Month: November 2022

Sinai, Adam published the artcileAryl-Diadamantyl Phosphine Ligands in Palladium-Catalyzed Cross-Coupling Reactions: Synthesis, Structural Analysis, and Application, Category: nitriles-buliding-blocks, the main research area is aryl diadamantyl phosphine ligand palladium catalyst preparation coupling; Buchwald Hartwig tosyl hydrazone coupling.

Synthesis, temperature-dependent NMR structure study and use of a new, stable and easily accessible aryl-diadamantylphosphine ligand family is reported. The bulky and electron-rich phosphorus center of the ligand enhances the catalytic activity of palladium in cross-coupling reactions of sterically demanding ortho-substituted aryl halides. In the authors’ study, the authors demonstrated the synthetic applicability of the new phosphine ligands in Buchwald-Hartwig and tosyl hydrazone coupling reactions.

European Journal of Organic Chemistry published new progress about Aryl halides Role: RCT (Reactant), RACT (Reactant or Reagent). 204078-32-0 belongs to class nitriles-buliding-blocks, name is 2-Morpholinobenzonitrile, and the molecular formula is C11H12N2O, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Hussain, Muhammad Asif published the artcileAn efficient hydration of nitriles with ruthenium-supported heterogeneous catalyst in water under moderate conditions, HPLC of Formula: 100-70-9, the main research area is nitrile hydration ruthenium supported manganese oxide catalyst moderate condition.

A facile eco-friendly heterogeneous catalytic system has been developed for amide synthesis that further utilized in pharmaceutical and organic chem. The Ru/MnO2 catalyst has shown outstanding and unprecedented activity for a wide range of aliphatic and benzylic nitriles in green solvent water at 60°C. The system has also exhibited a remarkable tolerance for selective hydration of heteroatom (e.g. nitrogen, oxygen and sulfur atoms) containing nitriles. Pharmaceutically important nicotinamides and pyrazinamide has been synthesized by hydration of the heteroat. nitriles with appreciable yields and selectivities. Moreover, the Ru/MnO2 catalyst has employed water as a benign solvent, with more than 30,000 TONs and reusability five times after isolation from the reaction mixture by centrifugation and easy workup that established a path for green environmental and technol. acceptable protocol.

Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) published new progress about Amides Role: IMF (Industrial Manufacture), PREP (Preparation). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, HPLC of Formula: 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Naraoka, Asuka published the artcileTransfer Hydration of Dinitriles to Dicarboxamides, COA of Formula: C8H4N2, the main research area is dicarboxamide preparation; dinitrile hydration palladium catalyst acetamide water donor.

A robust method for double transfer hydration of dinitriles to afford diamides was presented. The transfer hydration of 1,n-dinitriles (n = 1-6) proceeds smoothly in the presence of a palladium(II) catalyst with acetamide as a water donor, affording the corresponding diamides in moderate to high yields, without involving significant side reactions such as monohydration or cyclization. The equilibrium was shifted in the forward direction by removing coproduced acetonitrile under reduced pressure.

Synlett published new progress about Diamides Role: SPN (Synthetic Preparation), PREP (Preparation). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, COA of Formula: C8H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Moll, Johannnes published the artcileGreen-Light Activation of Push-Pull Ruthenium(II) Complexes, Recommanded Product: Picolinonitrile, the main research area is microwave irradiation preparation ruthenium carboxypyridylmethylaminepyridylpyridine dimethyldipyridinylpyridinediamine complex; crystal mol structure ruthenium carboxypyridylmethylaminepyridylpyridine dimethyldipyridinylpyridinediamine complex; luminescence ruthenium carboxypyridylmethylaminepyridylpyridine dimethyldipyridinylpyridinediamine complex; cyclic voltammetry ruthenium carboxypyridylmethylaminepyridylpyridine dimethyldipyridinylpyridinediamine complex; luminescence; photocatalysis; photochemistry; photophysics; ruthenium.

Synthesis, characterization, electrochem., and photophysics of homo- and heteroleptic ruthenium(II) complexes [Ru(cpmp)2]2+ (22+) and [Ru(cpmp)(ddpd)]2+ (32+) bearing the tridentate ligands 6,2”-carboxypyridyl-2,2′-methylamine-pyridyl-pyridine (cpmp) and N,N’-dimethyl-N,N’-dipyridin-2-ylpyridine-2,6-diamine (ddpd) are reported. The complexes possess one (32+) or two (22+) electron-deficient dipyridyl ketone fragments as electron-accepting sites enabling intraligand charge transfer (ILCT), ligand-to-ligand charge transfer (LL’CT) and low-energy metal-to-ligand charge transfer (MLCT) absorptions. The latter peak around 544 nm (green light). Complex 22+ shows 3MLCT phosphorescence in the red to near-IR spectral region at room temperature in deaerated acetonitrile solution with an emission quantum yield of 1.3% and a 3MLCT lifetime of 477 ns, whereas 32+ is much less luminescent. This different behavior is ascribed to the energy gap law and the shape of the parasitic excited 3MC state potential energy surface. This study highlights the importance of the excited-state energies and geometries for the actual excited-state dynamics. Aromatic and aliphatic amines reductively quench the excited state of 22+ paving the way to photocatalytic applications using low-energy green light as exemplified with the green-light-sensitized thiol-ene click reaction.

Chemistry – A European Journal published new progress about Charge transfer transition (ligand-to-ligand, metal-to-ligand). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Recommanded Product: Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Wang, Zijuan published the artcilePalladium(II)-Catalyzed Three-Component Tandem Cyclization Reaction for the One-Pot Assembly of 4-Arylquinazolines, SDS of cas: 1885-29-6, the main research area is quinazoline aryl preparation; aminobenzonitrile boronic acid triethyl orthocarboxylate tandem heterocyclization palladium catalyst.

A one-pot method for joining three sep. components leading to an assortment of 4-arylquinazolines I (R1 = H, 6-Cl, 7-Cl, 8-Cl, 6-Me, 6-Br; R2 = H, Me, Ph; R3 = C6H5, 4-ClC6H4, 4-CH3C6H4, etc.) in good to excellent yields is described. The method consists of a palladium(II)-catalyzed cascade reaction involving C(sp)-C(sp2) coupling followed by intramol. C-N bond formation. The reaction was readily scaled up to gram quantity and successfully applied to the synthesis of a translocator protein (TSPO) ligand II.

Synthesis published new progress about Boronic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, SDS of cas: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ke, Da published the artcileGeneral Construction of Amine via Reduction of N=X (X = C, O, H) Bonds Mediated by Supported Nickel Boride Nanoclusters, Application of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is primary amine preparation; nitrile reduction nickel boride nanocluster catalyst; nitro compound hydrogenation nickel boride nanocluster catalyst; benzaldehyde reduction nickel boride nanocluster catalyst; hydrogenation; nickel boride; primary amine; reductive amination.

Herein, an efficient catalyst for the general construction of amine mediated by nickel boride nanoclusters supported by a TS-1 mol. sieve was reported. Efficient production of amines RCH2NH2 (R = 5-aminopentyl, cyclohexyl, Ph, pyridin-2-yl, etc.), 3-R1-4-R2-C6H3NH2 (R1 = H, F; R2 = H, F, Cl, Me, Br, OH, NH2) was achieved via catalytic hydrogenation of N=X (X = C, O, H) bonds. In addition, the catalyst maintains excellent performance upon recycling. Compared with the previous reports, the high activity, simple preparation and reusability of the Ni-B catalyst in this work make it promising for industrial application in the production of amines.

International Journal of Molecular Sciences published new progress about Benzaldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ke, Da published the artcileGeneral Construction of Amine via Reduction of N=X (X = C, O, H) Bonds Mediated by Supported Nickel Boride Nanoclusters, COA of Formula: C6H4N2, the main research area is primary amine preparation; nitrile reduction nickel boride nanocluster catalyst; nitro compound hydrogenation nickel boride nanocluster catalyst; benzaldehyde reduction nickel boride nanocluster catalyst; hydrogenation; nickel boride; primary amine; reductive amination.

Herein, an efficient catalyst for the general construction of amine mediated by nickel boride nanoclusters supported by a TS-1 mol. sieve was reported. Efficient production of amines RCH2NH2 (R = 5-aminopentyl, cyclohexyl, Ph, pyridin-2-yl, etc.), 3-R1-4-R2-C6H3NH2 (R1 = H, F; R2 = H, F, Cl, Me, Br, OH, NH2) was achieved via catalytic hydrogenation of N=X (X = C, O, H) bonds. In addition, the catalyst maintains excellent performance upon recycling. Compared with the previous reports, the high activity, simple preparation and reusability of the Ni-B catalyst in this work make it promising for industrial application in the production of amines.

International Journal of Molecular Sciences published new progress about Benzaldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, COA of Formula: C6H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Dutta, Apurba published the artcileBase promoted metal-free approach towards synthesis of quinazolin-4(3H)-ones and 2,3-dihydroquinazolin-4(1H)-ones under microwave irradiation, Quality Control of 1885-29-6, the main research area is quinazolinone dihydroquinazolinone preparation microwave irradiation green chem.

A metal, solvent and oxidant free approach has been developed for the synthesis of quinazolin-4(3H)-ones in a concise and convergent fashion under microwave irradiation Using the same metal free catalyst 2,3-dihydroquinazolin-4(1H)-ones were also synthesized in water as green and sustainable solvent. Starting from 2-aminobenzonitriles and carbonyls, the desired products were isolated in good to excellent yields. These protocols provided a simplistic and an expeditious approach for the assembly of diverse structural quinazolinones.

Sustainable Chemistry and Pharmacy published new progress about Benzaldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Quality Control of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Pezzetta, Cristofer published the artcileEnantioselective Synthesis of N-Benzylic Heterocycles: A Nickel and Photoredox Dual Catalysis Approach, Computed Properties of 100-70-9, the main research area is benzylic heterocycle preparation enantioselective; heterocyclic carboxylic acid aryl bromide decarboxylative cross coupling; nickel photoredox dual catalysis.

Reported herein is a dual nickel- and photoredox-catalyzed modular approach for the preparation of enantioenriched N-benzylic heterocycles. α-Heterocyclic carboxylic acids, easily obtainable from common com. material, are reported as suitable substrates for a decarboxylative strategy in conjunction with a chiral pyridine-oxazoline (PyOx) ligand, providing quick access to enantioenriched drug-like products. The presence of a directing group on the heterocyclic moiety is shown to be beneficial, affording improved stereoselectivity in a number of cases.

Organic Letters published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Computed Properties of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhao, Huantian published the artcileSynthesis of 1H-Indazoles and Quinazolines Using Additive Intermediates of Grignard Reagents to 2-Amino Benzonitriles, Category: nitriles-buliding-blocks, the main research area is aminobenzonitrile bromide iron chloride catalyst one pot heterocyclization; indazole preparation; bromide aminobenzonitrile ester bismuth chloride catalyst one pot heterocyclization; quinazoline preparation.

A convenient and efficient approach to 1H-indazoles in one-pot under air atm., using additive intermediates of Grignard reagents to 2-aminobenzonitriles via a FeCl3/Bpy catalyzed N-N coupling was developed. Besides, such intermediates could reacted with esters in one-pot to yield quinazolines promoted by BiCl3/Ph3P. Both 1H-indazoles and quinazolines were prepared in good to excellent yields. The possible mechanisms for the formation of 1H-indazoles and quinazolines were proposed.

ChemistrySelect published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts