Month: November 2022

Master, Hoshang E. published the artcileDesign and synthesis of low molecular weight compounds with complement inhibition activity, Recommanded Product: 2,3-Dimethoxybenzonitrile, the main research area is tetrazole derivative preparation complement inhibitor; complement inhibitor phenylacrylic acid derivative preparation.

An attempt was made to synthesize a series of noncytotoxic low mol. weight compounds of varying substitutions and functionalities having pharmacophore activity like carbonyl compounds, carboxylic acid and bioisosteres like tetrazole and Ph acrylic acid. The in vitro assay of these analogs for the inhibition of complement activity revealed significant inhibitory activity for varying substituents and, particularly, for bioisosteres, i.e., tetrazole and Ph acrylic acid derivatives

Bioorganic & Medicinal Chemistry published new progress about Structure-activity relationship (complement-inhibiting). 5653-62-3 belongs to class nitriles-buliding-blocks, name is 2,3-Dimethoxybenzonitrile, and the molecular formula is C9H9NO2, Recommanded Product: 2,3-Dimethoxybenzonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Ogunsipe, Abimbola published the artcileSynthesis, characterization and photostability studies on aluminium phthalocyanine chloride, Safety of Phthalonitrile, the main research area is aluminum phthalocyanine chloride microwave radiation photostability.

The synthesis, characterization and photostability studies of aluminum phthalocyanine chloride are hereby presented. Aluminum phthalocyanine chloride was synthesized by a solvent-free procedure involving microwave irradiation of a mixture of hydrated zinc chloride and 1,2-dicyanobenzene (phthalonitrile); the product was thoroughly purified and dried. The percentage yield was 83.4%. The characterization of the blue product was done via Fourier Transform IR Spectroscopy (FTIR) and UV-Visible spectrophotometry, and the results were satisfactory. In the FTIR spectrum, the formation of zinc phthalocyanine was confirmed by the band due to CN vibrations (around 2100 cm-1) which was present in the phthalonitrile (starting material), but absent in the product (aluminum phthalocyanine chloride). The UV-Visible absorption spectrum showed an intense signal at 672 nm and a weaker one around 350 nm. These bands are taken to be due to π→π* transitions within the phthalocyanine mol. The Beer-Lambert’s plot for the product resulted in a molar extinction coefficient value of 202,118 M-1 cm-1. Photodegradation studies showed that zinc phthalocyanine is very stable towards photoirradiation, with a rather small photodegradation value of 2.73 x 10-8.

Chemistry Research Journal published new progress about Microwave irradiation. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Safety of Phthalonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Dai, Bencai published the artcileSustainable and recyclable palladium nanoparticles-catalyzed reduction of nitroaromatics in water/glycerol at room temperature, Application of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is palladium nanoparticle nitroarom catalytic reduction water glycerol temperature.

Palladium nanoparticles with unique catalytic activity and high stability are synthesized. These nanoparticles exhibit excellent catalytic reduction activity for nitroaroms. in green solvents in the presence of H2 at ambient pressure and temperature The prominent advantages of this nanotechnol. include low consumption of catalyst, excellent chemoselectivity, high reusability of the catalyst, and environmentally green solvents.

Journal of Chemical Research published new progress about Catalysis. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Jiao, Jing published the artcileIodine-Promoted Formal [5+1] Annulation of 2-Vinylanilines and Thiurams: A Facile Approach to the Synthesis of 2-Aminoquinolines, Application In Synthesis of 1885-29-6, the main research area is aryl dialkylamino quinoline preparation; vinylaniline tetraalkylthiuram disulfide iodine additive cycloaddition copper triflate catalyst.

A [5+1]-cyclization of 2-vinylanilines RC6H4C(=CH2)(2-NH2C6H3R1) [R = H, 2-Me, 3-Cl, 4-F, etc.; R1 = H, 5-Cl, 4-Me, 3-Et, etc.], 2-(1-naphthalen-1-yl-vinyl)-phenylamine, 2-(1-naphthalen-2-yl-vinyl)-phenylamine with tetraalkylthiuram disulfides (R2)2NC(S)SSC(S)N(R2)2 [R2 = Me, Et, n-Bu] in the presence of iodine and copper(II) triflate was described. This reaction directly employs readily available and low-cost thiuram as both a C1 synthon and a nitrogen source, providing a facile approach to one-step syntheses of a variety of 2-aminoquinolines I [R3 = H, 6-Cl, 7-Me, 8-Et, etc.], N,N-dimethyl-4-(naphthalen-1-yl)quinolin-2-amine, N,N-dimethyl-4-(naphthalen-2-yl)quinolin-2-amine in good to excellent yields.

Synlett published new progress about Anilines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (vinyl). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Application In Synthesis of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Das, Suman published the artcileAn imidazolin-2-iminato ligand organozinc complex as a catalyst for hydroboration of organic nitriles, SDS of cas: 100-70-9, the main research area is bridging imidazoliniminato ethylzinc complex preparation catalyst hydroboration nitrile; crystal structure dinuclear bridging imidazoliniminato ethylzinc complex methylthiophenylmethanammonium chloride; mol structure dinuclear bridging imidazoliniminato ethylzinc complex methylthiophenylmethanammonium chloride; hydroboration kinetics nitrile imidazoliniminatoethylzinc catalyst.

The reaction of diethylzinc with imidazolin-2-imines (ImRNH, R = Dipp (2,6-diisopropylphenyl)), Mes (2,4,6-trimethylphenyl), and tBu (tert-butyl) afforded the corresponding dimeric Zn(II) imidazolin-2-iminato complexes [{(ImRN)ZnEt}2] (R = Dipp, 1a; R = Mes, 1b; R = tBu, 1c). The Zn complexes were characterized using spectroscopic techniques and the mol. structure of complex 1b was established by single-crystal x-ray diffraction anal. Complex 1c was used as a catalyst for the chemoselective hydroboration of organic nitriles with pinacolborane (HBpin) at ambient temperature to obtain diborylamines of a broad substrate scope in high yield. Zn complex 1c exhibits a versatile substrate scope and good functional group tolerance for catalytic hydroboration reactions. A most plausible mechanism is proposed from the kinetic study.

New Journal of Chemistry published new progress about Crystal structure. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, SDS of cas: 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhang, Cuicui published the artcileBaicalein triazole prevents respiratory tract infection by RSV through suppression of oxidative damage, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is Secutellaria baicalein triazole respiratory syncytial virus infection antiviral; Anti-inflammatory; Bronchiolitis; Pneumonia; Tumor necrosis.

Baicalein, an isolate of secutellaria baicalensis is known for its anti-inflammatory activity. In the present study, 12-triazole derivatives of baicalein I (R = 2-OH, 4-Me, 2-Br, etc.) were synthesized and evaluated against RSV infected BEAS-2B cells in vitro and in mice model in vivo. The preventive effect of most active compound I (R = 2-CF3) against RSV infection was studied in detail. The compound I (R = 2-CF3) treatment increased IFN-β1 expression in BEAS-2B cells infected with RSV. In BEAS-2B cells treatment with compound I (R = 2-CF3) inhibited RSV-induced secretion of interleukin-6 and -8 cytokines. It decreased RSV-induced nitric oxide & malondialdehyde production and inhibited the RSV-mediated activation of NF-κB, COX-2, Stat3 and MAPK. RT-qPCR showed that compound I (R = 2-CF3) treatment of the RSV-infected mice significantly (P < 0.05) decreased viral load through reduction in the viral replication. In the mice model of RSV-infection compound I (R = 2-CF3) treatment decreased interleukin-6, -8 and tumor necrosis factor-a expression. In summary, compound I (R = 2-CF3) inhibits RSV-infection and prevents pulmonary airway inflammation through the activation of IFN signalling pathway. Microbial Pathogenesis published new progress about Human cell line BEAS-2B. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Wu, Yi published the artcileLigand regulation to prepare an Fe, N, S tri-codoped hollow carbon electrocatalyst for enhanced ORR performance and Zn-air batteries, Synthetic Route of 91-15-6, the main research area is iron nitrogen sulfur carbon electrocatalyst ORR zinc air battery.

It is significant to explore high-efficiency, low-cost, and stable electrocatalysts for the oxygen reduction reaction (ORR) to substitute the precious metal platinum in electrochem. energy conversion devices. Materials with an Fe-Nx center are considered as promising catalysts to achieve this. Herein, a feasible SiO2-ZnCl2 template strategy is used to obtain nitrogen-sulfur-Fe co-doped periodic porous hollow carbon by calcining the Fe-based complexes with different ligands (1,10-phenanthroline, 2,2-bipyridine, and 1,2-dicyanobenzene). Owing to the introduction of the SBA-15 template and pore-forming agent ZnCl2, the as-prepared materials possess a large sp. surface area (SSA) and a well-defined hollow structure. Most importantly, different ligands have a crucial effect on the nitrogen content of the obtained materials, which in turn directly affects the metal active sites of ORR. The appropriate selection of 1,10-phenanthroline as the ligand creates abundant Fe-Nx active sites after the pyrolysis process. Therefore, the optimal hollow carbon (denoted as Z-CNS-Fe) derived from the complex of Fe2+ and 1,10-phenanthroline exhibits better ORR performance with a half-wave potential of 0.880 V, which is 30 mV higher than that of com. Pt/C (0.850 V). Beyond this, Z-CNS-Fe shows long-term stability and superior tolerance to methanol crossover. In addition, when Z-CNS-Fe was applied as the cathode of a primary Zn-air battery, the obtained metal-air cell provided a power d. as high as 141 mW cm-2, which exceeded that of com. Pt/C (114 mW cm-2). The high open-circuit voltage and satisfactory durability also indicate its potential practical applicability.

Sustainable Energy & Fuels published new progress about Electric current-potential relationship Role: PRP (Properties), TEM (Technical or Engineered Material Use), USES (Uses). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Synthetic Route of 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Tomishige, Keiichi published the artcileCO2 Conversion with Alcohols and Amines into Carbonates, Ureas, and Carbamates over CeO2 Catalyst in the Presence and Absence of 2-Cyanopyridine, Related Products of nitriles-buliding-blocks, the main research area is carbonate urea carbamate catalyst cyanopyridine cerium oxide; Carbamate; Carbon dioxide; Cerium oxide; Organic carbonate; Urea.

Recent progress on the CeO2 catalyzed synthesis of organic carbonates, urea, and carbamates from CO2+alcs., CO2+amines, and CO2+alcs.+amines, resp., is reviewed. The reactions of CO2 with alcs. and amines are reversible ones and the degree of the equilibrium limitation of the synthesis reactions is strongly dependent on the properties of alcs. and amines as the substrates. When the equilibrium limitation of the reaction is serious, the equilibrium conversion of the substrate and the yield of the target product is very low, therefore, the shift of the equilibrium reaction to the product side by the removal of H2O is essential in order to get the target product in high yield. One of the effective method of the H2O removal from the related reaction systems is the combination with the hydration of 2-cyanopyridine to 2-picolinamide, which is also catalyzed by CeO2.

Chemical Record published new progress about Amines Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), PROC (Process). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Related Products of nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Lioret, Vivian published the artcilePyrene/coumarin-subphthalocyanine conjugates as light harvesting systems with intramolecular energy transfer, Related Products of nitriles-buliding-blocks, the main research area is pyrene coumarine subphthalocyanine photoinduced intramol energy transfer.

A series of subphthalocyanine-antenna dyads have been successfully designed, synthesized and characterized by 1H NMR, 13C NMR, high-resolution mass spectroscopy and X-ray diffraction for some of them. Pyrene and coumarin have been appended at the axial position of the subphthalocyanine scaffold using different types of linkers. Photophys. properties of the new compounds have been measured in toluene, THF, chloroform, DMSO and methanol. Energy transfer efficiencies between antenna and the subphthalocyanine platform have been investigated and almost quant. energy transfer occurs in the antenna-platform 5.

Dyes and Pigments published new progress about Crystal structure. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Related Products of nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Lesuisse, Dominique published the artcileDevelopment of a novel NURR1/NOT agonist from hit to lead and candidate for the potential treatment of Parkinson’s disease, Safety of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is Parkinson’s disease NURR1 NOT agonist hits HTS SAR neuroprotective.

In the course of a program aimed at identifying Nurr1/NOT agonists for potential treatment of Parkinson’s disease, a few hits from high throughput screening were identified and characterized. A combined optimization pointed to a very narrow and stringent structure activity relationship. A comprehensive program of optimization led to a potent and safe candidate drug displaying neuroprotective and anti-inflammatory activity in several in vitro and in vivo models.

Bioorganic & Medicinal Chemistry Letters published new progress about Anti-inflammatory agents. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Safety of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts