Month: November 2022

Di Terlizzi, Lorenzo published the artcileVisible Light-Driven, Gold(I)-Catalyzed Preparation of Symmetrical (Hetero)biaryls by Homocoupling of Arylazo Sulfones, Formula: C7H6N2, the main research area is arylazo sulfone gold catalyst photochem homocoupling; biaryl preparation.

The preparation of sym. (hetero)biaryls via arylazo sulfones was successfully carried out upon visible light irradiation in the presence of PPh3AuCl as the catalyst. The present protocol led to the efficient synthesis of a wide range of target compounds in an organic-aqueous solvent under photocatalyst-free conditions.

Journal of Organic Chemistry published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Formula: C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Bakherad, Mohammad published the artcileMetal-free green synthesis of aryl amines in magnetized distilled water: experimental aspects and molecular dynamics simulation, Formula: C11H12N2O, the main research area is aryl halide secondary amine arylation magnetized water green chem; arylamine preparation.

A simple, green, and transition metal-free approach to the N-arylation of secondary amines with aryl halides in magnetized distilled water (MDW), as a solvent was introduced. This method offered the advantages of short reaction times, low costs, and an additive-free process, and it also enabled new planning strategies for the construction of aryl amine-containing pharmacophores. Also, the reaction rates were followed spectrophotometrically by monitoring the changes in the absorption spectrum of the reaction mixture in ordinary and magnetized distilled water. Furthermore, the reliable mol. dynamics (MD) simulations were used as predictive tools to interpret and describe the interactions between reactants in the ordinary and magnetized distilled water. The RDFs anal. of interactions revealed that morpholine and iodobenzene reactants were surrounded by more solvents in MDW than ordinary distilled water (ODW) 90°C. Consequently, the high reactivity observed for two reactants in MDW at 90°C can be explained by MD simulation, and there comes an established synergy between the theor. calculation and experiment

Green Chemistry published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 204078-32-0 belongs to class nitriles-buliding-blocks, name is 2-Morpholinobenzonitrile, and the molecular formula is C11H12N2O, Formula: C11H12N2O.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhang, Zhi-hao published the artcileSynthesis, In Vitro Antiplatelet Activity of 4-Ethoxy-isophthalamides, HPLC of Formula: 1885-29-6, the main research area is ethoxyisophthalamide preparation antiplatelet activity.

The structural design, preparation, spectral confirmation of thirteen new 4-ethoxyisophthalamide compounds I (R = 2-OEt, 3-Br, 4-I, etc.; n = 0, 1) were described and completes their preliminary screening of in vitro antiplatelet activity in response to the following inducers: ADP (ADP) and collagen. Among them, when ADP was used as an inducer, compounds having activities higher or close to picotamide and IC50 values revealed that one compound I (R = m-CF3, n = 0) (IC50 : 0.26μmol L-1) was more than three times more active than pos. control drug picotamide. Meanwhile, cytotoxic effects in vitro of compound I (R = 4-I, n = 0) and compound I (R = m-CF3, n = 0) on L929 cells were analyzed. The structure-activity relationship showed that when electron-withdrawing groups nitro or trifluoromethyl are introduced at the meta- or para- position of the two side chain benzene rings, it is beneficial on the whole to the improvement of antiplatelet activity.

ChemistrySelect published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, HPLC of Formula: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ji, Dezhong published the artcileDesign, synthesis and biological evaluation of anthranilamide derivatives as potent SMO inhibitors, SDS of cas: 1885-29-6, the main research area is aryl amino benzoyl piperidinyl benzamide preparation antitumor smoothened inhibitor; Anthranilamide; Hedgehog signaling pathway; Molecular dynamics; Ring-opening; Smoothened inhibitor.

A series of anthranilamide derivativesI (R = Ph, 1-methyl-1H-pyrazol-5-yl, 4-phenylpyridine, etc.; R1 = 4-F, 2-CF3-4-F, 4-NO2, etc.; X = N, CH) and II was designed and synthesized as novel smoothened (SMO) inhibitors based on the SMO inhibitor taladegib (LY2940680), which can also inhibit the SMO-D473H mutant, via a ring-opening strategy. The phthalazine core in LY2940680 was replaced with anthranilamide, which retained the inhibitory activity towards the hedgehog (Hh) signaling pathway as evidenced by a dual luciferase reporter gene assay. Compound I (R = Ph; R1 = 2-CF3-4-F; R2 = CH) displayed the best inhibitory activity against the Hh signaling pathway with IC50 value of 34.09 nM, and exhibited better proliferation inhibitory activity towards the Daoy cell line (IC50 = 0.48μM) than LY2940680 (IC50 = 0.79μM).

Bioorganic & Medicinal Chemistry published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, SDS of cas: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhang, Yi published the artcile2-((1-Phenyl-1H-1,2,3-triazol-4-yl)methyl)-2-azabicyclo[3.2.1]octan-3-one derivatives: Simplification and modification of aconitine scaffold for the discovery of novel anticancer agents, Application In Synthesis of 1885-29-6, the main research area is phenyl triazolyl methylazabicyclooctanone preparation antitumor agent SAR mol docking; Aconitine; Antiproliferative activity; Hsp90 inhibitors; Structural simplification.

In this study, we designed and synthesized a series of I [R = H, 2-OH, 3-OH, 4-OH,..etc]. as potent Hsp90 inhibitors by simplifying and modifying the aconitine scaffold. Among these compounds, I [R = 3-Br] exhibited an excellent antiproliferative activity against LoVo cells with an IC50 value of 0.02μM and a significant Hsp90α inhibitory activity with an IC50 value of 0.71 nM. Mol. docking studies provided a rational binding model of I [R = 3-Br] in complex with Hsp90α. The following cell cycle and apoptosis assays revealed that compound I [R = 3-Br] could arrest cell cycle at G1/S phase and induce cell apoptosis via up-regulation of bax and cleaved-caspase 3 protein expressions while inhibiting the expressions of bcl-2. Moreover, I [R = 3-Br] could inhibit cell migration in LoVo and SW620 cell lines. Consistent with in vitro results, I [R = 3-Br] significantly repressed tumor growth in the SW620 xenograft mouse model.

European Journal of Medicinal Chemistry published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application In Synthesis of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Sunil Kumar, A. published the artcileSynthesis, characterization, crystal structures and biological screening of 4-amino quinazoline sulfonamide derivatives, Quality Control of 1885-29-6, the main research area is quinazolinylamino sulfonamide preparation crystal structure antibacterial antifungal antitumor human; phenyl benzenesulfonamide dimethyl formamidine condensation.

Three quinazolin-4-ylamino derivatives containing phenylbenzenesulfonamides I [R = Me, F, Cl] were synthesized by reacting (E)-N’-(2-cyanophenyl)-N,N-dimethyl formamidine with 4-amino-N-(phenyl)benzenesulfonamides and structural properties were further examined by single crystal X-ray diffraction method. The X-ray data showed that compounds I [R = Me, Cl] contain two mols. and compound I [R = F] contain one mol. in asym. unit. Comparison of conformation of two distinct mols., in the asym. unit of compounds I [R = Me, Cl] were studied with aid of reported literature. All the synthesized compounds I were tested for their in vitro antiproliferative activity against two breast cancer cell lines (MDA-MB-231 and MCF7), antibacterial and antifungal activities against tested strains. Among the tested compounds, compound I [R = F] observed as highest potent candidate against MDA-MB-231with IC50 of 5.44 μg/mL and compound I [R = Cl] was observed as most potent candidate against Gram-neg. bacterial strains.

Journal of Molecular Structure published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Quality Control of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Yilmaz, Ozgur published the artcileSynthesis of New Substituted Diamides. Investigation of Their Antioxidant and Antibacterial Properties, SDS of cas: 1885-29-6, the main research area is aryl diamide preparation antioxidant antibacterial.

Reaction between acyl chloride and substituted aromatic amines for the synthesis of new diamide compounds I [R = Ph, 2-FC6H4, 4-BrC6H4, etc.] was investigated. Compounds I were evaluated for 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity, 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) and ferrous ions (Fe2+) chelating activities in terms of antioxidant properties. The IC50 value was calculated for the compounds which showed activation in preliminary study and pos. controlled BHT, BHA and trolox. Compounds I were evaluated for antibacterial activity against Escherichia coli ATCC 25922, Staphylococcus aureus ATCC 25923, Enterococcus fecalis ATCC 29212, Pseudomonas aeruginosa ATCC 27853 and Enterobacter aerogenes ATCC 13048 and it was determined that compounds I [R = Ph, 2-F3CC6H4] showed activity close to pos. control against S. aureus and E. aerogenes bacteria, resp.

Russian Journal of Bioorganic Chemistry published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, SDS of cas: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ruan, Banfeng published the artcileSynthesis and structure-activity relationship study of pyrrolidine-oxadiazoles as anthelmintics against Haemonchus contortus, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is pyrrolidine oxadiazole preparation anthelmintic structure activity relationship; Anthelmintic; Drug discovery; Haemonchus contortus; Pyrrolidine-oxadiazoles; Structure-activity relationship.

Parasitic roundworms (nematodes) are significant pathogens of humans and animals and cause substantive socioeconomic losses due to the diseases that they cause. The control of nematodes in livestock animals relies heavily on the use of anthelmintic drugs. However, their extensive use has led to a widespread problem of drug resistance in these worms. Thus, the discovery and development of novel chem. entities for the treatment of parasitic worms of humans and animals is needed. Herein, authors describe the medicinal chem. optimization efforts of a phenotypic hit against Haemonchus contortus based on a pyrrolidine-oxadiazole scaffold I (R = H, 4-Cl, 3-OMe, etc.; R1 = 2-Me, 3-OH, 4-CN, etc.). This led to the identification of compounds with potent inhibitory activities (IC50 = 0.78-22.4μM) on the motility and development of parasitic stages of H. contortus, and which were found to be highly selective in a mammalian cell counter-screen. These compounds could be used as suitable chem. tools for drug target identification or as lead compounds for further optimization.

European Journal of Medicinal Chemistry published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Xiong, Yucong published the artcileBimetallic CoMoO4@C nanorod catalyzes one-pot synthesis of benzimidazoles from benzyl alcohol and o-phenylendiamine without alkali, Synthetic Route of 1885-29-6, the main research area is benzimidazole preparation green chem; alc aromatic diamine coupling carbon supported cobalt molybdenum oxide.

Benzimidazoles possess a series of applications for industrial chem. and biomedicine. However, the complicated synthetic steps and harsh reaction conditions limit its further development. Herein, authors reported an efficient, environmentally friendly, and stable bimetallic CoMoO4@C catalyst, which used low-cost cobalt and molybdenum as the basic raw material. In base-free conditions, it has been proved that the yield could achieve to 99.9% for the synthesis of benzimidazoles with liberating water as the sole byproduct, and the catalyst remains stable and efficient even after five successive cycle tests. Addnl., experiments and characterizations confirm the good oxidation activity of the catalyst benefits from the numerous oxygen vacancies provided by the high concentration of low-valent cobalt (Co2+) and the doping of carbon improves the intermol. transport of electrons. Furthermore, this strategy could potentially be applied in the industrial production of benzimidazoles.

Applied Organometallic Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Synthetic Route of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Gu, Yu published the artcileHighly Efficient Synthesis of Alkyl N-Arylcarbamates from CO2, Anilines, and Branched Alcohols with a Catalyst System of CeO2 and 2-Cyanopyridine, Related Products of nitriles-buliding-blocks, the main research area is arylcarbamate preparation; carbon dioxide aniline alc multicomponent reaction cerium dioxide catalyst.

Highly efficient synthesis of alkyl N-arylcarbamates from CO2, anilines, and alcs. using the CeO2 and 2-cyanopyridine catalyst system was substantiated by selecting branched alcs., such as 2-propanol and cyclohexanol, with minimized formation of byproducts, such as dialkyl carbonates and picolinamide. The catalyst system is operable even at low CO2 pressure (≤1 MPa), and the target carbamates were obtained with high arylamine-based yields (up to 94%). Alkyl N-phenylcarbamates were obtained from CO2, anilines, and alcs. with high yield and minimized formation of byproducts by using branched alcs.

ACS Sustainable Chemistry & Engineering published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Related Products of nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts