November 2022 - Page 116 of 123 - Nitriles-buliding-blocks

Yalcin, Ergin et al. published their research in Tetrahedron in 2019 |CAS: 2510-01-2

The Article related to amino heteroaryl blue emitting fluorescent dye preparation photophys property, Dyes, Organic Pigments, Fluorescent Brighteners, and Photographic Sensitizers: Fluorescent Brighteners and other aspects.Safety of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

On August 30, 2019, Yalcin, Ergin; Duyar, Halil; Cakmaz, Deniz; Sahin, Ertan; Seferoglu, Zeynel published an article.Safety of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile The title of the article was The synthesis of blue emitting 3-Amino-1-hetarylfluorenes and their unprecedented alkylated derivatives. And the article contained the following:

Novel 3-Amino-1-hetarylfluorene derivatives have medicinal uses and challenging transformation in organic synthesis have been synthesized via decyanation process. Surprisingly, the alkylated compounds derived from 3-Amino-1-hetarylfluorenes were obtained via further nucleophilic substitution to the 9-C and 3-N positions of the fluorene ring because of the harsh reaction condition employed. The synthesized compounds were characterized by spectroscopic techniques as well as X-ray single crystal diffraction anal. This new family of blue emitting fluorene derivatives have low to moderate quantum yields (the largest value of 蠁F = 0.52 for compound 15). The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Safety of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Hilf, Justin A. et al. published their patent in 2022 |CAS: 2510-01-2

The Article related to spiroindenequinazolinylpiperazine preparation kras protein g12c mutation inhibitor antitumor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.COA of Formula: C12H8N2

On June 2, 2022, Hilf, Justin A.; Rose, Tristin E.; Bartberger, Michael D.; O’Boyle, Brendan M.; Reeves, Corey M.; Loson, Oliver C.; Stoltz, Brian M.; McDermott, Martina; O’Brien, Neil A.; Slamon, Dennis published a patent.COA of Formula: C12H8N2 The title of the patent was Preparation of substituted N-(spiro[indene-2,7′-quinazolin]-4′-yl)piperazines as Kras G12C inhibitors. And the patent contained the following:

The invention relates to compounds I [x1 = C(O) or C(R1)(R2); x2 = a bond, CO, O, etc.; y1b and y1c = independently C=CH2, CO, O, S, etc.; z1-z4 = independently C and N; R1 and R2 = independently H and F; R3 = independently H, (halo)alkyl; R4-R7 = independently H, F, Cl, Me, etc., R8a = H, alkyl, cycloalkyl, etc.; R8b = H, CN, halo, etc.; with the provisons], and pharmaceutically acceptable salts thereof, and methods of making and using the same. The compounds I are effective in inhibiting KRAS protein with a G12C mutation and are suitable for use in methods of treating cancers mediated, in whole or in part, by KRAS G12C mutation. E.g., a multi-step synthesis of II鈥FA, starting from 5,6,7,8-tetrahydroquinazoline-2,4-diol, was described. Exemplified compounds I were tested for their KRAS G12C inhibitory activity (data given for representative compounds I). Pharmaceutical composition comprising compound I was disclosed. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).COA of Formula: C12H8N2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Feenstra, Roelof W. et al. published their patent in 2006 |CAS: 34662-29-8

The Article related to phenylpiperazine preparation dopamine d2 receptor serotonin reuptake inhibitor, cns agent phenylpiperazine preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Recommanded Product: 34662-29-8

On June 15, 2006, Feenstra, Roelof W.; Stoit, Axel; Terpstra, Jan-Willem; Pras-Raves, Maria L.; McCreary, Andrew C.; Van Vliet, Bernard J.; Hesselink, Mayke B.; Kruse, Cornelis G.; Van Scharrenburg, Gustaaf J. M. published a patent.Recommanded Product: 34662-29-8 The title of the patent was Preparation of phenylpiperazine derivatives with a combination of partial dopamine-d2 receptor agonism and serotonin reuptake inhibition. And the patent contained the following:

The invention relates to a group of novel phenylpiperazine derivatives I [X = S or O; R1 = H, alkyl, CF3, OH, etc.; R2 = H, halo, CN, or alkyl; R3 = H or alkyl; R4 = H, alkyl or haloalkyl; T = (un)substituted alkyl chain which may optionally contain a N atom; Ar = naphthyl, indolyl, benzothiophenyl, etc.], and their pharmaceutically acceptable salts, which are prepared and disclosed as possessing a dual mode of action: serotonin reuptake inhibition and partial agonism on dopamine-D2 receptors. Thus, e.g., II was prepared by oxidation of 1-(3-hydroxypropyl)-6-chloroindazole to the formyl derivative which underwent reductive coupling with 3-methyl-7-piperazinyl-3H-benzoxazole-2-one. Selected compounds of the invention possessed pKi values of 7.0-8.9 in dopamine-D2 binding assays. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Recommanded Product: 34662-29-8

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Feenstra, Roelof W. et al. published their patent in 2006 |CAS: 34662-29-8

On June 8, 2006, Feenstra, Roelof W.; Stoit, Axel; Terpstra, Jan-Willem; Pras-Raves, Maria L.; McCreary, Andrew C.; Van Vliet, Bernard J.; Hesselink, Mayke B.; Kruse, Cornelis G.; Van Scharrenburg, Gustaaf J. M. published a patent.Name: 3-Chloro-4-nitrobenzonitrile The title of the patent was Preparation of phenylpiperazine derivatives with a combination of partial dopamine-d2 receptor agonism and serotonin reuptake inhibition. And the patent contained the following:

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Sato, Nobuhiro et al. published their research in Journal of Heterocyclic Chemistry in 1988 |CAS: 5098-14-6

The Article related to aminopterincarboxylic acid, pteridinecarboxylic acid diamino, furan synthon carboxylic acid group, oxidation furan permanganate, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Category: nitriles-buliding-blocks

On December 31, 1988, Sato, Nobuhiro; Saito, Noriko published an article.Category: nitriles-buliding-blocks The title of the article was Studies on pyrazines. 17. An efficient synthesis of pteridine-6-carboxylic acids. And the article contained the following:

2,4-Diaminopteridine-6-carboxylic acid (I) and pterin-6-carboxylic acid (II) were prepared by permanganate oxidation of the corresponding 6-(2-furyl)-substituted pteridines under mild conditions. Several attempts to cleave the furan ring with other oxidizing agents are also described. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Category: nitriles-buliding-blocks

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Pastor, Stephen D. et al. published their research in Journal of Heterocyclic Chemistry in 1984 |CAS: 5098-14-6

The Article related to dihydroxypropylpyrazinecarboxylate lactone, pyrazinecarboxylate dihydroxypropyl lactone, dihydroxydioxohexanoate monoxime decarboxylation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Quality Control of 2-Aminomalononitrile 4-methylbenzenesulfonate

On June 30, 1984, Pastor, Stephen D.; Nelson, Aaron L. published an article.Quality Control of 2-Aminomalononitrile 4-methylbenzenesulfonate The title of the article was Substituted 5-(D,L-erythro-1′,2′-dihydroxypropyl)pyrazines. Potential precursors for the synthesis of biopterin derivatives. And the article contained the following:

Substituted 5-(D,L-erythro-1′,2′-dihydroxypropyl)pyrazines I (R = cyano, CO2CH2Ph) were prepared from crotonic acid. Functionalized 2-oximino-3-oxoesters II (R1 = Me, CMe3) showed anomalous behavior during decarboxylation. The structures of prepared compounds were determined by spectroscopic methods. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Quality Control of 2-Aminomalononitrile 4-methylbenzenesulfonate

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Li, Xiaochuan et al. published their research in Dyes and Pigments in 2009 |CAS: 2510-01-2

The Article related to merocyanine dye fluorescence solvatochromism optical, Dyes, Organic Pigments, Fluorescent Brighteners, and Photographic Sensitizers: Methines and Polymethines and other aspects.Related Products of 2510-01-2

On September 30, 2009, Li, Xiaochuan; Kim, Sung-Hoon; Son, Young-A. published an article.Related Products of 2510-01-2 The title of the article was Optical properties of donor-蟺-(acceptor)n merocyanine dyes with dicyanovinylindane as acceptor group and triphenylamine as donor unit. And the article contained the following:

Donor-蟺-(Acceptor)n (D-蟺-A) type dyes were synthesized and their absorption and emission spectra investigated in different solvents. Strong acceptor units imparted large red-shifts in absorption; the twisting of the dye’s structure imposed by an acceptor unit quenched fluorescence. Electron delocalization before and after excitation was observed according to MO calculations The results indicated potential use of the dyes as electro-optical materials. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Related Products of 2510-01-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Asiri, Abdullah Mohamed et al. published their research in Dyes and Pigments in 1999 |CAS: 2510-01-2

The Article related to arylidenedicyanomethylindan cyanine dye preparation spectra, indan derivative methine dye preparation, Dyes, Organic Pigments, Fluorescent Brighteners, and Photographic Sensitizers: Methines and Polymethines and other aspects.Safety of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

On June 11, 1999, Asiri, Abdullah Mohamed published an article.Safety of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile The title of the article was Synthesis and characterization of dyes exemplified by 2-arylidene-1-dicyanomethyleneindane. And the article contained the following:

The synthesis of methine dyes formed by Knoevenagel condensation of aromatic aldehydes with 1-(dicyanomethylene)indan afforded a novel series of dyes absorbing in the region 490-593 nm. Substituents on the aromatic aldehyde moiety had a significant effect on the visible absorption maxima of the dyes; increasing the solvent polarity also had a pronounced effect on the absorption maxima. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Safety of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Aadil, M. et al. published their research in Phosphorus, Sulfur and Silicon and the Related Elements in 1993 |CAS: 2510-01-2

The Article related to vilsmeier haack cyclization alkylidenemalonitrile, chlorocyanopyridine, selenolopyridine, thienopyridine, Organometallic and Organometalloidal Compounds: Groups Iva, Va, Via – Ge, Sn, Pb, As, Sb, Bi, Se, Te, Po and other aspects.Application of 2510-01-2

On September 30, 1993, Aadil, M.; Kirsch, G. published an article.Application of 2510-01-2 The title of the article was Synthesis of new 3-aminothieno- and -selenolo[2,3-b]pyridines. And the article contained the following:

Cyclization of alkylidenemalonitriles by the Vilsmeier-Haack reagent gives 2-chloro-3-cyanopyridines, e.g., I. These compounds are used as starting material for the synthesis of thieno[2,3-b]- and selenolo[2,3-b]pyridines, e.g., II (X = S, Se). The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Application of 2510-01-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Yamashita, Yoshiro et al. published their research in Heterocycles in 1981 |CAS: 75629-62-8

The Article related to indolizine addition ethoxyethylene, vinylindolizine, Heterocyclic Compounds (One Hetero Atom): Other Areno- and Diarenopyridines (Including Also Quinuclidines, etc.) and other aspects.Quality Control of 2-((1H-Indol-3-yl)methylene)malononitrile

On September 1, 1981, Yamashita, Yoshiro; Suzuki, Daisuke; Masumura, Mitsuo published an article.Quality Control of 2-((1H-Indol-3-yl)methylene)malononitrile The title of the article was Synthesis of vinyl-substituted indolizine derivatives by a novel reaction of indolizines with ethoxyethylenes having electron-withdrawing substituents. And the article contained the following:

The vinylindolizines I (R1 = Me, Ph, p-BrC6H4; R2, R3 = H, Me; R4 = R5 = CN, CO2Et, R4 = CN, COMe; R5 = CO2Et) were prepared in 22-85% yields by Michael addition of the indolizines II with EtOCH:CR4R5. Hydrolysis of I (R1 = Ph, R2 = H, Me; R3 = H, R4 = R5 = CN) gave the corresponding 3-formylindolizines. Pyrrole and 1-methylpyrrole underwent similar addition with EtOCH:C(CN)2 to give the pyrroles III (R = H, Me). The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Quality Control of 2-((1H-Indol-3-yl)methylene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts