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Van Doremaele, Gerardus Henricus Josephus et al. published their patent in 2015 |CAS: 1261686-95-6

The Article related to cyclic amidine titanium preparation polymerization catalyst, Organometallic and Organometalloidal Compounds: Groups Iiib, Ivb, Vb – Sc, Y, Lanthanides, Actinides, Ti, Zr, Hf, V, Nb, Ta and other aspects.Application In Synthesis of 2-(Bromomethyl)-6-fluorobenzonitrile

On August 6, 2015, Van Doremaele, Gerardus Henricus Josephus; Berthoud, Alexandra; Quiroga Norambuena, Victor; Rupnicki, Leszek; Karbaum, Peter published a patent.Application In Synthesis of 2-(Bromomethyl)-6-fluorobenzonitrile The title of the patent was Metal complex with a cyclic amidine ligand. And the patent contained the following:

The present invention relates to a metal complex, CyYMLjXn (Cy = cyclopentadienyl-type ligand; M = metal of group 4; L = neutral Lewis basic ligand wherein the number of said neutral ligands j = the range of 0 to the amount that satisfies the 18-electron rule; X = anionic ligand; n = integer denoting the number of anionic ligands X and is 1 or 2, preferably is 2; Y = cyclic amidine-containing ligand), wherein the amidine-containing ligand is covalently bonded to the metal M via the imine nitrogen atom. Thus, reaction of 2-cyclopentylisoindolin-1-imine hydrobromide with (C5Me5)3TiCl gave title polymerization catalyst, Me5CpTiCl2(NC(Ph)(c-C5H9N)). The experimental process involved the reaction of 2-(Bromomethyl)-6-fluorobenzonitrile(cas: 1261686-95-6).Application In Synthesis of 2-(Bromomethyl)-6-fluorobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Van Doremaele, Gerard et al. published their patent in 2015 |CAS: 1261686-95-6

The Article related to cyclic amidine titanium preparation polymerization catalyst, Organometallic and Organometalloidal Compounds: Groups Iiib, Ivb, Vb – Sc, Y, Lanthanides, Actinides, Ti, Zr, Hf, V, Nb, Ta and other aspects.Recommanded Product: 2-(Bromomethyl)-6-fluorobenzonitrile

On August 5, 2015, Van Doremaele, Gerard; Berthoud, Alexandra; Quiroga Norambuena, Victor; Rupnicki, Leszek; Karbaum, Peter published a patent.Recommanded Product: 2-(Bromomethyl)-6-fluorobenzonitrile The title of the patent was Metal complex with a cyclic amidine ligand. And the patent contained the following:

The present invention relates to a metal complex, CyYMLjXn (Cy = cyclopentadienyl-type ligand; M = metal of group 4; L = neutral Lewis basic ligand wherein the number of said neutral ligands j = the range of 0 to the amount that satisfies the 18-electron rule; X = anionic ligand; n = integer denoting the number of anionic ligands X and is 1 or 2, preferably is 2; Y = cyclic amidine-containing ligand), wherein the amidine-containing ligand is covalently bonded to the metal M via the imine nitrogen atom. Thus, reaction of 2-cyclopentylisoindolin-1-imine hydrobromide with (C5Me5)3TiCl gave title polymerization catalyst, Me5CpTiCl2(NC(Ph)(c-C5H9N)). The experimental process involved the reaction of 2-(Bromomethyl)-6-fluorobenzonitrile(cas: 1261686-95-6).Recommanded Product: 2-(Bromomethyl)-6-fluorobenzonitrile

The Article related to cyclic amidine titanium preparation polymerization catalyst, Organometallic and Organometalloidal Compounds: Groups Iiib, Ivb, Vb – Sc, Y, Lanthanides, Actinides, Ti, Zr, Hf, V, Nb, Ta and other aspects.Recommanded Product: 2-(Bromomethyl)-6-fluorobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Yoshikawa, Yoshinari et al. published their patent in 1990 |CAS: 34662-29-8

The Article related to sulfonanilide preparation antiinflammatory, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.HPLC of Formula: 34662-29-8

On January 25, 1990, Yoshikawa, Yoshinari; Ochi, Yutaka; Sekiuchi, Kazuto; Saito, Hideji; Hatayama, Katsuo published a patent.HPLC of Formula: 34662-29-8 The title of the patent was Preparation of sulfonanilide derivatives as antiinflammatory agents. And the patent contained the following:

Sulfonanilides [I; R1 = C1-4 alkyl; R2 = C1-4 alkyl, Ph, AR4 wherein R4 = Ph, halo-substituted Ph or cycloalkyl, A = O, S; R3 = halo, haloalkyl, Ph, CHO, alkoxycarbonyl, etc.] are prepared Reduction of 5.0 g nitro compound II (R = NO2) in EtOH over 5% Pd-C gave 4.4 g amine II (R = NH2), which (3.3 g) was diazotized and the diazonium salt treated with KCN to give 1.2 g cyano compound II (R = cyano) (III). III at 50 mg/kg p.o. showed 48.9% inhibition of carrageenan-induced edema in rats, vs. 41.6% inhibition with ibuprofen. Also prepared were 35 addnl. I. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).HPLC of Formula: 34662-29-8

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Vacca, Joseph P. et al. published their patent in 2020 |CAS: 1036991-35-1

The Article related to sulfonamido benzamide preparation neuroprotectant antitumor antiviral ophthalmol musculoskeletal drug, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Application In Synthesis of 3-Amino-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile

On June 11, 2020, Vacca, Joseph P.; Wager, Travis T. published a patent.Application In Synthesis of 3-Amino-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile The title of the patent was Preparation of substituted sulfonamido benzamides for the treatment of various diseases. And the patent contained the following:

The invention relates to preparation of substituted sulfonamido benzamides(I) for modulating inclusion formation and stress granules in cells related to the onset of neurodegenerative diseases, musculoskeletal diseases, cancer, ophthalmol. diseases, and viral infections. Compounds I wherein ring A is aryl or heteroaryl; R1 is H, C1-6 alkyl or C1-6 haloalkyl; R2 is C1-6 alkyl or C1-6 alkenyl, C1-6 heteroalkyl, etc.; R3-R5 each independently is H, halo, C1-6 alkyl; R6 is (un)substituted C1-6 alkyl; R7 is C1-6 alkyl, etc., are clamed. The example compound II was prepared using f 5-amino-2-chloro-benzoic acid as starting material (procedure given). Compounds I were evaluated for their biol. activity (data given). Compounds I can be used in treatment of neurodegenerative diseases, musculoskeletal diseases, cancer, ophthalmol. diseases, and viral infections. The experimental process involved the reaction of 3-Amino-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile(cas: 1036991-35-1).Application In Synthesis of 3-Amino-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Asiri, Abdullah Mohamed et al. published their research in Journal of King Abdulaziz University, Science in 1999 |CAS: 2510-01-2

The Article related to methine dye dicyanomethyleneindan preparation spectra, Dyes, Organic Pigments, Fluorescent Brighteners, and Photographic Sensitizers: Photographic Dyes, Dye Intermediates, and Sensitizers and other aspects.Product Details of 2510-01-2

Asiri, Abdullah Mohamed published an article in 1999, the title of the article was Synthesis, characterizations and absorption spectral studies of novel 2-arylidene-1-dicyanomethyleneindane dyes.Product Details of 2510-01-2 And the article contains the following content:

The synthesis and the absorption properties of methine dyes formed by Knoevenagel condensation of aromatic aldehydes with 1-(dicyanomethylene)indan afforded a novel series of dyes absorbing in the region of 490-593 nm. The substituents on the aromatic aldehyde have remarkable effects on the visible absorption maxima of the new dyes. Increasing the solvent polarity had pronounced effects on the absorption maxima. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Product Details of 2510-01-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Asiri, Abdullah Mohamed et al. published their research in Applied Organometallic Chemistry in 2001 |CAS: 2510-01-2

The Article related to ferrocene derivative donor acceptor dye preparation solvatochromism, Dyes, Organic Pigments, Fluorescent Brighteners, and Photographic Sensitizers: Photographic Dyes, Dye Intermediates, and Sensitizers and other aspects.Synthetic Route of 2510-01-2

On November 30, 2001, Asiri, Abdullah Mohamed published an article.Synthetic Route of 2510-01-2 The title of the article was Organometallic dyes: Part 1. Synthesis of orange to cyan dyes based on donor-conjugated-acceptor chromogenes using ferrocene as the donor group. And the article contained the following:

A novel series of organometallic donor-conjugated-acceptor dyes derived from ferrocene as the donor group have been synthesized via the Knoevenagel reaction of ferrocene carboxaldehyde and various active methylene compounds to give a range of dyes ranging from orange to blue-green in color. The most bathochromic dye is that derived from dialkyl thiobarbituric acid and the least is that derived from the tetralone. The dyes showed an unusual neg. solvatochromism as the solvent polarity increased. All dyes synthesized are expected to have some non-linear optical properties, as evidenced from the pronounced solvatochromism. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Synthetic Route of 2510-01-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Almonasy, Numan et al. published their research in Dyes and Pigments in 2002 |CAS: 2510-01-2

The Article related to indanylidenemalononitrile aromatic aldehyde condensate preparation disperse dye, Dyes, Organic Pigments, Fluorescent Brighteners, and Photographic Sensitizers: Photographic Dyes, Dye Intermediates, and Sensitizers and other aspects.Synthetic Route of 2510-01-2

On April 30, 2002, Almonasy, Numan; Nepras, Milos; Burgert, Ladislav; Lycka, Antonin published an article.Synthetic Route of 2510-01-2 The title of the article was Synthesis, visible absorption spectra and application properties of disperse dyes derived from 1-indanylidenemalononitrile. And the article contained the following:

Disperse dyes derived from 1-indanylidenemalononitrile and aromatic aldehydes were prepared and characterized. The purity of the dyes was checked by TLC and elemental anal.; the structures were confirmed by 1H and 13C NMR spectra. The relationships among dye structures and absorption characteristics and solvent polarity effects were investigated. The full optimized geometry was computed by the AM1 method and the theor. characteristics of electronic transitions were studied by PPP-MO, CNDO/S, and INDO/S procedures. Due to possible application of the dyes to polyester fiber, the coloristic characteristics were determined as well. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Synthetic Route of 2510-01-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Asiri, Abdullah Mohamed et al. published their research in Journal of Saudi Chemical Society in 2000 |CAS: 2510-01-2

The Article related to styryl dye preparation spectra substituent effect, dicyanomethylenedindan knoevenagel reaction methine dye preparation, Dyes, Organic Pigments, Fluorescent Brighteners, and Photographic Sensitizers: Photographic Dyes, Dye Intermediates, and Sensitizers and other aspects.SDS of cas: 2510-01-2

On March 31, 2000, Asiri, Abdullah Mohamed published an article.SDS of cas: 2510-01-2 The title of the article was Synthesis, characterizations and absorption spectral properties of new styryl dyes derived from 1-dicyanomethyleneindane. And the article contained the following:

The synthesis and the absorption properties of methine dyes formed by the Knoevenagel condensation of aromatic aldehydes with 1-(dicyanomethylene)indan afforded a novel series of dyes absorbing in the region of 490-593 nm. The substituents on the aromatic aldehyde have remarkable effects on the visible absorption maxima of the new dyes. Indole-3-carboxaldehyde gave a blue dye. The introduction of dicyanomethylene group into 1-indanone causes a large bathochromic shift of the visible absorption maxima of the new dyes when compared with the same dye obtained from 1-indanone itself. Steric effects cause even more of a bathochromic shift compared dyes having substituents in the ortho position and the same dyes having the same substituents in the para position. Increasing the solvent polarity had pronounced effects on the absorption maxima. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).SDS of cas: 2510-01-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Aariin, Kei Masaa et al. published their patent in 1984 |CAS: 75629-62-8

The Article related to halation inhibitor photog benzylidene dye, naphthalimide dye photog halation inhibitor, binder photog halation inhibiting layer, Radiation Chemistry, Photochemistry, and Photographic and Other Reprographic Processes: Silver Halide Photographic Chemistry and Processes and other aspects.Formula: C12H7N3

On November 29, 1984, Aariin, Kei Masaa; Piitaa, Maachin Koerushu published a patent.Formula: C12H7N3 The title of the patent was Optical filters for photoimaging materials. And the patent contained the following:

Optical filters contain 鈮? dye(s) selected from benzylidene and naphthalimide dyes and a binder composition containing phenol-formaldehyde resin in amount sufficient to cause optical shift in the absorption spectra of the dye(s). The filters are especially useful for UV- and visible light-sensitive photoimaging systems, and especially useful as photog. halation inhibiting layers. Thus, Disperse Yellow 31 60, Butvar B-76 (a butyral resin) 108, Resinox RS 7280 (a phenolic resin) modified with DD1-1410 (a diisocyanate compound) 1440 and MeCOEt 1720 g were mixed to give a halation inhibitor coating composition The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Formula: C12H7N3

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Kaur, Jasreen et al. published their research in World Journal of Pharmacy and Pharmaceutical Sciences in 2017 |CAS: 75629-62-8

The Article related to pyranoquinolone preparation, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Application In Synthesis of 2-((1H-Indol-3-yl)methylene)malononitrile

Kaur, Jasreen; Bariwal, Jatinder; Bedi, Preet Mohinder Singh; Kaur, Maninderjit; Kapoor, Amit; Kaur, Mandeep; Verma, Poonam published an article in 2017, the title of the article was Highly efficient synthesis of pyranoquinoline derivatives catalyzed by piperidine.Application In Synthesis of 2-((1H-Indol-3-yl)methylene)malononitrile And the article contains the following content:

A mild and efficient method for the synthesis of substituted pyranoquinolones I [R = 2-furyl, Ph, 4-ClC6H4, etc.; R1 = CN, COOEt] via a two-component reaction of 4-hydroxy-1-methyl-2(1H)-quinolinone and intermediate arylidenes catalyzed by piperidine was described. The reaction commenced very fast after heating of reaction mixture at 鈮?0掳C for 2-3 h and gives high yields. This new procedure had the advantages of mild reaction condition, high yields and metal-free catalyst. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Application In Synthesis of 2-((1H-Indol-3-yl)methylene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts