Month: November 2022

Nguyen, Vu T. published the artcileVisible-Light-Enabled Direct Decarboxylative N-Alkylation, SDS of cas: 1885-29-6, the main research area is visible light decarboxylative alkylation aromatic carbocyclic acid heterocycle amine; acridine catalyst; amination; carboxylic acids; copper catalysis; photocatalysis; visible light.

The development of efficient and selective C-N bond-forming reactions from abundant feedstock chems. remains a central theme in organic chem. owing to the key roles of amines in synthesis, drug discovery, and materials science. Herein, the authors present a dual catalytic system for the N-alkylation of diverse aromatic carbocyclic and heterocyclic amines directly with carboxylic acids, by-passing their preactivation as redox-active esters. The reaction, which is enabled by visible-light-driven, acridine-catalyzed decarboxylation, provides access to N-alkylated secondary and tertiary anilines and N-heterocycles. Addnl. examples, including double alkylation, the installation of metabolically robust deuterated Me groups, and tandem ring formation, further demonstrate the potential of the direct decarboxylative alkylation (DDA) reaction.

Angewandte Chemie, International Edition published new progress about Acridines Role: CAT (Catalyst Use), USES (Uses). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, SDS of cas: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zheng, Dan published the artcileAbsolute control of helicity at the C-termini in quinoline oligoamide foldamers by chiral oxazolylaniline moieties, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is helicity induction quinoline oligoamide foldamer chiral oxazolylaniline.

Absolute one-handed chiral quinoline tetramers and octamers containing different oxazolylanilines at the C-terminus have been synthesized (e.g., I). The absolute one-handed sense and diastereomeric excess values were valued by 1NMR. X-ray crystal diffraction and CD studies reveal that the S-oxazolylaniline always induces a P-handed helicity and the absolute helicity is driven by the stable three-center hydrogen bonding between protons in the amide and N atoms in oxazolylaniline and adjacent quinoline ring. CPL investigations demonstrated that S-CQn-a∼d are CPL active and its glum values are dependent on its length. Interestingly, the sizes of the substituents in the chiral centers are different, however, they exert no effect on the dissym. factors gabs and glum of quinoline oligoamide foldamers.

Chinese Chemical Letters published new progress about Chiral induction (induction of helical chirality). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Liu, Bingqi published the artcileConstruction of a Novel Z-Scheme Heterojunction with Molecular Grafted Carbon Nitride Nanosheets and V2O5 for Highly Efficient Photocatalysis, COA of Formula: C7H6N2, the main research area is grafted carbon nitride nanosheets vanadia efficient photocatalysis; photocatalytic water purification.

Mol. grafted carbon nitride (CN) nanosheets coupled with V2O5 to form a novel Z-scheme heterojunction photocatalyst V2O5/CNX (X is 2-aminobenzonitrile) by a facile in situ growth method was acquired. Its photocatalytic properties were investigated by hydrogen evolution and degradation of rhodamine B under simulated sunlight irradiation It was found that the assembled heterojunction could remarkably enhance photocatalytic activity in contrast to pure CN, V2O5, and previous reported heterojunctions. The great improvement of photocatalytic activity can be attributed to mol. grafting and the formation of the Z-scheme heterojunction, resulting in a remarkable red shift of the optical absorption, a rapid separation of charge carriers, an increase of sp. surface area, and introduction of defects. Moreover, exfoliation of bulk CNX into ultrathin nanosheets increases mobility of charges and sp. surface area. Different wt % ratios of V2O5-loaded heterojunctions were prepared, and 2% of V2O5-loaded heterojunctions were found to display optimal catalytic efficiency. The possible activity enhanced mechanism was proposed. This work reveals that the mol. grafted V2O5/CNX Z-scheme heterojunction can be utilized for highly efficient photocatalysis applied in energy conversion and environmental remediation.

Journal of Physical Chemistry C published new progress about Charge separation (photoinduced, electron-hole pair). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, COA of Formula: C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Malancona, Savina published the artcile5,6-Dihydroxypyrimidine Scaffold to Target HIV-1 Nucleocapsid Protein, Recommanded Product: Picolinonitrile, the main research area is dihydroxy pyrimidine derivative preparation HIV1 nucleocapsid protein ADME structure.

The HIV-1 nucleocapsid (NC) protein is a small basic DNA and RNA binding protein that is absolutely necessary for viral replication and thus represents a target of great interest to develop new anti-HIV agents. Moreover, the highly conserved sequence offers the opportunity to escape the drug resistance (DR) that emerged following the highly active antiretroviral therapy (HAART) treatment. On the basis of our previous research, nordihydroguaiaretic acid 1 acts as a NC inhibitor showing moderate antiviral activity and suboptimal drug-like properties due to the presence of the catechol moieties. A bioisosteric catechol replacement approach led us to identify the 5-dihydroxypyrimidine-6-carboxamide substructure as a privileged scaffold of a new class of HIV-1 NC inhibitors. Hit validation efforts led to the identification of optimized analogs, as represented by compound 28, showing improved NC inhibition and antiviral activity as well as good ADME and PK properties.

ACS Medicinal Chemistry Letters published new progress about Anti-HIV agents (anti-HIV-1 agents, Anti-HIV-1 drugs). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Recommanded Product: Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Chen, Ban Chin published the artcileNitrogen-15 NMR spectroscopy. Part X. Nitrogen-15 NMR spectra of azoles with two heteroatoms, SDS of cas: 87150-13-8, the main research area is heterocyclic azole nitrogen NMR; tautomerism ring chain oxazolidine.

The 15N-NMR spectra of azoles, with natural isotope abundance, have been measured under different exptl. conditions, and chem. shifts are reported for imidazoles, pyrazoles, oxazoles, isoxazoles, thiazoles, and isothiazoles. General trends of substituent effects in this heterocyclic series are discussed based on the data of 67 substituted azoles, dihydro- and tetrahydroazoles. 15N, 1H spin-coupling constants have been determined from spectra obtained by [1H] → 15N polarization-transfer experiments, i.e. an application of INEPT and DEPT pulse sequences. Two-bond and three-bond coupling constants are fully assigned and are discussed in terms of the specific pathways in azoles. The potential of structural applications of the new data is illustrated for isomeric nitro-imidazoles and highly-substituted pyrazoles, and in the case of ring-chain tautomerism of 2-substituted tetrahydrooxazoles.

Helvetica Chimica Acta published new progress about Heterocyclic compounds, nitrogen Role: PRP (Properties). 87150-13-8 belongs to class nitriles-buliding-blocks, name is 4-(5-Oxazolyl)benzonitrile, and the molecular formula is C10H6N2O, SDS of cas: 87150-13-8.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nishino, Mayuko published the artcileCopper-Mediated and Copper-Catalyzed Cross-Coupling of Indoles and 1,3-Azoles: Double C-H Activation, Formula: C10H6N2O, the main research area is copper catalyst cross coupling indole azole.

Copper-mediated intermol. cross-coupling of indoles and 1,3-azoles occurred with chelation assistance of a 2-pyrimidyl group. A catalytic variant has been achieved by using atm. O2 as the sole oxidant. E.g., in presence of 20 mol% Cu(OAc)2 and AcOH, reaction of N-(2-pyrimidyl)indole and benzoxazole in air gave 59% I. The cross-coupling occurs exclusively at the indole C2-postion. The 2-pyrimidyl group may be removed by treatment with NaOMe in DMSO.

Angewandte Chemie, International Edition published new progress about Azoles Role: RCT (Reactant), RACT (Reactant or Reagent). 87150-13-8 belongs to class nitriles-buliding-blocks, name is 4-(5-Oxazolyl)benzonitrile, and the molecular formula is C10H6N2O, Formula: C10H6N2O.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Odani, Riko published the artcileCopper-Mediated Dehydrogenative Biaryl Coupling of Naphthylamines and 1,3-Azoles, SDS of cas: 87150-13-8, the main research area is dehydrogenative regioselective cross coupling naphthylamine azole picolinamide directing group; copper catalyst dehydrogenative regioselective cross coupling naphthylamine azole.

A copper-mediated dehydrogenative biaryl cross-coupling of naphthylamines and 1,3-azoles has been developed. The key to its success is the introduction of an N,N-bidentate coordination system based on the picolinamide directing group. The reaction proceeds smoothly without precious transition metal catalysts and provides highly π-extended heterobiaryls directly. E.g., in presence of Cu(OAc)2 and pivalic acid in mesitylene, dehydrogenative cross-coupling of N-(2-pyridylcarbonyl)-substituted 2-naphthylamine (I) with benzoxazole gave 73% II.

Journal of Organic Chemistry published new progress about Azoles Role: RCT (Reactant), RACT (Reactant or Reagent). 87150-13-8 belongs to class nitriles-buliding-blocks, name is 4-(5-Oxazolyl)benzonitrile, and the molecular formula is C10H6N2O, SDS of cas: 87150-13-8.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Labbe, Gerrit published the artcileSynthesis of fused dihydro-1,2,4-thiadiazolimines from cyano-substituted azides and acyl isothiocyanates, Application In Synthesis of 73217-11-5, the main research area is fused hydrothiadiazolimine; cyano substituted azide cycloaddition acyl isothiocyanate; mechanism cycloaddition acyl isothiocyanate.

Organic azides, bearing a nitrile function at the γ- or δ-position, react with acyl isothiocyanates to give fused dihydro-1,2,4-thiadiazolimines. Representative examples are given. In the case of 2-NCC6H4CH2N3 and BzNCS, the formation of I is accompanied by two side products, II and III. Mechanisms are presented to explain the formation of the products.

Journal of the Chemical Society, Perkin Transactions 10: Organic and Bio-Organic Chemistry published new progress about Azides Role: RCT (Reactant), RACT (Reactant or Reagent). 73217-11-5 belongs to class nitriles-buliding-blocks, name is 2-(2-(Bromomethyl)phenyl)acetonitrile, and the molecular formula is C9H8BrN, Application In Synthesis of 73217-11-5.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Sharma, Simmi published the artcileTin(II) triflate Catalysed Synthesis of 3-Methyleneisoindolin-1-ones, SDS of cas: 1885-29-6, the main research area is isoindolinone methylene preparation; acetyl carboxylic acid amine heterocyclization tin triflate catalyst.

A simple and straightforward tin(II) triflate catalyzed facile protocol for the synthesis of 3-methyleneisoindolin-1-ones I (R = 4-BrC6H4, CH2CH(CH3)2, CH2C6H5, etc.; X = C=CH2, CHCH3) and applied to broad range of substrates, which simultaneously offers the functional group tolerance of the reaction and the stability of these scaffolds to the reaction conditions has been described. In addition, in situ reduction of the exocyclic double bond in 3-methyleneisoindolin-1-ones I using PMHS is also reported.

ChemistrySelect published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, SDS of cas: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Lang, Xian-Dong published the artcileProtic ionic liquid-catalyzed synthesis of oxazolidinones using cyclic carbonates as both CO2 surrogate and sustainable solvent, Related Products of nitriles-buliding-blocks, the main research area is oxazolidinone preparation; aniline cyclic carbonate carboxylative cyclization.

The synthesis of oxazolidinones I [R1 = H, 3-Me, 4-Cl, etc.; R2 = H, Me] via the carboxylative cyclization of anilines with cyclic carbonate using protic ionic liquid 1,8-diazabicyclo[5.4.0]-7-undecenium imidazolide [HDBU][Im] as the bifunctional catalyst under mild conditions without addition of conventional organic solvents was reported. The distinguished features of this protocol included low catalyst loading, wide functionality tolerance and convenient recycling of the catalyst. A series of functional groups such as -Cl, -Br, -CH3, -OCH3 and -NO2 can be well tolerated under the reaction conditions, provided the corresponding products in moderate to good yields (61-92%). In addition, to shed light on the cooperative interactions of [HDBU][Im]/EC and [HDBU][Im]/aniline, NMR technique and DFT study were also performed, resp.

Catalysis Today published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Related Products of nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts