Month: November 2022

El-Remaily, Mahmoud Abd El Aleem Ali Ali published the artcileIron (III)-porphyrin Complex FeTSPP as an efficient catalyst for synthesis of tetrazole derivatives via [2 + 3] cycloaddition reaction in aqueous medium, HPLC of Formula: 100-70-9, the main research area is tetrazole tetrazolylguanidine green preparation; iron sulfonatophenylporphyrin recyclable catalyst cycloaddition azide nitrile; cyanoguanidine cycloaddition fluorinated aryl azide iron catalyst; aqueous ethanol solvent cycloaddition azide nitrile iron sulfonatophenylporphyrin catalyst.

In the presence of a tetrakis(sulfonatophenyl)porphyrin iron complex, sodium azide and aryl, alkyl, and fluoroaryl azides underwent green cycloaddition reactions with nitriles and cyanoguanidine in aqueous EtOH to give tetrazoles and tetrazolylguanidines; the iron catalyst was recovered by precipitation and reused.

Applied Organometallic Chemistry published new progress about 1,3-Dipolar cycloaddition catalysts. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, HPLC of Formula: 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Geyl, Kirill published the artcileConvenient entry to N-pyridinylureas with pharmaceutically privileged oxadiazole substituents via the acid-catalyzed C-H activation of N-oxides, Recommanded Product: Picolinonitrile, the main research area is oxadiazolyl pyridine oxide dialkylcyanamide methanesulfonic acid catalyst; dialkyl oxadiazolyl pyridinyl urea regioselective preparation green chem.

Pyridine-N-oxides bearing a pharmacophoric oxadiazole moiety could be C-H functionalized via the acid-catalyzed reaction with dialkylcyanamides, providing access to hitherto undescribed pyridine-2-yl substituted ureas, which have potential as “”lead-like”” scaffolds for medicinal chem. Atom-economy, environmental friendliness (no halide-containing or toxic reagents), simple work-up, as well as scalability are the main advantages of the employed procedure.

Tetrahedron Letters published new progress about C-H bond activation (regioselective). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Recommanded Product: Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Biryan, Fatih published the artcileElectrical, thermal behaviors and synthesis of intramolecular cobalt phthalocyanine with single-chain polymer structure, Safety of Phthalonitrile, the main research area is vinyl polymer cobalt phthalocyanine complex graphene nanocomposite.

Firstly, poly[4-((4-vinylbenzyl)oxy)phthalonitrile]-co-styrene, [poly(VBOP-co-St)], which is used as a linear copolymer precursor containing phthalonitrile pendant group was prepared from copolymerization of VBOP and St by atom transfer radical polymerization method at 110°. Then, complex synthesis of cobalt phthalocyanine in the single-chain polymer (SCP-CoPc complex) via the intramol. macrocyclization reaction of cobalt and phthalonitrile group in poly(VBOP-co-St) was carried out at 150° in the presence of excess cyclohexanol. Both linear copolymer precursor and formation of cobalt phthalocyanine within a single-chain polymer were confirmed by FT-IR, 1H-NMR, 13C-NMR and UV/Vis spectroscopy techniques. Particularly, the formation of SCP-CoPc complex was characterized by almost disappearance of -C≃N band at 2230 cm-1 of the FT-IR and appearance of Q band around 672 nm and the B band in the near UV region at 350 nm of UV/Vis spectroscopy. The pure poly(VBOP-co-St), SCP-CoPc complex and the residue SCP-CoPc complex heated to 500° were characterized by SEM images, and the element analyses were estimated from x-ray energy dispersive spectroscopy (x-ray EDS). The EDS elemental anal. results of the residual of SCP-CoPc complex degraded to 500° showed that CoO [cobalt(II)oxide] compound occurred. The thermal properties of poly(VBOP-co-St) and SCP-CoPc complex were investigated through thermogravimetric anal. and differential scanning calorimeter. The conducting nanographene-based SCP-CoPc composites were prepared DC and a.c. elec. conductivity and dielec. properties were investigated. The ac dielec. measurements of poly(VBOP-co-St), SCP-CoPc complex and composites were investigated at room temperature between 100 and 20 kHz depending on the a.c. conductivities. Also, the activation energy profile of SCP-CoPc/4% (by weight) nanographene composite was revealed by measuring the DC conductivity of individual composite material.

Polymer Bulletin (Heidelberg, Germany) published new progress about Atom transfer radical polymerization. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Safety of Phthalonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Song, Zehua published the artcileInnate pharmacophore assisted selective C-H functionalization to therapeutically important nicotinamides, HPLC of Formula: 1885-29-6, the main research area is amino nicotinamide preparation regioselective; amine nicotinamide carbon hydrogen amination; aryloxy nicotinamide preparation regioselective; nicotinamide phenol carbon hydrogen etherification.

The application of the pre-validated pharmacophore 2-(2-oxazolinyl)anilines (R)/(S)-I (R = H, Me, Et, benzyl) as an innate directing group in the C-H etherification and amination of nicotinamides II for the efficient synthesis of drug- and agrochem.-like mols. was determined An operationally simple, and regioselective C-H functionalization of nicotinamides (R)/(S)-II was first accomplished using a complicated variation of copper salts. All the specific procedures used were easy to utilize, without external oxidants or ligands. The feasibility is highlighted using an alternative synthesis of diflufenican with a rapid synthesis of niacin related pharmaceuticals or analogs III (R1 = H, 3-CH3OC6H4O, 2-methoxy-4-(prop-2-en-1-yl)phenyl, 4-methylpiperidin-1-yl, etc.; R2 = H, 2-methoxy-4-(prop-2-en-1-yl)phenyl, 3-methylpiperidin-1-yl, etc.).

Organic Chemistry Frontiers published new progress about Amination catalysts (regioselective). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, HPLC of Formula: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Li, Gang published the artcileRuthenium-catalyzed meta-C-H bond alkylation of aryl 2-pyridyl ketones, HPLC of Formula: 100-70-9, the main research area is aryl pyridyl ketone bromo alkanoate ruthenium catalyst regioselective alkylation; picolinoyl aryl alkyl ester preparation.

The first example of meta-selective CAr-H bond functionalization of aryl 2-pyridyl ketones were developed using [Ru(p-cymene)Cl2]2 as the catalyst and alkyl bromide as the coupling reagent. This development provided an efficient strategy for modifying the meta-position of aryl 2-pyridyl ketone skeletons, which were found in various functional mols.

Chemical Communications (Cambridge, United Kingdom) published new progress about Alkylation catalysts, regioselective. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, HPLC of Formula: 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Sun, Zhuming published the artcileHarnessing the Intrinsic Reactivity of 2-Cyano-Substituted Heteroarenes to Achieve Programmable Double Alkylation, Related Products of nitriles-buliding-blocks, the main research area is alpha tertiary amine regioselective preparation; cyanoarene acid sequential double alkylation photochem cross coupling.

Study of tertiary radicals, generated through visible light decarboxylation, alkylating 2-cyanoarenes through radical cross-coupling at ipso- or para- positions of cyano groups was reported. Synthesis of a variety of α-tertiary amines containing quaternary centers, e.g., I was described. The approach enabled regioselective sequential double alkylation on either 2-cyanopyridine or 2-cyanopyrimidine with high efficiency. This report illustrated synthetic utility of α-heteroatom-substituted tertiary radicals in synthesis of substituted heteroarenes.

Advanced Synthesis & Catalysis published new progress about Alkylation catalysts, regioselective. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Related Products of nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Li, Zi-Qi published the artcileLigand-Controlled Regiodivergence in Nickel-Catalyzed Hydroarylation and Hydroalkenylation of Alkenyl Carboxylic Acids, SDS of cas: 100-70-9, the main research area is alkenyl carboxylate hydroarylation hydroalkenylation nickel ligand catalyst regiodivergence; alkene functionalization; cross-coupling; hydrofunctionalization; nickel; regiodivergence.

A nickel-catalyzed regiodivergent hydroarylation and hydroalkenylation of unactivated alkenyl carboxylic acids is reported, whereby the ligand environment around the metal center dictates the regiochem. outcome. Markovnikov hydrofunctionalization products were obtained under mild ligand-free conditions, with up to 99% yield and >20:1 selectivity. Alternatively, anti-Markovnikov products can be accessed with a novel 4,4-disubstituted Pyrox ligand in excellent yield and >20:1 selectivity. Both electronic and steric effects on the ligand contribute to the high yield and selectivity. Mechanistic studies suggest a change in the turnover-limiting and selectivity-determining step induced by the optimal ligand. DFT calculations reveal that in the anti-Markovnikov pathway, repulsion between the ligand and the alkyl group is minimized (by virtue of it being 1° vs. 2°) in the rate- and regioselectivity-determining transmetalation transition state.

Angewandte Chemie, International Edition published new progress about Addition reaction (anti-Markovnikov). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, SDS of cas: 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Lai, Calvine published the artcileAdvances in Stereoselective Iron(II)-Catalyzed Synthesis of Sulfilimines with N-Mesyloxycarbamates, HPLC of Formula: 100-70-9, the main research area is sulfilimine preparation enantioselective diastereoselective; thioether mesyloxycarbamate amination iron catalyst stereoselective.

A stereoselective amination of thioethers R1SR2 to access sulfilimines (R)-R1R2SNC(O)OR3 [R1 = Ph, naphthalen-2-yl, thiophen-2-yl, etc., R2 = Me, Et, R3 = (4-methylphenyl)methyl, diphenylmethyl, 2,2,2-trichloroethyl, etc.] using N-mesyloxycarbamates MsOHNC(O)OR3 in a catalytic system composed of iron(II) chloride and a pyridine oxazoline (PyOX) ligand, e.g., (S)-5,5-dimethyl-4-phenyl-2-(pyridin-2-yl)-4,5-dihydrooxazole, has been developed. The reaction proceeds with modest to good yields and selectivities (up to 86:14 d.r. and 72:28 e.r.). Selectivity was controlled by both the structure of the chiral ligand and the amination reagent.

Helvetica Chimica Acta published new progress about Amination catalysts (stereoselective). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, HPLC of Formula: 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Wrzeszcz, Zuzanna published the artcileHeteroaromatic N-oxides modified with a chiral oxazoline moiety, synthesis and catalytic applications, SDS of cas: 100-70-9, the main research area is oxazoline chiral heteroaromatic nitrogen oxide preparation stereoselective catalytic reaction; heteroaromatic oxide preparation oxidation amino alc heterocyclization.

A multi-step synthesis of a series of chiral oxazoline substituted pyridine N-oxides I (R1 = i-pr, t-bu, Ph; R2 = H; R1 = R2 = indane, trimethyl-bicyclo[2.2.1]heptane), alkyl derived of pyridine N-oxides II, bipyridine N-oxides III, and isoquinoline N-oxides IV, based on amino alcs. R1(NH2)HC-CH(OH)R2 derived from natural amino acids or other previously prepared, is presented herein. Various synthetic pathways have been designed and tested according to the properties and limitations imposed by the target products. The encountered problems related to the stability of the products were discussed. The resulting compounds (eighteen structures) were tested as catalysts in the allylation of benzaldehyde (obtaining up to 79% ee) as well as in nitroaldol reaction (obtaining up to 48% ee).

Catalysts published new progress about Allylation catalysts, stereoselective. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, SDS of cas: 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Chapas, Richard B. published the artcileNef-type transformation in basic solution, HPLC of Formula: 34133-58-9, the main research area is Nef reaction nitro nitrile ketone; mechanism aromatic Nef reaction.

The replacement of the nitro group of o-O2NC6H4CN to give 2-hydroxyisophthalonitrile (I) (by the action of NaCN in Me2SO) occurred via a Nef-type reaction of the cyanide ion adduct of the nitro nitrile. The normal 2nd product of the Nef reaction, N2O was produced in yield comparable to that of I. P-O2NC6H4CN and p-O2NC6H4COPh reacted similarly. The mechanism was discussed.

Journal of Organic Chemistry published new progress about Nitro compounds Role: PRP (Properties). 34133-58-9 belongs to class nitriles-buliding-blocks, name is 4-Hydroxyisophthalonitrile, and the molecular formula is C8H4N2O, HPLC of Formula: 34133-58-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts