Month: November 2022

Oxidation of hexamethylbenzene and 2,3,4,5,6-pentamethylbenzyl cation in fluorosulfonic acid was written by Rudenko, A. P.;Zarubin, M. Ya.;Fedorova, E. M.. And the article was included in Zhurnal Organicheskoi Khimii in 1985.Synthetic Route of C15H15N3 The following contents are mentioned in the article:

Oxidation of hexamethylbenzene (I) in HSO₃F-PbO₂ involved the conversion of protonated I to 2,3,4,5,6-pentamethylbenzyl cation, which underwent further oxidation to give products such as II and III. This study involved multiple reactions and reactants, such as 2,2′,2”-(2,4,6-Trimethylbenzene-1,3,5-triyl)triacetonitrile (cas: 16144-65-3Synthetic Route of C15H15N3).

2,2′,2”-(2,4,6-Trimethylbenzene-1,3,5-triyl)triacetonitrile (cas: 16144-65-3) belongs to nitriles. Nitrile carbon shifts are in the range of 115–125 ppm whereas in isonitriles the shifts are around 155–165 ppm. In addition, Nitriles can react with alkynes, which leads to an increase in carbon chain length (carbocyanation).Synthetic Route of C15H15N3

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Mild and Efficient Synthesis of N¹,N⁵,N¹⁰-Tri-tert-butoxycarbonyl Spermine was written by Feng, Xiangjun;Xia, Wenpin;Luo, Yu;Lu, Wei. And the article was included in Synthetic Communications in 2012.Product Details of 194808-59-8 The following contents are mentioned in the article:

This article describes a mild and efficient synthesis of N¹,N⁵,N¹⁰-tri-tert-butoxycarbonyl spermine from putrescine, with a 41% overall yield. The key steps include a Michael addition and Raney nickel (W-2) reduction The advantages of this synthesis include a simple procedure, mild conditions, and good yields. This study involved multiple reactions and reactants, such as Di-tert-butyl butane-1,4-diylbis((2-cyanoethyl)carbamatE) (cas: 194808-59-8Product Details of 194808-59-8).

Di-tert-butyl butane-1,4-diylbis((2-cyanoethyl)carbamatE) (cas: 194808-59-8) belongs to nitriles. The R-C-N bond angle in and nitrile is 180° which give a nitrile functional group a linear shape. Both the carbon and the nitrogen are sp hydridized which leaves them both with two p orbitals which overlap to form the two π bond in the triple bond. Alkyl nitriles are sufficiently acidic to undergo deprotonation of the C-H bond adjacent to the CN group.Strong bases are required, such as lithium diisopropylamide and butyl lithium. The product is referred to as a nitrile anion. Product Details of 194808-59-8

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

PS-SNAP, a practical polymer-supported nitrosation reagent in organic synthesis was written by Roche, Didier;Lardy, Claude;Tournier, Lucie;Prunier, Marc;Valeur, Eric. And the article was included in Tetrahedron Letters in 2010.HPLC of Formula: 319016-04-1 The following contents are mentioned in the article:

PS-SNAP was designed and evaluated as a practical nitrosating polymer-supported reagent for the nitrosation of sec-amines. Nitrosated dialkyl amines, alkyl anilines, and bis-anilines were obtained in good yields and high purities after shaking the corresponding amines in the presence of an excess of the newly described reagent followed by simple filtration and removal of solvents. This study involved multiple reactions and reactants, such as 4-((4-Methoxyphenyl)amino)benzonitrile (cas: 319016-04-1HPLC of Formula: 319016-04-1).

4-((4-Methoxyphenyl)amino)benzonitrile (cas: 319016-04-1) belongs to nitriles. Nitriles are polar, as indicated by high dipole moments. As liquids, they have high relative permittivities, often in the 30s. Nitrile groups in organic compounds can undergo a variety of reactions depending on the reactants or conditions. A nitrile group can be hydrolyzed, reduced, or ejected from a molecule as a cyanide ion.HPLC of Formula: 319016-04-1

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Topological correspondence between crystal structure of 2,4,6-trimethylbenzene-1,3,5-tris(methanaminium) 2,4,6-trimethylbenzene-1,3,5-triacetate and cesium chloride was written by Podlaha, Jaroslav;Cisarova, Ivana;Alexander, Daniel;Holy, Petr;Kraus, Tomas;Zavada, Jiri. And the article was included in Collection of Czechoslovak Chemical Communications in 2000.HPLC of Formula: 16144-65-3 The following contents are mentioned in the article:

Solid-state self-assembly of 2,4,6-trimethylbenzene-1,3,5-tris(methanaminium) 2,4,6-trimethylbenzene-1,3,5-triacetate is mediated by hydrogen bonding. It gives rise to three-dimensional network of hydrogen bonds in which each trication is coordinated with eight trianions and vice versa. The resulting crystal structure topol. corresponds to the simple inorganic cesium chloride type. This study involved multiple reactions and reactants, such as 2,2′,2”-(2,4,6-Trimethylbenzene-1,3,5-triyl)triacetonitrile (cas: 16144-65-3HPLC of Formula: 16144-65-3).

2,2′,2”-(2,4,6-Trimethylbenzene-1,3,5-triyl)triacetonitrile (cas: 16144-65-3) belongs to nitriles. Nitrile function is a very important functional group because it can be manipulated to other functional groups such as carboxylic acid by hydrolysis or amine by reduction, respectively. In conventional organic reductions, nitrile is reduced by treatment with lithium aluminium hydride to the amine. Reduction to the imine followed by hydrolysis to the aldehyde takes place in the Stephen aldehyde synthesis, which uses stannous chloride in acid.HPLC of Formula: 16144-65-3

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Synthesis of C₁-symmetric chiral tripodal oxazolines through an oxazoline exchange reaction with amino alcohols was written by Kim, Sung-Gon;Seong, Hye Ran;Kim, Jeongryul;Ahn, Kyo Han. And the article was included in Tetrahedron Letters in 2004.Category: nitriles-buliding-blocks The following contents are mentioned in the article:

Various C₁-sym. chiral tripodal tris(oxazolines), e.g., I, with two different oxazoline units were synthesized from chiral C₃-sym. tris(oxazolines) through an oxazoline exchange reaction with amino alcs. in the presence of zinc chloride. Evaluation of the oxazolines as chiral mol. receptor showed that some of the receptors have chiral discrimination ability. This study involved multiple reactions and reactants, such as 2,2′,2”-(2,4,6-Trimethylbenzene-1,3,5-triyl)triacetonitrile (cas: 16144-65-3Category: nitriles-buliding-blocks).

2,2′,2”-(2,4,6-Trimethylbenzene-1,3,5-triyl)triacetonitrile (cas: 16144-65-3) belongs to nitriles. Nitrile function is a very important functional group because it can be manipulated to other functional groups such as carboxylic acid by hydrolysis or amine by reduction, respectively. Industrially, the main methods for producing nitriles are ammoxidation and hydrocyanation. Both routes are green in the sense that they do not generate stoichiometric amounts of salts.Category: nitriles-buliding-blocks

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Synthesis of 2-methylpyrrolo[1,2-a]pyrazin-1(2H)-one was written by Brimble, Margaret A.;Brimble, Mark T.;Hodges, Richard;Lane, Geoffrey A.. And the article was included in Australian Journal of Chemistry in 1988.SDS of cas: 123257-07-8 The following contents are mentioned in the article:

The synthesis of 2-methylpyrrolo[1,2-α]pyrazin-1(2H)-one (I) present in the insect feeding deterrent peramine through oxidation of the saturated lactam is described. The preparation of the related 6-methyl-1H-pyrrolo[2,3-c]pyridin-7(6H)-one (II) through a Lewis-acid-catalyzed cyclization of the amide acetal III is also described. This study involved multiple reactions and reactants, such as Methyl 1-(cyanomethyl)-1H-pyrrole-2-carboxylate (cas: 123257-07-8SDS of cas: 123257-07-8).

Methyl 1-(cyanomethyl)-1H-pyrrole-2-carboxylate (cas: 123257-07-8) belongs to nitriles. Nitrile function is a very important functional group because it can be manipulated to other functional groups such as carboxylic acid by hydrolysis or amine by reduction, respectively. Some nitriles are manufactured by heating carboxylic acids with ammonia in the presence of catalysts. This process is used to make nitriles from natural fats and oils, the products being used as softening agents in synthetic rubbers, plastics, and textiles and for making amines.SDS of cas: 123257-07-8

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Electrochemical oxidation of organic compounds in fluorosulfuric acid. VIII. Current-voltage characteristics of the oxidation of aromatic compounds in fluorosulfuric acid and acetonitrile was written by Rudenko, A. P.;Zarubin, M. Ya.;Pragst, Fritz. And the article was included in Zhurnal Organicheskoi Khimii in 1984.Category: nitriles-buliding-blocks The following contents are mentioned in the article:

Cyclic voltammograms were obtained for the oxidation of polysubstituted benzenes and diphenylmethanes containing electron-withdrawing groups (e.g., SO₂F, NO₂, CN, CO₂H) in HSO₃F and MeCN. In most cases the oxidation in HSO₃F leads reversibly to the cation radical at low rates of potential scanning; in MeCN the process is irreversible even at high scanning rates (up to 100 V/s). This study involved multiple reactions and reactants, such as 2,2′,2”-(2,4,6-Trimethylbenzene-1,3,5-triyl)triacetonitrile (cas: 16144-65-3Category: nitriles-buliding-blocks).

2,2′,2”-(2,4,6-Trimethylbenzene-1,3,5-triyl)triacetonitrile (cas: 16144-65-3) belongs to nitriles. Nitrile compounds can be prepared by the incorporation of a cyanide source through C–C bond formation or by dehydration of primary carboxamides. Asymmetric bioreduction of nitriles is an attractive route to produce optically active nitriles as current metal-catalyzed hydrogenations tend to have low reactivity.Category: nitriles-buliding-blocks

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Solid-Phase synthesis of diamine and polyamine amino acid derivatives as HIV-1 tat-TAR binding inhibitors was written by Jimenez Bueno, G.;Klimkait, T.;Gilbert, I. H.;Simons, C.. And the article was included in Bioorganic & Medicinal Chemistry in 2003.Formula: C20H34N4O4 The following contents are mentioned in the article:

A series of diamine and polyamine derivatives, either free amines or salts (HCl or TFA), of aspartic and glutamic acid were prepared in excellent yields using Rink Amide solid-phase synthesis. The asparagine and glutamine derivatives were all evaluated for their ability to inhibit Tat-TAR binding using a FIGS (fusion induced gene stimulating) cellular assay, with the polyamine derivatives exhibiting the most promising binding activity. This study involved multiple reactions and reactants, such as Di-tert-butyl butane-1,4-diylbis((2-cyanoethyl)carbamatE) (cas: 194808-59-8Formula: C20H34N4O4).

Di-tert-butyl butane-1,4-diylbis((2-cyanoethyl)carbamatE) (cas: 194808-59-8) belongs to nitriles. Nitriles are polar, as indicated by high dipole moments. As liquids, they have high relative permittivities, often in the 30s. Asymmetric bioreduction of nitriles is an attractive route to produce optically active nitriles as current metal-catalyzed hydrogenations tend to have low reactivity.Formula: C20H34N4O4

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Dual-parameter correlation analysis of the redox potential data of 1-methyl-2-formyl-5-substituted pyrroles and their hydrazones was written by He, Hai Ying;Lin, Chen;Zhao, Cheng Xue;Jiang, Xi Kui. And the article was included in Chinese Chemical Letters in 2001.Safety of 5-Formyl-1-methyl-1H-pyrrole-2-carbonitrile The following contents are mentioned in the article:

By using 1-methyl-2-formyl-5-substituted pyrroles (1-Y), 1-methyl-2-formyl-5-substituted pyrrole phenylhydrazones (2-Y) and 1-methyl-2-formyl-5-substituted pyrrole (4-nitrophenyl)-hydrazones (3-Y) as model structures for N-containing heterocyclic aromatic compounds, correlation anal. of their redox potential data show that the transition states (TS) of the polarog. process are mainly affected by the polar effects, but spin-delocalization effects also exist. This study involved multiple reactions and reactants, such as 5-Formyl-1-methyl-1H-pyrrole-2-carbonitrile (cas: 81698-03-5Safety of 5-Formyl-1-methyl-1H-pyrrole-2-carbonitrile).

5-Formyl-1-methyl-1H-pyrrole-2-carbonitrile (cas: 81698-03-5) belongs to nitriles. The R-C-N bond angle in and nitrile is 180° which give a nitrile functional group a linear shape. Both the carbon and the nitrogen are sp hydridized which leaves them both with two p orbitals which overlap to form the two π bond in the triple bond. In addition, Nitriles can react with alkynes, which leads to an increase in carbon chain length (carbocyanation).Safety of 5-Formyl-1-methyl-1H-pyrrole-2-carbonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Mass spectra of substituted N-alkylpyrroles and related compounds was written by Lin, Shaw Tao;Shiue, Gong Yih;Kuo, Yueh Hsiung;Shih, Kae Shyang. And the article was included in Journal of the Chinese Chemical Society (Taipei, Taiwan) in 1994.Synthetic Route of C7H6N2O The following contents are mentioned in the article:

Under EI conditions, substituents on N-alkylpyrroles affect fragmentation of the alkyl groups. The electron-withdrawing character of the cyano group retarded formation of an N-methylene cation, and a labile substituent, i.e., CHO, CH₂COOMe, competed with an N-alkyl group to be an initial fragmentation center. MNDO calculation of the heat of formation of possible fragment ions showed that protonated pyridine is the most stable among the isobaric ions. This study involved multiple reactions and reactants, such as 5-Formyl-1-methyl-1H-pyrrole-2-carbonitrile (cas: 81698-03-5Synthetic Route of C7H6N2O).

5-Formyl-1-methyl-1H-pyrrole-2-carbonitrile (cas: 81698-03-5) belongs to nitriles. Trimerization of aromatic nitriles requires harsh reaction conditions, high temperatures, long reaction times, and pressure. In conventional organic reductions, nitrile is reduced by treatment with lithium aluminium hydride to the amine. Reduction to the imine followed by hydrolysis to the aldehyde takes place in the Stephen aldehyde synthesis, which uses stannous chloride in acid.Synthetic Route of C7H6N2O

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts