Month: November 2022

Garcia-Alvarez, Rocio published the artcileArene-Ruthenium(II) Complexes Containing Inexpensive Tris(dimethylamino)phosphine: Highly Efficient Catalysts for the Selective Hydration of Nitriles into Amides, Name: 2-(3-Benzoylphenyl)propanenitrile, the main research area is ruthenium aminophosphine sandwich complex preparation catalyst hydration nitrile; areneruthenium aminophosphine sandwich complex preparation crystal structure hydration catalyst; mol structure areneruthenium aminophosphine sandwich complex; amide aromatic preparation.

The catalytic hydration of nitriles into amides, in H2O under neutral conditions, was studied using arene-Ru(II) derivatives containing the com. available and inexpensive ligand tris(dimethylamino)phosphine. Among them, best results were obtained with [RuCl2(η6-C6Me6){P(NMe2)3}], which selectively provided the desired amides in excellent yields and short times (TOF values up to 11,400 h-1). The process was operative with both aromatic, heteroaromatic, aliphatic, and α,β-unsaturated organonitriles and showed a high functional group tolerance. The stability of [RuCl2(η6-C6Me6){P(NMe2)3}] in H2O was evaluated, observing its progressive decomposition into the less-active dimethylamine-Ru(II) complex [RuCl2(η6-C6Me6)(NHMe2)] by hydrolysis of the coordinated P(NMe2)3 ligand. The x-ray crystal structure determination of the toluene complex [RuCl2(η6-C6H5Me){P(NMe2)3}] is also included.

Organometallics published new progress about Amides Role: SPN (Synthetic Preparation), PREP (Preparation) (aryl). 42872-30-0 belongs to class nitriles-buliding-blocks, name is 2-(3-Benzoylphenyl)propanenitrile, and the molecular formula is C16H13NO, Name: 2-(3-Benzoylphenyl)propanenitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Muddagoni, Narasimha published the artcileTin ( IV ) chloride catalyzed one-pot synthesis, characterization and docking studies of 4-aminoquinoline derivatives as Myt1 inhibitors, Formula: C7H6N2, the main research area is amino benzonitrile aryl methanone tin chloride catalyst heterocyclization; aryl aminoquinoline preparation mol docking.

An efficient and practical method for the series of 4-aminoquinoline derivatives I [R = 3-cyanophenyl, 2,3-dihydro-1H-inden-5-yl, 5-chlorothiophen-2-yl, etc.; R1 = H, Cl] was developed via Tin (lV) chloride catalyzed cascade cyclization from 2-aminobenzonitrile and different acetophenones. These novel chem. entities I were characterized by their 1HNMR, 13CNMR spectra and high-resolution mass spectrometer (HRMS) with their docking studies were performed to identify potential inhibitors of Myt1kinase protein. The synthesized analogs I were docked with Myt1 kinase protein. Among these, compounds I [R = 4-methylthiophen-2-yl, 3-cyanophenyl, 2-bromo-4-chlorophenyl; R1 = H] were showing promising Glide score, prime-MMGBSA and ADME properties similar to Neratinib, Pelitinib cancer inhibiting drugs of Myt1 kinase protein. The amino acid ASP251of Myt1 kinase protein was consistently binding to novel chem. entities I and existing drugs, indicating that the amino acid is crucial and responsible for its inhibition. Docking studies revealed that the compounds I [R = 4-methylthiophen-2-yl, 3-cyanophenyl, 2-bromo-4-chlorophenyl; R1 = H] indicated that they can act as strong inhibitors of Myt1 kinase protein as that of comparable existing drugs Neratinib, Pelitinib.

Journal of Heterocyclic Chemistry published new progress about Alkyl aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Formula: C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Chintawar, Chetan C. published the artcileEnantioselective Au(I)/Au(III) Redox Catalysis Enabled by Chiral (P,N)-Ligands, Computed Properties of 1885-29-6, the main research area is oxychroman preparation enantioselective DFT; iodoaryl alkene alc oxyarylation gold catalyst; aminochroman preparation enantioselective DFT; aromatic amine iodoaryl alkene aminoarylation gold catalyst.

The enantioselective Au(I)/Au(III) redox catalysis, enabled by a newly designed hemilabile chiral (P,N)-ligand (ChetPhos) e.g., I was reported. The potential of this concept has been demonstrated by the development of enantioselective 1,2-oxyarylation and 1,2-aminoarylation of alkenes 2-I-3-R1-4-R2-5-R3-6-R4C6OCH2CH=CH2 (R1 = H; R2 = H, F, Me, NO2, etc.; R1R2 = -CH=CHCH=CH-; R3 = H, OMe, C(O)OMe, CF3; R4 = H, Me, OMe) which provided direct access to the medicinally relevant 3-oxy- and 3-aminochromans II [R5 = H, Me, Et, i-Pr, (2-bromophenyl)methyl] III (R6 = 4-nitrophenyl, 4-bromo-2-nitrophenyl, 3-cyanothiophen-2-yl, etc.) (up to 88% yield and 99% ee). DFT studies were carried out to unravel the enantiodetermining step, which revealed that the stronger trans influence of phosphorus allows selective positioning of the substrate in the C2-sym. chiral environment present around nitrogen, imparting a high level of enantioselectivity.

Journal of the American Chemical Society published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent) (iodoaryl). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Computed Properties of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ma, Zhuang published the artcileStable and reusable Ni-based nanoparticles for general and selective hydrogenation of nitriles to amines, Safety of Picolinonitrile, the main research area is aryl nitrile nickel nanocatalyst selective hydrogenation; aromatic primary amine preparation; recyclable silica support nickel catalyst preparation.

Silica supported ultrasmall Ni-nanoparticles allow for general and selective hydrogenation of all kinds of nitriles to primary amines under mild conditions. By calcination of a template material generated from Ni(II)nitrate and colloidal silica under air and subsequent reduction in the presence of mol. hydrogen the optimal catalyst was prepared The prepared supported nanoparticles are stable, was conveniently used and easily recycled. The applicability of the optimal catalyst material was shown by hydrogenation of >110 diverse aliphatic and aromatic nitriles including functionalized and industrially relevant substrates. Challenging heterocyclic nitriles, specifically cyanopyridines, provided the corresponding primary amines in good to excellent yields. The resulting amines serve as important precursors and intermediates for the preparation of numerous life science products and polymers.

Chemical Science published new progress about Aliphatic nitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Safety of Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ma, Zhuang published the artcileStable and reusable Ni-based nanoparticles for general and selective hydrogenation of nitriles to amines, Synthetic Route of 1885-29-6, the main research area is aryl nitrile nickel nanocatalyst selective hydrogenation; aromatic primary amine preparation; recyclable silica support nickel catalyst preparation.

Silica supported ultrasmall Ni-nanoparticles allow for general and selective hydrogenation of all kinds of nitriles to primary amines under mild conditions. By calcination of a template material generated from Ni(II)nitrate and colloidal silica under air and subsequent reduction in the presence of mol. hydrogen the optimal catalyst was prepared The prepared supported nanoparticles are stable, was conveniently used and easily recycled. The applicability of the optimal catalyst material was shown by hydrogenation of >110 diverse aliphatic and aromatic nitriles including functionalized and industrially relevant substrates. Challenging heterocyclic nitriles, specifically cyanopyridines, provided the corresponding primary amines in good to excellent yields. The resulting amines serve as important precursors and intermediates for the preparation of numerous life science products and polymers.

Chemical Science published new progress about Aliphatic nitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Synthetic Route of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Kong, Xianqiang published the artcileCyanation and cyanomethylation of trimethylammonium salts via electrochemical cleavage of C-N bonds, Product Details of C6H4N2, the main research area is trimethylammonium salt tosyl cyanide chemoselective electrocatalytic cyanation; nitrile preparation; azido methylbutenol trimethylammonium salt chemoselective electrocatalytic cyanomethylation; acetonitrile preparation.

A practical and mild electrochem. protocol for cyanation and cyanomethylation of trimethylammonium salts through a pathway involving C-N bond cleavage without the need for an external stoichiometric reducing agent or a sacrificial anode was developed. The reaction employed tosyl cyanide (TsCN) or azido allyl alc. as the cyanation or cyanomethylation reagent, resp. It showed high functional group compatibility and can be applied for the cyanation of natural product derivatives Preliminary mechanistic studies indicated the involvement of a radical addition pathway.

Organic Chemistry Frontiers published new progress about Acetonitriles Role: SPN (Synthetic Preparation), PREP (Preparation). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Product Details of C6H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Xiong, Hao published the artcileThe Reaction of o-Aminoacetophenone N-Tosylhydrazone and CO2 toward 1,4-Dihydro-2H-3,1-benzoxazin-2-ones, Product Details of C7H6N2, the main research area is aminoacetophenone tosylhydrazone carbon dioxide fixation carbene insertion reaction; dihydrobenzoxazinone preparation.

A transition-metal-free reaction of o-aminoacetophenone N-tosylhydrazone and CO2 has been developed, leading to a series of 1,4-dihydro-2H-3,1-benzoxazin-2-ones in moderate to good yields. This procedure proceeds with the sequential fixation of CO2 by amino leading to carbamic acid and the intra- mol. insertion of hydroxyl to carbene.

Advanced Synthesis & Catalysis published new progress about Benzoxazinones Role: SPN (Synthetic Preparation), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Product Details of C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Schneekoenig, Jacob published the artcileCobalt pincer complexes for catalytic reduction of nitriles to primary amines, Safety of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is nitrile cobalt pincer complex catalyst reduction; alkylamine preparation.

Various cobalt pincer type complexes I [R = iPr, Cy, Ph; X = Cl, Br] and II [X = Cl, Br] were applied for the catalytic hydrogenation of nitriles to amines. Among these, catalyst I [R = Ph, X = Cl] was the most efficient, allowing the reduction of aromatic as well as aliphatic nitriles in moderate to excellent yields.

Catalysis Science & Technology published new progress about Aralkyl amines Role: SPN (Synthetic Preparation), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Safety of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ding, Yi published the artcileAlkylaluminum Complexes as Precatalysts in Hydroboration of Nitriles and Carbodiimides, HPLC of Formula: 100-70-9, the main research area is aluminum diketiminate alkyl complex preparation hydroboration nitrile carbodiimide catalyst; crystal structure aluminum diketiminate alkyl complex; mol structure aluminum diketiminate alkyl complex.

The metathesis reaction of aluminum(III) dihydride β-diketiminate LAlH2 (1, L = (DippN:CMe)2CH, Ar = 2,6-iPr2C6H3) with BuLi and Bu2Mg, resp., resulted in di-Bu aluminum complex LAlBu2 (2). Meanwhile 1 reacted with MeLi producing di-Me aluminum LAlMe2 (3). Complexes 2 and 3 were characterized by NMR and elemental anal., and 2 was addnl. studied by single-crystal X-ray diffraction. The reported synthesis allows for access of dialkylaluminum complexes from aluminum(III) dihydride compound (1) with excellent yields. The chemoselective double hydroboration of nitriles or single hydroboration of carbodiimides was studied with pinacolborane (HBpin) using LAl(n-Bu)2 (2) as the precatalyst to afford bis(boryl)amines (4a-4m) and N-borylamines (6a-6d) under solvent-free and mild conditions (60 °C). The records show that the catalytic reactions proceed in quant. yields and short time. Moreover, nearly quant. yield of di(boryl)(silyl)amine (5) was obtained, when cyanobenzene was reacted with equal amounts of HBpin and phenylsilane in the presence of precatalyst 2. A comparison of the previously reported hydroboration reactions with nitriles in the literature and our results in the presence of the precatalyst LAl(n-Bu)2 show convincingly the better results of short reaction time, mild reaction conditions, and quant. yields.

Organometallics published new progress about Aralkyl amines Role: SPN (Synthetic Preparation), PREP (Preparation). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, HPLC of Formula: 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ma, Yueyue published the artcileDirect Arylation of α-Amino C(sp3)-H Bonds by Convergent Paired Electrolysis, Category: nitriles-buliding-blocks, the main research area is tertiary amine benzonitrile TEMPO catalyst electrochem arylation; benzylic amine preparation regioselective; C−H activation; arylation; cross-coupling; electrocatalysis; tertiary amines.

A metal-free convergent paired electrolysis strategy to synthesize benzylic amines through direct arylation of tertiary amines and benzonitrile derivatives at room temperature was developed. This TEMPO-mediated electrocatalytic reaction made full use of both anodic oxidation and cathodic reduction without metals or stoichiometric oxidants, thus showing great potential and advantages for practical synthesis. This convergent paired electrolysis method provided a straightforward and powerful means to activate C-H bonds and realize cross-coupling with cathodically generated species.

Angewandte Chemie, International Edition published new progress about Aralkyl amines Role: SPN (Synthetic Preparation), PREP (Preparation). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts