Month: November 2022

Ren, Shishuai published the artcileDehydration of primary amides to nitriles catalyzed by [CNC]-pincer hydrido cobalt(III) complexes, Application In Synthesis of 100-70-9, the main research area is amide nitrile cobalt hydride catalyst dehydration selective safety; nitrile preparation.

The dehydration reactions from primary amides to nitriles were catalyzed by the [CNC]-pincer hydrido cobalt(III) complexes [(ortho-F4C6-CH=N-C10H6)Co(III)(H)(PMe3)2], [(2,5-F2C6H2-CH=N-C10H6)Co(III)(H)(PMe3)2] (I) and [(2,4,5-F3C6H-CH=N-C10H6)Co(III)(H)(PMe3)2] as catalysts with (EtO)3SiH as an efficient reducing agent. These hydrido cobalt(III) complexes as catalysts are suitable for many substrates and have good functional group tolerance. Among the three cobalt hydrides, complex I is the best catalyst. This is the first hydrido cobalt complex-catalyzed dehydration of primary amides to nitriles.

Catalysis Communications published new progress about Amides Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Application In Synthesis of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhang, Wandi published the artcileSynthesis of nitriles via palladium-catalyzed water shuffling from amides to acetonitrile, HPLC of Formula: 5653-62-3, the main research area is amide dehydration palladium; nitrile preparation; palladium dehydration catalyst.

Palladium-catalyzed synthesis of nitriles from amides has been described. Two similar, but complementary reaction conditions have been identified to convert various amides including α,β,γ,δ-unsaturated amides, cinnamides, aromatic amides and alkyl amides to the corresponding nitriles in good to excellent yield.

Organic & Biomolecular Chemistry published new progress about Amides Role: RCT (Reactant), RACT (Reactant or Reagent). 5653-62-3 belongs to class nitriles-buliding-blocks, name is 2,3-Dimethoxybenzonitrile, and the molecular formula is C9H9NO2, HPLC of Formula: 5653-62-3.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Bhattacharjee, Jayeeta published the artcileN-Heterocyclic Carbene-Phosphinidenide Complexes as Hydroboration Catalysts, Recommanded Product: Picolinonitrile, the main research area is hydroboration catalyst ruthenium osmium NHC carbene phosphinidene half sandwich; crystal structure mol ruthenium osmium NHC phosphinidene half sandwich; ruthenium osmium heterocyclic carbene phosphinidene half sandwich preparation; mechanism kinetics hydroboration ruthenium catalyst NHC phosphinidenide nitrile.

The reactions of the N-heterocyclic carbene-phosphinidene adducts (NHC)PSiMe3 and (NHC)PH with the dinuclear ruthenium and osmium complexes [(η6-p-cymene)MCl2]2 (M = Ru, Os) afforded the half-sandwich complexes [(η6-p-cymene){(NHC)P}MCl] and [(η6-p-cymene){(NHC)PH}MCl2] with two- and three-legged piano-stool geometries, resp. (NHC = IDipp, IMes; IDipp = 1,3-bis(2,6-diisopropylphenyl)imidazolin-2-ylidene; IMes = 1,3-bis(2,4,6-trimethylphenyl)imidazolin-2-ylidene). The complexes were initially tested as precatalysts for the hydroboration of benzonitrile, and the most active species, the ruthenium complex [(η6-p-cymene){(IMes)P}RuCl], was further used for the efficient hydroboration of a wide range (ca. 50 substrates) of nitriles, carboxylic esters, and carboxamides in neat pinacolborane (HBpin) under comparatively mild reaction conditions (60-80°C, 3-5 mol % catalyst loading). Preliminary mechanistic and kinetic studies are reported, and stoichiometric reactions with HBpin indicate the initial formation of the monohydride complex [(η6-p-cymene){(IMes)P}RuH] as the putative catalytically active species.

Journal of Organic Chemistry published new progress about Amides Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Recommanded Product: Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhou, Ping-Xin published the artcilePalladium/copper-catalyzed decarbonylative heteroarylation of amides via C-N bond activation, SDS of cas: 87150-13-8, the main research area is aryl oxazole preparation; amide oxazole decarbonylative heteroarylation palladium copper catalyst.

A novel strategy for the synthesis of 2-arylated oxazole derivatives, e.g., 5-(1-naphthalenyl)-2-phenyloxazole via palladium/copper-catalyzed decarbonylative heteroarylation of amides RC(O)NR1R2 (R = C6H5, 2-FC6H4, 1-naphthyl, etc.; R1R2 = -C(O)(CH2)3C(O)-, -C(O)(CH2)2C(O)-) via C-N bond activation by ground-state destabilization has been reported. This transformation shows good functional group tolerance and delivers the versatile 2-arylated oxazole derivatives in moderate to good yields. This transformation provides unique and efficient strategies for converting readily available amides and the precursor carboxylic acids into valuable chems.

Organic Chemistry Frontiers published new progress about Amides Role: RCT (Reactant), RACT (Reactant or Reagent). 87150-13-8 belongs to class nitriles-buliding-blocks, name is 4-(5-Oxazolyl)benzonitrile, and the molecular formula is C10H6N2O, SDS of cas: 87150-13-8.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Assaf, Jaber published the artcileReconsidering mass spectrometric fragmentation in electron ionization mass spectrometry – new insights from recent instrumentation and isotopic labeling exemplified by ketoprofen and related compounds, Recommanded Product: 2-(3-Benzoylphenyl)propanenitrile, the main research area is electron ionization mass spectrometry isotopic labeling ketoprofen compound.

Rationale : In various fields of chem. analyses, structurally unknown analytes are considered. Proper structure confirmation may be challenged by the low amounts of analytes that are available, e.g. in early stage drug development, in metabolism studies, in toxicol. or in environmental analyses. In these cases, mass spectrometric techniques are often used to build up structure proposals for these unknowns. Fragmentation reactions in mass spectrometry are known to follow definite pathways that may help to assign structural elements by fragment ion recognition. This work illustrates an investigation of fragmentation reactions for gas chromatog./electron ionization mass spectrometric characterization of benzophenone derivatives using the analgesic drug ketoprofen and seven of its related compounds as model compounds Methods : Deuteration and 18O-labeling experiments along with high-resolution accurate mass and tandem mass spectrometry (MS/MS) were used to further elucidate fragmentation pathways and to substantiate rationales for structure assignments. Low-energy ionization was investigated to increase confidence in the identity of the mol. ion. Results : The high-resolution mass analyses yielded unexpected differences that led to reconsideration of the proposals. Site-specific isotopic labeling helped to directly trace back fragment ions to their resp. structural elements. The proposed fragmentation pathways were substantiated by MS/MS experiments Conclusions : The described method may offer a perspective to increase the level of confidence in unknown analyses, where reference material is not (yet) available.

Rapid Communications in Mass Spectrometry published new progress about Gas chromatography-electron ionization mass spectrometry. 42872-30-0 belongs to class nitriles-buliding-blocks, name is 2-(3-Benzoylphenyl)propanenitrile, and the molecular formula is C16H13NO, Recommanded Product: 2-(3-Benzoylphenyl)propanenitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Lu, Kui published the artcileSynthesis of Substituted Pyrroles via Copper-Catalyzed Cyclization of Ethyl Allenoates with Activated Isocyanides, Product Details of C16H15NO3S, the main research area is pyrrole preparation; ethyl allenoate isocyanide cyclization copper catalyst; allenoates; copper; cyclization; isocyanides; pyrrole synthesis.

A new method for the synthesis of di- and trisubstituted pyrroles I (R1 = H, CH3, t-Bu, Bn, Ph, etc.; R2 = H, CH3, C2H5, Bn, 4-CH3OC6H4, 4-FC6H4; R3 = Ts, 4-ClC6H4SO2, 4-FC6H4SO2, 4-CH3OC6H4SO2, C6H5SO2) via copper-catalyzed cyclization of Et allenoates with activated isocyanides has been developed. In contrast to related annulation reactions previously reported, this new process features a skeletal rearrangement in which the aryl sulfonyl moiety, which functions as the electron-withdrawing group in the α-carbon of the isocyanide, was found to migrate to the γ-carbon of the starting allenoate in the final product for the first time.

Chemistry – An Asian Journal published new progress about Allenes Role: RCT (Reactant), RACT (Reactant or Reagent). 263389-54-4 belongs to class nitriles-buliding-blocks, name is a-Tosyl-(4-methoxybenzyl) isocyanide, and the molecular formula is C16H15NO3S, Product Details of C16H15NO3S.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Banerjee, Indrani published the artcileAlkali Metal Catalysed Double Hydrophosphorylation of Nitriles and Alkynes, Category: nitriles-buliding-blocks, the main research area is alkali metal silylamide catalyzed hydrophosphorylation nitrile alkyne; crystal mol structure phosphoryl diphenylphosphinic amide.

Catalytic C-P and N-P bond formation via double hydrophosphorylation of nitriles with diphenylphosphine oxide using alkali metal precatalyst [MN(SiMe3)2] (M = Li, Na, K) is reported. The potassium congener was observed to be the most efficient catalyst for converting aryl nitriles to the corresponding N-((diphenyl-phosphoryl)(aryl)methyl)-P,P-diphenylphosphinic amide [ArCHP(O)-Ph2NHP(O)Ph2] at mild temperature (60°) and with neat reactants. Double hydrophosphorylation of alkynes with HP(O)Ph2 is also very effective when [KN(SiMe3)2] is used as a precatalyst at room temperature and gives the corresponding 1,2-diylbis(diphenyl-phosphine) oxide [RCHP(O)Ph2CH2P(O)Ph2] as the product. A wider substrate scope of both reactions is explored.

European Journal of Inorganic Chemistry published new progress about Alkynes Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Gajurel, Sushmita published the artcileCuO-NiO bimetallic nanoparticles supported on graphitic carbon nitride with enhanced catalytic performance for the synthesis of 1,2,3-triazoles, bis-1,2,3-triazoles, and tetrazoles in parts per million level, COA of Formula: C6H4N2, the main research area is triazole preparation green chem; arylboronic acid arylacetylene heterocyclization copper nickel dioxide nanocatalyst; benzylhalide arylacetylene heterocyclization copper nickel dioxide nanocatalyst; epoxide phenyl acetylene heterocyclization copper nickel dioxide nanocatalyst; bistriazolyl methane preparation green chem; diazidomethyl methoxybenzene alkyne heterocyclization copper nickel dioxide nanocatalyst; tetrazole preparation green chem; aromatic nitrile heterocyclization copper nickel dioxide nano catalyst.

The unification of CuCl2 ·2H2O and NiCl2·6H2O with the support of graphitic carbon nitride yielded to form an efficient, synergistic, bimetallic nano-catalyst CuO-NiO@g-C3N4. Catalyst with three different molar ratios of Cu and Ni, i.e., Cu75Ni25 (Cu:Ni = 3:1; catalyst-a), Cu50Ni50 (Cu:Ni = 1:1; catalyst-b), and Ni66Cu33 (Ni:Cu = 2:1; catalyst-c), was synthesized, and their catalytic activity was examined The synergistic interaction of one metal with the other on the surface of extremely stable graphitic carbon nitride has enhanced the catalytic performance in the synthesis of triazoles I (R1 = Ph, (4-bromophenyl)methyl, 2-hydroxy-1-phenylethyl, etc.; R2 = H, 4-F, 3-Me, 4-Me, 4-OMe), tetrazoles II (R3 = Ph, pyrazin-2-yl, 4-formylphenyl, etc.), and bis-triazole derivatives III to such a distinguished level (in ppm level), which a monometal fail to possess. The aforementioned statement has been supported by the catalytic activity data provided for both the monometallic and bimetallic catalyst herein. In addition to this, benign reaction conditions, in situ generation of azides, wide reaction scopes, and reusability of the catalyst were also the major advantages leading toward safe and sustainable chem. beyond doubt.

Applied Organometallic Chemistry published new progress about Alkynes Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, COA of Formula: C6H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Fleckenstein, Christoph A. published the artcile9-Fluorenylphosphines for the Pd-catalyzed Sonogashira, Suzuki, and Buchwald-Hartwig coupling reactions in organic solvents and water, Product Details of C11H12N2O, the main research area is fluorenylphosphine phosphine catalyst Sonogashira Suzuki Buchwald Hartwig coupling reaction.

The lithiation/alkylation of fluorene leads to various 9-alkylfluorenes (alkyl = Me, Et, iPr, Pr, C18H25) in >95% yields, for which lithiation and reaction with R2PCl (R = Cy, iPr, tBu) generates 9-alkyl, 9-PR2-fluorenes which constitute electron-rich and bulky phosphine ligands. The in-situ-formed palladium-phosphine complexes ([Na2PdCl4], phosphonium salt, base, substrates) were tested in the Sonogashira, Suzuki, and Buchwald-Hartwig reactions of aryl chlorides and aryl bromides in organic solvents. The Sonogashira coupling of aryl chlorides at 100-120° leads to >90% yields with 1 mol% of Pd catalyst. The Suzuki coupling of aryl chlorides typically requires 0.05 mol% of Pd catalyst at 100° in dioxane for quant. product formation. To carry out “”green”” cross-coupling reactions in water, 9-ethylfluorenyldicyclohexylphosphine was reacted in sulfuric acid to generate the resp. 2-sulfonated phosphonium salt. The Suzuki coupling of activated aryl chlorides by using this water-soluble catalyst requires only 0.01 mol% of Pd catalyst, while a wide range of aryl chlorides can be quant. converted into the resp. coupling products by using 0.1-0.5 mol% of catalyst in pure water at 100°C. Difficult substrate combinations, such as naphthylboronic acid or 3-pyridylboronic acid and aryl chlorides are coupled at 100° by using 0.1-0.5 mol% of catalyst in pure water to obtain the resp. N-heterocycles in quant. yields. The copper-free aqueous Sonogashira coupling of aryl bromides generates the resp. tolane derivatives in >95% yield.

Chemistry – A European Journal published new progress about Alkynes Role: RCT (Reactant), RACT (Reactant or Reagent). 204078-32-0 belongs to class nitriles-buliding-blocks, name is 2-Morpholinobenzonitrile, and the molecular formula is C11H12N2O, Product Details of C11H12N2O.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Mo, Xueling published the artcileCopper-Catalyzed Enantioselective Sonogashira Type Coupling of Alkynes with α-Bromoamides, Name: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is copper catalyst enantioselective Sonogashira coupling alkyne alpha bromoamide; Sonogashira reaction; copper catalysis; enantioselectivety; terminal alkynes; α-bromoamide.

An asym. copper-catalyzed Sonogashira type coupling between alkynes and α-bromoamides was developed. This method represents a facile approach to synthetically useful β, γ-alkynyl amides from two readily available starting materials in a highly enantioselective manner. A Bisoxazoline diphenylaniline (BOPA) serves as the effective chiral ligand. Preliminary mechanistic studies support the formation of alkyl radical species.

Angewandte Chemie, International Edition published new progress about Alkynes Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Name: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts