November 2022 - Page 120 of 123 - Nitriles-buliding-blocks

Fu, Jiya et al. published their patent in 2021 |CAS: 2510-01-2

The Article related to axial chiral fluoramine phenol derivative preparation tandem one pot, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Dibenzocyclobutenes, Acenaphthenes, Fluorenes, and Their Benzo Analogs, Such As Fluoranthenes and other aspects.Computed Properties of 2510-01-2

On September 3, 2021, Fu, Jiya; Yuan, Jinfang; Li, Ran; Deng, Yihang; Wang, Yanbo; Zhu, Junyan; Ding, Tao published a patent.Computed Properties of 2510-01-2 The title of the patent was Preparation of axially chiral fluoramine phenol derivatives. And the patent contained the following:

The invention discloses a preparation of axially chiral fluoramine phenol derivatives, which has the advantages of high efficiency, convenience, low cost and good application prospect. Axially chiral fluoramine phenol derivatives are shown in structure I, wherein R1 is selected from: CN or CO2Me; R2 is selected from substituted or unsubstituted Ph, substituted or unsubstituted pyridyl, substituted or unsubstituted furanyl, substituted or unsubstituted naphthyl. Axially chiral fluoramine phenol derivatives were prepared via one pot multi-step reaction of 2-benzofuranone derivatives and 1-indene methylene malononitrile derivatives The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Computed Properties of 2510-01-2

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Nitrile – Wikipedia,
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Xie, Ya-Sa et al. published their research in Chemical Communications (Cambridge, United Kingdom) in 2020 |CAS: 2510-01-2

The Article related to functionalized fluorene fluorenone preparation, indanylidene malononitrile morita baylis hillman carbonate benzannulation metal free, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Dibenzocyclobutenes, Acenaphthenes, Fluorenes, and Their Benzo Analogs, Such As Fluoranthenes and other aspects.Electric Literature of 2510-01-2

Xie, Ya-Sa; Huang, Run-Feng; Li, Ran; Zhang, Chuan-Bao; Fu, Ji-Ya; Zhao, Li-Li; Yuan, Jin-Fang published an article in 2020, the title of the article was Metal-free [3+3] benzannulation of 1-indanylidene-malononitrile with Morita-Baylis-Hillman carbonates: direct access to functionalized fluorene and fluorenone derivatives.Electric Literature of 2510-01-2 And the article contains the following content:

An efficient [3+3] benzannulation of Morita-Baylis-Hillman carbonates with 1-indanylidenemalononitrile was achieved under metal-free reaction conditions selectively delivering a wide range of functional multi-substituted fluorene I (R1 = H, 7-F, 6-Me, 6-OMe; R2 = H, 4-F, 3-Br, etc.) or fluorenone compounds II in high yields, resp. (up to 86% yield). Moreover, experiments and quantum chem. calculations were also performed to study the mechanism of the transformation. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Electric Literature of 2510-01-2

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Nitrile – Wikipedia,
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Motiyenko, Roman A. et al. published their research in Journal of Physical Chemistry A in 2015 |CAS: 5098-14-6

The Article related to aminomalononitrile millimeter wave spectroscopy ab initio, Physical Organic Chemistry: Absorption, Emission, Reflection, and Scattering Spectra (Ultraviolet and Visible, Infrared and Fourier Transform Infrared, Raman, Microwave, Photoelectron, Fluorescence, Phosphorescence, etc.) and other aspects.Safety of 2-Aminomalononitrile 4-methylbenzenesulfonate

On February 12, 2015, Motiyenko, Roman A.; Margules, Laurent; Alekseev, Eugen A.; Guillemin, Jean-Claude published an article.Safety of 2-Aminomalononitrile 4-methylbenzenesulfonate The title of the article was High-Resolution Millimeter Wave Spectroscopy and Ab Initio Calculations of Aminomalononitrile. And the article contained the following:

The HCN trimer aminomalononitrile (H2NCH(CN)2, AMN) is considered as a key compound in prebiotic chem. and a potential candidate for detection in the interstellar medium. In this view, we studied the rotational spectrum of AMN in the 120-245 GHz frequency range. The spectroscopic work was augmented by high-level ab initio calculations The calculations showed that between two existing rotamers, sym. and asym., the most stable is the asym. conformation, and it is the only conformation observed in the recorded spectra. The sym. conformation is 6.7 kJ/mol higher in energy and thus has a very low Boltzmann factor. The anal. of the rotational spectra of the A conformation has shown that the observed lines exhibit a doublet or quartet structure owing to two large-amplitude motions, C-N torsion and amino group inversion. To study the large-amplitude motions in detail, we calculated a two-dimensional potential energy surface and determined the barrier heights for the torsion and inversion, Vt = 12.5 kJ/mol and Vi = 19.1 kJ/mol. About 2500 assigned rotational transitions in the ground vibrational state were fitted within exptl. accuracy using the reduced axes system Hamiltonian. The set of obtained spectroscopic parameters allows accurate calculation of transition frequencies and intensities for an astrophys. search of AMN. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Safety of 2-Aminomalononitrile 4-methylbenzenesulfonate

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Nitrile – Wikipedia,
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Estrada, Leandro A. et al. published their research in Physical Chemistry Chemical Physics in 2016 |CAS: 2510-01-2

The Article related to indanylidene malononitrile fluorenylidene malononitrile excited state deactivation mechanism nonradiative, Physical Organic Chemistry: Absorption, Emission, Reflection, and Scattering Spectra (Ultraviolet and Visible, Infrared and Fourier Transform Infrared, Raman, Microwave, Photoelectron, Fluorescence, Phosphorescence, etc.) and other aspects.Reference of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

Estrada, Leandro A.; Frances-Monerris, Antonio; Schapiro, Igor; Olivucci, Massimo; Roca-Sanjuan, Daniel published an article in 2016, the title of the article was Mechanism of excited state deactivation of indan-1-ylidene and fluoren-9-ylidene malononitriles.Reference of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile And the article contains the following content:

Herein, we report complementary computational and exptl. evidence supporting the existence, for indan-1-ylidene malononitrile and fluoren-9-ylidene malononitrile, of a non-radiative decay channel involving double bond isomerization motion. The results of UV-Vis transient absorption spectroscopy highlight that the decay takes place within hundreds of picoseconds. In order to understand the related mol. mechanism, photochem. reaction paths were computed by employing multiconfigurational quantum chem. The results indicate that the excited state deactivation occurs via concerted double bond twisting of the dicyanovinyl (DCV) unit coupled with a pyramidalization of its substituted carbon. It is also shown that the observed differences in the excited state lifetimes when passing from indan-1-ylidene malononitrile to fluoren-9-ylidene are associated with the change in the topog. of the conical intersection driving the decay from intermediate to sloped, resp. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Reference of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

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Nitrile – Wikipedia,
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Chen, Xiaohang et al. published their research in Chinese Journal of Chemistry in 2009 |CAS: 2510-01-2

The Article related to dicyanoethylaminodiethylfluorene moiety blue light emitting star shaped compound, dual fluorescence blue light emitting star shaped compound oled, Physical Organic Chemistry: Absorption, Emission, Reflection, and Scattering Spectra (Ultraviolet and Visible, Infrared and Fourier Transform Infrared, Raman, Microwave, Photoelectron, Fluorescence, Phosphorescence, etc.) and other aspects.Synthetic Route of 2510-01-2

On May 31, 2009, Chen, Xiaohang; Chen, Xiaopeng; Zhao, Zujin; Lu, Ping; Wang, Yanguang published an article.Synthetic Route of 2510-01-2 The title of the article was 2,4-dicyano-3-diethylamino-9,9-diethylfluorene based blue light-emitting star-shaped compounds: synthesis and properties. And the article contained the following:

Two new star-shaped mols. I and II containing a triphenylamine/benzene moiety as the central core and three 2,4-dicyano-3-diethylamino-9,9-diethylfluorene moieties as the peripheral functional groups were synthesized and characterized. Charge transfer properties for these compounds were observed in photophys. experiments due to their D-A mol. structure. I presented dual fluorescence in high polar solvents. Moreover, these compounds exhibited moderate fluorescence and high thermal stabilities, indicating their potential application to blue light emitting materials. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Synthetic Route of 2510-01-2

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Nitrile – Wikipedia,
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Wang, Hung-Kai et al. published their research in Molecules in 2020 |CAS: 13544-06-4

The Article related to quinindoline preparation, anilino bromophenyl acrylonitrile dual cyclization copper catalyst, n-heterocycle, copper-catalyzed, cyclization, natural alkaloid, quinindoline and other aspects.Category: nitriles-buliding-blocks

Wang, Hung-Kai; Chio, Yu-Lun; Pallikonda, Gangaram; Wu, Hsyueh-Liang; Su, Haw-Lih; Hsieh, Jen-Chieh published an article in 2020, the title of the article was Copper-catalyzed dual cyclization for the synthesis of quinindolines.Category: nitriles-buliding-blocks And the article contains the following content:

A synthetic approach to quinindoline derivatives I (R = H, F, CF3, OMe, ; R1 = H, F, Me, OMe, NMe2; R2 = H, F, CF3, OMe; R3 = H, F, Cl, Me, NMe2, N(n-C4H9)2, OMe; R4 = H; RR1 = R2R3 = -OCH2O-; R3R4 = -CH:CH-CH:CH-) by the Cu-catalyzed dual cyclization has been developed. This catalytic reaction is a practical method for the systematic synthesis of quinindoline core structure I, which contains a limited-step synthetic strategy and can tolerant a wide variety of substituents. In addition, the mechanistic study reveals that the reaction initiates from a Lewis acid accelerated addition of aniline to nitrile and provides the indole substructure, and then the subsequent Cu-catalyzed C-N coupling reaction furnishes the quinoline subunit and affords the quinindoline structure I. The experimental process involved the reaction of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile(cas: 13544-06-4).Category: nitriles-buliding-blocks

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Nitrile – Wikipedia,
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Berdini, Valerio et al. published their patent in 2008 |CAS: 1036991-35-1

The Article related to bicyclic heterocyclic imidazopyridine preparation fibroblast growth factor receptor inhibitor, fgfr3 inhibitor antitumor bicyclic heterocyclic imidazopyridine preparation and other aspects.Product Details of 1036991-35-1

On July 3, 2008, Berdini, Valerio; Besong, Gilbert Ebai; Callaghan, Owen; Carr, Maria Grazia; Congreve, Miles Stuart; Gill, Adrian Liam; Griffiths-Jones, Charlotte Mary; Madin, Andrew; Murray, Christopher William; Nijjar, Rajdeep Kaur; O’Brien, Michael Alistair; Pike, Andrew; Saxty, Gordon; Taylor, Richard David; Vickerstaffe, Emma published a patent.Product Details of 1036991-35-1 The title of the patent was Preparation of bicyclic heterocyclic compounds as FGFR inhibitors. And the patent contained the following:

The title compounds I [X1, X2, X3 = C or N, such that at least one of X1-X3 = N; X4 = CR3 or N; X5 = CR5, N or C(O); provided that no more than 3 of X1-X5 = N; R1 = NHCONR4R5, NHCO2R4, NHCSOR4, etc.; R3 = halo, H, alkyl, etc.; R3 = H, halo, alkyl, etc.; R4, R5 = H, alkyl, cycloalkyl, etc.; A = (un)substituted (non)aromatic carbocyclic or heterocyclic group; with the provisos], useful in the treatment of diseases, e.g. cancer, were prepared E.g., a 2-step synthesis of II, starting from 6-chloro-3-iodoimidazo[1,2-a]pyridine with 3-acetylaminophenylboronic acid, was given. Exemplified compounds I were tested in in vitro FGFR3 and PDGFR kinase assays. Many compounds I showed IC50 of <10 渭M or provided at least 50% inhibition of the FGFR3 activity at a concentrate of 10 渭M. Preferred I showed IC50 of <1 渭M or provided at least 50% inhibition of the FGFR3 activity at a concentrate of 1 渭M. Pharmaceutical composition comprising the compound I is disclosed. The experimental process involved the reaction of 3-Amino-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile(cas: 1036991-35-1).Product Details of 1036991-35-1

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Konstantinova, Lidia S. et al. published their research in Journal of the Chemical Society in 1999 |CAS: 2510-01-2

The Article related to indenothiazine preparation, indenodithiole preparation, indenothiophene preparation, thiazine indeno preparation, dithiole indeno preparation, thiophene indeno preparation and other aspects.Synthetic Route of 2510-01-2

On April 21, 1999, Konstantinova, Lidia S.; Rakitin, Oleg A.; Rees, Charles W.; Souvorova, Ljudmila I.; Torroba, Tomas published an article.Synthetic Route of 2510-01-2 The title of the article was One-pot synthesis of indeno-1,2-thiazines, -[1,2]dithioles and thiophenes; new liquid crystalline materials. And the article contained the following:

In a search for further examples of a new type of discotic liquid crystal, the authors have examined the reactions of S2Cl2 in the presence of a chlorinating agent (NCS) and a base (Hunig’s base or DABCO), mostly in THF, with cyclopent-1-enylacetic acid (I), inden-3-ylacetic acid (II) and its nitrile (III) and 1-(dicyanomethylene)indane (IV). The cyclopentene acid I gives purple crystals of the trichlorocyclopenta[1,2]dithiole ester, the product of heterocyclic ring formation, chlorination and dehydrochlorination and, unexpectedly, conversion of the acid in THF into its 4-chlorobutyl ester. Indenylacetic acid II gives methyleneindenes, the tricyclic 1,2-dithiolone V and the deep purple thiophene VI. Indenylacetonitrile III gives E-1-(伪-chloro-伪-cyanomethylene)indane and E- and Z-1-(伪-chloro-伪-cyanomethylene)-2,3-dichloroindene and Z-2-chloro-1-(伪-cyanomethylene)indane, depending upon the precise reaction conditions. Dicyanomethylene indane IV gives 1-(dicyanomethylene)-2,3-dichloroindene (VII) and the red, thermochromic 3,9-dichloro-4-cyanoindeno[1,2-e]-1,2-thiazine; the analogous cyano-ester gives the corresponding products. On melting, crystals of VI and VII are strongly birefringent. Mechanisms are proposed for the new transformations. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Synthetic Route of 2510-01-2

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Nitrile – Wikipedia,
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Jung, J. et al. published their research in Journal of Hazardous Materials in 2019 |CAS: 5098-14-6

The Article related to prebiotic chem inspired media stormwater greywater disinfection, antimicrobial media, disinfection, filter media, greywater, prebiotic chemistry inspired polymer, stormwater and other aspects.Recommanded Product: 2-Aminomalononitrile 4-methylbenzenesulfonate

On October 15, 2019, Jung, J.; Menzies, D. J.; Thissen, H.; Easton, C. D.; Evans, R. A.; Henry, R.; Deletic, A.; McCarthy, D. T. published an article.Recommanded Product: 2-Aminomalononitrile 4-methylbenzenesulfonate The title of the article was New prebiotic chemistry inspired filter media for stormwater/greywater disinfection. And the article contained the following:

Greywater and stormwater have received significant attention due to increasing water scarcity. Passive filtration such as biofiltration has been a popular treatment method with its low energy input and environmental friendliness. However, pathogen removal capacity needs improvement to achieve safe water quality. In this study, a prebiotic chem. inspired copolymer based on aminomalononitrile and 3,4,5-trihydroxybenzaldehyde (AMNT30) was introduced to develop antimicrobial media for passive filtration. The AMNT30 polymer provided an adhesive coating on zeolite substrates following a spontaneous polymerization process at room temperature AMNT30 coated media were investigated for metal loading capacity, surface morphol., E. coli removal and metal leaching after filtration of different water sources (i.e. stormwater, greywater, and deionized water) at low/high conductivity The coating enhanced metal ion loading on the surface and demonstrated that >8 log reduction of E. coli can be achieved for silver loaded materials compared to a 1 log reduction for copper loaded materials. The coating also increased the stability of the metals on the media irresp. of inflow characteristics. This study provided the first example using AMNT30 to create antimicrobial water purification media. It is expected that this technol. will find applications in the water treatment industry. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Recommanded Product: 2-Aminomalononitrile 4-methylbenzenesulfonate

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Bernasconi, Claude F. et al. published their research in Journal of the American Chemical Society in 1996 |CAS: 13544-06-4

The Article related to deprotonation nitrophenylacetonitrile piperidine kinetics mechanism, broensted lfer deprotonation nitrophenylacetonitrile, solvent effect deprotonation nitrophenylacetonitrile and other aspects.Synthetic Route of 13544-06-4

On November 20, 1996, Bernasconi, Claude F.; Wenzel, Philip J. published an article.Synthetic Route of 13544-06-4 The title of the article was Kinetics of Proton Transfer from 2-Nitro-4-X-phenylacetonitriles to Piperidine and Morpholine in Aqueous Me2SO. Solvent and Substituent Effects on Intrinsic Rate Constants. Transition State Imbalances. And the article contained the following:

Rate constants (k1B) for the deprotonation of 2-nitro-4-X-phenylacetonitrile, 2-X (X = NO2, SO2CH3, CN, CF3, Br, and Cl) by piperidine and morpholine and for the reverse reaction (k-1BH) have been determined in 90% Me2SO-10% water, 50% Me2SO-50% water, and water (X = NO2, SO2CH3, CN only). Broensted 尾B values (dlog k1B/dpKaBH), Broensted 伪CH values (dlog k1B/dlog KaCH), and intrinsic rate constants (log ko = log(k1/q) for pKaBH – pKaCH + log(p/q) = 0) were calculated from these data. 伪CH Is smaller than 尾B, implying an imbalance which is consistent with a transition state in which delocalization of the neg. charge into the 2-nitrophenyl moiety lags behind proton transfer. A consequence of this imbalance is that the intrinsic rate constant decreases with increasing electron withdrawing strength of X. For 蟺-acceptor substituents (NO2, SO2CH3, CN) there is a further decrease in ko due to a lag in the delocalization of the charge into X. The intrinsic rate constants depend very little on the Me2SO content of the solvent which is shown to be the result of compensation of mainly two competing factors. One is the stabilization of the polarizable transition state by the polarizable Me2SO which increases ko; the other is attributed to a lag in the solvation of the developing carbanion behind proton transfer at the transition state which leads to a decrease in ko. The experimental process involved the reaction of 2-(2-Nitro-4-(trifluoromethyl)phenyl)acetonitrile(cas: 13544-06-4).Synthetic Route of 13544-06-4

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts