Month: November 2022

Yuan, Chang; Tan, Hao; Jiang, Xue-Fei; Liu, Si; Jiang, Lu; Cao, Qi-Ying; Xu, Xing-Jie; Deng, Xiao-Yan; Pan, Guan-Nan; Chen, Jian-Yang; Cui, Hai-Lei published an article in 2019, the title of the article was Phosphine-Catalyzed [3+2] Cycloaddition and Vinylation of Indole-Derived 伪,伪-Dicyanoolefins with 纬-Substituted Allenoates.COA of Formula: C12H7N3 And the article contains the following content:

A phosphine-catalyzed [3+2] cycloaddition of 纬-substituted allenoates RCH=C=CHR1 (R = H, Ph, 4-chlorophenyl, (CH2)4CH3; R1 = C(O)OCH2C6H5, C(O)OMe, C(O)OEt) with 伪,伪-dicyanoolefins I (R2 = SO2C6H5, tosyl, CH2C6H5, etc.; R3 = H, 5-Br, 5-MeO, 6-Cl) has been established, affording indole-incorporated highly functionalized cyclopentenes II. In addition, the vinylated indole-derived 伪,伪-dicyanoolefins III (R4 = Ph, 4-chlorophenyl, phenethyl) have also been realized under the same reaction conditions by switching to indole-derived 伪,伪-dicyanoolefins without protective group at N-1 position I (R2 = H). The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).COA of Formula: C12H7N3

The Article related to indole dicyanoolefin preparation regioselective diastereoselective enantioselective, dicyanoolefin allenoate cycloaddition reaction phosphine catalyst, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.COA of Formula: C12H7N3

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On June 30, 2011, Jain, Shubha; Bhimireddy, Nagi Reddy; Kolisetty, Sambasiva Rao published an article.Computed Properties of 75629-62-8 The title of the article was L-proline catalyzed Knoevenagel condensation: synthesis of some new indole derivatives and biological activities. And the article contained the following:

Knoevenagel condensation of various heteroaromatic aldehydes with active methylene compounds like malononitrile, Et cyanoacetate, barbituric acid, meldrum’s acid and dimedone proceeds smoothly with stirring under conventional heating. Twenty Knoevenagel condensation products were synthesized with excellent yields. The indole derivatives, e.g., I, were also screened for their antibacterial activity. The work-up procedure is very simple and the products do not require further purification The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Computed Properties of 75629-62-8

The Article related to indole substituted preparation bacterial infection antibacterial activity, indolecarboxaldehyde active methylene knoevenagel condensation proline catalyst, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Computed Properties of 75629-62-8

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Siddegowda, K. Somashekarappa; Zabiulla, K. Mohammed; Yellappa, Shivaraj published an article in 2016, the title of the article was Synthesis of new potential indole-3-yl derivatives via Knoevenagel condensation.Safety of 2-((1H-Indol-3-yl)methylene)malononitrile And the article contains the following content:

Knoevenagel reaction between indole-3-carboxaldehyde and active methylene or non-active methylene compounds RCH2R1 [R = CN, NO2, C(O)OCH2CH3, C(O)OCH3; R1 = CN, H, C(O)OCH2CH3, C(O)OCH3] yielded the corresponding condensation product, indole-3-yl derivatives I (R2 = H) and then their N-acetylation with acetyl chloride afforded N-acetyl-1H-indol-3-yl derivatives I [R2 = CH3C(O)]. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Safety of 2-((1H-Indol-3-yl)methylene)malononitrile

The Article related to indolylcarboxaldehyde methylene compound knoevenagel, indolyl methylene preparation acetyl chloride acylation, acetyl indolyl methylene preparation green chem, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Safety of 2-((1H-Indol-3-yl)methylene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On October 9, 2002, Dombroski, Mark Anthony; Laird, Ellen Ruth; Letavic, Michael Anthony; McClure, Kim Francis published a patent.Application In Synthesis of 3-Chloro-4-nitrobenzonitrile The title of the patent was Preparation of novel benzotriazoles as anti-inflammatory compounds. And the patent contained the following:

The title compounds [I; Het = (un)substituted pyrrolyl, imidazolyl, pyrazolyl, oxazolyl, etc.; R2 = H, alkyl, cycloalkyl, etc.; R3 = H, alkyl, Ph, etc.; s = 0-5] which are potent inhibitors of MAP kinases, preferably p38 kinase (no data given), and are useful in the treatment of inflammation, osteoarthritis, rheumatoid arthritis, cancer, reperfusion or ischemia in stroke or heart attack, autoimmune diseases and other disorders, were prepared Thus, treating a solution of 3-isopropyl-3H-benzotriazole-5-carbaldehydein THF with concentrate NH4OH followed by addition of piperazine and isocyanide II afforded III. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Application In Synthesis of 3-Chloro-4-nitrobenzonitrile

The Article related to benzotriazole preparation map p38 kinase inhibitor antiinflammatory, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Application In Synthesis of 3-Chloro-4-nitrobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On October 30, 2020, Wang, Wenlong; Li, Jia; Zhou, Yubo; Yu, Lijie; Meng, Xiangdong; Feng, Bo; Wang, Zhijia; Wu, Jing published a patent.Application of 34662-29-8 The title of the patent was Preparation and pharmaceutical applications oxadiazole derivatives. And the patent contained the following:

The present invention relates to the preparation of oxadiazole derivatives, a pharmaceutical composition and application, and belongs to the tech. field of medicine. In particular, oxadiazoles I [wherein, X1, X2, X3, X4 are each independently selected from N, CR1, CR2, CR3; wherein R1, R2, R3 are each independently selected from substituted aromatic ring, NHR4, COR5, -CH2NHRa, etc., where Ra is (un)substituted furanyl, (un)substituted tetrahydrofuranyl, thienyl etc.]. Further [substituted aromatic ring, substituted heteroaromatic ring, substituted alkenyl and substituents on substituted cyclopropyl are independently selected from -F, -Cl, mono- or di-substituted NHCOR6 etc., where R4 is (un)substituted C1-6 alkyl, R5 is C1-6 alkoxy or C1-10 alkylamino or aromatic ring substituted benzylamino or substituted anilino, R6 is (un)substituted furanyl, thienyl, chloromethyl, etc.; or substituted aromatic ring is 1-methyl-2,3-dioxo-4H-quinoxalin-6-yl, 4-(1-piperidyl)phenyl, 1-isopropyl-2,3-dioxo-4H-quinoxalin-6-yl, etc.] were prepared The oxygen-containing five-membered heterocycle of the present invention has the biol. activity of inhibiting protein tyrosine phosphatase SHP2, and can be used as a tool compound to study the biol. function relevance of protein tyrosine phosphatase SHP2 in the process of cell signal transduction, for prevention and provide new methods for the treatment of cancer, metabolism and immune diseases. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Application of 34662-29-8

The Article related to oxadiazole derivative preparation protein tyrosine phosphatase shp inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Application of 34662-29-8

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Mandour, A. H.; Fathalla, O. A.; Basyouni, W. M. published an article in 2000, the title of the article was Synthesis of 2-(3-indolyl)-3,5-dihydro-[1,2,4]triazolo-[1,5-a]-5-pyridone and 2-pyridone derivatives.Recommanded Product: 75629-62-8 And the article contains the following content:

Indole-3-carboxaldehyde condensed with cyanoacetohydrazide to yield 3-indolylidinecyanoacetohydrazide (I). I condensed with different arylidenemalononitriles in presence of a base to give 7-aryl-6,8-dicyano-2-(3-indolyl)[1,2,4]triazolo[1,5-a]-pyridin-5-ones. Also, the condensation of I with different Et arylidenecyanoacetates gave the corresponding 4-aryl-3,5-dicyano-6-hydroxy-N-1-(3-indolylidine)pyridin-2-ones. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Recommanded Product: 75629-62-8

The Article related to indolyltriazolopyridinone preparation, triazolopyridinone indolyl preparation, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Recommanded Product: 75629-62-8

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On March 31, 2021, Ramana Reddy, Ch. Venkata; Reddy, G. Ganga published an article.HPLC of Formula: 75629-62-8 The title of the article was Simple, Stepwise and Alternative Syntheses of Indolyl Triazoles via Huisgen’s 1,3-dipolar Cycloaddition Reaction. And the article contained the following:

A series of new 2-((1-((1-(4-methoxy-3-nitrophenyl)-1H-1,2,3-triazol-4-yl)methyl)1H-indol-3-yl)methylene)malononitrile derivatives I (X = H, NO2, Br; R1 = H, NO2; R2 = Me, OMe, CN) were synthesized by the 1,3-dipolar cycloaddition reaction (click reaction) of 2-((1-(prop-2-yn-1-yl)-1H-indol-3-yl)methylene)malononitrile with different aryl azides in the presence of sodium ascorbate and copper sulfate in good yields. The advantages of this method are efficient, clean, high yields, easy workup procedures, and shorter reaction time. These reactions are very facile, giving products by simple processing that does not require purification by column chromatog. Spectroscopic methods confirmed all the newly synthesized compounds The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).HPLC of Formula: 75629-62-8

The Article related to indolyl triazole preparation, propynyl indolyl methylene malononitrile aryl azide huisgens dipolar cycloaddition, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.HPLC of Formula: 75629-62-8

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Shi, Wei-Min; Liu, Feng-Ping; Wang, Zhi-Xin; Bi, Hong-Yan; Liang, Cui; Xu, Li-Ping; Su, Gui-Fa; Mo, Dong-Liang published an article in 2017, the title of the article was Synthesis of 1-Vinyl/Arylbenzotriazole 3-Oxides through a Copper-Mediated C-N Bond Coupling Reaction.COA of Formula: C7H3ClN2O2 And the article contains the following content:

An efficient synthesis of 1-vinyl/arylbenzotriazole 3-oxides, e.g., I via the copper-promoted coupling of N-hydroxybenzotriazoles with alkenyl- or arylboronic acids is reported. This strategy features mild reaction conditions, good functional group tolerance, broad substrate scope and rapid introduction of benzotriazole N-oxide moieties into mols. D. functional theory calculations revealed that the formation of the favored N-coupling product depends on the kinetically more favorable C-N bond formation pathway. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).COA of Formula: C7H3ClN2O2

The Article related to vinylbenzotriazole arylbenzotriazole oxide preparation, hydroxybenzotriazole alkenylboronic arylboronic acid coupling copper catalyst, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.COA of Formula: C7H3ClN2O2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On February 1, 2007, Brooks, Carl; Cleary, Pamela A.; Goodman, Krista B.; Peace, Simon; Philp, Joanne; Sehon, Clark A.; Smethurst, Christian; Watson, Stephen Paul published a patent.Electric Literature of 13544-06-4 The title of the patent was Preparation of azolylmethylbenzenesulfonamides as CCR2 chemokine receptor antagonists.. And the patent contained the following:

Title compounds [I; R1 = (substituted) aryl, thienyl, benzothienyl, imidazolyl, pyridyl, isoquinolinyl, piperonyl, benxoxathiadiazolyl, benzodiazolyl; m = 1-3; R2 = halo, cyano, OCF3, CF3; R3 = (substituted) heteroaryl, heterocycloalkyl], were prepared as CCR2 chemokine receptor antagonists (no data). Thus, [5-chloro-2-(1H-1,2,3-triazol-1-ylmethyl)phenyl]amine (preparation given) in pyridine was treated with 4-dimethylaminopyridine and 3,4-dichlorobenzoyl chloride followed by heating of the mixture at 90掳 for 4 h to give 3,4-dichloro-N-[5-chloro-2-(1H-1,2,3-triazol-1-ylmethyl)phenyl]benzenesulfonamide. The experimental process involved the reaction of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile(cas: 13544-06-4).Electric Literature of 13544-06-4

The Article related to azolylmethylbenzenesulfonamide preparation ccr2 chemokine receptor antagonist, benzenesulfonamide azolylmethyl preparation ccr2 chemokine receptor antagonist, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Electric Literature of 13544-06-4

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts