Month: November 2022

Cao, Yu published the artcileSelf-[3+2] annulation reaction of pyridinium salts: synthesis of N-indolizine-substituted pyridine-2(1H)-ones, Quality Control of 1885-29-6, the main research area is benzyolmethyl pyridinium bromide cycloaddition; aroyl arylindolizinyl pyridinone preparation; aniline benzyolmethyl pyridinium bromide cycloaddition; benzoyl phenylindolizinylpyridinylideneamino benzonitrile preparation.

A self-[3+2] annulation reaction of pyridinium salts was developed for the synthesis of N-indolizine-substituted pyridine-2(1H)-ones. This protocol was carried out under mild reaction conditions without any precious catalysts in generally moderate to good yields. Addnl., a plausible mechanism for the transformation was proposed.

New Journal of Chemistry published new progress about [3+2] Cycloaddition reaction. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Quality Control of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Fatahi, Hosna published the artcileSynthesis of α-Aminonitriles and 5-Substituted 1H-Tetrazoles Using an Efficient Nanocatalyst of Fe3O4@SiO2-APTES-supported Trifluoroacetic Acid, Synthetic Route of 100-70-9, the main research area is iron oxide supported silylpropylammonium trifluoroacetic acid preparation surface structure; carbonyl compound aniline heterogeneous catalyst Strecker reaction green chem; phenylamino acetonitrile preparation; sodium azide aryl nitrile heterogeneous catalyst cycloaddition green chem; aryl tetrazole preparation.

Fe3O4@SiO2-APTES-supported trifluoroacetic acid nanocatalyst was used for the one-pot synthesis of α-aminonitriles via a three-component reaction of aldehydes (or ketones), amines and sodium cyanide. This method produced a high yield of 75-96% using only a small amount of the catalyst (0.05 g) in EtOH at room temperature The catalyst was also employed for the synthesis of 5-substituted 1H-tetrazoles from nitriles and sodium azide in EtOH at 80°. The tetrazoles were produced with good-to-excellent yields in a short reaction time of 4 h. Both synthetic methods were carried out in the absence of an organic volatile solvent. Because the supported trifluoroacetic acid generated a solid acid on the surface, thus the acid corrosiveness was not a serious challenge. This heterogeneous nanocatalyst was magnetically recovered and reused several times without significant loss of catalytic activity.

Journal of Heterocyclic Chemistry published new progress about [3+2] Cycloaddition reaction. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Synthetic Route of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ghafouri-Nejad, Raziyeh published the artcileSynthesis and characterization of Cu-N, N’-Dicyclohexylcarbodiimide supported on CMK-3 as a novel, efficient and recoverable nanocatalyst for synthesis of tetrazole, polyhydroquinoline, and sulfoxide derivatives, Product Details of C8H4N2, the main research area is dicyclohexylcarbodiimide carbon nanocatalyst tetrazole polyhydroquinoline sulfoxide derivative.

Mesoporous carbon CMK-3 was prepared using SBA-15 silica mesoporous as a hard template. Then, Cu-N, N’-Dicyclohexylcarbodiimide was supported on CMK-3 as a reusable and highly efficient nanocatalyst for the synthesis of tetrazole, polyhydroquinoline, and sulfoxide derivatives This new catalyst was characterized by FT-IR spectroscopy, XRD, SEM, BET, TGA, EDX, and ICP-OES techniques. After completing reactions, the catalyst was easily separated from the reaction mixture using centrifuge and reusable five times without significant loss of their catalytic efficiency.

Reaction Kinetics, Mechanisms and Catalysis published new progress about [3+2] Cycloaddition reaction. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Product Details of C8H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nikoorazm, Mohsen published the artcileCopper and nickel immobilized on cytosine@MCM-41: as highly efficient, reusable and organic-inorganic hybrid nanocatalysts for the homoselective synthesis of tetrazoles and pyranopyrazoles, Safety of Phthalonitrile, the main research area is copper mmobilized cytosine functionalized mesoporous silica catalyst preparation; nickel immobilized cytosine functionalized mesoporous silica catalyst preparation; pyranopyrazole preparation green chem; phenyl tetrazole preparation green chem.

In this work, a green approach was reported for efficient synthesis of biol. active tetrazole and pyranopyrazole derivatives in the presence of Cu-Cytosine@MCM-41 and Ni-Cytosine@MCM-41 (copper (II) and nickel (II) catalyst on the modified MCM-41 using cytosine). The synthesis of tetrazoles and pyranopyrazoles in the presence of these catalysts was performed in green solvents such as water or poly (ethylene glycol) (PEG). All products were obtained in high TOF (turnover frequency) numbers in the presence of these catalysts, which indicate the high efficiency of these catalysts in the synthesis of tetrazole and pyranopyrazole derivatives The prepared catalysts were characterized by various techniques such as BET, TGA, XRD, FT-IR, SEM, EDS, WDX, TEM, and AAS. Mesoporous structure of these catalysts was confirmed by nitrogen adsorption-desorption isotherms. These catalysts can be recovered and reused for several runs without significant change in their catalytic activity or metal capacity. The recovered catalysts have been characterized by XRD, SEM, EDS, WDX, FT-IR and AAS techniques, by which their heterogeneous nature has been confirmed.

Applied Organometallic Chemistry published new progress about [3+2] Cycloaddition reaction. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Safety of Phthalonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Kal-Koshvandi, Afsaneh Taheri published the artcileSynthesis and Characterization of Ultrapure HKUST-1 MOFs as Reusable Heterogeneous Catalysts for the Green Synthesis of Tetrazole Derivatives, Application of Phthalonitrile, the main research area is copper benzene tricarboxylate metal organic framework preparation surface structure; phenyltetrazole preparation green chem; phenyl tetrazolopyrimidine preparation green chem.

An ultrapure HKUST-1 MOFs synthesized through a precised methodol. as a heterogeneous catalyst for a green approach to the synthesis of tetrazole derivatives via two-, three-, and four-component reactions in milder reaction conditions was presented. Various preparation methods to produce HKUST-1 such as microwave irradiation, reflux, hydrothermal technique, and ultrasonication was precisely compared and it was proved that the best result was obtained during the hydrothermal technique. This was the first design, preparation, characterization and application in the present of HKUST-1 MOFs to the synthesis of the biol. and pharmaceutically important tetrazole compounds in green conditions. Moreover, plausible mechanisms of reactions was suggested for the catalytic activity of the presented catalyst. The catalyst was characterized by various techniques such as FT-IR, SEM, EDX, and XRD. Addnl., HKUST-1 was recoverable as well as reusable without any significant loss of its activity, which strongly supports the heterogeneous nature of the catalyyst. This novel catalysis protocol offered several advantages such as eco-friendly conditions, lower reaction time, milder reaction conditions, excellent catalytic activity and an easy separation of the catalyst make it a good heterogeneous system.

ChemistrySelect published new progress about [3+2] Cycloaddition reaction. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Application of Phthalonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ishida, Shintaro published the artcileStructures and Properties of Phenylene-Bridged 1,3-Diaza-2-silole and Related 2H-Azasilirenes Obtained by the Reactions of a Dialkylsilylene with Arylnitriles, Safety of Phthalonitrile, the main research area is silylene cycloaddition nitrile dinitrile preparation azasilirene disilolocyclooctene spirocycle; crystal mol structure azasilirene diazasilolocyclooctene spirocycle.

Cycloadditions of diorganosilylenes with nitriles afforded azasilirenes, while phthalonitrile gave dibenzobis[1,3,2]-diazasilolocyclooctene I (10) and spirocycle II (11) with 2,2,5,5-tetra-TMS-1-silacyclopentylidene. Silylene cycloaddition with unsaturated compounds have been extensively explored as convenient and efficient routes to silacycles. Among these, reactions of silylenes with nitriles are still limited and the electronic properties of the resulting azasilacycles such as 2H-azasilirene and 1,3-diaza-2-siloles are less examined We report herein synthesis of a phenylene-bridged 1,3-diaza-2-silole and C-aryl 2H-azasilirenes using cycloaddition reactions of a silylene as well as their structures and UV/Vis absorption spectra. Treatment of an isolable dialkylsilylene, 2,2,5,5-tetra-TMS-1-silacyclopentylidene, with o-phthalonitrile afforded a phenylene-bridged 1,3-diazasilole 10 and an isomeric dearomatized product 11. Similar reactions with p-substituted benzonitriles gave new 2H-azasilirenes. UV/Vis absorption spectra and theor. calculations showed that high-lying n(C:N) orbitals in 1,3-diaza-2-siloles and 2H-azasilirenes and low-lying π*(1,3-diaza-2-silole) orbitals are important for their electronic characters. Computational studies revealed that 1,3-dipolar cycloaddition of silylene nitrile complexes (nitrile silaylides) with the second nitrile and an aromatic C:C bond of 2-cyanophenyl group are key steps for the cycloaddition

European Journal of Inorganic Chemistry published new progress about [1+2] Cycloaddition reaction. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Safety of Phthalonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Cranston, Rosemary R. published the artcileN-type solution-processed tin versus silicon phthalocyanines: Comparison of performance in organic thin-film transistors and in organic photovoltaics, Product Details of C8H4N2, the main research area is tin phthalocyanine silicon organic photovoltaic thin film transistor; photostability solution processing semiconductor.

Tin(IV) phthalocyanines (SnPcs) are promising candidates for low-cost organic electronic devices, and have been employed in organic photovoltaics (OPVs) and organic thin-film transistors (OTFTs). However, they remain relatively understudied compared to their silicon phthalocyanine (SiPc) analogs. Previously, we reported the first solution-processed SnPc semiconductors for OTFTs and OPVs; however, the performances of these derivatives were unexpected. Herein to further study the behavior of these derivatives in OPVs and OTFTs, we report the synthesis along with optical and thermal characterization of seven axially substituted (OR)2-SnPcs, five of which were synthesized for the first time. D. functional theory (DFT) was used to predict charge-carrier mobilities for our materials in their crystal state. The application of these SnPcs as ternary additives in poly(3-hexylthiophene) (P3HT)/phenyl-C61-butyric acid Me ester (PC61BM) OPVs and as semiconductors in solution-processed n-type OTFTs was also investigated. When employed as ternary additives in OPVs, all (OR)2-SnPcs decreased the power conversion efficiency, open-circuit voltage, short-circuit current, and fill factor. However, in OTFTs, four of the seven materials exhibited greater electron field-effect mobility with similar threshold voltages compared to their previously studied SiPc analogs. Among these SnPcs, bis(triisobutylsilyl oxide) SnPc displayed the greatest electron field-effect mobility of 0.014 cm2 V-1 s-1, with a threshold voltage of 31.4 V when incorporated into OTFTs. This difference in elec. performance between OTFT and OPV devices was attributed to the low photostability of SnPcs.

ACS Applied Electronic Materials published new progress about Organic thin film transistors. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Product Details of C8H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhu, Sheng-Qing published the artcileDirect and Regioselective C-H Oxidative Difluoromethylation of Heteroarenes, Recommanded Product: 4-(5-Oxazolyl)benzonitrile, the main research area is difluoromethyl heterocycle preparation; heteroarene regioselective oxidative difluoromethylation.

The difluoromethyl group (CF2H) is of great interest in the area of medicinal chem. However, the investigation of mol. scaffolds containing this group has been hampered by the limitation of synthetic methods for the introduction of CF2H into heteroarenes. Herein we disclose a new strategy for the direct introduction of a difluoromethyl group into heteroarenes via the copper-mediated C-H oxidative difluoromethylation of heteroarenes with TMSCF2H. This mild and regioselective method enables the convenient synthesis of a range of difluoromethylated heteroarenes in high yields. The usage of 9,10-phenanthrenequinone (PQ) as an oxidant is critical to the success of this new difluoromethylation reaction.

Journal of the American Chemical Society published new progress about Fluoromethylation (oxidative). 87150-13-8 belongs to class nitriles-buliding-blocks, name is 4-(5-Oxazolyl)benzonitrile, and the molecular formula is C10H6N2O, Recommanded Product: 4-(5-Oxazolyl)benzonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Kimura, Takeshi published the artcilePreparation and Optical and Electrochemical Properties of Boron (III) Subphthalocyanines with One to Three Trithiole Rings, Synthetic Route of 91-15-6, the main research area is boron subphthalocyanine trithiole ring preparation electrochem redox emission ESR.

The reaction of 5,6-dicyano-4,7-diethylbenzo[1,2,3]trithiole (1) with trichloroborane in p-xylene and subsequent substitution of the chloro group with phenol produced boron subphthalocyanine (2) with three trithiole rings. Upon treatment of 1 with trichloroborane in p-xylene in the presence of unsubstituted phthalonitrile or tetrafluorophthalonitrile, unsym. subphthalocyanines (3, 4, 6, and 7) with one or two trithiole rings were obtained after the reaction with phenol. The Q-band absorption of 2 appeared at λmax = 611 nm in the UV-visible spectrum and the emission was observed at λe = 630 nm. Decreasing the number of fused trithiole rings and Et groups resulted in higher energy shifts of the Q-band absorption in the UV-visible spectra and downfield chem. shifts of the 11B NMR signals. Compounds 2-4 were treated by pentachloro antimonate in CH2Cl2, the solution of which showed strong ESR signals. The structures of simplified model compounds were optimized using the DFT method with the Gaussian 09 program at the B3LYP/6-31G (d, p) level.

European Journal of Inorganic Chemistry published new progress about ESR (electron spin resonance). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Synthetic Route of 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ochiai, Kotaro published the artcileStructure-property and structure-activity relationships of phenylferrocene derivatives as androgen receptor antagonists, Application In Synthesis of 1885-29-6, the main research area is phenylferrocene derivative androgen receptor antagonist structure activity relationship; Androgen receptor; Antagonist; Ferrocene; Hydrophobic pharmacophore.

Ferrocene is a representative organometallic compound having a sandwich structure with high stability and hydrophobicity. In this study, we determined the physicochem. properties of a series of nitro- and cyanophenylferrocenes, and evaluated their biol. activity as androgen receptor (AR) antagonists. Ferrocene derivatives exhibited hydrophobicity parameter π values in the range between 2.54 and 3.23, depending on the substituents, indicating that the hydrophobicity of ferrocene is suitable for its application as a hydrophobic core structure of nuclear receptor ligands. The synthesized ferrocene derivatives showed AR-antagonistic activity, and among them, 3-nitrophenylferrocene 14 exhibited the most potent activity with an IC50 value of 0.28 μM. The developed compounds may be candidates for further structural development as AR antagonists. These findings also support the utility of organometallic species as structural options for drug discovery.

Bioorganic & Medicinal Chemistry Letters published new progress about Androgen receptor antagonists. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application In Synthesis of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts