Month: November 2022

Tamilselvan, Pitchiah published the artcileCobalt(II)-catalyzed dehydration of aldoximes. A highly efficient practical procedure for the synthesis of nitriles, COA of Formula: C9H9NO2, the main research area is aryl aldoxime dehydration cobalt catalyst; aromatic nitrile preparation.

Cobalt(II) chloride catalyzes the conversion of a variety of aldoximes, including salicylaldoxime and substituted salicylaldoximes, into corresponding nitriles in the presence of an inorganic base in acetonitrile. The reaction proceeds under mild conditions and the yields are generally very good to excellent.

Catalysis Communications published new progress about Aldoximes Role: RCT (Reactant), RACT (Reactant or Reagent). 5653-62-3 belongs to class nitriles-buliding-blocks, name is 2,3-Dimethoxybenzonitrile, and the molecular formula is C9H9NO2, COA of Formula: C9H9NO2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Abele, E. published the artcileNovel synthesis of aromatic and heteroaromatic nitriles from aldehydes under liquid-liquid phase transfer catalysis conditions, Safety of 2,3-Dimethoxybenzonitrile, the main research area is aldehyde conversion nitrile phase transfer catalysis; nitrile preparation.

A PTC method of synthesis of aromatic nitrile from the corresponding aldehydes was developed based on dichlorocarbene-mediated dehydration of intermediate aldoximes and products were isolated in 37-67% yields. The method was less successful in the case of heteroaromatic nitriles, especially for pyridine derivatives because of side reactions.

Latvijas Kimijas Zurnals published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 5653-62-3 belongs to class nitriles-buliding-blocks, name is 2,3-Dimethoxybenzonitrile, and the molecular formula is C9H9NO2, Safety of 2,3-Dimethoxybenzonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Coskun, Necdet published the artcileDirect conversion of aldehydes to nitriles via O-phenylcarbamoylated aldoximes, Synthetic Route of 5653-62-3, the main research area is aldehyde conversion nitrile; phenylcarbamoylated aldoxime preparation conversion nitrile; nitrile preparation.

O-arylcarbamoylated hydroxylamine tosylate reacts with aldehydes at room temperature to give the corresponding O-carbamoylated oximes. The reaction of carbamoylated hydroxylamine with aromatic aldehydes in THF or in toluene at reflux affords the corresponding nitriles and anilinium tosylate in high yield. Attempts to cyclize the O-carbamoylated oximes in the presence of AcCl lead again to the formation of nitriles.

Tetrahedron published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 5653-62-3 belongs to class nitriles-buliding-blocks, name is 2,3-Dimethoxybenzonitrile, and the molecular formula is C9H9NO2, Synthetic Route of 5653-62-3.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Das, Asit Kumar published the artcileCu(OAc)2 catalysed aerobic oxidation of aldehydes to nitriles under ligand-free conditions, Synthetic Route of 1885-29-6, the main research area is aldehyde ammonium acetate copper catalyst oxidation reaction green chem; nitrile preparation.

An economically efficient and environmentally benign approach for the direct oxidative transformation of aldehydes to nitriles was developed using com. available non-toxic copper acetate as an inexpensive catalyst and ammonium acetate as the source of nitrogen in the presence of aerial oxygen as an eco-friendly oxidant under ligand-free conditions. The reactions were associated with high yield and various sensitive moieties like allyloxy, benzyloxy, t-butyldimethylsilyloxy, hetero-aryl, formyl, keto, chloro, bromo, methylenedioxy and cyano were well tolerated in the aforesaid method. The kinetic studies showed first order dependency on the aldehyde substrate in the reaction rate. The reaction was faster with the electron deficient aldehydes as confirmed by Hammett anal. Moreover, the present oxidative method was effective on larger scales showing potential for industrial application.

RSC Advances published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Synthetic Route of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Das, Asit Kumar published the artcileCu(OAc)2 catalysed aerobic oxidation of aldehydes to nitriles under ligand-free conditions, Safety of Picolinonitrile, the main research area is aldehyde ammonium acetate copper catalyst oxidation reaction green chem; nitrile preparation.

An economically efficient and environmentally benign approach for the direct oxidative transformation of aldehydes to nitriles was developed using com. available non-toxic copper acetate as an inexpensive catalyst and ammonium acetate as the source of nitrogen in the presence of aerial oxygen as an eco-friendly oxidant under ligand-free conditions. The reactions were associated with high yield and various sensitive moieties like allyloxy, benzyloxy, t-butyldimethylsilyloxy, hetero-aryl, formyl, keto, chloro, bromo, methylenedioxy and cyano were well tolerated in the aforesaid method. The kinetic studies showed first order dependency on the aldehyde substrate in the reaction rate. The reaction was faster with the electron deficient aldehydes as confirmed by Hammett anal. Moreover, the present oxidative method was effective on larger scales showing potential for industrial application.

RSC Advances published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Safety of Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Sisko, Joseph published the artcileAn investigation of imidazole and oxazole syntheses using aryl-substituted TosMIC reagents, SDS of cas: 263389-54-4, the main research area is imidazole phenyl preparation; oxazole aryl preparation; tosylmethyl isonitrile cyclocondensation imine; amine aldehyde tosylmethyl isonitrile cyclocondensation; amino acid aldehyde tosylmethylisonitrile cyclocondensation; aldehyde ammonium hydroxide cyclization tosylmethyl isonitrile.

Efficient and mild protocols are described for preparing polysubstituted imidazoles in a single pot from aryl-substituted tosylmethyl isocyanide (TosMIC) reagents and imines generated in situ. Traditional imine-forming reactions employing virtually any aldehyde and an amine followed by addition of the TosMIC reagent gave 1,4,5-tri-substituted imidazoles with predictable regiochem. Thus, condensation of pyruvaldehyde with (MeO)2CHCH2NH2 in THF at ambient temperature for 15 min and subsequent reaction with 4-FC6H4CH(Tos)N+C- [Tos = 4-MeC6H4SO2] in the presence of piperazine for 18 h gave 71% [(fluorophenyl)imidazolyl]ethanone I. Employing chiral amines and aldehydes, particularly those derived from α-amino acids, gave imidazoles, e.g. II, with asym. centers appended to N-1 or C-5 with excellent retention of chiral purity. 1,4-Disubstituted imidazoles were also readily prepared by a simple variant of the above procedure. Selection of glyoxylic acid as the aldehyde component of the procedure lead to intermediates such as III which readily underwent decarboxylation and elimination of the tosyl moiety to give 1,4-disubstituted imidazoles in high yields. Alternatively, using NH4OH as the amine component in conjunction with a variety of aldehydes gave 4,5-disubstituted imidazoles in moderate to good yields in a single pot while avoiding the need for protecting groups. Finally, the facile preparation of mono- and disubstituted oxazoles, e.g. IV, from these TosMIC reagents and aldehydes was described.

Journal of Organic Chemistry published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 263389-54-4 belongs to class nitriles-buliding-blocks, name is a-Tosyl-(4-methoxybenzyl) isocyanide, and the molecular formula is C16H15NO3S, SDS of cas: 263389-54-4.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Pieczykolan, Michal published the artcileAn Efficient Method for the Programmed Synthesis of Multifunctional Diketopyrrolopyrroles, Application In Synthesis of 100-70-9, the main research area is aldehyde primary amine nitrile diethyl oxalacetate diastereoselective cyclization fluorescence; diketopyrrolopyrrole preparation; donor-acceptor systems; dyes; fluorescence; heterocycles; lactams.

A new, transformative methodol. for the preparation of diketopyrrolopyrroles from aldehydes, primary amines, nitriles, and di-Et oxalacetate has been developed. It is now possible to prepare diketopyrrolopyrroles, e.g., I, bearing an ordered arrangement of three different substituents from abundant and com. available materials, allowing the independent regulation of all desired physicochem. properties. For the first time very electron-rich (carbazol-3-yl, dimethylaminophenyl, pyrrolo[3,2-b]pyrrolyl), and sterically hindered substituents (naphthalen-1-yl, quinolin-4-yl, acridin-9-yl, imidazo[1,5-a]pyridin-1-yl, 2-bromophenyl etc.) can be appended to the diketopyrrolopyrrole core by condensation of an appropriate nitrile with a pyrrolidin-2-one intermediate. Even greater synthetic possibilities are related to the fact that such demanding substituents as 4-dimethylaminophenyl, indol-3-yl, and 2-methoxyphenyl can be incorporated from aldehyde precursors, bypassing problems with the nitriles reactivity.

Angewandte Chemie, International Edition published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Application In Synthesis of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Mujahed, Shrouq published the artcileA High-Valent Ru-PCP Pincer Catalyst for Hydrogenation of Carbonyl and Carboxyl Compounds under Molecular Hydrogen, Safety of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is high valent ruthenium phosphorus carbon PCP pincer catalyst hydrogenation; carbonyl carboxyl nitrile compound hydrogenation catalyst preparation; crystal mol structure ruthenium phosphorus carbon PCP pincer complex; cooperative catalysis; esters; high-valent ruthenium; hydrogenation; pincer complexes.

Low-valent metals traditionally dominate the domain of catalytic hydrogenation. However, metal-ligand cooperating (MLC) catalytic systems, operating through heterolytic H-H bond splitting by a Lewis acidic metal and a basic ligand site, do not require an electron-rich metal. On the contrary, high-valent metals that induce weaker back donation facilitate heterolytic bond activation. Here authors report, for the first time, the efficient hydrogenation of carbonyl and carboxyl compounds under mol. hydrogen catalyzed by a structurally well-defined RuIV catalyst bearing a bifunctional PCP pincer ligand. The catalyst exhibits reactivity toward mol. hydrogen superior to that of the low-valent analog and allows hydrogen activation even at room temperature

Chemistry – A European Journal published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Safety of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Wang, Shichun published the artcileSynthesis and reactivity of the uranium phosphinidene metallocene [η5-1,3-(Me3Si)2C5H3]2U(:P-2,4,6-iPr3C6H2)(OPMe3): influence of the coordinated Lewis base, Product Details of C8H4N2, the main research area is reactivity uranium phosphinidene metallocene Lewis base; isothiocyanate aldehyde nitrile isonitrile azide reactivity uranium phosphinidene metallocene.

This paper describes the synthesis and reactivity of [η5-1,3-(Me3Si)2C5H3]2U(:P-2,4,6-iPr3C6H2)(OPMe3) (6) which is accessible from a ligand exchange reaction between [η5-1,3-(Me3Si)2C5H3]2U(:P-2,4,6-iPr3C6H2)(OPPh3) (2) and Me3PO at ambient temperature Phosphinidene 6 exhibits no reactivity towards internal alkynes, but readily reacts with various hetero-unsaturated mols. such as isothiocyanates, aldehydes, nitriles, isonitriles, and organic azides, forming uranium sulfido, oxido, imido, and uranaheterocyclic compounds Nevertheless, with the bidentate ortho-dicyanobenzene o-C6H4(CN)2 the zwitterionic species [η5-1,3-(Me3Si)2C5H3]2U[NHC(N){C6H4CP(2,4,6-iPr3C6H2)CH2PMe2O}] (13) is isolated in good yield. Moreover, 6 converts with Ph2S2 to the uranium(III) phenylthiolate compound [η5-1,3-(Me3Si)2C5H3]2USPh(OPMe3) (7) in good isolated yield. Furthermore, the influence of the Lewis base on the reactivity of the uranium phosphinidene metallocenes has also been evaluated.

Dalton Transactions published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Product Details of C8H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Wang, Deqiang published the artcileA Lewis Base Supported Terminal Uranium Phosphinidene Metallocene, HPLC of Formula: 91-15-6, the main research area is uranium phospinidene metallocene preparation reactivity imine diazene carbodiimide nitrile; phospinidene uranium metallocene adduct imine diazene nitrile preparation; crystal structure uranium phospinidene metallocene adduct imine diazene nitrile; mol structure uranium phospinidene metallocene adduct imine diazene nitrile.

A Lewis base supported terminal U phosphinidene, [η5-1,3-(Me3C)2C5H3]2U(:P-2,4,6-tBu3C6H2)(OPMe3) (5), is isolated from the reaction of the U Me chloride [η5-1,3-(Me3C)2C5H3]2U(Cl)Me (4) with 2,4,6-(Me3C)3C6H2PHK in toluene in the presence of Me3PO. Also, the reactivity of the U phospinidene 5 toward small mols. were comprehensively explored. While no reactivity of 5 with internal alkynes is observed attributed to steric hindrance, it readily reacts with various small mols. including isothiocyanates, aldehydes, imines, diazenes, carbodiimides, nitriles, isonitriles, and organic azides, yielding U sulfides, oxides, metallaheterocycles, and imido complexes, in good yields. A Lewis base supported actinide phosphinidene metallocene was isolated and its reactivity toward small mols. was studied. It exhibits a rich reaction chem. toward a variety of heterounsatd. mols. and the steric hindrance imposed by the Cp ligand plays an important role in the formation and reaction chem. of U phosphinidene metallocenes.

Inorganic Chemistry published new progress about Aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, HPLC of Formula: 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts