Month: November 2022

Suryawanshi, Manjusha published the artcileSynthesis, characterization and photophysical properties of novel thiazole substituted pyridine derivatives, Name: Picolinonitrile, the main research area is pyridylthiazole preparation photophys property.

Three series of isomeric 2-pyridyl 4-aryl thiazoles were synthesized by reacting 2/3/4-pyridine thioamides derived from the corresponding nitriles with various 4-substituted phenacyl bromides using Hantzsch thiazole synthesis. Amongst the three isomeric series, 2-pyridyl and 4-pyridyl isomers are found to exhibit better photophys. properties than 3-pyridyl series. 4-Pyridyl isomer with methoxy substituent on Ph ring is found to exhibit high luminescence quantum yield. The relationship between the structure and the photophys. properties have been studied using DFT calculations

Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry published new progress about Haloketones Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Name: Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Kumar, Gadde Sathish published the artcilePaired Electrolysis for Decarboxylative Cyanation: 4-CN-Pyridine, a Versatile Nitrile Source, Quality Control of 100-70-9, the main research area is cyano pyridine amino acid decarboxylative cyanation electrochem; aniline cyano pyridine regioselective cyanation electrochem; aminoacetonitrile preparation.

A decarboxylative cyanation of amino acids under paired electrochem. reaction conditions was developed. 4-CN-pyridine was found to be a new and effective cyanation reagent under catalyst-free conditions. Mechanistic studies support a nucleophilic reaction pathway, and the cyanation protocol can be applied to diverse substrates including N,N-dialkyl aniline and indole derivatives

Organic Letters published new progress about Amino acids Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Quality Control of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Barzano, Guido published the artcileTandem Photoredox and Copper-Catalyzed Decarboxylative C(sp3)-N Coupling of Anilines and Imines Using an Organic Photocatalyst, Application of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is photoredox copper catalyzed decarboxylative carbon nitrogen coupling; coupling aniline imine alkyl amine preparation organic photocatalyst.

An organic photoredox catalyst, 4CzIPN, was used in combination with a copper catalyst, CuCl, to effect decarboxylative C(sp3)-N coupling. The coupling worked with both anilines and imines as nitrogen sources and could be used to prepare a variety of alkyl amines from readily available alkyl carboxylic acids.

Organic Letters published new progress about Amines Role: SPN (Synthetic Preparation), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Uengoeren, S. Hakan published the artcileThe Motifs from Isocytosine and Fused Isocytosine with Quinazoline: Organocatalytic Cascade Reaction of β-Ketoamides, Safety of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is isocytosine preparation; ketoamide cyanamide cyclization tandem reaction diazabicycloundecene catalyst.

A method for the synthesis of isocytosine analogs I (R = H, 4-chlorophenyl, pyridin-2-yl, etc.), II, III (R1 = H, Cl) and IV (R2 = H, Cl, Br; R3 = Me, Ph, 4-methoxyphenyl, 3,4-dimethoxyphenyl) from β-ketoamides R4C(O)CH2C(O)NHR5 [R4 = Me, (4-methylphenyl)aminyl, Ph, etc.; R5 = H, 4-chloro-2-cyanophenyl, pyridin-2-yl, etc.] was investigated. Application of the method to β-ketoamides including a 2-cyanoaryl group leads to isocytosine fused quinazolines by the organocatalytic Cascade reaction. 20 Examples of pyrimidone derivatives I, II, III and IV were synthesized in different patterns.

ChemistrySelect published new progress about Amides, oxo Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Safety of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ounkham, Whalmany L. published the artcileAqueous-Phase Nitrile Hydration Catalyzed by an In Situ Generated Air-Stable Ruthenium Catalyst, Category: nitriles-buliding-blocks, the main research area is aqueous phase nitrile hydration air stable ruthenium catalyst; benzamide amide preparation green chem; aqueous-phase catalysis; homogeneous catalysis; nitrile hydration; ruthenium; sustainable chemistry.

RuCl2(PTA)4 (PTA=1,3,5-triaza-7-phosphaadamantane) is an active, recyclable, air-stable, aqueous-phase nitrile hydration catalyst. The development of an in situ generated aqueous-phase nitrile hydration catalyst (RuCl3·3 H2O + 6 equiv PTA) is reported. The activity of the in situ catalyst is comparable to RuCl2(PTA)4. The effects of [PTA] on the activity of the reaction were investigated: the catalytic activity, in general, increases as the pH goes up, which shows a pos. correlation with [PTA]. The pH effects were further explored for both the in situ and RuCl2(PTA)4 catalyzed reaction in phosphate buffer solutions with particular attention given to pH 6.8 buffer. Increased catalytic activity was observed at pH 6.8 vs. water for both systems with turnover frequency (TOF) up to 135 h-1 observed for RuCl2(PTA)4 and 64 h-1 for the in situ catalyst. Catalyst loading down to 0.001 mol % was examined with turnover numbers as high as 22 000 reported. Similar to the preformed catalyst, RuCl2(PTA)4, the in situ catalyst could be recycled more than five times without significant loss of activity from either water or pH 6.8 buffer.

Chemistry – A European Journal published new progress about Amides Role: SPN (Synthetic Preparation), PREP (Preparation). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Trivedi, Manoj published the artcileRu(II)- and Ru(IV)-dmso complexes catalyze efficient and selective aqueous-phase nitrile hydration reactions under mild conditions, Application In Synthesis of 100-70-9, the main research area is ruthenium dmso complex catalyst preparation; amide green preparation; nitrile hydration ruthenium catalyst.

New water-soluble ruthenium(II)- and ruthenium(IV)-dmso complexes [RuCl2(dmso)2(NH3)(CH3CN)], [RuCl2(dmso)3(CH3CN)] and [RuCl2(dmso)3(NH3)]·PF6·Cl had been synthesized and characterized using elemental analyzes, IR, 1H and 31P NMR and electronic absorption spectroscopy. The mol. structures of complexes were determined crystallog. The reactivity of complexes had been tested for aqueous-phase nitrile hydration at 60°C in air, and good efficiency and selectivity are shown for the corresponding amide derivatives RC(O)NH2 [R = t-Bu, Ph, 4-BrC6H4, etc.]. Best performance is achieved with complex [RuCl2(dmso)3(NH3)]·PF6·Cl. Amide conversions of 56-99% were obtained with a variety of aromatic, alkyl and vinyl nitriles. The reaction tolerated hydroxyl, nitro, bromo, formyl, pyridyl, benzyl, alkyl and olefinic functional groups. Amides were isolated by simple decantation from the aqueous-phase catalyst. A catalyst loading down to 0.0001 mol% was examined and turnover numbers as high as 990000 were observed The catalyst was stable for weeks in solution and could be reused more than seven times without significant loss in catalytic activity. The gram-scale reaction was also performed to produce the desired product in high yields.

New Journal of Chemistry published new progress about Amides Role: SPN (Synthetic Preparation), PREP (Preparation). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Application In Synthesis of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Guo, Beibei published the artcileHydration of nitriles using a metal-ligand cooperative ruthenium pincer catalyst, Formula: C6H4N2, the main research area is nitrile water ruthenium pincer catalyst hydration; amide preparation.

The catalytic nitrile hydration using ruthenium catalysts based on a pincer scaffold with a dearomatized pyridine backbone. These complexes catalyzed the nucleophilic addition of H2O to a wide variety of aliphatic and (hetero)aromatic nitriles in tBuOH as solvent. Reactions occurred under mild conditions (room temperature) in the absence of additives. A mechanism for nitrile hydration was proposed that is initiated by metal-ligand cooperative binding of the nitrile.

Chemical Science published new progress about Amides Role: SPN (Synthetic Preparation), PREP (Preparation). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Formula: C6H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Wu, Mei published the artcileDIPEA-induced activation of OH- for the synthesis of amides via photocatalysis, Formula: C7H6N2, the main research area is nitrile eosin Y photocatalyst diisopropylethylamine hydration; amide preparation green chem.

Herein, an efficient light-mediated strategy for the synthesis of amides in which a weak organic base acts as a reductant to induce the formation of OH- from water under metal-free conditions was reported. A mechanistic study revealed that the generation of an N,N-diisopropylethylamine (DIPEA) radical via single electron transfer (SET), with the assistance of photocatalyst, that increased the nucleophilicity of the water mols. with respect to the cyanides was essential. Moreover, the removal rate of nitrile in wastewater can be as high as 83%, indicating that this strategy had excellent potential for nitrile degradation

RSC Advances published new progress about Amides Role: SPN (Synthetic Preparation), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Formula: C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Czegeni, Csilla Eniko published the artcileSelective hydration of nitriles to corresponding amides in air with Rh(I)-N-heterocyclic complex catalysts, Synthetic Route of 100-70-9, the main research area is rhodium heterocyclic complex catalyst nitrile hydration crystal structure.

A new synthetic method for obtaining [RhCl(cod)(NHC)] complexes (1-4) (cod = η4 -1,5- cyclooctadiene, NHC = N-heterocyclic carbene: IMes, SIMes, IPr, and SIPr, resp.) is reported together with the catalytic properties of 1-4 in nitrile hydration. In addition to the characterization of 1-4 in solution by 13C NMR spectroscopy, the structures of complexes 3, and 4 have been established also in the solid state with single-crystal X-ray diffraction anal. The Rh(I)-NHC complexes displayed excellent catalytic activity in hydration of aromatic nitriles (up to TOF = 276 h-1) in water/2-propanol (1/1 volume/volume) mixtures in air.

Catalysts published new progress about Amides Role: SPN (Synthetic Preparation), PREP (Preparation). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Synthetic Route of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Vyas, Komal M. published the artcileArene-ruthenium(II)-phosphine complexes: Green catalysts for hydration of nitriles under mild conditions, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is ruthenium arene phosphine complex green catalyst nitrile hydration amide; crystal structure mol ruthenium arene phosphine complex preparation.

Three new arene-ruthenium(II) complexes were prepared by treating [{RuCl(μ-Cl)(η6-arene)}2] (η6-arene = p-cymene) dimer with tri(2-furyl)phosphine (PFu3) and 1,3,5-triaza-7-phosphaadamantane (PTA), resp. to obtain [RuCl2(η6-arene)PFu3] [Ru]-1, [RuCl(η6-arene)(PFu3)(PTA)]BF4 [Ru]-2 and [RuCl(η6-arene)(PFu3)2]BF4 [Ru]-3. All the complexes were structurally identified using anal. and spectroscopic methods including single-crystal X-ray studies. The effectiveness of resulting complexes as potential homogeneous catalysts for selective hydration of different nitriles into corresponding amides in aqueous medium and air atm. was explored. There was a remarkable difference in catalytic activity of the catalysts depending on the nature and number of phosphorus-donor ligands and sites available for catalysis. Exptl. studies performed using structural analogs of efficient catalyst concluded a structural-activity relationship for the higher catalytic activity of [Ru]-1, being able to convert huge variety of aromatic, heteroaromatic and aliphatic nitriles. The use of eco-friendly water as a solvent, open atm. and avoidance of any organic solvent during the catalytic reactions prove the reported process to be truly green and sustainable.

Inorganic Chemistry Communications published new progress about Amides Role: SPN (Synthetic Preparation), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts