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Stazi, Federica et al. published their research in Synthesis in 2010 |CAS: 13544-06-4

The Article related to arylacetonitrile preparation, acetonitrile aryl preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Nitriles, Isonitriles, and Acyl Cyanides and other aspects.Application In Synthesis of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile

On October 1, 2010, Stazi, Federica; Maton, William; Castoldi, Damiano; Westerduin, Pieter; Curcuruto, Ornella; Bacchi, Sergio published an article.Application In Synthesis of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile The title of the article was Efficient methods for the synthesis of arylacetonitriles. And the article contained the following:

Various approaches to [2-fluoro-4-(trifluoromethyl)phenyl]acetonitrile were investigated. Two of these methods were selected and applied to a variety of electron-deficient substrates, thereby expanding the scopes of the procedures. The experimental process involved the reaction of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile(cas: 13544-06-4).Application In Synthesis of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Waghmare, Smita R. et al. published their research in Indian Journal of Chemistry in 2021 |CAS: 75629-62-8

The Article related to alkene preparation stereoselective green chem, aldehyde active methylene compound knoevenagel condensation ammonium chloride peg400, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Nitriles, Isonitriles, and Acyl Cyanides and other aspects.Safety of 2-((1H-Indol-3-yl)methylene)malononitrile

Waghmare, Smita R. published an article in 2021, the title of the article was Ammonium chloride catalyzed Knoevenagel condensation in PEG-400 as ecofriendly solvent.Safety of 2-((1H-Indol-3-yl)methylene)malononitrile And the article contains the following content:

A simple and selective green methodol. has been successfully developed for Knoevenagel condensation in polyethylene glycol-400 using 10 mol % ammonium chloride as catalyst. The method is applicable to a wide range of aromatic, heteroaromatic and 伪,尾-unsaturated aldehydes. The reactions have been found to be clean and free from the formation of the Michael adduct. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Safety of 2-((1H-Indol-3-yl)methylene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Koeckritz, Peter et al. published their patent in 1985 |CAS: 2510-01-2

The Article related to aminocyanobutadiene pharmaceutical synthon, cyanobutadiene amino pharmaceutical synthon, butadiene aminocyano pharmaceutical synthon, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Nitriles, Isonitriles, and Acyl Cyanides and other aspects.Computed Properties of 2510-01-2

On February 20, 1985, Koeckritz, Peter; Liebscher, Alexander published a patent.Computed Properties of 2510-01-2 The title of the patent was N,N,1,2,3-Pentasubstituted 4-amino-1-cyano-1,3-butadiene. And the patent contained the following:

R2R3NCH:CR1CR:CXCN [R,R1 = alkyl, aryl; RR1 = (CH2)n (n = 3-5); R2, R3 = alkyl, aryl; R2R3 = (CH2)4, (CH2)5, (CH2)2O(CH)2; X = CN, carbonyl such as acyl, alkoxycarbonyl, H2NCO, NO2, aryl], useful as synthons for pharmaceuticals were prepared by reaction of R1CH2CR:CXCN with HC(OR4)3 (R4 = alkyl) and HNR2R3 in the presence of acidic condensation agent by 8 methods. A mixture of 2-O2NC6H4CO2H and 0.01 mol HNPhMe was treated with 0.015 mol HC(OEt)3 and 0.01 mol Me2C:C(CN)2 and the mixture refluxed 30 min. to give 65% MePhNCH:CHCMe:C(CN)2. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Computed Properties of 2510-01-2

Referemce:
Nitrile – Wikipedia,
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Yadav, Jhillu S. et al. published their research in European Journal of Organic Chemistry in 2004 |CAS: 75629-62-8

The Article related to arylaldehyde cyanoacetate knoevenagel condensation, arylidene cyanoacetate stereoselective preparation, phosphane knoevenagel condensation catalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Nitriles, Isonitriles, and Acyl Cyanides and other aspects.COA of Formula: C12H7N3

On January 30, 2004, Yadav, Jhillu S.; Reddy, Basi V. Subba; Basak, Ashok K.; Visali, Boddapati; Narsaiah, Akkirala Venkat; Nagaiah, Kommu published an article.COA of Formula: C12H7N3 The title of the article was Phosphane-catalyzed Knoevenagel condensation: A facile synthesis of 伪-cyanoacrylates and 伪-cyanoacrylonitriles. And the article contained the following:

Triphenylphosphane has been utilized as an efficient catalyst for the Knoevenagel condensation of aldehydes with acidic methylene compounds such as Et cyanoacetate and malononitrile to afford substituted olefins, e.g., I. The reaction proceeded smoothly under solvent-free conditions and the products were obtained in excellent yields with an E-geometry. This method was applied to a wide range of aldehydes including aromatic, aliphatic and heterocyclic substrates. Microwave irradiation has been used to achieve enhanced reaction rates and improved yields. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).COA of Formula: C12H7N3

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Haight, Anthony R. et al. published their research in Organic Process Research & Development in 2004 |CAS: 5098-14-6

The Article related to fiduxosin scalable synthesis, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Recommanded Product: 2-Aminomalononitrile 4-methylbenzenesulfonate

On December 31, 2004, Haight, Anthony R.; Bailey, Anne E.; Baker, William S.; Cain, Michael H.; Copp, Richard R.; DeMattei, John A.; Ford, Kelley L.; Henry, Rodger F.; Hsu, Margaret C.; Keyes, Robert F.; King, Steven A.; McLaughlin, Maureen A.; Melcher, Laura M.; Nadler, William R.; Oliver, Patricia A.; Parekh, Shyamal I.; Patel, Hemant H.; Seif, Louis S.; Staeger, Mike A.; Wayne, Gregory S.; Wittenberger, Steven J.; Zhang, Weijiang published an article.Recommanded Product: 2-Aminomalononitrile 4-methylbenzenesulfonate The title of the article was A Scaleable Synthesis of Fiduxosin. And the article contained the following:

Fiduxosin (I) is under development for the treatment of benign prostatic hyperplasia. A convergent strategy required methodologies for preparation of an enantiomerically pure 3,4-cis-disubstituted pyrrolidine and a 2,3,5-trisubstituted thienopyrazine in a regiospecific manner. A [3+2] cycloaddition of an enantiopure azomethine ylide followed by a diastereoselective crystallization was employed to prepare the benzopyranopyrrolidine in high diastereomeric and enantiomeric purity. Conditions for reduction of an O-aryl lactone susceptible to epimerization were developed, and cyclization of the alc./phenol to the ether was accomplished in high yield. The thienopyrazine was prepared by condensation of Me thioglycolate and a regiospecifically prepared 2-bromo-3-cyano-5-phenylpyrazine. Conditions for effective halogen substitutive deamination to prepare regiospecific trisubstituted pyrazines is described. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Recommanded Product: 2-Aminomalononitrile 4-methylbenzenesulfonate

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Shey, Chun Feng et al. published their research in Shida Xuebao (Taipei) in 1984 |CAS: 5098-14-6

The Article related to aminopteridine, pteridine diamino, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Quality Control of 2-Aminomalononitrile 4-methylbenzenesulfonate

Shey, Chun Feng; Chen, Chao Tung; Horng, Jhy Ming; Wang, Cheng Hsia published an article in 1984, the title of the article was Synthesis of 2,4-diamino-6-substituted pteridine.Quality Control of 2-Aminomalononitrile 4-methylbenzenesulfonate And the article contains the following content:

Title compounds I (R = Cl, OH), intermediates for methotrexate, were prepared Thus, cyclocondensation of 2,4,5,6-tetraaminopyrimidine with CO(CH2OH)2 gave I (R = OH) whereas cyclocondensation of 2-amino-3-cyano-5-chloromethylpyrazine with guanidine gave I (R = Cl). The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Quality Control of 2-Aminomalononitrile 4-methylbenzenesulfonate

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Grosse, Sandrine Celine et al. published their patent in 2020 |CAS: 1261686-95-6

The Article related to heterocycle preparation antiviral, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.COA of Formula: C8H5BrFN

On December 3, 2020, Grosse, Sandrine Celine; Deratt, Lindsey Graham; Vandyck, Koen; Raboisson, Pierre Jean-Marie Bernard; Pieters, Serge Maria Aloyssius; Kesteleyn, Bart Rudolf Romanie; Verschueren, Wim Gaston; Berke, Jan Martin; LeComte, Morgan Charles R.; Martinez Lamenca, Carolina; Jonckers, Tim Hugo Maria; Deng, Gang; Jiang, Yimin; Xu, Yanping; Cheng, Zhangling; Hu, Lili; Kuduk, Scott D. published a patent.COA of Formula: C8H5BrFN The title of the patent was Fused heterocyclic derivatives as antiviral agents and their preparation. And the patent contained the following:

The application describes fused heterocycle derivatives of formula I, pharmaceutical compositions comprising these compounds, chem. processes for preparing these compounds and their use in the treatment of diseases associated with HBV infection. Compounds of formula I wherein A is absent and CH2; X is CH2 and O; Y is NH and derivatives; W is CHR3 and CH:CH2; Z is CO and CS; R1 is (un)substituted 5- to 10-membered (mono/bi)cyclic ring optionally containing heteroatoms; R2 is H and (un)substituted C1-4 alkyl; R3 is H, F, OH, (un)substituted C1-4 alkyl, etc.; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by cyclization of Et 2-(2-aminoethyl)-5-(3,4-dichlorobenzoyl)-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine-3-carboxylate bistrifluoroacetate. The invention compounds were evaluated for their antiviral activity. From the assay, it was determined that compound II exhibited an EC50 value 9.628渭M and a CC50 value of > 50渭M. The experimental process involved the reaction of 2-(Bromomethyl)-6-fluorobenzonitrile(cas: 1261686-95-6).COA of Formula: C8H5BrFN

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Yalcin, Ergin et al. published their research in Tetrahedron in 2019 |CAS: 2510-01-2

The Article related to amino heteroaryl blue emitting fluorescent dye preparation photophys property, Dyes, Organic Pigments, Fluorescent Brighteners, and Photographic Sensitizers: Fluorescent Brighteners and other aspects.Safety of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

On August 30, 2019, Yalcin, Ergin; Duyar, Halil; Cakmaz, Deniz; Sahin, Ertan; Seferoglu, Zeynel published an article.Safety of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile The title of the article was The synthesis of blue emitting 3-Amino-1-hetarylfluorenes and their unprecedented alkylated derivatives. And the article contained the following:

Novel 3-Amino-1-hetarylfluorene derivatives have medicinal uses and challenging transformation in organic synthesis have been synthesized via decyanation process. Surprisingly, the alkylated compounds derived from 3-Amino-1-hetarylfluorenes were obtained via further nucleophilic substitution to the 9-C and 3-N positions of the fluorene ring because of the harsh reaction condition employed. The synthesized compounds were characterized by spectroscopic techniques as well as X-ray single crystal diffraction anal. This new family of blue emitting fluorene derivatives have low to moderate quantum yields (the largest value of 蠁F = 0.52 for compound 15). The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Safety of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Hilf, Justin A. et al. published their patent in 2022 |CAS: 2510-01-2

The Article related to spiroindenequinazolinylpiperazine preparation kras protein g12c mutation inhibitor antitumor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.COA of Formula: C12H8N2

On June 2, 2022, Hilf, Justin A.; Rose, Tristin E.; Bartberger, Michael D.; O’Boyle, Brendan M.; Reeves, Corey M.; Loson, Oliver C.; Stoltz, Brian M.; McDermott, Martina; O’Brien, Neil A.; Slamon, Dennis published a patent.COA of Formula: C12H8N2 The title of the patent was Preparation of substituted N-(spiro[indene-2,7′-quinazolin]-4′-yl)piperazines as Kras G12C inhibitors. And the patent contained the following:

The invention relates to compounds I [x1 = C(O) or C(R1)(R2); x2 = a bond, CO, O, etc.; y1b and y1c = independently C=CH2, CO, O, S, etc.; z1-z4 = independently C and N; R1 and R2 = independently H and F; R3 = independently H, (halo)alkyl; R4-R7 = independently H, F, Cl, Me, etc., R8a = H, alkyl, cycloalkyl, etc.; R8b = H, CN, halo, etc.; with the provisons], and pharmaceutically acceptable salts thereof, and methods of making and using the same. The compounds I are effective in inhibiting KRAS protein with a G12C mutation and are suitable for use in methods of treating cancers mediated, in whole or in part, by KRAS G12C mutation. E.g., a multi-step synthesis of II鈥FA, starting from 5,6,7,8-tetrahydroquinazoline-2,4-diol, was described. Exemplified compounds I were tested for their KRAS G12C inhibitory activity (data given for representative compounds I). Pharmaceutical composition comprising compound I was disclosed. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).COA of Formula: C12H8N2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Feenstra, Roelof W. et al. published their patent in 2006 |CAS: 34662-29-8

The Article related to phenylpiperazine preparation dopamine d2 receptor serotonin reuptake inhibitor, cns agent phenylpiperazine preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Recommanded Product: 34662-29-8

On June 15, 2006, Feenstra, Roelof W.; Stoit, Axel; Terpstra, Jan-Willem; Pras-Raves, Maria L.; McCreary, Andrew C.; Van Vliet, Bernard J.; Hesselink, Mayke B.; Kruse, Cornelis G.; Van Scharrenburg, Gustaaf J. M. published a patent.Recommanded Product: 34662-29-8 The title of the patent was Preparation of phenylpiperazine derivatives with a combination of partial dopamine-d2 receptor agonism and serotonin reuptake inhibition. And the patent contained the following:

The invention relates to a group of novel phenylpiperazine derivatives I [X = S or O; R1 = H, alkyl, CF3, OH, etc.; R2 = H, halo, CN, or alkyl; R3 = H or alkyl; R4 = H, alkyl or haloalkyl; T = (un)substituted alkyl chain which may optionally contain a N atom; Ar = naphthyl, indolyl, benzothiophenyl, etc.], and their pharmaceutically acceptable salts, which are prepared and disclosed as possessing a dual mode of action: serotonin reuptake inhibition and partial agonism on dopamine-D2 receptors. Thus, e.g., II was prepared by oxidation of 1-(3-hydroxypropyl)-6-chloroindazole to the formyl derivative which underwent reductive coupling with 3-methyl-7-piperazinyl-3H-benzoxazole-2-one. Selected compounds of the invention possessed pKi values of 7.0-8.9 in dopamine-D2 binding assays. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Recommanded Product: 34662-29-8

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts