Month: November 2022

Davies, Sarah published the artcileDevelopment of a self-immolative linker for tetrazine-triggered release of alcohols in cells, Quality Control of 100-70-9, the main research area is antibacterial drug triclosan prodrug preparation cycloocten tetrazine bond cleavage.

Bioorthogonal decaging reactions are a promising strategy for prodrug activation because they involve bond cleavage to release a mol. of interest. The trans-cyclooctene (TCO)-tetrazine inverse electron-demand Diels-Alder reaction has been widely applied in vivo for decaging of amine prodrugs, however, the release of alc.-containing bioactive compounds has been less well studied. Here, we report a TCO-carbamate benzyl ether self-immolative linker for the release of OH-mols. upon reaction with a tetrazine trigger. The benzyl ether linker proved to be highly stable and can rapidly liberate alcs. under physiol. conditions upon reaction with tetrazines. The mechanism and decaging yield were systematically examined by fluorescence and HPLC anal. by using a fluorogenic TCO-benzyl ether-coumarin probe and different 3,6-substituted tetrazine derivatives This study revealed that decaging occurs rapidly (t1/2 = 27 min) and the cycloaddition step happens within seconds (t1/2 = 7 s) with reaction rates of ≈100 M-1s-1. Importantly, the reaction is compatible with living organisms as demonstrated by the decaging of a prodrug of the antibacterial compound triclosan in the presence of live E. coli, that resulted in complete cell killing by action of the released “”OH-active drug””. Overall, this work describes a new linker for masking alc. functionality that can be rapidly reinstated through tetrazine-triggered decaging.

Organic & Biomolecular Chemistry published new progress about Antibacterial agents. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Quality Control of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Kim, Michelle B. published the artcileThe Synthesis and Antimicrobial Activity of Heterocyclic Derivatives of Totarol, Quality Control of 5653-62-3, the main research area is totarol heterocyclic derivative preparation antimicrobial.

The synthesis and antimicrobial activity of heterocyclic analogs of the diterpenoid totarol, e.g., I, are described. An advanced synthetic intermediate with a ketone on the A-ring is used to attach fused heterocycles, and a carbon-to-nitrogen atom replacement is made on the B-ring by de novo synthesis. A-ring analogs with an indole attached exhibit, for the first time, enhanced antimicrobial activity relative to the parent natural product. Preliminary experiments demonstrate that the indole analogs do not target the bacterial cell division protein FtsZ as had been hypothesized for totarol.

ACS Medicinal Chemistry Letters published new progress about Antibacterial agents. 5653-62-3 belongs to class nitriles-buliding-blocks, name is 2,3-Dimethoxybenzonitrile, and the molecular formula is C9H9NO2, Quality Control of 5653-62-3.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ilin, Mikhail V. published the artcileAminonitrones as highly reactive bifunctional synthons. An expedient one-pot route to 5-amino-1,2,4-triazoles and 5-amino-1,2,4-oxadiazoles – potential antimicrobials targeting multi-drug resistant bacteria, Computed Properties of 100-70-9, the main research area is aminonitrone synthon triazole oxadiazole preparation antibacterial multidrug agent.

The developed one-pot protocol to 5-amino-1,2,4-triazoles or 5-amino-1,2,4-oxadiazoles includes an interplay between aminonitrones R1C(NH2)N+(Me)O- (R1 = Alk, Ar, Het), isocyanides R2NC (R2 = Alk, Ar), Br2, and hydrazines (for the triazoles) or hydroxylamine (for the oxadiazoles). This formally four-component reaction, involving aminonitrones, isocyanides, bromine, and N-nucleophiles, proceeds very rapidly under mild conditions (10 min, 20-25°), and is insensitive to moisture and air (in undried CHCl3-MeOH, in air) and it gives the heterocyclic systems in good yields (up to 86%; 26 examples). The reaction scope includes aromatic-, heteroaromatic-, and aliphatic aminonitrones and also aliphatic- and aromatic isocyanides. Results of DFT calculations (M06-2X/6-311+G(d,p) level of theory) indicate that the O-nucleophilic center of bifunctional aminonitrones is more reactive than the N center; it first reacts with in situ generated R2NCBr2 to grant 2-methyl-1,2,4-oxadiazolium salts, which are then converted to the target heterocyclic systems upon treatment with hydrazines or hydroxylamine. The nature and strength of the intramol. hydrogen bonds N-H···N and O-H···N, which significantly contribute to the total energies of different transition states and products of the nucleophilic substitution, were studied theor. using the topol. anal. of the electron d. distribution within the framework of Bader’s theory (QTAIM method). Several new 5-amino-3-aryl-1,2,4-triazoles and -1,2,4-oxadiazoles exhibit high antibacterial activity against multidrug-resistant bacteria strains such as Staphylococcus aureus and Klebsiella pneumoniae (MIC = 8 mg L-1).

New Journal of Chemistry published new progress about Antibacterial agents. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Computed Properties of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Frejat, Firas O. A. published the artcileNew 1,2,4-oxadiazole/pyrrolidine hybrids as topoisomerase IV and DNA gyrase inhibitors with promising antibacterial activity, Product Details of C6H4N2, the main research area is pyrrolidine oxadiazole moiety DNA gyrase topoisomerase antibacterial activity; DNA; bacterial resistance; cell viability; gyrase; topoisomerase.

A series of hybridized pyrrolidine compounds with a 1,2,4-oxadiazole moiety were synthesized to develop effective mols. against the enzymes DNA gyrase and topoisomerase IV (Topo IV). Compounds 8-20 were developed based on a previously disclosed series of compounds from our lab, but with small structural modifications in the hopes of increasing the compounds′ biol. activity. In comparison to novobiocin, with IC50 = 170 nM, the findings of the DNA gyrase inhibitory assay revealed that compounds 16 and 17 were the most potent of all synthesized derivatives, with IC50 values of 180 and 210 nM, resp. Compound 17 had the strongest inhibitory effect against Escherichia coli Topo IV of all the synthesized compounds, with an IC50 value of 13 μM, which was comparable to novobiocin (IC50 = 11 μM). Therefore, hybrids 16 and 17 appeared to be potential dual-target inhibitors. In the minimal inhibitory concentration (MIC) assays, compound 17 outperformed ciprofloxacin against E. coli, with an MIC of 55 ng/mL, compared to 60 ng/mL for ciprofloxacin. Finally, the docking study, along with the in vitro experiments, supports our promising approach to effectively develop potent leads for further optimization as dual DNA gyrase and Topo IV inhibitors.

Archiv der Pharmazie (Weinheim, Germany) published new progress about Antibacterial agents. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Product Details of C6H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Frejat, Firas Obaid Arhema published the artcileNovel 1,2,4-oxadiazole/pyrrolidine hybrids as DNA gyrase and topoisomerase IV inhibitors with potential antibacterial activity, Application In Synthesis of 100-70-9, the main research area is DNA gyrase topoisomerase IV inhibitor antibacterial oxadiazole pyrrolidine hybrids.

DNA gyrase is a promising target for antibacterial agents. Several classes of small-mol. inhibitors have been discovered in recent decades, but none of these have reached the market. We have designed a small library of 1,2,4-oxadiazole/pyrrolidine hybrids with mid nanomolar inhibitory and potent antibacterial activities against DNA gyrase and topoisomerase IV. Compounds 9, 15, 16, 19, and 21 inhibited Escherichia coli DNA gyrase to a similar extent as the reference compound, novobiocin, with inhibitory values ranging from 120 nM to 270 nM. Compound 16 was one of the most potent compounds in the series, with an IC50 value of 120 nM against E. coli gyrase, which is lower than the IC50 value of novobiocin (170 nM). Compound 16 had the highest inhibitory activity, with min. inhibitory concentrations (MIC) of 24 and 62 ng/mL against Staphylococcus aureus and E. coli, resp., which compared favorably with ciprofloxacin (30 and 60 ng/mL, resp.). Compounds 9, 15, 19, and 21 were similar to novobiocin in terms of their activity against E. coli and S. aureus topoisomerase IV, while compound 16 was more potent than novobiocin.

Arabian Journal of Chemistry published new progress about Antibacterial agents. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Application In Synthesis of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Sharma, Sonika published the artcileVanadium(IV) coordination complexes with excellent biological activities: a synthetic, characterization, and density functional theory approach, SDS of cas: 100-70-9, the main research area is oxidovanadium coordination complex preparation antibacterial antifungal; mol structural calculation oxidovanadium coordination complex.

A set of new oxidovanadium(IV) complexes, [VO(4-NO2C6H4CH:CHCONHO)2] (1), [VO(4-NO2C6H4CH:CHCONHO)2(2-CNC5H4N)] (2), and [VO(4-NO2C6H4CH:CHCONHO)2(4-CNC6H4NH2)] (3), were synthesized and characterized by different anal. techniques (magnetic susceptibility, molar conductivity, elemental anal.) and spectroscopic techniques, viz., FTIR, UV-visible, EPR, and mass spectrometry. The magnetic susceptibility, EPR, and ESI-MS data indicate that exists as monomer and a distorted square pyramidal geometry around vanadium is ascertained. The electrochem. study of showed that it is electrochem. active exhibiting VOV/VOIV quasi-reversible redox couple. The biol. activity of 1-3 was studied against various pathogenic bacteria Staphylococcus epidermidis, Klebsiella pneumoniae, Staphylococcus aureus, Escherichia coli, Salmonella paratyphi, and Salmonella typhi, and fungi Brachypsectra fulva, Candida albicans, and Fusarium oxysporum by min. inhibitory concentration (MIC) method. In some cases, the synthesized complexes showed superior antibacterial and antifungal activity than the known standard drugs tetracycline hydrochloride and fluconazole. The cytotoxicity of 1-3 was studied on a human cervix carcinoma HeLa cell derivative (mammalian transformed cell line Hep2c) by MTT assay. D. functional theory (DFT) studies were carried out to determine their relative free energy of formation and optimized mol. structures of 1-3. Time-dependent d. functional theory (TD-DFT) based calculations were performed to find out the frontier MOs and corroborate with the exptl. observed electronic transitions of 1. Other parameters like HOMO, LUMO energies, and global reactivity descriptors clearly support higher biol. activity of 2 and 3 than 1.

Journal of Coordination Chemistry published new progress about Antibacterial agents. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, SDS of cas: 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Shit, Manik published the artcileSupramolecular assembly of an Au(III) complex of 2-(3-phenyl-1H-1,2,4-triazol-5-yl)pyridine: Structure, biological studies and charge transportation, Category: nitriles-buliding-blocks, the main research area is crystal structure gold phenyltriazolylpyridine complex; gold phenyltriazolylpyridine preparation biol charge transport study.

An Au(III) complex, [Au(2-ptp)2]Cl (1) (2-ptp = 2-(3-phenyl-1H-1,2,4-triazol-5-yl)pyridine), was characterized by single-crystal x-ray diffraction technique and other spectroscopic data. Presence of different noncovalent interactions gives 3-dimensional supramol. structure. The complex 1 exhibits antibacterial activity against Gram-pos. (MIC) (Staphylococcus aureus [240μg/mL], Bacillus subtilis [645μg/mL]) and Gram-neg. ( Escherichia coli [270μg/mL], Enterococcus faecalis [820μg/mL], Klebsiella pneumonia [785μg/mL]) bacteria. Also, the toxicity of 1 was checked by MTT assay. The complex shows promising anticancer activity against Vero cells and the CC50 is 405μg/mL. The complex also shows improved conductivity (Λ) by one order difference on illumination (Λdark, 7.42 × 10-5 Sm-1 and Λillumination, 2.45 x 10-4 Sm-1).

Applied Organometallic Chemistry published new progress about Antibacterial agents. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Aydin, Ali published the artcileIn-Vitro Anticancer and Antibacterial Activities of Brominated Indeno[1,2-b]qinoline Amines Supported with Molecular Docking and MCDM, Application In Synthesis of 1885-29-6, the main research area is brominated indenoqinoline amine anticancer antibacterial activity mol docking MCDM.

The present study describes mono substituted indeno[1,2-b]quinolines (3 a-c and 5) have much more antiproliferative potentials than pos. controls against A549, HeLa, MCF7 and Hep3B cell lines (IC50 values 1.1-29.6 μg/mL) and show similar cytotoxicity (14.3% to 19.8%) to cells such as controls. Moreover, the mono substituted indeno[1,2-b]quinoline amines (3 a-c and 5) exhibit significant antimicrobial activity with MIC values between 15.62 μ g/mL and 250 μg/mL. The compounds can also bind to DNA in the groove binding mode with a binding constant range of 1.1×103-1.1×105 M-1. The anticancer and antibacterial properties of compounds were confirmed with the mol. docking simulation for their pharmacokinetic. As a result, the preliminary exptl. data and a multi-criteria decision-making methodol. (MCDM) indicated that the mono substituted indeno[1,2-b]quinoline amine derivatives, especially 3 a and 5, exhibit effective pharmacol. properties. parameters and their interaction with related cells at the mol. level.

ChemistrySelect published new progress about Antibacterial agents. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application In Synthesis of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zheng, Bing-De published the artcileA non-aggregated zinc(II) phthalocyanine with hexadeca cations for antitumor and antibacterial photodynamic therapies, Application of Phthalonitrile, the main research area is nonaggregated zinc phthalocyanine hexadeca cation antitumor antibacterial photodynamic therapy; Antibacterial; Anticancer; Cationic zinc(II) phthalocyanine; Non-aggregation; Photodynamic therapy.

With a view to developing highly efficient photosensitizers for both antitumor and antimicrobial photodynamic therapies, herein, we reported a super cationic zinc(II) phthalocyanine (Pc4), which was prepared through the quaternization of the N, N-dimethyl-3-aminophenoxyl-hexadeca-substituted precursor Pc3. Meanwhile, two disubstituted analogs (Pc1 and Pc2) were also prepared as controls. The cationic Pc2 and Pc4 had higher photoactivities including fluorescence and singlet oxygen than the neutral counterparts Pc1 and Pc3, probably because of the inhibition of intramol. charge transfer (ICT) effect of the amino groups. With the bulky steric effect and high hydrophilicity, Pc4 presented non-aggregated behavior in aqueous solutions Therefore, it exhibited the highest in vitro photodynamic activity toward HepG2 cancer cells with an IC50 value as low as 0.04 μM. Furthermore, Pc4 showed a highly efficient in vivo PDT effect on H22 tumor-bearing mice with 98.7% tumor growth inhibition. In addition, Pc4 also exhibited an excellent in vitro and in vivo photodynamic inactivation against S. aureus. The results indicate that the non-aggregated hexadeca-cationic Pc4 could serve as a promising photosensitizer for both antitumor and antimicrobial photodynamic therapies.

Journal of Photochemistry and Photobiology, B: Biology published new progress about Antibacterial agents. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Application of Phthalonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Xue, Wenjie published the artcileN-thiadiazole-4-hydroxy-2-quinolone-3-carboxamides bearing heteroaromatic rings as novel antibacterial agents: Design, synthesis, biological evaluation and target identification, Computed Properties of 100-70-9, the main research area is thiadiazole hydroxy quinolone carboxamide preparation antibacterial docking pharmacokinetic antitumor; Antibacterial agent; Antibiotic resistance; DNA gyrase B; MRSA; Molecular docking.

In this study, N-thiadiazole-4-hydroxy-2-quinolone-3-carboxamide derivatives I (R1 = Et, cyclopentyl, 3-fluorophenyl, 1,3-thiazol-4-yl, etc.; R2 = Me, Et, n-Pr) were designed and synthesized and evaluated for their antibacterial activity against S. aureus ATCC29213, which led to the identification of ten potent antibacterial agents with min. inhibitory concentration (MIC) values below 1μg/mL. Next, bacterial growth inhibition assays against a panel of drug-resistant clin. isolates, including methicillin-resistant S. aureus, and cytotoxicity assays with HepG2 and HUVEC cells were performed. One of the tested compounds named I [R1 = 1,3-thiazol-2-yl; R2 = Et] (A) showed 2 to 128-times improvement compared with vancomycin in term of antibacterial potency against the tested strains (MICs: 0.25-1μg/mL vs. 1-64μg/mL) and an optimal selective toxicity (HepG2/MRSA, 110.6 to 221.2; HUVEC/MRSA, 77.6-155.2). Further, comprehensive evaluation indicated that (A) did not induce resistance development of MRSA over 20 passages, and it has been confirmed as a bactericidal, metabolically stable, orally active antibacterial agent. More importantly, the S. aureus DNA gyrase B as its potential target is identified and a potential binding mode by mol. docking is proposed. Taken together, the present work reports the most potent derivative of this chem. series (A) and uncovers its potential target, which lays a solid foundation for further lead optimization facilitated by the structure-based drug design technique.

European Journal of Medicinal Chemistry published new progress about Antibacterial agents. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Computed Properties of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts