Month: November 2022

Ram, Shankar published the artcilePolystyrene-Supported Palladium (Pd@PS)-Catalyzed Carbonylative Annulation of Aryl Iodides Using Oxalic Acid as a Sustainable CO Source for the Synthesis of 2-Aryl Quinazolinones, SDS of cas: 1885-29-6, the main research area is reusable polystyrene support palladium catalyst preparation; aminobenzamide iodobenzene oxalic acid palladium catalyst carbonylation heterocyclization; aryl quinazolinone preparation green chem; aminobenzamides; aminobenzonitriles; oxalic acid dihydrate; palladium nanoparticles; quinazolinones.

An efficient and convenient strategy for the synthesis of diversely substituted quinazolinones from o-carbamoyl/cyano aniline and aryl iodides using oxalic acid as a CO source under polystyrene supported palladium (Pd@PS) nanoparticles (NPs) catalyzed conditions was developed. The oxalic acid were employed as safe, economic, environmentally benign, sustainable and bench-stable, solid CO surrogate under Double-Layer-Vial (DLV) system for the synthesis of 2-aryl quinazolinones. This methodol. does not require any special high-pressure equipment like autoclaves, microwaves, etc. Moreover, a simple procedure for catalyst preparation, catalyst recyclability, easy handling of reaction, additive and base-free generation of CO, excellent to good yields and vast substrate scope were the addnl. features of developed protocol.

Chemistry – A European Journal published new progress about Aromatic amides Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, SDS of cas: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Wang, Yajie published the artcileAn Air-Stable N-Heterocyclic [PSiP] Pincer Iron Hydride and an Analogous Nitrogen Iron Hydride: Synthesis and Catalytic Dehydration of Primary Amides to Nitriles, Computed Properties of 100-70-9, the main research area is iron nitrogen heterocyclic pincer hydride catalyst dehydration primary amide; nitrile preparation.

An air-stable N-heterocyclic PSiP pincer iron hydride FeH(PMe3)2(SiPh(NCH2PPh2)2C6H4) was synthesized by Si-H activation of a Ph-substituted [PSiP] pincer ligand. The analogous strong electron-donating iPr-substituted [PSiP] pincer ligand was prepared and introduced into iron complex to give an iron nitrogen complex FeH(N2)(PMe3)(SiPh(NCH2PiPr2)2C6H4). Both complexes showed similar high efficiency for catalytic dehydration of primary amides to nitriles. Air-stable iron hydride FeH(PMe3)2(SiPh(NCH2PPh2)2C6H4) was the best catalyst for its stabilization and convenient preparation A diverse range of cyano compounds including aromatic and aliphatic species was obtained in moderate to excellent yields. A plausible catalytic reaction mechanism was proposed.

Organometallics published new progress about Aromatic amides Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Computed Properties of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Chang, Guoliang published the artcileLewis acid promoted dehydration of amides to nitriles catalyzed by [PSiP]-pincer iron hydrides, Product Details of C6H4N2, the main research area is phosphorus silicon iron hydrido pincer ligand preparation crystal structure; aryl nitrile preparation; amine aryl dehydration Lewis acid promoted iron catalyst.

The dehydration of primary amides to their corresponding nitriles using four [PSiP]-pincer hydrido iron complexes [(2-Ph2PC6H4)2MeSiFe(H)(PMe3)2, (2-Ph2PC6H4)2HSiFe(H)(PMe3)2, (2-(iPr)2PC6H4)2HSiFe(H)(PMe3)2 and (2-(iPr)2PC6H4)2MeSiFe(H)(PMe3)2] as catalysts in the presence of (EtO)3SiH as dehydrating reagent was explored in the good to excellent yields. It was proved for the first time that Lewis acid could significantly promote this catalytic system under milder reaction conditions than other Lewis acid-promoted system, such as shorter reaction time or lower reaction temperature This was also the first example that dehydration of primary amides to nitriles RCN [R = 4-ClC6H4, 2-thienyl, Bn, etc.] was catalyzed by silyl hydrido iron complexes bearing [PSiP]-pincer ligands with Lewis acid as additive. This catalytic system had good tolerance for many substituents. Among the four iron hydrides (2-Ph2PC6H4)2MeSiFe(H)(PMe3)2 was the best catalyst. The effects of substituents of the [PSiP]-pincer ligands on the catalytic activity of the iron hydrides were discussed. A catalytic reaction mechanism was proposed. Complex (2-(iPr)2PC6H4)2MeSiFe(H)(PMe3)2 was a new iron complex and was fully characterized. The mol. structure of complex (2-(iPr)2PC6H4)2MeSiFe(H)(PMe3)2 was determined by single crystal X-ray diffraction.

Applied Organometallic Chemistry published new progress about Aromatic amides Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Product Details of C6H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Muthukumar, Alagesan published the artcileZn(OTf)2-catalyzed access to symmetrical and unsymmetrical bisindoles from α-keto amides, Name: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is phenyl oxoamide preparation indole zirconium triflate catalyst chemoselective arylation; indolyl phenyl hydroxyamide indole zirconium triflate catalyst chemoselective arylation; bisindolyl phenyl acetamide preparation.

Zn(OTf)2-catalyzed synthesis of 3,3′-bisindolyl acetamides from α-keto amides was developed. Both aromatic α-keto amides substituted with electron-donating as well as -withdrawing groups and aliphatic α-keto amides were well tolerated to provide sym. bisindoles in moderate to excellent yields. The chemoselective bisindolylation of the keto group of α-keto amides in the presence of a simple keto functionality was successfully achieved in good yields. The transformation was further extended to the synthesis of challenging unsym. bisindoles by treating indolyl α-hydroxy amides with substituted indoles. The unsym. bisindoles were isolated in good to excellent yields.

Organic & Biomolecular Chemistry published new progress about Amides, hydroxy Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Name: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Tamoradi, Taiebeh published the artcileLa complex supported on magnetic nanoparticles: green, efficient, novel and reusable nanocatalyst for the synthesis of 5-substituted tetrazoles and the oxidation reactions in neat condition, Recommanded Product: Phthalonitrile, the main research area is iron oxide lanthanum complex nanocatalyst tetrazole preparation green chem.

In the present work, we were interested in the synthesis of green and novel magnetic nanocatalyst by anchoring La complex on Fe3O4. The nanocatalyst was successfully synthesized and characterized by FT-IR, SEM, TGA, XRD, EDX, and ICP techniques. The designed procedure shows many benefits such as short reaction time, high yield, excellent purity, eco-friendly catalyst, easy workup and easy recovery from the reaction mixture by external magnet.

Journal of the Iranian Chemical Society published new progress about Disulfides Role: IMF (Industrial Manufacture), PREP (Preparation). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Recommanded Product: Phthalonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Yang, Wu published the artcileEnantioselective Hydroxylation of Dihydrosilanes to Si-Chiral Silanols Catalyzed by In Situ Generated Copper(II) Species, Application In Synthesis of 1885-29-6, the main research area is silanol chiral preparation reactivity; crystal structure mol optimized silanol chiral ligand phosphine catalyst; enantioselective hydroxylation dihydrosilane copper phosphine catalyst mechanism transition state; Asymmetric Catalysis; Copper; Metathesis; Silanols; Single-Electron Transfer (SET) Oxidation.

Catalytic enantioselective hydroxylation of prochiral dihydrosilanes with water is expected to be a highly efficient way to access Si-chiral silanols, yet has remained unknown up to date. Herein, we describe a strategy for realizing this reaction: using an alkyl bromide as a single-electron transfer (SET) oxidant for invoking CuII species and chiral multidentate anionic N,N,P-ligands for effective enantiocontrol. The reaction readily provides a broad range of Si-chiral silanols with high enantioselectivity and excellent functional group compatibility. In addition, we manifest the synthetic potential by establishing two synthetic schemes for transforming the obtained products into Si-chiral compounds with high structural diversity. Our preliminary mechanistic studies support a mechanism involving SET for recruiting chiral CuII species as the active catalyst and its subsequent σ-metathesis with dihydrosilanes.

Angewandte Chemie, International Edition published new progress about Bromocycloalkanes Role: RGT (Reagent), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application In Synthesis of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Fang, Zhongxue published the artcileThe [4+1] cyclization reaction of 2-hydroxylimides and trimethylsulfoxonium iodide for the synthesis of 3-amino-2,3-dihydrobenzofurans, Product Details of C7H6N2, the main research area is amino dihydro benzofuran preparation green chem; hydroxylimide trimethylsulfoxonium iodide cyclization.

The [4+1] cyclization reaction of 2-hydroxylimides I (R1 = H, MeO, Cl; R2 = H, Br, Cl, NO2; R3= H; R2R3 = -CH=CH-CH=CH-; R4 = H, Me; R5 = 2,4,6-trimethylphenyl, quinolin-8-yl, pyrimidin-2-yl, etc.) and trimethylsulfoxonium iodide was investigated. This cyclization reaction exhibits wide scope and compatibility with functional groups. The 3-amino-2,3-dihydrobenzofurans II were obtained in reasonable to high yields under mild conditions. This methodol. was utilized to synthesize highly substituted 3-amino-2,3-dihydrobenzofuran derivatives II.

New Journal of Chemistry published new progress about Benzofurans Role: SPN (Synthetic Preparation), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Product Details of C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Dandia, Anshu published the artcileOne-Pot Copper(I)-Catalyzed Synthesis of 2-Aryl-quinazolin-4(3H)-ones via N-benzylation/Csp3-H Oxidation/CN Hydrolysis/Cyclization, Name: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is benzyl bromide aminobenzonitrile copper tandem benzylation oxidation hydrolysis heterocyclization; phenylquinazolinone selective preparation.

A Cu(I)-catalyzed straightforward synthesis of quinazolin-4(3H)-ones was attained by the reaction of 2-aminobenzonitrile with benzyl bromides. The reaction proceeded via one pot N-benzylation/CSp3- H oxidation/CN hydrolysis/cyclization sequence. Numerous controlled experiments were carried out to establish the appropriate mechanism and prerequisite of the reactions. The process was truly selective as only quinazolinones formed as desired product over dihydrogenated quinazolinones.

ChemistrySelect published new progress about Aralkyl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Name: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Hu, Yongke published the artcileCopper-catalyzed tandem oxidative synthesis of quinazolinones from 2-aminobenzonitriles and benzyl alcohols, Quality Control of 1885-29-6, the main research area is quinazolinone preparation green chem; aminobenzonitrile benzyl alc copper catalyst tandem oxidative.

An efficient and practical copper-catalyzed process for the synthesis of substituted quinazolinones I (R1 = C6H5, 4-MeOC6H4, 4-FC6H4, etc.; R2 = 6-Me, 6-OMe, 5-F, etc.) from simple and readily available 2-aminobenzonitriles and benzyl alcs. is described. This method features high functional-group tolerance and could afford a variety of desirable products in good to excellent yields with air as the sole oxidant. Moreover, a possible reaction mechanism is proposed according to the control experiments and reported literature.

Organic Chemistry Frontiers published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Quality Control of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Drageset, Audun published the artcileA two-step telescoped continuous flow switchable process leading to nitriles, diaziridine or hydrazine derivatives, COA of Formula: C6H4N2, the main research area is nitrile preparation; diaziridine preparation; hydrazine preparation.

Primary and benzylic alcs. RCH2OH (R = Ph, 2-methylpropyl, 2-nitrophenyl, etc.) were cost-effectively transformed into their corresponding nitriles RCN using a classical batch approach and a continuous flow process implemented on a multi-jet oscillating disk (MJOD) reactor platform. The alcs. as substrates were treated with (2,2,6,6-tetra-methylpiperidin-1-yl)oxidanyl (TEMPO) free radical as the pre-catalyst with 1,3-dichloro-5,5-dimethylhydantoin (DCH) as the terminal oxidant to produce their corresponding carbonyl compds RCHO. The reaction was conducted at a reaction temperature of 35 °C and a flow reactor residence time of 5 min. This alc. to carbonyl oxidation step was telescoped with a subsequent step that involved treatment with aqueous ammonium hydroxide and 1,3-diiodo-5,5-dimethylhydantoin (DIH) at a reaction temperature of 65 °C with concomitant oxidation to nitrile using a flow reactor residence time of 15 min. A solvent exchange process was conducted in-between the two synthetic reaction steps by means of an in-line extraction process with Et acetate, a step that was concatenated by using an in-line liquid-liquid separation process using a hold-up tank. The second synthetic step was revealed to be tunable, since four distinct products might be produced at varying degrees of selectivity. When DIH was used as the terminal oxidant, a high selectivity towards the original target nitrile was achieved, but if DIH was replaced with DCH as the terminal oxidant, 1,2-di((E)-benzylidene)hydrazine and two different stereoisomers of the 1,3,5-triazabicyclo[3.1.0]hexane scaffold were produced. The selectivity towards the various products was highly influenced by the reaction temperature A scope and limitation study of the nitrile process with an assortment of primary alcs. as substrates provided excellent yields which revealed good functional group tolerance.

Reaction Chemistry & Engineering published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, COA of Formula: C6H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts