Month: November 2022

Lv, Cong published the artcileFrom amides to urea derivatives or carbamates with chemospecific C-C bond cleavage at room temperature, Safety of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is diaryl acetamide copper catalyst chemoselective bond cleavage; aryl aldehyde preparation; amine pyridinyl diphenylacetamide copper catalyst chemoselective bond cleavage; pyridinyl urea preparation; alc methylpyridinyl diphenylacetamide copper catalyst chemoselective bond cleavage; methylpyridinyl carbamate preparation.

Herein, a significant advancement in this area and present a general method for copper-catalyzed chemospecific C-C bond cleavage of amides to synthesize urea derivatives and carbamates at room temperature was reported. A catalytic process via a resonant six-membered N,O-chelated copper cycle and superoxide radical was proposed according to mechanistic and control experiments The combination of chelation assistance and radical oxygenation strategies opened a door for C-C bond cleavage of common substrates which possess multiple reactive sites and was envision that this broadly applicable method will be of great interest in organic synthesis, the pharmaceutical industry and the agrochem. industry.

Organic Chemistry Frontiers published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Safety of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Sun, Kangkang published the artcileEfficient iron single-atom catalysts for selective ammoxidation of alcohols to nitriles, Quality Control of 100-70-9, the main research area is iron single atom catalyst preparation; nitrile preparation chemoselective; alc ammoxidation iron catalyst.

Zeolitic imidazolate frameworks derived Fe1-N-C catalysts with isolated single iron atoms were synthesized and applied for selective ammoxidation reactions. For the preparation of the different Fe-based materials, benzylamine as an additive proved to be essential to tune the morphol. and size of ZIFs resulting in uniform and smaller particles, which allowed stable atomically dispersed Fe-N4 active sites. The optimal catalyst Fe1-N-C achieved an efficient synthesis of various aryl, heterocyclic, allylic, and aliphatic nitriles from alcs. in water under very mild conditions. With its chemoselectivity, recyclability, high efficiency under mild conditions this new system complemented the toolbox of catalysts for nitrile synthesis, which were important intermediates with many applications in life sciences and industry.

Nature Communications published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Quality Control of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Wei, Xiangyang published the artcileDecyanative Cross-Coupling of Cyanopyrimidines with O-, S-, and N-Nucleophiles: A Route to Alkoxylpyrimidines, Aminopyrimidines and Alkylthiopyrimidines, Formula: C6H4N2, the main research area is decyanative cross coupling cyanopyrimidine alc thiol amine; preparation alkoxylpyrimidine aminopyrimidine alkylthiopyrimidine.

The transition metal-free cross-coupling reactions of cyanopyrimidines with aliphatic alcs., thiols (or S-alkylisothiourea salts) and amines, giving the corresponding alkoxylpyrimidines, aminopyrimidines, and alkylthiopyrimidines, are reported. Preliminary mechanistic studies reveal that it probably involves a sequential nucleophilic addition-intramol. rearrangement process, which is promoted by an intramol. N-H···N five-membered hydrogen bonding interaction. The presence of a nitrogen atom next to the cyano group is indispensable. The wide substrate scope with excellent yields makes cyanopyrimidines a promising alternative substrate class to the frequently used pyrimidines halides for the formation of C-O, C-S, and C-N bonds through the decyanative cross-coupling reaction.

European Journal of Organic Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Formula: C6H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Senadi, Gopal Chandru published the artcileSustainable methine sources for the synthesis of heterocycles under metal- and peroxide-free conditions, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is quinazolinone green preparation; alc amino benzamide cascade oxidative cleavage; ether amino benzamide cascade oxidative cleavage; benzimidazole green preparation; amino benzylamine methoxyethanol cascade oxidative cleavage.

Alcs. and ethers were identified as sustainable methine sources for synthesizing quinazolinones I [R = H, 8-Me, 7-NO2, etc.; R1 = OMe, allyl, Ph, etc,] and benzimidazoles II [R2 = H, 5-Cl, 6,7-di-Me, etc.] using a combination of TsOH·H2O/O2 and appropriate bis-nucleophiles for the first time. Deuterium labeling studies clearly proved that the C2 hydrogen of the synthesized heterocycles came from the methine source. These unique reaction conditions were successfully applied to the synthesis of echinozolinone I [R = H; R1 = CH2CH2OH, 2-(1H-indol-3-yl)ethyl] (a common precursor of rutaecarpine and (±) evodiamine) and dimedazole II [R2 = 5,6-di-Me]. Notable features of this method included its low toxicity, use of com. feedstocks as substrates, low cost, broad functional group tolerance and suitability for a wide range of bis-nucleophilic starting materials.

Green Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Doan, Son H. published the artcileTropylium-promoted Ritter reactions, HPLC of Formula: 100-70-9, the main research area is amide preparation microwave continuous flow; alc nitrile Ritter reaction tropylium salt catalyst.

Herein, the development of a new method using salts of the tropylium ion to promote the Ritter reaction was reported. This method works well on a range of alcs., e.g., 1-phenylethanol and nitriles, e.g., acetonitrile, giving the corresponding products, e.g., N-(1-phenylethyl)acetamide in good to excellent yields. This reaction protocol is amenable to microwave and continuous flow reactors, offering an attractive opportunity for further applications in organic synthesis.

Chemical Communications (Cambridge, United Kingdom) published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, HPLC of Formula: 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Stentzel, Michael R. published the artcileFunctionalized fluorenes via dicationic electrophiles, Computed Properties of 100-70-9, the main research area is alc biphenyl ketone cyclization; fluorenyl ether preparation; nitrile biphenyl ketone cyclization; amido fluorene preparation; Carbocation; Heterocycle; Superacid; Superelectrophile.

Dicationic fluorenyl cations were shown to react with nitriles to provide amide-functionalized fluorenes. A similar reaction with alcs. gave ether derivatives The chem. was initiated by the reactions of N-heterocyclic ketones in a superacidic solution This led to cyclizations involving 2-biphenyl groups and formation of the reactive fluorenyl cations.

Tetrahedron Letters published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Computed Properties of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Talukdar, Ranadeep published the artcileIrIII-Catalyzed direct syntheses of amides and esters using nitriles as acid equivalents: a photochemical pathway, HPLC of Formula: 91-15-6, the main research area is amide preparation photochem; amine nitrile amidation iridium photocatalyst; ester preparation photochem; nitrile alc esterification iridium photocatalyst.

An unprecedented IrIII[df(CF3)ppy]2(dtbbpy)PF6-catalyzed simple photochem. process for direct addition of amines RNHR1 [R = H, iso-Pr, benzyl, 4-methoxyphenyl, Bu, adamantan-1-yl; R1 = H, iso-Pr, benzyl, hydroxyethyl; RR1 = -(CH2)4-, -(CH2)5-, -(CH2)2O(CH2)2-] and alcs. R2OH (R2 = Bu, cyclohexyl, benzyl, indol-1-yl, etc.) to the relatively less reactive nitrile triple bond is described herein. Various amides RN(R1)C(O)R3 (R3 = Me, cyclohexyl, Ph, pyridin-4-yl, etc.) and esters R2OC(O)R3 are synthesized as the reaction products, with nitriles R3CN being the acid equivalent A mini-library of different types of amides and esters is made using this mild and efficient process, which uses only 1 mol% of photocatalyst under visible light irradiation (λ = 445 nm). The reaction strategy is also efficient for gram-scale synthesis.

New Journal of Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, HPLC of Formula: 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Bains, Amreen K. published the artcileBorrowing Hydrogen-Mediated N-Alkylation Reactions by a Well-Defined Homogeneous Nickel Catalyst, HPLC of Formula: 1885-29-6, the main research area is borrowing hydrogen mediated nitrogen alkylation aniline alc; well defined homogeneous nickel catalyzed alkylation redox active ligand.

We report herein a well-defined and bench-stable azo-phenolate ligand-coordinated nickel catalyst which can efficiently execute N-alkylation of a variety of anilines by alc. We demonstrate that the redox-active azo ligand can store hydrogen generated during alc. oxidation and redelivers the same to an in-situ-generated imine bond to result in N-alkylation of amines. The reaction has wide scope, and a large array of alcs. can directly couple to a variety of anilines. Mechanistic studies including deuterium labeling to the substrate establishes the borrowing hydrogen method from alcs. and pinpoints the crucial role of the redox-active azo moiety present on the ligand backbone. Isolation of the ketyl intermediate in its trapped form with a radical quencher and higher kH/kD for the alc. oxidation step suggest altogether a hydrogen-atom transfer (HAT) to the reduced azo backbone to pave alc. oxidation as opposed to the conventional metal-ligand bifunctional mechanism. This example clearly demonstrates that an inexpensive base metal catalyst can accomplish an important coupling reaction with the help of a redox-active ligand backbone.

ACS Catalysis published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, HPLC of Formula: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Yamaguchi, Eiji published the artcileRuthenium polypyridyl complex-catalyzed aryl alkoxylation of styrenes: improving reactivity using a continuous flow photo-microreactor, Related Products of nitriles-buliding-blocks, the main research area is diarylethyl ether preparation photochem; styrene aryldiazonium tetrafluoroborate alc alkoxylation ruthenium polypyridyl complex catalyst.

In this report, an improved protocol for the synthesis of diarylethyl ethers R1C6H4CH2CH(R2)C6H4R3 [R1 = H, 4-Me, 2-CN, etc.; R2 = OMe, OEt, OiPr, OBn, OC(O)H; R3 = 2-Me, 4-MeO, 4-tBu, etc.] via ruthenium polypyridyl complex catalyzed aryl alkoxylation of styrenes with aryldiazonium tetrafluoroborates and alcs. using continuous flow photo-microreactor was described.

Reaction Chemistry & Engineering published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Related Products of nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Yamaguchi, Eiji published the artcileOlefin Bifunctionalization: A Visible-light Photoredox-catalyzed Aryl Alkoxylation of Olefins, Product Details of C7H6N2, the main research area is diarylethyl ether photochem preparation; ruthenium photoredox catalyst arylalkoxylation aryl alkene diazonium salt alc; photochem arylalkoxylation aryl alkene diazonium salt alc; alkoxylation; bifunctionalization; olefins; photoredox catalyst; visible light.

Aryl alkenes such as RCH:CH2 (R = Ph, 4-MeCOC6H4, 4-MeO2CC6H4, 4-BrC6H4, 4-ClC6H4, 4-MeC6H4, 3-MeC6H4, 2-MeC6H4, 4-MeC6H4, 1-naphthyl, 2-naphthyl) underwent photoredox arylalkoxylation under visible light with aryldiazonium tetrafluoroborates such as R1N2+BF4- (R1 = 4-O2NC6H4, 3-O2NC6H4, 4-MeCOC6H4, 4-MeO2CC6H4, 4-NCC6H4, 3-NCC6H4, 2-NCC6H4, 4-F3CC6H4, 3-BrC6H4, 2-BrC6H4, 4-ClC6H4, 4-FC6H4) and methanol, ethanol, or 1-propanol in acetonitrile/alc. mixtures in the presence of Ru(bpy)3Cl2 to yield diarylethyl ethers such as R1CH2CH(OMe)R (R = Ph, 4-MeCOC6H4, 4-MeO2CC6H4, 4-BrC6H4, 4-ClC6H4, 4-MeC6H4, 3-MeC6H4, 2-MeC6H4, 4-MeC6H4, 1-naphthyl, 2-naphthyl; R1 = 4-O2NC6H4, 3-O2NC6H4, 4-MeCOC6H4, 4-MeO2CC6H4, 4-NCC6H4, 3-NCC6H4, 2-NCC6H4, 4-F3CC6H4, 3-BrC6H4, 2-BrC6H4, 4-ClC6H4, 4-FC6H4).

Chemistry – An Asian Journal published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Product Details of C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts