Month: November 2022

Su, Tianyue published the artcileSynthesis of Quinazolinones Via a Tandem Hydrogen-Transfer Strategy Catalyzed by N,S Co-doped Carbon-Anchored Co Nanoparticles, Computed Properties of 1885-29-6, the main research area is quinazolinone preparation carbon supported cobalt heterogeneous catalyst; benzyl alc nitrobenzonitrile tandem hydrogen transfer.

A N,S codoped carbon-anchored Co nanoparticle (NP) material (Co@NSC-1) has been developed via the pyrolysis of the mixture of Co/Zn-zeolitic imidazolate frameworks (ZIFs) and thiourea. This catalyst exhibits excellent catalytic activity for the synthesis of quinazolinones from 2-nitrobenzonitriles and benzyl alcs. under additive-free conditions. The superior activity is mainly attributed to the dispersed Co NPs, large sp. surface areas, strong acid-base sites, and the synergistic effects between cobalt NPs and doping of N,S atoms. It is worth noting that Co NPs are protected by the N,S codoped carbon shells of this catalyst, so it displays no significant loss in activity after six runs.

ACS Sustainable Chemistry & Engineering published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Computed Properties of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Hikawa, Hidemasa published the artcileGold(III)/Sodium Diphenylphosphinobenzene-3-sulfonate (TPPMS) Catalyzed Dehydrative N-Benzylation of Electron-Deficient Anilines in Water, Application In Synthesis of 1885-29-6, the main research area is amine aryl benzyl preparation; aniline benzylation benzylic alc gold sodium diphenylphosphinobenzenesulfonate catalyst.

A strategy for the dehydrative N-benzylation of electron-deficient anilines R1NH2 (R1 = 4-O2NC6H4, 2-Me-3-O2NC6H3, 2-NCC6H4, etc.) in water has been developed. The gold(III)/sodium diphenylphosphinobenzene-3-sulfonate (TPPMS) catalyst is highly effective as a Lewis acid for the activation of alcs. R2R3CHOH (R2 = Ph, 4-CH3C6H4, PhCH:CH, etc.; R3 = H, Ph, 4-FC6H4, 4-ClC6H4) and tolerates aerobic conditions. A Hammett study in the reaction of para-substituted benzhydryl alcs. R2R3CHOH (R2 = 4-MeOC6H4, 4-MeC6H4, Ph, 4-FC6H4, 4-BrC6H4; R3 = Ph) shows neg. σ values, indicating a build-up of cationic charge during the rate-determining sp3 C-O bond-cleavage step. The inverse kinetic solvent isotope effect (KSIE = 0.6) is consistent with a specific acid catalysis mechanism. This simple protocol can be performed under mild conditions in an atom-economic process without the need for base or other additives, furnishing the electron-deficient N-benzylic anilines R1NHCHR2R3 in moderate to excellent yields along with water as a sole co-product.

Synthesis published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application In Synthesis of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Bergagnini-Kolev, Mackenzie published the artcileSynthesis of trifluoromethyl substituted nucleophilic glycine equivalents and the investigation of their potential for the preparation of α-amino acids, Safety of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is amino acid synthesis trifluoromethyl nucleophilic glycine equivalent; substituted pyroglutamic acid synthesis; nickel complex glycine Schiff base phase transfer catalyzed alkylation; oxazoladinone amide unsaturated substituted carboxylic acid Michael addition.

The synthetic preparation of several Ni(II) complexed Schiff bases of glycine will be introduced, as well as investigations into their reactivity and utility. Key to these investigations is the incorporation of electron-withdrawing trifluoromethyl groups within the framework of the conjugated system that stabilizes the enolate derived from the glycine component. Reactivity was evaluated for each of the complexes under phase transfer catalyzed alkylations with hydroxide bases, as well as the DBU catalyzed Michael additions of optically active 3′-substituted-2-oxazoladinone amides of unsaturated carboxylic acids. It was found that the trifluoromethyl containing nucleophilic glycine equivalent were more reactive than their non-trifluoromethyl analogs in both reaction types. Therefore, the application of these modified Ni(II) complexes of glycine Schiff bases are useful for the preparation of α-amino acids through phase transfer catalyzed alkylation as well as the preparation of optically pure β-substituted pyroglutamic acid precursors.

Tetrahedron published new progress about Amino acids Role: SPN (Synthetic Preparation), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Safety of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ji, Meishan published the artcileCatalyst-free, radical-mediated intermolecular 1,2-arylheteroarylation of alkenes by cleaving inert C-C bond, Synthetic Route of 1885-29-6, the main research area is polyarylalkane preparation photochem; aryldiazonium salt alkene radical tandem arylheteroarylation.

A novel photoinduced intermol. 1,2-arylheteroarylation of alkenes RCH=CH2 (R = t-Bu, Ph, furan-2-yl, etc.) and the efficient synthesis of valuable polyarylalkanes R1-2-MeC(O)C6H3CH2CH(R2)R (R1 = H, 4-Cl, 5-Me, etc.; R2 = pyridin-2-yl, thiazol-2-yl, benzothiazol-2-yl, etc.) are reported. The reaction is operationally simple, proceeds under mild conditions and with no addnl. catalyst and reagents. The strategically designed radical cascade reaction is enabled by electron transfer, and involves cleavage of an inert C-C bond. The process features broad functional group compatibility as well as high product transformability.

Science China: Chemistry published new progress about Alkylarenes Role: SPN (Synthetic Preparation), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Synthetic Route of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Varala, Ravi published the artcileScope and utility of CsOH·H2O in amination reactions via direct coupling of aryl halides and sec-alicyclic amines, SDS of cas: 204078-32-0, the main research area is coupling aryl halide alicyclic amine cesium hydroxide catalyst.

Direct coupling of aryl halides with sec-alicyclic amines promoted by CsOH·H2O in DMSO to the corresponding aryl substituted amines, with good to excellent yields, is reported herein. A variety of aryl halides and sec-alicyclic amines with a broad range of electronic diversity and functional groups was studied in this transformation, thus offering general applicability in organic synthesis.

Synlett published new progress about Alicyclic amines Role: RCT (Reactant), RACT (Reactant or Reagent). 204078-32-0 belongs to class nitriles-buliding-blocks, name is 2-Morpholinobenzonitrile, and the molecular formula is C11H12N2O, SDS of cas: 204078-32-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhang, Yetong published the artcilePalladium(II)-catalyzed three-component tandem reactions: synthesis of multiply substituted quinolines, Application In Synthesis of 1885-29-6, the main research area is polysubstituted quinoline preparation; aminobenzonitrile arylboronic acid ketone three component tandem palladium catalyst.

The three-component tandem reaction of 2-aminobenzonitriles, arylboronic acids and ketones allowing the synthesis of polysubstituted quinolines I [R1 = H, 7-Me, 6-F, etc.; R2 = Me, Ph, 2-thienyl, etc.; R3 = Ph, 2-naphthyl, 3-thienyl, etc.; R4 = H, Et, Br, etc.; R2R4 = CH2CH2CH2; CH2(CH2)2CH2, etc.] was reported. This strategy presented a practical, efficient, one-pot procedure that delivered functional quinolines in moderate to good yields with high functional group tolerance. To enrich the synthetic applications in accessing diverse quinolines, a new method for the introduction of halogen substituents into target products was developed as well, which showed potential for further synthetic elaborations.

Organic Chemistry Frontiers published new progress about Arylboronic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application In Synthesis of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Liu, Jingya published the artcileMn(III)-Catalyzed cascade cyclization reaction of o-acyl aromatic isocyanides with boronic acids, Related Products of nitriles-buliding-blocks, the main research area is hydroxyindolenine preparation; acylarom isocyanide preparation boronic acid tandem heterocyclization manganese catalyst.

A Mn(III)-catalyzed cascade cyclization of o-acyl aromatic isocyanides 2-CN-R1C6H3C(O)R2 (R1 = H, 4-F, 3-Me, 2-Cl, etc.; R2 = Me, 2-isocyano-5-methylphenyl, 5-chloro-2-isocyanophenyl, 2-isocyanophenyl) with boronic acids R3B(OH)2 (R3 = Ph, naphthalen-1-yl, thiophen-2-yl, etc.) was carried out via a single-step route to generate a series of 3-hydroxyindolenines I under mild conditions. A plausible mechanism involving a cascade transmetalation, nucleophilic addition and intramol. cyclization sequence was proposed and confirmed. In addition, the reaction procedure featured simple synthesis, wide substrate scope, and excellent functional group compatibility.

Organic Chemistry Frontiers published new progress about Arylboronic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Related Products of nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Lian, Zhong published the artcileCooperative redox activation for carbon dioxide conversion, Application In Synthesis of 42872-30-0, the main research area is diaryldisilane carbon dioxide aryl iodide palladium Hiyama Denmark coupling; diarylketone preparation.

The conversion of CO2 with diaryldisilanes, which through cooperative redox activation generated carbon monoxide and a diaryldisiloxane that actively participated in a palladium-catalyzed carbonylative Hiyama-Denmark coupling for the synthesis of an array of pharmaceutically relevant diarylketones was reported. Thus the disilane reagent not only served as the oxygen abstracting agent from CO2, but the silicon-containing ‘waste’, produced through oxygen insertion into the Si-Si bond, participated as a reagent for the transmetalation step in the carbonylative coupling. Hence this concept of cooperative redox activation opened up for new avenues in the conversion of CO2.

Nature Communications published new progress about Aryl ketones Role: SPN (Synthetic Preparation), PREP (Preparation). 42872-30-0 belongs to class nitriles-buliding-blocks, name is 2-(3-Benzoylphenyl)propanenitrile, and the molecular formula is C16H13NO, Application In Synthesis of 42872-30-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Rina, Yesmin Akter published the artcileDouble Hydrophosphorylation of Nitriles Catalyzed by Rare-Earth-Metal Lanthanum, Safety of Picolinonitrile, the main research area is hydrophosphorylation aromatic nitrile hydrophosphonate preparation phosphono amidophosphate lanthanum catalyst; lanthanum dimethylbenzylamine catalyst double hydrophosphorylation nitrile preparation phosphoryl amidophosphate.

A high-yielding and atom-efficient protocol for the double hydrophosphorylation of aromatic nitriles using a lanthanum-based N,N-dimethylbenzylamine complex (La(DMBA)3) as a precatalyst is reported, giving α-phosphonylated N-benzylphosphoramidates ArCH[P(O)(OEt)2]NHP(O)(OEt)2 (3a-v; Ar = substituted Ph, 2-naphthyl, pyridyl) with high yields and chemoselectivities. This method provides a straightforward and convenient approach for the synthesis of biol. important organophosphorus compounds known as N-(α-phosphoryl)amidophosphates in good to excellent yields. Nitriles with a broad range of addnl. functionality were tolerated, including those with halides, ethers, amines, and pyridyl groups.

Journal of Organic Chemistry published new progress about Aromatic nitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Safety of Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ghadermazi, Mohammad published the artcileIntroduction of Fe into mesoporous MCM-41 for the synthesis of 5-substituted 1H-Tetrazoles from aryl nitriles in water, Related Products of nitriles-buliding-blocks, the main research area is mesoporous supported iron silica catalyst preparation; tetrazole sulfoxide preparation green chem; aryl nitrile sulfide oxidation water.

In this exploration, new recyclable mesoporous-supported iron particles with the ligand and without ligand (MCM-41@ 3,4,5-tri hydroxyphenyl acetic acid @Fe and MCM-41@Fe) have been developed through post-functionalization modification of silica MCM-41. These catalysts were demonstrated to be novel, effective, and green for the synthesis of 5-substituted 1H-tetrazoles from aryl nitriles in water. In these systems, 5-substituted 1H-tetrazoles are produced as the only product. Fe3+ species were identified as active sites. The ordered mesoporous iron-silica catalyst with the ligand displayed better catalytic activity compared to iron-silica catalyst without the ligand, which was ascribed to the improvement of the inter-action of iron with the support. The catalysts can be easily separated using simple recovery and reused several times with consistent activity.

Microporous and Mesoporous Materials published new progress about Aromatic nitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Related Products of nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts