Month: November 2022

Cheng, Xiao-jing published the artcileTacrine-Hydrogen Sulfide Donor Hybrid Ameliorates Cognitive Impairment in the Aluminum Chloride Mouse Model of Alzheimer’s Disease, HPLC of Formula: 1885-29-6, the main research area is tacrine hydrogen sulfide Alzheimer antiAlzheimer acetylcholinesterase; AChE; HS donor; Tacrine; hepatotoxicity; neuroinflammation; synaptic plasticity.

Alzheimer’s disease (AD) is a neurodegenerative disorder, characterized by progressive loss of memory and cognitive function, and is associated with the deficiency of synaptic acetylcholine, as well as chronic neuroinflammation. Tacrine, a potent acetylcholinesterase (AChE) inhibitor, was previously a prescribed clin. therapeutic agent for AD, but was recently withdrawn because it caused widespread hepatotoxicity. Hydrogen sulfide (H2S) has neuroprotective, hepatoprotective and anti-inflammatory effects. In this study, we synthesized a new compound, a tacrine- H2S donor hybrid (THS) by introducing H2S-releasing moieties (ACS81) to tacrine. Subsequently, pharmacol. and biol. evaluations of THS were conducted in the aluminum trichloride (AlCl3)-induced AD mice model. We found that THS (15mmol/kg) improved cognitive and locomotor activity in AD mice in the step-through test and open field test resp. THS showed strong AChE inhibitory activity in the serum and hippocampus of AD mice and induced increased hippocampal H2S levels. Furthermore, THS reduced mRNA expression of the proinflammatory cytokines, TNF-α, IL-6, and IL-1β and increased synapse-associated proteins (synaptophysin and postsynaptic d. protein 95) in the hippocampus of AD mice. Importantly, THS, unlike tacrine, did not increase liver transaminases (alanine transaminase and aspartate transaminase) or proinflammatory cytokines, indicating THS is much safer than tacrine. Therefore, the multifunctional effects of this new hybrid compound of tacrine and H2S indicate it is a promising compound for further research into the treatment of AD.

ACS Chemical Neuroscience published new progress about Alzheimer disease. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, HPLC of Formula: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Macha, Baswaraju published the artcileDesign and Friedlander Reaction Based Synthesis of New Cycloalkyl Ring Fused Quinolines as Multifunctional Agents for Alzheimer’s Treatment: In Silico Studies, Safety of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is cycloalkyl ring fused quinoline preparation acetylcholinesterase butyrylcholinesterase inhibitor.

A new series of acetylcholinesterase and butyrylcholinesterase inhibitors were designed based on the structure of tacrine and synthesized in multicomponent Friedlander reaction between 2-aminobenzonitrile and cycloalkanones. The synthesized tacrine analogs were characterized by spectral data and evaluated for acetylcholinesterase and butyryl cholinesterase inhibitory activity by following Ellman method. Compound I and II with piperazine containing acetamide and butyrylamide chains have shown equal potency to that of tacrine with IC50 values 0.71 +/= 0.04 and 1.01 +/= 0.03μM, and 0.52 +/= 0.03 and 0.73 +/= 0.04μM, against AChE and BuChE resp. when compared to standard tacrine with IC50 of 0.23 +/= 0.4μM and 0.31 +/= 0.03, whereas rivastigmine showed 0.47 +/= 0.2 and 0.65 +/= 0.02μM against AChE and BuChE, resp. Also, some of the potent compounds were tested for liver toxicity and were found to be much safer than tacrine. Thus, these new tacrine analogs with five, six and seven membered ‘C’ rings have emerged as new cholinesterase inhibitors for further exploitation as anti-Alzheimer’s agents. Docking studies of all the mols. disclosed close hydrogen bond interactions within the binding site.

ChemistrySelect published new progress about Alzheimer disease. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Safety of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Rossi, Michele published the artcileSustainable Drug Discovery of Multi-Target-Directed Ligands for Alzheimer’s Disease, HPLC of Formula: 1885-29-6, the main research area is sustainable drug multitarget ligand Alzheimer disease Anacardium neuroprotective.

The multifactorial nature of Alzheimer’s disease (AD) is a reason for the lack of effective drugs as well as a basis for the development of “”multi-target-directed ligands”” (MTDLs). As cases increase in developing countries, there is a need of new drugs that are not only effective but also accessible. With this motivation, we report the first sustainable MTDLs, derived from cashew nutshell liquid (CNSL), an inexpensive food waste with anti-inflammatory properties. We applied a framework combination of functionalized CNSL components and well-established acetylcholinesterase (AChE)/butyrylcholinesterase (BChE) tacrine templates. MTDLs were selected based on hepatic, neuronal, and microglial cell toxicity. Enzymic studies disclosed potent and selective AChE/BChE inhibitors (5, 6, and 12), with subnanomolar activities. The X-ray crystal structure of 5 complexed with BChE allowed rationalizing the observed activity (0.0352 nM). Investigation in BV-2 microglial cells revealed antineuroinflammatory and neuroprotective activities for 5 and 6 (already at 0.01μM), confirming the design rationale.

Journal of Medicinal Chemistry published new progress about Alzheimer disease. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, HPLC of Formula: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhu, Daoyun published the artcileStudy of Direct Synthesis of DMC from CO2 and Methanol on CeO2: Theoretical Calculation and Experiment, SDS of cas: 100-70-9, the main research area is dimethyl carbonate synthesis carbon dioxide methanol ceria theor calculation.

Rare earth metal oxides are known to have good catalytic effectiveness in the direct synthesis of di-Me carbonate (DMC) from CO2 and methanol. In this work, we screened ceria (CeO2) catalysts by analyzing their capacity for CO2 adsorption. The effects of the crystal surface morphol. and oxygen vacancy on the catalytic performance of the ceria catalyst were studied by using d. functional theory (DFT). The results show that the (110) surface and higher oxygen vacancy content can better promote the synthesis of DMC and that the rod-shaped CeO2 catalyst has a better catalytic effect. The oxygen vacancy content on the catalyst was improved by freeze-drying and confirmed by thermogravimetric anal., Raman spectroscopy, and ESR. The freeze-dried CeO2 (CeO2-FD) then showed a higher catalytic performance. The conversion rate of methanol and the yield of DMC were 33.95% and 584 mmol g-1cat, resp., under mild conditions (140°C and 1 MPa).

Industrial & Engineering Chemistry Research published new progress about Adsorption energy. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, SDS of cas: 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Levay, Krisztina published the artcileTuning the chemoselectivity of the Pd-catalyzed hydrogenation of pyridinecarbonitriles: an efficient and simple method for preparing pyridyl- or piperidylmethylamines, Synthetic Route of 100-70-9, the main research area is pyridinecarbonitrile palladium catalyst hydrogenation; pyridylmethylamine chemoselective preparation; piperidylmethylamine chemoselective preparation.

An effective method for the chemoselective, liquid-phase heterogeneous catalytic hydrogenation of some pyridinecarbonitriles [4-, 3- or 2-pyridinecarbonitrile] to the corresponding pyridyl- or piperidylmethylamines over a Pd/C catalyst was developed. Using our process, not only could an adequate primary amine selectivity to the desired pyridine derivatives [4-, 3- or 2-(aminomethyl)pyridine] be achieved, but it had also been proved to be effective for the selective preparation of piperidylmethylamines [4-, 3- or 2-(aminomethyl)piperidine] by further hydrogenation of the pyridine ring in addition to the nitrile group. The essence of this method was that the synthesis could be fine-tuned by simply adjusting the amount of acidic additive (H2SO4) based on whether the product to be prepared was pyridyl- or piperidylmethylamine. Complete conversions were obtained under mild conditions (30-50°C, 6 bar), in all cases, but the very high selectivity to 2-(aminomethyl)piperidine or 2-(aminomethyl)pyridine (98 and 93%, resp.) decreased to 76% (3-(aminomethyl)piperidine) and 72% (3-(aminomethyl)pyridine), as well as 10% (2-(aminomethyl)piperidine) and 57% (2-(aminomethyl)pyridine) by changing the position of the nitrile group in the pyridine ring. The possible reasons for the diversed primary amine selectivities observed in the hydrogenation of the constitutional isomers of pyridinecarbonitriles were confirmed by quantum chem. calculations (DFT). Adsorption energy profiles regarding the interactions between the nitrile starting materials, imine intermediates or amine products and palladium were computed to clarify the selectivity changes.

Catalysis Science & Technology published new progress about Adsorption energy. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Synthetic Route of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Long, Xiangdong published the artcileDirect Oxidative Amination of the Methyl C-H Bond in N-Heterocycles over Metal-Free Mesoporous Carbon, Synthetic Route of 100-70-9, the main research area is amide heterocyclic preparation density functional theory kinetic study; heterocycle oxidative amination mesoporous carbon catalyst SAR.

Herein, direct and efficient oxidative amination of the Me C-H bond in a wide range of N-heterocycles such as 2-methylpyridine, 3-methylquinoline, 4-methylpyrimidine, etc. to access the corresponding amides RC(O)NH2 (R = pyridin-2-yl, quinolin-2-yl, 1-methyl-1H-imidazol-2-yl, etc.) over metal-free porous carbon is successfully developed. To understand the fundamental structure-activity relationships of carbon catalysts, the surface functional groups and the graphitization degree of porous carbon have been purposefully tailored through doping with nitrogen or phosphorus. The results of characterization, kinetic studies, liquid-phase adsorption experiments, and theor. calculations indicate that the high activity of the carbon catalyst is attributed to the synergistic effect of surface acidic functional groups (hydroxyl/carboxylic acid/phosphate) and more graphene edge structures exposed on the surface of carbon materials with a high graphitization degree, in which the role of acidic functional groups is to adsorb the substrate mol. and the role of the graphene edge structure is to activate O2.

ACS Catalysis published new progress about Adsorption energy. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Synthetic Route of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Gao, Zeng published the artcileBronsted Acid Catalyzed Cyclization of Inert N-Substituted Pyrroles to Benzo[ f ]pyrrolo[1,2-a][1,4]diazepines, HPLC of Formula: 1885-29-6, the main research area is benzopyrrolodiazepine preparation; substituted pyrrole tandem intramol dehydroxylation cyclization Bronsted Acid catalyzed; enantioselective preparation benzopyrrolodiazepine; pyrrolylphenyl methanamine chiral phosphoric acid catalyzed intermol addition.

Two approaches involving intramol. and intermol. cyclization, resp., were developed for the direct and practical construction of a series of important benzo[f]pyrrolo[1,2-a][1,4]azepines such as I [R = H, Me, Ph, etc.; R1 = H, Me, Cl] by using Bronsted acid catalysts. Upon catalysis by TsOH, the intramol. dehydroxylation/ring closure of 3-hydroxy-2-[2-(1 H-pyrrol-1-yl)benzyl]isoindolin-1-ones provided various racemic benzo[f]pyrrolo[1,2-a][1,4]azepines in high yields. Furthermore, enantioenriched benzo[f]pyrrolo[1,2-a][1,4]azepines II [R = H, Me; R1 = H, Cl; R2 = H, Cl, F] were also obtained by chiral phosphoric acid catalyzed intermol. addition of [2-(1 H-pyrrol-1-yl)phenyl]methanamines to 2-formylbenzoates under mild conditions.

Synlett published new progress about Addition reaction. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, HPLC of Formula: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Qian, Wenyuan published the artcileAccelerating Effect of Triazolyl and Related Heteroaryl Substituents on SNAr Reactions: Evidence of Hydrogen-Bond Stabilized Transition States, Category: nitriles-buliding-blocks, the main research area is accelerating triazolyl heteroaryl SNAr hydrogen bond transition.

The remarkable accelerating effect of 1,2,3-triazolyl substituents on SNAr reactions was studied through systematic experiments and d. functional theory calculations The lone pair electrons of an ortho-triazolo substituent play a key role in lowering the activation energy for nucleophilic addition via formation of a preferential hydrogen bond with the amine nucleophile at the transition state for addition In an extension of this finding, related heteroaryl groups with similar electron pair donor properties also facilitate SNAr reactions. The exptl. determined solvent effect provides further support for this rationale, which was used to achieve an ortho-selective substitution on a difluoroarene substrate.

Journal of the American Chemical Society published new progress about Activation energy. 204078-32-0 belongs to class nitriles-buliding-blocks, name is 2-Morpholinobenzonitrile, and the molecular formula is C11H12N2O, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Mapukata, Sivuyisiwe published the artcileThe photocatalytic properties of zinc phthalocyanines supported on hematite nanofibers for use against methyl orange and Staphylococcus aureus, Computed Properties of 91-15-6, the main research area is photocatalytic property zinc phthalocyanin hematite nanofiber methyl orange; Staphylococcus aureus.

Heterogeneous photocatalysis is a promising approach for environmental remediation from contaminants including microorganisms and organic pollutants. In this work, hematite nanofibers are fabricated and modified with a novel monosubstituted Pc (4) as well as an asym. tetrasubstituted Pc (5) with the aim of creating hybrid photocataysts. The photocatalytic activities of the unmodified and phthalocyanine modified hematite nanofibers were compared based on their efficiencies in the photoinactivation of S. aureus and photooxidation of methyl orange. For both applications, the hybrid nanofibers were found to be more efficient photocatalysts than the unmodified hematite nanofibers. Comparison of the modified nanofibers (4-Fe2O3 and 5-Fe2O3) showed that they have comparable antibacterial activity while the 5-Fe2O3 nanofibers are the best for the photooxidation of methyl orange. The singlet oxygen generation efficiency, high activity, versatility, regenerability and thus reusability of the fabricated hybrid nanofibers makes them ideal candidates for real life water treatment studies.

Journal of Photochemistry and Photobiology, A: Chemistry published new progress about Absorption spectra. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Computed Properties of 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts