Month: November 2022

On September 10, 1982, Colvin, Ernest W.; Kirby, Gordon W.; Wilson, Arthur C. published an article.Category: nitriles-buliding-blocks The title of the article was O-(Diphenylphosphinyl)hydroxylamine: a new reagent for electrophilic C-amination. And the article contained the following:

Ph2P(O)ONH2 (I) efficiently aminated (EtO)2P(O)CH-CO2CH2Ph, (EtO2C)2CH-, (NC)2CH-, PhMgBr, and Me(CH2)5MgBr in THF at -78掳 under Ar. E.g., treatment of (EtO)2P(O)CH2CO2CH2Ph with NaH at room temperature under Ar, then I at -78掳 gave 60% (EtO)2P(O)CH(NH2)CO2CH2Ph. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Category: nitriles-buliding-blocks

The Article related to phosphinylhydroxylamine amination phosphonoacetate malonate anion, grignard reagent amination phosphinylhydroxylamine, hydroxylamine phosphinyl amination phosphonoacetate anion and other aspects.Category: nitriles-buliding-blocks

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On December 15, 2010, Chandrappa, S.; Vinaya, K.; Ramakrishnappa, T.; Rangappa, K. S. published an article.Safety of 3-Chloro-4-nitrobenzonitrile The title of the article was An efficient method for aryl nitro reduction and cleavage of azo compounds using iron powder/calcium chloride. And the article contained the following:

A novel, efficient Fe/CaCl2 system was revealed for the reduction of nitro-arenes and reductive cleavage of azo compounds by catalytic transfer hydrogenation. The selective reduction of nitro compounds in the presence of sensitive functional groups including halides, carbonyl, hydroxyl, aldehyde, Me, methoxy, acetyl, nitrile, and ester substituents with an excellent yields is reported. The simple exptl. procedure and easy purification make the protocol advantageous. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Safety of 3-Chloro-4-nitrobenzonitrile

The Article related to nitro aryl reduction iron calcium chloride catalytic transfer hydrogenation, azo aromatic cleavage iron calcium chloride catalytic transfer hydrogenation, aryl amine preparation and other aspects.Safety of 3-Chloro-4-nitrobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Jain, S.; Reddy, B. N.; Rao, K. S. published an article in 2012, the title of the article was Synthesis of biheterocycles containing indole nucleus and their antibacterial activity.Computed Properties of 75629-62-8 And the article contains the following content:

Indole-3-carboxaldehydes underwent condensation with Et cyanoacetate and malononitrile to give the acrylonitrile which on reaction with hydrazine hydrate yield 3,5-diamino-5-hydroxy-4-(3-indolylmethylene)pyrazoles and 3-amino-5-hydroxy-4-(3-indolylmethylene)pyrazoles, resp. The new compounds were also screened for their antibacterial activity. The experimental process involved the reaction of 2-((1H-Indol-3-yl)methylene)malononitrile(cas: 75629-62-8).Computed Properties of 75629-62-8

The Article related to indole carboxaldehyde malononitrile cyanoacetate condensation, indolyl acrylonitrile preparation antibacterial hydrazine cyclocondensation, indolylidene aminopyrazole preparation antibacterial and other aspects.Computed Properties of 75629-62-8

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Alizadeh, Abdolali; Sedighian, Hadi; Yasub Hosseini, Seyed; Zhu, Long-Guan published an article in 2015, the title of the article was Synthesis of Polysubstituted Benzenes via the Vinylogous Michael Addition of Alkylidenemalononitriles to 2-(1,3-Dioxo-1H-inden-2(3H)-ylidene)malononitrile.Product Details of 2510-01-2 And the article contains the following content:

An efficient synthesis for polysubstituted benzenes I [R1 = H; R1R2 = CH2CH2CH2, CH2CH2CH2CH2, etc.; R2 = C6H5, 4-H3CC6H4, chromen-2-one-3yl, etc.; R3 = CH3, CH2CH3] were successfully developed by the reaction of ninhydrin (2,2-dihydroxyindane-1,3-dione), malononitrile (propanedinitrile) and alkylidenemalononitrile. The method involves vinylogous Michael addition of alkylidenemalononitrile to 2-(1,3-dioxo-1H-inden-2(3H)-ylidene)malononitrile, which formed by condensation of malononitrile and ninhydrin in the presence of Et3N, and the alc. solvent has participated in the reaction as a reagent. The method has the advantages of good yields and of not requiring a metal catalyst. The structures were confirmed spectroscopically and in the case of compound I [R1R2 = -CH2CH2CH2CH2-; R3 = CH3], by X-ray crystallog. A plausible mechanism for this reaction is proposed. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Product Details of 2510-01-2

The Article related to malononitrile ninhydrin condensation triethylamine catalyst, dioxo indenylidene malononitrile preparation alkylidenemalononitrile vinylogous michael addition, polysubstituted benzene preparation and other aspects.Product Details of 2510-01-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On May 5, 2008, Wang, Xiang-Shan; Wu, Jian-Rong; Li, Qing; Yao, Chang-Sheng; Tu, Shu-Jiang published an article.Reference of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile The title of the article was A novel and green method for the synthesis of indeno[2,1-c]pyridine derivatives in ionic liquid catalyzed by malononitrile. And the article contained the following:

1-Aryl-9H-indeno[2,1-c]pyridine-4-carbonitrile derivatives, e.g., I, were unexpectedly obtained from the reaction of 2-(2,3-dihydroinden-3-ylidene)malononitrile (II), aldehydes (such as 4-tolualdehyde), and malononitrile in ionic liquid at 90 °C. Modification of the novel reaction protocol resulted in a two-component reaction between II and aryl and heteroaryl aldehydes catalyzed by 10 mol% malononitrile. A 1,5-hydrogen transfer was proposed to occur in the formation of the product. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Reference of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

The Article related to dihydroindenylidene malononitrile aryl aldehyde malononitrile catalyst heterocyclization, aryl indenopyridine carbonitrile derivative preparation, ionic liquid green chem heterocyclization solvent and other aspects.Reference of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On April 25, 2002, Nakao, Kazunari; Okumura, Yoshiyuki; Matsumizu, Miyako; Uneo, Naomi; Hashizume, Yoshinobu; Kato, Tomoki; Kawai, Akiyoshi; Miyake, Yoriko; Nukui, Seiji; Shinjyo, Katsuhiro; Taniguchi, Kana published a patent.Recommanded Product: 3-Chloro-4-nitrobenzonitrile The title of the patent was Preparation of imidazoarenes as antiinflammatory and analgesic agents.. And the patent contained the following:

Title compounds [I; Y1-Y4 = N, CH, CL; R1 = H, (substituted) alkyl, alkenyl, alkynyl, cycloalkyl, alkoxy, pyrrolidinyl, amino, etc.; A = (substituted) 5-6 membered monocyclic aromatic ring optionally containing up to 3 heteroatoms selected from O, N, S, etc.; B = halo-substituted alkylene, cycloalklylene, alkenylene, alkynylene, alkyleneoxy, etc., optionally substituted with an oxo group; W = amino, O, S, bond, etc.; R2 = H, OH, alkyl, alkoxy; Z = 5-12 membered (substituted) monocyclic or bicyclic aryl optionally containing up to 3 heteroatoms selected from O, N and S, etc.; L = halo, alkyl, haloalkyl, OH, alkoxy, haloalkoxy, alkylthio, NO2, amino, etc.], were prepared as prostaglandin E2 receptor antagonists, preferably as EP4 receptor antagonists. Thus, to 2-[4-(2-ethyl-5,7-dimethyl-3H-imidazo[4,5-b]pyridin-3-yl)phenyl]ethylamine (preparation given) in CH2Cl2 was added p-toluenesulfonyl isocyanate followed by stirring for 3 h to give 56% 2-ethyl-5,7-dimethyl-3-[4-[2-[[[[(4-methylphenyl)sulfonyl]amino]carbonyl]amino]ethyl]phenyl]-3H-imidazo[4,5-b]pyridine. Preferred I inhibited PGE2-induced thermal hyperalgesia in rats with ED50<60 mg/kg. The experimental process involved the reaction of 3-Chloro-4-nitrobenzonitrile(cas: 34662-29-8).Recommanded Product: 3-Chloro-4-nitrobenzonitrile

The Article related to imidazoarene preparation antiinflammatory analgesic, prostaglandin receptor antagonist imidazoarene preparation, benzimidazole imidazopyridine preparation ep4 antagonist analgesic antiinflammatory and other aspects.Recommanded Product: 3-Chloro-4-nitrobenzonitrile

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On April 5, 2019, Chen, Yiyang; Lu, Ping; Wang, Yanguang published an article.Related Products of 2510-01-2 The title of the article was 3-Amino-fluorene-2,4-dicarbonitriles (AFDCs) as Photocatalysts for the Decarboxylative Arylation of α-Amino Acids and α-Oxy Acids with Arylnitriles. And the article contained the following:

1-(4-(9H-Carbazol-9-yl)phenyl)-3-amino-9H-fluorene-2,4-dicarbonitrile as a new photocatalyst for the decarboxylative cross-coupling reaction of α-amino acids or α-oxy carboxylic acids with arylnitriles is described. This light-driven reaction enables a variety of benzylic amines and ethers to be prepared from readily available starting materials under mild conditions. The experimental process involved the reaction of 2-(2,3-Dihydro-1H-inden-1-ylidene)malononitrile(cas: 2510-01-2).Related Products of 2510-01-2

The Article related to aminofluorene dicarbonitrile preparation photocatalyst decarboxylative arylation, arylation alpha amino acid oxy carboxylic acid arylnitrile, benzylic amine ether preparation cross coupling reaction and other aspects.Related Products of 2510-01-2

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On May 8, 2017, Menzies, Donna J.; Ang, Andrew; Thissen, Helmut; Evans, Richard A. published an article.Formula: C10H11N3O3S The title of the article was Adhesive Prebiotic Chemistry Inspired Coatings for Bone Contacting Applications. And the article contained the following:

New and improved bone-contacting medical devices are required to provide excellent bioactivity at the biointerface. Here, we have used coatings based on prebiotic chem. inspired polymerization of aminomalonitrile (AMN) in combination with comonomers 3,4-di- and 3,4,5-trihydroxybenzaldehyde (DHBA and THBA). The comonomers were incorporated into the AMN coatings to enhance polymerization kinetics, adhesive properties, metal binding efficacy, and human mesenchymal stem cell (hMSC) response. Incorporation of DHBA and THBA as sep. comonomers enhanced the polymerization kinetics compared to that of AMN polymerization alone, with 30 mol % THBA (30T) resulting in a 6-fold increase in thickness over 24 h. Furthermore, the adhesion of AMN coatings to silicon was enhanced when copolymerized with the HBA monomers, where the interfacial adhesion of the 30T coating was increased 20-fold. The ability of the coatings to incorporate zinc ions was investigated, and XPS anal. demonstrated that incorporating 30T increased the binding efficiency 4-fold compared to that of AMN alone. The attachment, proliferation, and morphol. of human mesenchymal stem cells (hMSC) on these coatings was investigated and reported. Finally, the utility of the coatings as osteogenic support matrixes via the induced osteogenic differentiation of hMSCs is reported. The AMN and 30T coatings resulted in the greatest efficiency of osteogenic differentiation, as measured by intracellular ALP activity and mineralization. Incorporation of zinc had a stimulatory effect on hMSC proliferation with 30T coatings, while enhanced mineralization was observed with the zinc functionalized AMN and 30T coatings. This study highlights the potential of prebiotic chem. inspired coatings in biomedical applications. The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).Formula: C10H11N3O3S

The Article related to adhesive prebiotic chem coating bone contacting application surface polymerization, adhesive coating, bioactive coatings, osteogenic differentiation, prebiotic chemistry, stem cells, universal coatings and other aspects.Formula: C10H11N3O3S

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

On April 21, 2003, Hirota, Kosaku; Kazaoka, Kazunori; Niimoto, Itaru; Sajiki, Hironao published an article.SDS of cas: 5098-14-6 The title of the article was Efficient synthesis of 2,9-disubstituted 8-hydroxyadenine derivatives. And the article contained the following:

An efficient and general method for the synthesis of 2,9-disubstituted 8-hydroxyadenines, e.g. I, which are expected to have various biol. activities, was realized. 5-Amino-4-cyano-2-hydroxyimidazoles, e.g. II, were prepared from aminomalononitrile and isocyanates as key intermediates. The condensation of II with amidines, imidates, guanidine, urea and thioureas afforded 8-hydroxyadenines, e.g. III, possessing various substituents at the 2-position. Furthermore, selective alkylation of 2-amino- and 2-hydroxyadenines (IV and V) successively proceeded to give the corresponding 2-alkylamino- and 2-alkoxyadenines, resp. 2-Alkylthioadenines, e.g. VI, were prepared by an analogous reaction of II with benzoyl isothiocyanate and subsequent S-alkylation. The imidazoles, e.g. II, are most useful intermediates for the synthesis of 8-hydroxyadenine derivatives The experimental process involved the reaction of 2-Aminomalononitrile 4-methylbenzenesulfonate(cas: 5098-14-6).SDS of cas: 5098-14-6

The Article related to disubstituted hydroxyadenine adenine preparation condensation imidazole amidine imidate thiourea, alkoxyadenine alkylaminoadenine disubstituted adenine preparation alkylation hydroxyadenine aminoadenine and other aspects.SDS of cas: 5098-14-6

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts