colorless prisms, while 3-(piperidinomethylene)-3H-indole and 3-(morpholinomethylene)-3H-indole readily polymerized in refluxing benzene. Reaction of I with electrophiles, such as alkyl and acyl halides, gave 1-substituted 3-aminomethylene-3H-indolium salts, which were converted to the corresponding 1-substituted 3-indolecarboxaldehydes by hydrolysis. Reaction of I with active methylene compounds proceeded under mild conditions to afford the condensation products in good yields. Successive reaction of I with electrophiles and nucleophiles provided a convenient route to 1,3-disubstituted indole derivatives The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Application of 75629-62-8

The Article related to indolecarboxaldehyde enamine preparation reaction, aminomethyleneindole preparation substitution, indolium salt aminomethylene, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Application of 75629-62-8

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On June 30, 2009, Li, Xun; Ng, Raymond A.; Zhang, Yongzheng; Russell, Ronald K.; Sui, Zhihua published an article.Safety of 4,5-Diamino-2-(trifluoromethyl)benzonitrile The title of the article was An efficient synthetic process for scale-up production of 4,5-diamino-2-(trifluoromethyl)benzonitrile and 5-bromo-3-(trifluoromethyl)benzene-1,2-diamine. And the article contained the following:

Starting from 4-amino-2-(trifluoromethyl)benzonitrile, an efficient and nonchromatog. process was developed for multihundred gram production of 4,5-diamino-2-(trifluoromethyl)benzonitrile in 73% yield and 98 HPLC area% purity over four synthetic steps. The same synthetic strategy was applied to 4-bromo-2-(trifluoromethyl)aniline that afforded 5-bromo-3-(trifluoromethyl)benzene-1,2-diamine in 81% overall yield and 99% HPLC area% purity. The experimental process involved the reaction of 4,5-Diamino-2-(trifluoromethyl)benzonitrile(cas: 882978-62-3).Safety of 4,5-Diamino-2-(trifluoromethyl)benzonitrile

The Article related to fluoromethyldiaminobenzonitrile production, bromotrifluoromethylbenzenediamine production, amination aniline fluoromethyl derivative, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Safety of 4,5-Diamino-2-(trifluoromethyl)benzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts