Month: November 2022

Jatangi, Nagesh published the artcileBase-catalyzed synthesis of quinazolines in aqueous medium, Application In Synthesis of 1885-29-6, the main research area is quinazoline preparation green chem; ketimine preparation aryl isothiocyanate heterocyclization sodium hydroxide catalyst; aminobenzonitrile magnesium bromide Grignard reaction.

An alternative green and step economy reaction of readily available 2-aminobenzonitriles 2-NH2-5-XC6H3CN (X = H, Cl, OCH3, NO2, etc.) with various organometallic reagents RMgBr (R = Ph, 3-methoxyphenyl, Bu, etc.) led to ortho-aminoaryl NAH ketimine 2-NH2-5-XC6H3C(R)=NH species. The subsequent base catalyzed NAC bond formation with various isothiocyanates ArNCS (Ar = Ph, 4-nitrophenyl, 2,4-difluorophenyl, etc.) afforded quinazoline scaffolds I in aqueous medium. The salient features of this protocol are use of readily available inexpensive precursors, water as a green environmentally benign solvent, short reaction time, operational simplicity, easy workup procedure and good functional group tolerance.

Tetrahedron Letters published new progress about Aromatic nitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application In Synthesis of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Betori, Rick C. published the artcileReductive Arylation of Arylidene Malonates Using Photoredox Catalysis, Application In Synthesis of 100-70-9, the main research area is diaryl malonate preparation; arylidene malonate reductive arylation photoredox catalysis.

A strategy with arylidene malonates provides access to β-umpolung single-electron species. Reported here is the utilization of these operators in intermol. radical-radical arylations, while avoiding conjugate addition/dimerization reactivity that is commonly encountered in enone-based photoredox chem. This reactivity relies on tertiary amines that serve to both activate the arylidene malonate for single-electron reduction by a proton-coupled electron transfer mechanism as well as serve as a terminal reductant. This photoredox catalysis pathway demonstrates the versatility of stabilized radicals for unique bond-forming reactions.

ACS Catalysis published new progress about Aromatic nitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Application In Synthesis of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Samim, Sk. Abdus published the artcileCobalt-Catalyzed Tandem Transformation of 2-Aminobenzonitriles to Quinazolinones Using Hydration and Dehydrogenative Coupling Strategy, COA of Formula: C7H6N2, the main research area is cobalt catalyzed hydration dehydrogenative coupling aminobenzonitrile alc quinazolinone synthesis.

A tandem synthesis of quinazolinones from 2-aminobenzonitriles is demonstrated here by using an aliphatic alc.-water system. For this transformation, a cheap and easily available cobalt salt and P(CH2CH2PPh2)3 (PP3) ligand were employed. The substrate scope, scalability, and synthesis of natural products exhibited the vitality of this protocol.

Journal of Organic Chemistry published new progress about Aromatic nitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, COA of Formula: C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Morozov, Vyacheslav published the artcileMetal-Free Rapid Diastereoselective Construction of Isocryptolepine Core via Electrophilic Dearomatization – Intramolecular Michael Addition Sequence, HPLC of Formula: 1885-29-6, the main research area is methoxyphenyl cyclohexanol aryl nitrile diastereoselective elecrophilic dearomatization Michael addition; indoloacridinone preparation; xanthenoindolone preparation.

A method for rapid construction of indolo[3,2-l]acridin-7-one systems bearing isocryptolepine scaffold was described. Metal-free condensation of (4-methoxyphenyl)cyclohexan carbinols with ortho-amino/hydroxybenzonitriles in concentrated sulfuric acid yielded polyannulated compounds with four new stereogenic centers in a highly diastereoselective manner. The reaction included elecrophilic dearomatization of methoxyarene, formation of spirocyclic intermediate and intramol. 1,4-nucleophilic addition sequence.

ChemistrySelect published new progress about Aromatic nitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, HPLC of Formula: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Wang, Tengfei published the artcileExploration of catalytic species for highly efficient preparation of quinazoline-2,4(1H,3H)-diones by succinimide-based ionic liquids under atmospheric pressure: Combination of experimental and theoretical study, HPLC of Formula: 1885-29-6, the main research area is quinazoline carbon dioxide absorption ionic liquid catalyst.

Cyclization reaction of carbon dioxide (CO2) and 2-aminobenzonitriles is of significance for the sustainable development, however, the harsh reaction condition especially for the high CO2 pressure is still an obstacle. Herein, a novel ionic liquid benzyltrimethylammonium succinimide ([BzTMA+][Suc-]) is designed and synthesized, in which no active hydrogen atom is included in cation. It displays the excellent catalytic activity achieving the 98.8% yield for quinazoline-2,4(1H,3H)-diones even under the atm. pressure. By combination of NMR spectroscopy (1H NMR and 13C NMR), CO2 absorption measurements, d. functional theory (DFT) calculations, and the frontier MO anal., the real catalytic species and synergistic effect of cation and anion on the catalytic performance are elucidated. The [Suc-] anion affords to introduce the CO2 into the organic phase even under the atm. pressure by formation of [Suc-CO-2]. However, the real catalytic species is [BzTMA+] cation and [Suc-] anion rather than [BzTMA+] and [Suc-CO-2]. If the active hydrogen atom is included in the cation, the CO2 absorption capacity of [Suc-] anion would be weakened by the strong interaction between active hydrogen atom in cation and [Suc-] anion resulting in the inferior catalytic behavior. The cooperation of [BzTMA+] and [Suc-] finally results in the high catalytic activity under the atm. pressure. Involvement of active hydrogen atom in cation is not an insurance to prepare the robust catalyst.

Fuel published new progress about Aromatic nitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, HPLC of Formula: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Liu, Qixing published the artcileCopper-Catalyzed One-Pot Synthesis of 2,3-Dihydroquinazolin-4(1 H )-ones from 2-Nitrobenzonitriles and Carbonyl Compounds Mediated by Diboronic Acid in Methanol-Water, Synthetic Route of 1885-29-6, the main research area is dihydroquinazolinone preparation nitrobenzonitrile carbonyl Pinner Dimroth rearrangement.

A copper-catalyzed one-pot synthesis of 2,3-dihydroquinazolin-4(1 H)-ones with diboronic acid as a reductant in an aqueous medium is described. Various 2,3-dihydroquinazolin-4(1 H)-ones were prepared with good functional-group tolerance in good yields under mild conditions from readily available 2-nitrobenzonitriles and various carbonyl compounds

Synlett published new progress about Aromatic nitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Synthetic Route of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Miao, Meng published the artcileVisible-light-mediated external-reductant-free reductive cross coupling of benzylammonium salts with (hetero)aryl nitriles, Product Details of C8H4N2, the main research area is diarylmethane preparation; benzylammonium salt aryl nitrile photocatalyst cross coupling.

A novel visible-light-mediated external reductant-free reductive cross coupling for the construction of C sp2-C sp3 bonds was reported. A variety of benzylammonium salts RCH(R1)N+(CH3)3O-S(O)2CF3 (R = naphthalen-2-yl, 1-benzothiophen-3-yl, 4-tert-butylphenyl, etc.; R1 = H, Me, n-Pr) and 1,2,3,4-tetrahydro-N,N,N-trimethyl-1-naphthalenaminium 1,1,1-trifluoromethanesulfonate underwent selective coupling with (hetero)aryl nitriles R2CN (R2 = 4-cyano-3-methylphenyl, 2-phenylpyridin-4-yl, isoquinolin-1-yl, etc.) to deliver important diarylmethanes RCH(R1)R2 and 4-(1,2,3,4-tetrahydronaphthalen-1-yl)benzonitrile under mild reaction conditions. Importantly, photocatalysts can be omitted for many cases, which might involve the electron donor acceptor (EDA) complex. Mechanistic studies indicated that benzylic radicals might be involved as the key intermediates. Moreover, the in situ NMe3 generated via cleavage of C-N bond in ammonium salts acts as the electron donor, thus avoiding the use of external-reductant.

Science China: Chemistry published new progress about Aromatic nitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Product Details of C8H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ping, Ran published the artcileCatalytic Conversion of CO2 from Simulated Flue Gases with Aminophenol-Based Protic Ionic Liquids to Produce Quinazoline-2,4(1H,3H)-diones under Mild Conditions, Synthetic Route of 1885-29-6, the main research area is quinazolinedione synthesis carbon dioxide flue gas aminophenol ionic liquid.

Novel aminophenol-based protic ionic liquids (APILs) were designed and synthesized via one-step neutralization, and they were used as catalysts for conversion of 2-aminobenzonitriles and CO2 from simulated flue gases to produce quinazoline-2,4(1H,3H)-diones under mild conditions. The effects of anion-cation structures of APILs, various solvents, reaction parameters, and water contents on the product yields were investigated in detail. The catalyst recyclability and general applicability to different substrates were examined It showed that both the basicity of the reaction media and the synergistic activation of zwitterions to reactants played important roles during the catalysis. The optimum [HTMG][m-AP] catalyst cooperating with the DMF (DMF) solvent could selectively convert CO2 into various quinazoline-2,4(1H,3H)-diones with good to excellent product yields at 60°C and in a 0.1 MPa simulated flue gas atm. In addition, [HTMG][m-AP]/DMF was easily recycled and could be reused in up to five consecutive cycles without an obvious loss of activity. By comparison with the reported catalysts, [HTMG][m-AP]/DMF here showed a superior catalytic performance and a great potential for development. Finally, the activation behaviors of [HTMG][m-AP]/DMF to reactants were studied, and a synergistic catalytic mechanism was proposed.

ACS Sustainable Chemistry & Engineering published new progress about Aromatic nitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Synthetic Route of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Sharma, Abhilash published the artcileA palladium-catalyzed cascade process for spirooxindole: an alternative way for the synthesis of spiro(indoline-3,2′-quinazolin)-2-ones, Product Details of C7H6N2, the main research area is spiroindolinequinazolinone preparation one pot palladium catalyst; aminobenzonitrile arylboronic acid isatin three component reaction.

A palladium-catalyzed cascade strategy has been developed for one-pot synthesis of functionalized spiro(indoline-3,2′-quinazolin)-2-one derivatives I (R = H, Me; R1 = H, 3-Me, 4-OMe, etc.; R2 = H, Me, F, etc.; R3 = H, Me, Ph, Bn) from readily available starting materials. The reaction proceeds via C-C and two C-N bond formations in a single reaction operation. This method offers an attractive pathway for the synthesis of a broad range of spiro(indoline-3,2′-quinazolin)-2-ones in good yields.

Organic & Biomolecular Chemistry published new progress about Aromatic nitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Product Details of C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Kudashev, Anton published the artcileSite-Selective Pd-Catalyzed C(sp3)-H Arylation of Heteroaromatic Ketones, Category: nitriles-buliding-blocks, the main research area is aryl heteroaryl alkyl propanone chemoselective preparation; heteroaryl ketone aryl iodide arylation catalyst palladium; C−H activation; arylation; palladium; site-selectivity.

A ligand-controlled site-selective C(sp3)-H arylation of heteroaromatic ketones had been developed using Pd catalysis to gave ArC(O)CHR1CH2R2 [Ar = thiazol-2-yl, 2-pyridyl, 2-quinolyl, etc.; R1 = Ph, 4-MeC6H4, 2-naphthyl, etc.; R2 = H, Me, ph, etc.]. The reaction occurred selectively at the α- or β-position of the ketone side-chain. The switch from α- or β-arylation was realized by addition of a pyridone ligand. The α-arylation process showed broad scope and high site- and chemoselectivity, whereas the β-arylation was more limited. Mechanistic investigations suggested that α-arylation occurs through C-H activation/oxidative addition/reductive elimination whereas β-arylation involves desaturation and aryl insertion.

Chemistry – A European Journal published new progress about Aromatic nitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts