Month: November 2022

On January 24, 2013, Wang, Xueqing; Meyer, Michael; Yao, Betty; Guo, Tao; Wei, Guo Pingrobert; Wang, Lijuan Jane published a patent.Name: 4-Oxochroman-6-carbonitrile The title of the patent was Preparation of 1,6-naphthyridine derivatives as chemokine receptor antagonists. And the patent contained the following:

The invention relates to 1,6-naphthyridine derivatives of formula I and pharmaceutically acceptable salts, solvates and prodrugs thereof as chemokine receptor antagonists; their preparation and use in the treatment of pain. Compounds of formula I wherein X1 is CR1 and N; X2 is CR2 and N; X3 is CR3 and N; R1, R2 and R3 are independently H, CN, halo, etc.; G1 is NR4R5, substituted pyridinyl, etc.; R4 is H,(halo)alkyl, alkoxyalkyl, etc.; R5 is (un)substituted heterocyclyl, Ph, naphthyl, cycloalkyl, etc.; and pharmaceutically acceptable salts, solvates and prodrugs thereof, are claimed. Example compound II 鈥?succinate was prepared by a multistep procedure (procedure given). All the invention compounds were evaluated for their chemokine receptor antagonistic activity. From the assay, it was determined that example compound II 鈥?succinate exhibited Kb value ranged from 0.003 渭M to 0.006 渭M. The experimental process involved the reaction of 4-Oxochroman-6-carbonitrile(cas: 138801-92-0).Name: 4-Oxochroman-6-carbonitrile

The Article related to naphthyridine preparation chemokine receptor antagonist treatment pain, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Name: 4-Oxochroman-6-carbonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On January 5, 2018, Bollier, Melanie; Klupsch, Frederique; Six, Perrine; Dubuquoy, Laurent; Azaroual, Nathalie; Millet, Regis; Leleu-Chavain, Natascha published an article.Electric Literature of 5098-14-6 The title of the article was One- or Two-Step Synthesis of C-8 and N-9 Substituted Purines. And the article contained the following:

A novel and original strategy to obtain rapidly a large diversity of C-8 and N-9 substituted purines was developed. The present procedure describes annulation reactions in one or two steps starting from 5-aminoimidazole-4-carbonitriles 1-8 in moderate to good yields. 8,9-Disubstituted-6,9-dihydro-1H-purin-6-ones 9-14, 6-amino-8,9-disubstituted-3,9-dihydro-2H-purin-2-ones 15-20, 8,9-disubstituted-3,9-dihydro-2H-purin-2,6-diamines 21-24 and 6-imino-1-phenyl-8,9-disubstituted-6,9-dihydro-1H-purin-2-(3H)-ones 25-26 were synthesized in one step using formic acid, urea, guanidine carbonate, and Ph isocyanate, resp., whereas 8,9-disubstituted-9H-purin-6-amines 27-31 and 6-imino-8,9-disubstituted-6,9-dihydro-1H-purin-1-amines 32-33 were obtained in two steps using formamide and hydrazine, resp. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Electric Literature of 5098-14-6

The Article related to disubstituted purine preparation, aminoimidazole carbonitrile preparation cyclization urea guanidine carbonate phenyl isocyanate, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Electric Literature of 5098-14-6

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On January 31, 2020, Kuroda, Chiaki; Kobayashi, Reiri; Kurebayashi, Saeka; Tazawa, Kanako; Masuda, Arisa; Takeuchi, Ryo; Washio, Ayako; Onuki, Hiroyuki published an article.Formula: C10H11N3O3S The title of the article was Reaction of Aminomalononitrile and Benzylic Compounds as a Plausible Route to Phenylalanine. And the article contained the following:

As a possible route to phenylalanine, reaction of aminomalononitrile with benzylic compounds was studied. 2-Benzyl-2-aminomalononitrile was obtained in a good yield when aminomalononitrile p-toluenesulfonate was treated with benzyl bromide in THF using triethylamine as a base. The reaction proceeded in the presence of water. 2-Benzyl-2-aminomalononitrile was hydrolyzed to afford phenylalanine. The aminomalononitrile route can explain the presence of not only 1 methylene in aromatic amino acids, but also 伪-hydrogen in all 20 proteinogenic amino acids. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Formula: C10H11N3O3S

The Article related to aminomalononitrile benzylic compound benzylation, benzyl aminomalononitrile hydrolysis, phenylalanine preparation, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Carboxylic Acids and Peroxycarboxylic Acids and Their Sulfur-Containing Analogs and Salts and other aspects.Formula: C10H11N3O3S

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On November 30, 1991, Buckle, Derek R.; Eggleston, Drake S.; Houge-Frydrych, Catherine S. V.; Pinto, Ivan L.; Readshaw, Simon A.; Smith, David G.; Webster, Richard A. B. published an article.Application of 138801-92-0 The title of the article was Conformational and steric modifications of the pyran ring of the potassium channel activator cromakalim. And the article contained the following:

The syntheses of analogs of the novel smooth muscle relaxant cromakalim, (I), in which the C-2 Me groups have been successively replaced by hydrogen, are described and the relative stereochem. of the two corresponding, isomeric monomethyl compounds, unambiguously assigned by 1H NMR spectroscopic techniques. Single-crystal x-ray anal. of the 2伪-monomethyl compound showed that it existed in a distorted half-chair conformation in the solid state and confirmed the relative orientation of the C-2, C-3 and C-4 substituents. The 2尾-Me isomer appeared to exist in a single conformation in solution, with the pyran ring adopting a half-chair conformation and with all the substituents in this ring occupying a pseudoequatorial position. The solution behavior of the 2伪-Me isomer is more complex, however, although it seems likely to exist as a distorted half-chair conformer similar to that found in the solid state. The syntheses of two related benzoxepines are also described. All compounds were less potent than cromakalim itself, which is consistent with the view that di-Me substitution at C-2 is essential for optimal activity. The experimental process involved the reaction of 4-Oxochroman-6-carbonitrile(cas: 138801-92-0).Application of 138801-92-0

The Article related to cromakalim analog preparation conformation, Heterocyclic Compounds (One Hetero Atom): Benzopyrans (Including Coumarins, Isocoumarins, Chromones, Benzopyrones, Dibenzopyrans, and Other Arenopyrans) and other aspects.Application of 138801-92-0

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Magar, Rupali L.; Thorat, Prashant B.; Waware, Jagdish L.; More, Rameshwar R.; Solanke, Usha A.; Patil, Bhagwan R.; Pawar, Rajendra P. published an article in 2015, the title of the article was Synthesis of Some Novel 3-Substituted Indole Derivatives Using Polyamine Functionalized Heterogeneous Catalyst.Recommanded Product: 2-((1H-Indol-3-yl)methylene)malononitrile And the article contains the following content:

In present work, we have described the use of polyamine solid supported GN3 as catalyst in organic transformations using 1H-indole-3-carbaldehyde. To the best of our knowledge, reports for the synthesis of chromene substituted at 3C position of indole are extremely rare in the literature. The polyamine functionalized immobilized silica (GN3) was found to be an excellent catalyst for synthesis of novel 2-amino-4-(1H-indol-3-yl)-5-oxo-4,5-dihydropyrano[3,2-c]chromene-3-carbonitrile derivatives and Knoevenagel condensation. Catalyst GN3 was able to furnish excellent yield for a wide range of products. Moreover, the catalyst was reusable and reused for several times without loss of its catalytic activity. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Recommanded Product: 2-((1H-Indol-3-yl)methylene)malononitrile

The Article related to indole preparation gn3 reusability catalyst mechanism nucleophile condensation reaction, Heterocyclic Compounds (One Hetero Atom): Benzopyrans (Including Coumarins, Isocoumarins, Chromones, Benzopyrones, Dibenzopyrans, and Other Arenopyrans) and other aspects.Recommanded Product: 2-((1H-Indol-3-yl)methylene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On February 12, 2015, Motiyenko, Roman A.; Margules, Laurent; Alekseev, Eugen A.; Guillemin, Jean-Claude published an article.Safety of 2-Aminomalononitrile 4-methylbenzenesulfonate The title of the article was High-Resolution Millimeter Wave Spectroscopy and Ab Initio Calculations of Aminomalononitrile. And the article contained the following:

The HCN trimer aminomalononitrile (H2NCH(CN)2, AMN) is considered as a key compound in prebiotic chem. and a potential candidate for detection in the interstellar medium. In this view, we studied the rotational spectrum of AMN in the 120-245 GHz frequency range. The spectroscopic work was augmented by high-level ab initio calculations The calculations showed that between two existing rotamers, sym. and asym., the most stable is the asym. conformation, and it is the only conformation observed in the recorded spectra. The sym. conformation is 6.7 kJ/mol higher in energy and thus has a very low Boltzmann factor. The anal. of the rotational spectra of the A conformation has shown that the observed lines exhibit a doublet or quartet structure owing to two large-amplitude motions, C-N torsion and amino group inversion. To study the large-amplitude motions in detail, we calculated a two-dimensional potential energy surface and determined the barrier heights for the torsion and inversion, Vt = 12.5 kJ/mol and Vi = 19.1 kJ/mol. About 2500 assigned rotational transitions in the ground vibrational state were fitted within exptl. accuracy using the reduced axes system Hamiltonian. The set of obtained spectroscopic parameters allows accurate calculation of transition frequencies and intensities for an astrophys. search of AMN. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Safety of 2-Aminomalononitrile 4-methylbenzenesulfonate

The Article related to aminomalononitrile millimeter wave spectroscopy ab initio, Physical Organic Chemistry: Absorption, Emission, Reflection, and Scattering Spectra (Ultraviolet and Visible, Infrared and Fourier Transform Infrared, Raman, Microwave, Photoelectron, Fluorescence, Phosphorescence, etc.) and other aspects.Safety of 2-Aminomalononitrile 4-methylbenzenesulfonate

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts