Month: November 2022

Goksu, Haydar published the artcileA Novel Hydrogenation of Nitroarene Compounds with Multi Wall Carbon Nanotube Supported Palladium/Copper Nanoparticles (PdCu@MWCNT NPs) in Aqueous Medium, Safety of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is multi wall carbon nanotube supported palladium copper nanocatalyst; aryl amine preparation; nitroarene hydrogenation palladium copper nanocatalyst.

A novel nanocatalyst, multi-wall carbon nanotube supported palladium/copper (PdCu@MWCNT) nanoparticles, was synthesized for the reduction of nitroarene compds to afford aryl amines ArNH2 [Ar = 4-MeC6H4, 3-HOC6H4, 1-naphthyl, etc.]. Characterization of the nanocatalyst was achieved by XRD, XPS, TEM, and Raman spectroscopy anal. In this study, the hydrogenation of nitroarenes to primary amine compounds was achieved in aqueous medium at room temperature The aniline derivatives were synthesized with high yields at mild conditions via novel PdCu@MWCNT nanocatalyst. The conversion of nitroarenes to amine derivatives was accomplished at 99% efficiency. In addition to its high activity, the PdCu@MWCNT catalyst was determined to be stable and reusable after the 3rd consecutive use for the reaction and provided 99% conversion of various compounds in the reduction reaction.

Scientific Reports published new progress about Aromatic amines Role: SPN (Synthetic Preparation), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Safety of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Shuai, Qi published the artcileMetal-free chemoselective reduction of nitroaromatics to anilines via hydrogen transfer strategy, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is aromatic amine preparation chemoselective green chem; nitro aromatic reduction.

A novel protocol for chemoselective reduction of aromatic nitro compounds ArNO2 (Ar = Ph, 1,3-benzothiazol-6-yl, quinolin-8-yl, 4-NCC6H4, etc.) to aromatic amines ArNH2 has been established. The metal-free reduction goes through a hydrogen transfer process. Various easily reducible functional groups can be well tolerated under the optimized reaction conditions.

Chemical Papers published new progress about Aromatic amines Role: SPN (Synthetic Preparation), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Du, Jialei published the artcileCommercially Available CuO Catalyzed Hydrogenation of Nitroarenes Using Ammonia Borane as a Hydrogen Source, Product Details of C7H6N2, the main research area is nitroarene ammonia borane copper oxide catalyst hydrogenation; arylamine preparation.

The com. available CuO powder was demonstrated as robust catalyst for hydrogenation of nitroarenes using ammonia borane as a hydrogen source under mild conditions. Numerous amines (even sterically hindered, halogenated, and diamines) were obtained through this method. This monometallic catalyst is characteristic of support-free, excellent chemoselectivity, low-cost, and high recyclability, which will favor its future utilization in preparative reduction chem. Mechanistic studies were also carried out to clarify that diazene and azoxybenzene are key intermediates of this heterogeneous reduction

ChemCatChem published new progress about Aromatic amines Role: SPN (Synthetic Preparation), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Product Details of C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Hazarika, Shikharani published the artcileSilica supported spinel structured cobalt ferrite multifunctional nanocatalyst for hydration of nitriles and oxidative decarboxylation of phenylacetic acids, Application In Synthesis of 1885-29-6, the main research area is aryl aldehyde preparation green chem; phenyl acetic acid oxidative decarboxylation silica support ferrite nanocatalyst; amide preparation green chem; nitrile hydration silica support cobalt ferrite nanocatalyst.

The silica-supported cobalt ferrite spinel nanocatalyst has been successfully synthesized by the coprecipitation method and extensively characterized by FTIR, XRD, SEM-EDX, TEM, BET, VSM, XPS, TGA, and ICP-AES anal. The bands observed at 3435 cm-1 (μOH of Si-OH) and 1637 cm-1 (γOH of Si-OH) in the FTIR spectrum of the as-synthesized nanocatalyst unambiguously tell the presence of silica support. Moreover, a very weak intensity and a medium intensity peak at 683 cm-1 and 463 cm-1 suggested intrinsic stretching vibrations of Fe-O and Co-O of cobalt ferrite, resp. The XRD pattern confirms the formation of CoFe2O4 spinel. The average crystallite size was found to be 5.4 nm as calculated by using the Debye-Scherrer equation based on the (220) plane while the average particle size was found to be 5.08 nm from TEM anal. The crystalline nature of the nanocomposite was confirmed by the SAED pattern. The successful incorporation of CoFe2O4 on the surface of silica was established by the BET surface area measurements. The silica-supported cobalt ferrite nanocatalyst has been explored as a heterogeneous multifunctional catalyst for hydration of nitriles RCN (R = Ph, pyridin-3-yl, 4-cyanobutyl, etc.) and oxidative decarboxylation of phenylacetic acids R1CH2C(O)OH (R1 = Ph, 2-hydroxynaphthalen-1-yl, 2,5-dimethoxyphenyl, etc.) as well under mild reaction conditions with moderate to excellent isolated yield of the desired products (60-99%). The catalyst was magnetically recoverable within a time frame of ~90 s and reusable up to the fifth catalytic cycle without profound loss of activity. A magnetic hysteresis study was performed to elucidate the magnetic behavior of the catalyst. The saturation magnetization value of 39.785 emu/g with a coercivity value of 110.87 Oe and saturation remanence value of 5.185 emu/g clearly indicated the presence of a ferromagnetic component in the material.

Applied Organometallic Chemistry published new progress about Aromatic amides Role: SPN (Synthetic Preparation), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application In Synthesis of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zeynizadeh, Behzad published the artcileA hassle-free and cost-effective transfer hydrogenation strategy for the chemoselective reduction of arylnitriles to primary amines through in situ-generated nickel (II) dihydride intermediate in water, Name: Phthalonitrile, the main research area is benzonitrile reduction chemoseslective green chem; benzyl amine preparation.

A new, simple, efficient, inexpensive, and chemoselective transfer hydrogenation strategy was introduced for the straightforward reduction of arylnitriles to corresponding primary amines using sodium borohydride (NaBH4) and nickel acetate tetrahydrate (Ni(OAc)2â€?H2O) through in situ-generated nickel (II) dihydride intermediate in the water medium at 50°. The presented methodol. featured moderate reaction conditions, nickel boride (Ni2B)-free trajectory, good-to-excellent yields of the products, relatively short reaction times, satisfactory chemoselectivity, and did not involve the use of toxic organic solvent and also any base or ligand.

Journal of Molecular Structure published new progress about Aromatic amides Role: SPN (Synthetic Preparation), PREP (Preparation). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Name: Phthalonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Liu, Yuliang published the artcilePhotoinduced Cross-Coupling of Aryl Iodides with Alkenes, Recommanded Product: Phthalonitrile, the main research area is aryl iodide alkene photoinduced cross coupling UV absorption.

A protocol for photoinduced cross-coupling of aryl iodides having polar π-functional groups or elongated π-conjugation with alkenes was developed. The radical cascade mechanism involving generation of aryl radicals via C-I bond homolysis of photoexcited aryl iodides and their subsequent addition to alkenes was proposed. The method enabled iodide-selective cross-coupling over other halogen leaving groups with functional group compatibility on both arene and alkene motifs.

Organic Letters published new progress about Aralkyl ketones Role: SPN (Synthetic Preparation), PREP (Preparation). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Recommanded Product: Phthalonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Chen, Wanting published the artcileEnantioselective Oxidative Coupling of β-Ketocarbonyls and Anilines by Joint Chiral Primary Amine and Selenium Catalysis, Product Details of C7H6N2, the main research area is enantioselective nitroso aldol oxidative coupling ketocarbonyl aniline; chiral primary amine selenium catalyzed enantioselective nitroso aldol.

An enantioselective primary amine-catalyzed total N-selective nitroso aldol reaction (N-NA) was achieved through the oxidation of primary aromatic amines to the corresponding nitrosoarenes catalyzed by selenium reagents and 30% H2O2. This protocol provides a facile and highly efficient access to α-hydroxyamino carbonyls bearing chiral quaternary centers under exceedingly mild and green reaction conditions with high chemo- and enantiocontrol.

Organic Letters published new progress about Aldol addition catalysts, stereoselective (N-selective nitroso aldol). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Product Details of C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Watanabe, Koh published the artcileReductive Cross-Coupling between Arylaldehydes and (Hetero)aryl Electrophiles Using Silylboronate Reductant, HPLC of Formula: 91-15-6, the main research area is diarylmethanol preparation; arylaldehyde heteroaryl electrophile cross coupling reaction.

A catalytic reductive cross-coupling between arylaldehydes ArCHO (Ar = Ph, 2-methylphenyl, naphthalen-2-yl, thiophen-2-yl, etc.) and aryl electrophiles RX (R = pyridin-2-yl, 3-methylpyridin-2-yl, 1,3-benzothiazol-2-yl, etc.; X = F, Cl, CN) using a silylboronate Si(Et)3(B)C(Me)2C(Me)2 as a terminal reductant is described. The reaction involves a copper-catalyzed silylboration of aldehydes affording the O-borylated α-silyl alcs. ArCH(R)OSi(Et)3 (I) followed by a nucleophilic aromatic substitution reaction with aryl electrophiles. This protocol offers a new opportunity to access 1,1-diarylmethanol derivatives (I) without rare metals or highly basic organometallic reagents.

European Journal of Organic Chemistry published new progress about Alcohols, silyl Role: SPN (Synthetic Preparation), PREP (Preparation). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, HPLC of Formula: 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Wolinska, Ewa published the artcileChiral pyridine oxazoline and 1,2,4-triazine oxazoline ligands incorporating electron-withdrawing substituents and their application in the Cu-catalyzed enantioselective nitroaldol reaction, Product Details of C7H6N2, the main research area is nitro alc preparation enantioselective diastereoselective; aldehyde nitromethane nitroaldol pyridine triazine oxazoline copper catalyst.

Eight pyridine-containing and four 1,2,4-triazine-containing chiral oxazoline ligands incorporating electron-withdrawing substituents have been oxazolines I (R1 = Ph, t-Bu; R2 = H, F; R3 = H, Cl; R4 = H, F, Cl, nitro; R5 = H, Br), II and III synthesized by two-step route including Buchwald-Hartwig amination. Enantio-inducing activity of the ligands has been assessed in the copper-catalyzed asym. nitroaldol reactions and the influence of the electron-withdrawing substituents on the ligands’ activity has been investigated.

Monatshefte fuer Chemie published new progress about Alcohols, nitro Role: SPN (Synthetic Preparation), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Product Details of C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Yamamuro, Daisuke published the artcileSynthesis and biological activity of 5-(4-methoxyphenyl)oxazole derivatives, Safety of 4-(5-Oxazolyl)benzonitrile, the main research area is oxazole thiazole imidazole preparation antibacterial antifungal anticancer agent; 5-(4�Methoxyphenyl)-oxazole; Caenorhabditis elegans; Hatch inhibition.

5-(4-Methoxyphenyl)oxazole (MPO), originally reported as a synthetic compound, was isolated from a fungal culture broth as an inhibitor of hatch and growth of Caenorhabditis elegans. Nineteen MPO derivatives were chem. synthesized, but showed no effect on C. elegans hatch and growth. These findings strongly suggested that the whole structure of MPO is essential for anti-C. elegans activity. The title compounds thus formed included 5-(4-methoxyphenyl)oxazole, 4-(5-oxazolyl)phenol, 4-(5-oxazolyl)benzoic acid Me ester, 4-[5-(4-methoxyphenyl)-2-oxazolyl]benzoic acid, 5-(4-methoxyphenyl)thiazole, 5-(4-methoxyphenyl)-1H-imidazole. The synthesis of the target compounds was achieved by a reaction of aldehydes with 1-[(isocyanatomethyl)sulfonyl]-4-methylbenzene (TosMIC).

Bioorganic & Medicinal Chemistry Letters published new progress about Acute promyelocytic leukemia (human promyelocytic leukemia cell line). 87150-13-8 belongs to class nitriles-buliding-blocks, name is 4-(5-Oxazolyl)benzonitrile, and the molecular formula is C10H6N2O, Safety of 4-(5-Oxazolyl)benzonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts