Month: November 2022

Li, Quan-Quan published the artcileSubstituent changes in the salen ligands of CuIINaI-complexes to induce various structures and catalytic activities towards 2-imidazolines from nitriles and 1,2-diaminopropane, Recommanded Product: Picolinonitrile, the main research area is copper sodium salen complex preparation cyclization catalyst magnetism DFT; crystal structure copper sodium salen complex.

Based on various comparable salen ligands, three synthesized CuIINaI-complexes present efficient catalytic activities for the coupling and cyclization reaction of 1,2-diaminopropane with nitriles towards 2-imidazolines. The catalytic results show that salen ligands with an electron-donating substituent and small steric hindrance improve the catalytic activity.

Chemical Communications (Cambridge, United Kingdom) published new progress about Crystal structure. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Recommanded Product: Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Liu, Yuji published the artcileConstruction of Bicyclic 1,2,3-Triazine N-Oxides from Aminocyanides, Application of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is bicyclic triazine oxide preparation aminocyanide nitration cyclization.

Using a facile and cost-effective method, nine bicyclic 1,2,3-triazine 2-oxides were synthesized from o-aminocyanide substrates through an unusual nitration cyclization. The reaction mechanism was studied exptl. and theor. Moreover, nine 1,2,3-triazine 3-oxides were also obtained in good yields.

Organic Letters published new progress about Crystal structure. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Luc, Nhu-Quynh published the artcileMicro-rod single-crystalline phthalocyanine for photodetector development, Formula: C8H4N2, the main research area is phthalocyanine microrod single crystal photodetector development.

This paper reports a development of metallo-phthalocyanime complexes (MPcs) based photodetector. Metal-organic semiconductor-metal structure (MSM)-based photodetectors were developed using β-MPc crystals (β-CuPc and β-ZnPc). Dark current reduction accompanied photocurrent enhancement was observed in the β-ZnPc device by comparison to the β-CuPc device. The β-ZnPc photodetector exhibits good photosensitive performance with high responsivity, 11.6 AW-1, and external quantum efficiency 1.3 x 104% under UV illumination. The photocurrent is linear to light intensity under white light illumination. The detector shows an excellent response speed through fast rise and decay time (τr = 0.142 s and τd = 0.186 s).

Materials Science in Semiconductor Processing published new progress about Crystal structure. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Formula: C8H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Kajiwara, Rikuo published the artcileBipyridine-Type Bidentate Auxiliary-Enabled Copper-Mediated C-H/C-H Biaryl Coupling of Phenols and 1,3-Azoles, Quality Control of 87150-13-8, the main research area is heterobiaryl preparation; phenol azole coupling bipyridine type bidentate auxiliary copper.

A copper-mediated dehydrogenative C-H/C-H biaryl coupling of phenols and 1,3-azoles has been developed. The key to its success is the introduction of a bipyridine-type bidentate auxiliary, 4,4′-di(tert-butyl)-2,2′-bipyridine, on the phenol oxygen, which is readily prepared and easily attachable, detachable, and recyclable. The reaction proceeds smoothly in the presence of copper salt alone to form the corresponding phenol-azole heterobiaryls, which are prevalent motifs in functional mols. such as excited-state intramol. proton transfer materials.

Organic Letters published new progress about Coupling reaction. 87150-13-8 belongs to class nitriles-buliding-blocks, name is 4-(5-Oxazolyl)benzonitrile, and the molecular formula is C10H6N2O, Quality Control of 87150-13-8.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ming, Zheng published the artcileDye-polyoxometalate coordination polymer as a photo-driven electron pump for photocatalytic radical coupling reactions, Related Products of nitriles-buliding-blocks, the main research area is coordination polymer preparation electron pump photocatalytic radical coupling.

To alleviate diffusion-limited photoinduced electron transfer (PET) in solution, a triphenylamine-derived dye and a Keggin polyoxometalate-type electron relay were coupled into a coordination polymer to photoinduce long-lived charge-separation pairs with enough reductive/oxidative potential to pump multiple electrons unidirectionally from external electron donors to acceptors, thus furnishing photocatalytic radical couplings to afford value-added α-amino C-H arylation products.

Chemical Communications (Cambridge, United Kingdom) published new progress about Charge separation. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Related Products of nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhao, Ziming published the artcilePreparation of a magnetic mesoporous Fe3O4-Pd@TiO2 photocatalyst for the efficient selective reduction of aromatic cyanides, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is iron oxide palladium titania mesoporous composite photoreduction photocatalyst hydrogenation.

Herein, a hierarchical magnetic mesoporous microsphere was successfully prepared as a photocatalyst via a simple and reproducible route. Typically, Pd nanoparticles (NPs) were evenly dispersed on the surface of a magnetic Fe3O4 microsphere and then coated with a porous anatase-TiO2 shell to form Fe3O4-Pd@TiO2. The core-shell structure could efficiently suppress the conglomeration of Pd NPs during the calcination process at high temperatures as well as the shedding of Pd during the catalytic reaction process in the liquid phase. The as-prepared photocatalyst was characterized by TEM, XRD, XPS, VSM, and N2 adsorption-desorption. Fe3O4-Pd@TiO2 exhibits high photocatalytic activity for the selective reduction of aromatic cyanides to aromatic primary amines in an acidic aqueous solution Moreover, this magnetic photocatalyst could be easily recovered from the reaction mixture by an external magnet and reused five times without significant reduction in its activity. The superior photocatalytic efficiency of the proposed photocatalyst may be attributed to its high charge separation efficiency and charge transfer rate, which are caused by the Schottky junction and large interface area. The results indicate that the strategy of coating the active noble metal sites with a mesoporous semiconductor shell has a significant potential for application in metal-semiconductor-based photocatalytic reactions.

New Journal of Chemistry published new progress about Charge separation. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Moeini, Nazanin published the artcileSynthesis and characterization of magnetic Fe3O4@Creatinine@Zr nanoparticles as novel catalyst for the synthesis of 5-substituted 1H-tetrazoles in water and the selective oxidation of sulfides with classical and ultrasonic methods, Product Details of C8H4N2, the main research area is magnetic creatinine zirconium nanoparticle sulfoxidation cycloaddition catalyst sulfoxide tetrazole.

Tetrazoles and sulfoxide compounds have a wide range of applications in industries and are of great expectation to be environmentally friendly and cost-effective. This paper reports the introduction of zirconium supported on Fe3O4 nanoparticles through creatinine post-functionalization modification of Fe3O4 (Fe3O4@Creatinine@Zr). The Fe3O4@Creatinine@Zr was characterized by a vibrating sample magnetometer, X-ray powder diffractometry, Fourier transforms IR, scanning electron microscope, energy dispersive X-Ray anal., thermogravimetric anal., and inductively coupled plasma. Fourier transform-IR spectroscopy results confirmed that creatinine was successfully immobilized on the surface of Fe3O4-Cl with the presence of ν(C = N), and ν(C = O) bands of creatinine. X-ray diffraction data confirmed that the crystalline phase of Fe3O4 was not destroyed after modification. Vibrating sample magnetometer anal. showed that the saturation magnetization of the Fe3O4@Creatinine@Zr was 28.6 emu/g. The SEM-EDX results revealed that the zirconium complex was successfully incorporated into the structure of Fe3O4. This catalyst displayed high catalytic performance in the synthesis of 5-substituted 1H-tetrazoles and the selective oxidation of sulfides with classical and ultrasonic methods. The catalyst conferred strong Lewis’s acidity sites for the activity and selectivity of the reactions. The obtained results showed that the fast oxidation of sulfides occurred with 0.2 mmol g -1 of zirconium immobilized on the Fe3O4 nanoparticle at optimum condition (sulfide (1 mmol), H2O2 (0.6 mL), ethanol (3 mL) and catalyst (Fe3O4@Creatinine@Zr, 60 mg) at room temperature). The results showed that ultrasonic was an appropriate method for the oxidation of sulfides to the related sulfoxide at the optimum condition. The 5-substituted 1H-tetrazoles were afforded at optimum condition (nitrile (1 mmol), NaN3 (1.2 mmol), H2O (3 mL), catalyst (100 mg) at 90°C). The catalyst was separated by simple recovery and reused for seven cycles without any remarkable decrease in the catalysis activity and selectivity. The output of this research can open a window for the synthesis the other organic materials under mild condition.

Journal of Molecular Structure published new progress about Catalyst supports. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Product Details of C8H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Shi, Xian-Lei published the artcileA novel fiber-supported superbase catalyst in the spinning basket reactor for cleaner chemical fixation of CO2 with 2-aminobenzonitriles in water, Quality Control of 1885-29-6, the main research area is PEEK fiber supported catalyst spinning reactor cycloaddition aminobenzonitrile quinazolinedione.

The chem. fixation of CO2 with a more effective pathway is of great significance from the sustainable chem. viewpoint. Herein, a novel fiber-supported superbase was successfully synthesized by rooting 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) into the surface layer of com. available polyetheretherketone (PEEK) fiber and efficiently served as a heterogeneous catalyst for the conversion of CO2 in a sample spinning basket reactor. The resulting fiber samples were characterized detailedly by elemental anal., mech. property, FTIR spectroscopy and morphol. during both of the preparation and the utilization processes. Moreover, the fiber catalyst was applied in the spinning basket reactor under mild conditions (100°C and 1 MPa) for the cycloaddition of CO2 with a series of 2-aminobenzonitriles in water to obtain good to excellent yields of the corresponding quinazoline-2,4-(1H,3H)-diones (82-95%). In addition, the fiber-supported TBD in impellers of the agitation system was shown to be reused over 15 times without distinctly performance degradation, and stored on shelves remained equally active after at least up to 4 mo. Furthermore, the operation process was convenient and effective for scaling-up procedure and thereby the fiber catalyst has good prospects in industrial applications.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about Breaking strength. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Quality Control of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Saito, Tetsuji published the artcile6,7-Dihydro-5H-cyclopenta[d]pyrazolo[1,5-a]pyrimidines and their derivatives as novel corticotropin-releasing factor 1 receptor antagonists, HPLC of Formula: 170737-93-6, the main research area is cyclopentapyrazolopyrimidine derivative preparation corticotropin releasing factor antagonist SAR pharmacokinetic.

To identify an orally active corticotropin-releasing factor 1 receptor antagonist, a series of 6,7-dihydro-5H-cyclopenta[d]pyrazolo[1,5-a]pyrimidines and their derivatives were designed, synthesized and evaluated. An in vitro study followed by in vivo and pharmacokinetic studies of these heterotricyclic compounds led to the discovery of an orally active CRF1 receptor antagonist, I. The results of a structure-activity relationship study are presented.

Bioorganic & Medicinal Chemistry published new progress about Anxiety disorders. 170737-93-6 belongs to class nitriles-buliding-blocks, name is 2-(2-Chloro-4-methoxyphenyl)acetonitrile, and the molecular formula is C9H8ClNO, HPLC of Formula: 170737-93-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Maspero, Marco published the artcileTacrine-xanomeline and tacrine-iperoxo hybrid ligands: Synthesis and biological evaluation at acetylcholinesterase and M1 muscarinic acetylcholine receptors, Application of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is xanomeline tacrine iperoxo hybrid preparation acetylcholinesterase muscarinic acetylcholine receptor; Allosteric modulation; Bitopic ligands; Ellman’s assay; Inositol monophosphate; Iperoxo; M(1) muscarinic acetylcholine receptor; Multitarget compounds; Phospholipase C; Tacrine; Xanomeline.

A set of new hybrid derivatives, in which apolymethylene spacer chain of variable length connected the pharmacophoric moiety of xanomeline are synthesized ,anM1/M4preferring orthosteric muscarinic agonist, with that of tacrine, a well-known acetylcholinesterase (AChE) inhibitor abletoallosterically modulatemuscarinicacetylcholinereceptors(mAChRs). When tested in vitro in a colorimetric assay for their ability to inhibit AChE, the new compounds showed higher or similar potency compared to that of tacrine. Docking analyses were performed on the most potent inhibitors to rationalize their exptl. inhibitory power against AChE. Next, the signaling cascade at M1 mAChRs by exploring the interaction of Gαq-PLC-β3 proteins through split luciferase assays and the myo-Inositol 1 phosphate (IP1) accumulation in cells is evaluated. The results were compared with those obtained on the known derivatives, two quite potent AChE inhibitors in which tacrine is linked to iperoxo, an exceptionally potent muscarinic orthosteric activator. Interestingly, it was found that iprexo tacrine hybrids behaved as partial agonists of the M1 mAChR, at variance with hybrids containing xanomeline as the orthosteric mol. fragment, which were all unable to activate the receptor subtype response.

Bioorganic Chemistry published new progress about Alzheimer disease. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts