Month: November 2022

Heydari, Somayyeh published the artcileAn overview on the progress and development on the palladium catalyzed direct cyanation, SDS of cas: 91-15-6, the main research area is aryl nitrile preparation; arylsulfonyl cyanamide phenylboronic acid cyanation palladium catalyst.

The simultaneous use of the new Pd nano-catalyst as well as the three types of the N-arylsulfonyl cyanamides 4-ClC6H4N(CN)S(O)2C6H4(4-X) (X = CH3, Br, NO2) as potent reagents for the in situ generation of the pos. CN ion for the direct cyanation of phenylboronic acids ArB(OH)2 [Ar = 4-ClC6H4, pyridin-3-yl, 2-(dihydroxyboranyl)phenyl, etc.] in acetonitrile at reflux conditions has been described.

Inorganica Chimica Acta published new progress about Aromatic nitriles Role: SPN (Synthetic Preparation), PREP (Preparation). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, SDS of cas: 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Wang, Shengyu published the artcilePd@CeO2-catalyzed cyanation of aryl iodides with K4Fe(CN)6·3H2O under visible light irradiation, Category: nitriles-buliding-blocks, the main research area is aryl nitrile preparation green chem photochem; potassium ferricyanide aryl iodide cyanation palladium catalyst.

A new protocol based on the combination of the catalyst Pd@CeO2, nontoxic cyanide source K4Fe(CN)6·3H2O, and driving force visible light irradn was developed. The reaction is performed at relatively moderate temperature (55°C) and exhibits good catalytic efficiency of product aryl nitriles RCN (R = Ph, 2-nitrophenyl, thiophen-2-yl, etc.) (yields of 89.4%). Moreover, the catalyst Pd@CeO2 possesses good reusability with a slight loss of photocatalytic activity after five consecutive runs. The reaction system based on the above combination shows a wide range of functional group tolerance under the same conditions. Reaction conditions such as temperature, time, the component of catalyst, and solutions are optimized by studying cyanation of 1-iodo-4-nitrobenzene as model reaction. According to these results, the possible mechanism of Pd@CeO2-catalyzed cyanation of aryl iodides RI under visible light irradiation is proposed based on the influence of visible light on the catalyst and reactant compounds In all, an environmental and economic method for preparation of aryl nitriles from cyanation of aryl iodides based on the goal of green chem. for sustainable development was provided.

Applied Organometallic Chemistry published new progress about Aromatic nitriles Role: SPN (Synthetic Preparation), PREP (Preparation). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Liu, Si-Zhan published the artcileCopper-promoted cyanation of aryl iodides with N,N-dimethyl aminomalononitrile, Product Details of C6H4N2, the main research area is iodoarene dimethyl aminomalononitrile copper catalyst cyanation; aryl nitrile preparation.

A copper-promoted cyanation of aryl iodides was successfully developed by using N,N-di-Me aminomalononitrile as the cyanide source with moderate toxicity and better stability. The reaction featured broad substrate scope, excellent reaction yields, readily available catalyst, and simple reaction conditions.

Tetrahedron Letters published new progress about Aromatic nitriles Role: SPN (Synthetic Preparation), PREP (Preparation). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Product Details of C6H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nasrollahzadeh, Mahmoud published the artcilePd nanocatalyst adorning coral reef nanocomposite for the synthesis of nitriles: utility of Cucurbita pepo leaf extract as a stabilizing and reducing agent, Application In Synthesis of 91-15-6, the main research area is palladium nanocatalyst coralreef nanocomposite nitrile Cucurbita stabilizing reducing agent; Cucurbita pepo; Pd nanoparticles; Pd/coral reef nanocomposite; aryl halide; cyanation.

A simple procedure for the palladium-catalyzed cyanation of aryl halides is described via a nucleophilic non-toxic cyanide source, K4[Fe(CN)6] in the presence of Pd/coral reef nanocomposite as a heterogeneous catalyst; the protocol provides a useful and easy method for the synthesis of aryl nitriles that are generated from the corresponding variant aryl halides, with sodium carbonate as a base. The nanocatalyst was prepared by a biol. process using aqueous extract of leaves of Cucurbita pepo as a stabilizing and reducing agent and coral reef as a natural support, without deploying any hazardous chems. The catalyst, that is easily separable from the reaction mixture and reused multiple times, was characterized by FT-IR (Fourier-Transform IR Spectroscopy), ICP-AES (Inductively Coupled Plasma Atomic Emission Spectroscopy), XRD (X-ray Diffraction), TEM (Transmission Electron Microscopy), FE-SEM (Field Emission SEM), EDS (Energy Dispersive X-ray Spectroscopy) and elemental mapping.

Nanomaterials published new progress about Aromatic nitriles Role: SPN (Synthetic Preparation), PREP (Preparation). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Application In Synthesis of 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ushijima, Sousuke published the artcileOne-pot conversion of aromatic bromides and aromatics into aromatic nitriles via aryllithiums and their DMF adduct, HPLC of Formula: 5653-62-3, the main research area is aryl halide butyl lithium DMF iodine reaction; aromatic nitrile preparation.

Various aromatic bromides and iodides were smoothly converted into the corresponding aromatic nitriles in good to moderate yields by the treatment with n-butyllithium and subsequently DMF, followed by treatment with mol. iodine in aq NH3. The same treatment of typical aromatics and heteroaromatics with n-butyllithium and subsequently DMF, followed by treatment with mol. iodine in aq NH3 also provided the corresponding aromatic nitriles in good yields. Moreover, the same treatment of aromatic bromides and aromatics with half amount of DIH (1,3-diiodo-5,5-dimethylhydantoin) instead of mol. iodine worked effectively to give the corresponding aromatic nitriles, resp., in good yields. These reactions are novel and environmentally benign one-pot methods for the preparation of aromatic nitriles from aromatic bromides and aromatics, resp., through the formation of aryllithiums and their DMF adducts.

Tetrahedron published new progress about Aromatic nitriles Role: SPN (Synthetic Preparation), PREP (Preparation). 5653-62-3 belongs to class nitriles-buliding-blocks, name is 2,3-Dimethoxybenzonitrile, and the molecular formula is C9H9NO2, HPLC of Formula: 5653-62-3.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Thakore, Ruchita R. published the artcileLate-stage Pd-catalyzed Cyanations of Aryl/Heteroaryl Halides in Aqueous Micellar Media, Application of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is haloarene zinc cyanide palladium catalyst cyanation green chem; heterohaloarene zinc cyanide palladium catalyst cyanation green chem; aryl cyanide preparation; heteroaryl cyanide preparation.

New technol. was described that enables late stage ppm Pd-catalyzed cyanations of highly complex mols., as well as a wide variety of aryl and heteroaryl halides possessing sensitive functional groups. These reactions are efficient in water containing nanomicelles, formed from a com. available and inexpensive surfactant. The implications for advancing drug synthesis and discovery are apparent.

ChemCatChem published new progress about Aromatic nitriles Role: SPN (Synthetic Preparation), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Saikia, Rakhee published the artcileAn Insight into Nitromethane as an Organic Nitrile Alternative Source towards the Synthesis of Aryl Nitriles, Product Details of C7H6N2, the main research area is nitromethane aryl halide copper catalyst cyanation DFT transition state; aryl nitrile preparation.

Directed by an unusual in situ reduction of CuII, our protocol is a simple CuI-mediated synthesis of aryl nitriles, with inexpensive and readily available nitromethane as the cyanating source, in moderate to good yields. Exhibiting a wide substrate scope, the method involves simple reaction conditions, is additive free with low catalyst loading. The plausible mechanism of cyanation of aryl halides is elucidated by a congregation of three cycles, namely the in situ reduction of CuII species by nitromethane, generation of HCN species from nitromethane and a regular organometallic pathway which releases the nitrile derivative The detail of the mechanism of generation of CN- from nitromethane is computationally validated. Our protocol holds the distinction of involving a rarely encountered CuI catalytic species as well as facile in situ generation of nucleophilic CN- to yield synthetically useful aromatic nitriles.

European Journal of Organic Chemistry published new progress about Aromatic nitriles Role: SPN (Synthetic Preparation), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Product Details of C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Niknam, Esmaeil published the artcilePalladium-Catalyzed Cyanation of Aryl Halides Using Formamide and Cyanuric Chloride as a New “”CN”” Source, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is aryl halide cyanuric chloride formamide palladium cyanation catalyst; cyanide aryl preparation.

A new source of “”CN”” employing formamide and cyanuric chloride is introduced for the cyanation reactions. The treatment of formamide and 2,4,6-trichloro-1,3,5-triazine (TCT; cyanuric chloride) afforded an efficient cyanating agent which it can be used as a nontoxic, readily available, and non-expensive reagent in the cyanation transformations. In this study, palladium-catalyzed cyanation of aryl halides was successfully accomplished using this new “”CN”” source in high yields.

European Journal of Organic Chemistry published new progress about Aromatic nitriles Role: SPN (Synthetic Preparation), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Yan, Yonggang published the artcilePhotochemically Enabled, Ni-Catalyzed Cyanation of Aryl Halides, Recommanded Product: Phthalonitrile, the main research area is dicyanobenzene haloarene nickel catalyst photochem cyanation; aryl nitrile preparation.

A light-promoted Ni-catalyzed cyanation of aryl halides employing 1,4-dicyanobenzene as a cyanating agent was reported. A broad array of aryl bromides, chlorides and druglike mols. could be converted into their corresponding nitriles (65 examples). Mechanistic studies suggest that upon irradiation, the oxidative addition product Ni(II)(dtbbpy)(p-C6H4CN)(CN) underwent homolytic cleavage of the Ni-aryl bond to generate an aryl radical and a Ni(I)-CN species, the latter of which initiated subsequent cyanation reactions.

Organic Letters published new progress about Aromatic nitriles Role: SPN (Synthetic Preparation), PREP (Preparation). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Recommanded Product: Phthalonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nasrollahzadeh, Mahmoud published the artcileSynthesis, characterization and catalytic performance of Pd(II) complex immobilized on Fe3O4@SiO2 nanoparticles for the ligand-free cyanation of aryl halides using K4Fe(CN)6, Recommanded Product: Phthalonitrile, the main research area is reusable iron oxide supported palladium nanocatalyst preparation surface area; potassium ferrocyanate aryl halide reusable palladium nanocatalyst cyanation; aryl nitrile preparation green chem.

The preparation of a novel magnetic catalyst via immobilization of Pd(II)-N-benzyl-N-(4-bromophenyl)-5-amino-1H-tetrazole complex on the Fe3O4@SiO2 nanoparticles (NPs). The application of Fe3O4@SiO2 NPs supported Pd(II)-N-benzyl-N-(4-bromophenyl)-5-amino-1H-tetrazole complex [Fe3O4@SiO2-BAT-Pd(II)] nanocatalyst was described for the cyanation of aryl iodides and bromides to the corresponding aryl nitriles using potassium hexacyanoferrate(II) [K4Fe(CN)6] as a non-toxic and economic cyanating agent under ligand- and additive-free conditions. Some aryl nitriles were efficiently synthesized from the corresponding aryl bromides and iodides in the presence of Fe3O4@SiO2-BAT-Pd(II) nanocomplex. The core-shell nanocomplex demonstrated the superior catalytic performance for the synthesis of synthetically valuable aryl nitriles within good to excellent yields. This process eliminated the need to handle highly toxic metal cyanides and it was easily recovered and reused for six consecutive runs with no decreasing of its catalytic capability. Preparation of Pd(II) complex immobilized on Fe3O4@SiO2 nanoparticles [Fe3O4@SiO2-BAT-Pd(II) nanocomplex]. Characterization of Fe3O4@SiO2-BAT-Pd(II) nanocomplex using XRD, FT-IR, EDS, VSM, TEM and FESEM analyses. Catalytic cyanation of the various aryl halides with K4Fe(CN)6 under ligand-free conditions. The nanocomplex was recovered and isolated six times with no significant loss of its catalytic ability.

Applied Organometallic Chemistry published new progress about Aromatic nitriles Role: SPN (Synthetic Preparation), PREP (Preparation). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Recommanded Product: Phthalonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts