Month: November 2022

Sojka, Martin published the artcileBifurcated hydrogen bonds in platinum(II) complexes with phosphinoamine ligands, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is platinum phosphinoamine chloro complex preparation conformational energy DFT; crystal structure platinum phosphinoamine chloro.

In this work we report an investigation of the influence of bifurcated intramol. hydrogen bonds on conformations of platinum(II) complexes with phosphinoamine ligands. The series of new cis and trans-PtCl2L2 complexes with phosphinoamine ligands was synthesized and characterized by 1H, 31P, 195Pt NMR, IR, and mol. structures of 8 complexes were determined by X-ray crystallog. The hydrogen bonds are observed between NH···ClPt and NH···R (R = COOCH3, C(O)CH3, F, CN) moieties of the ligands and Pt core. The structural data from X-ray diffraction are linked to calculated conformational energies from d. functional theory (DFT) and topol. anal. results obtained from quantum theory of atoms in mols. (QTAIM) calculations The most prominent NH···ClPt interactions are found in the cis complexes with para substituted phosphinoamine ligands, which show delocalization indexes (DI) up to 0.09. The ortho substituted phosphinoamine ligands decrease the DI values down to zero for C(O)OCH3 and C(O)CH3 moieties.

Polyhedron published new progress about phosphinoamines). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Bao, Wen published the artcileCopper-catalyzed cyclization of 2-cyanobenzaldehydes and 2-isocyanoacetates: an efficient strategy for the synthesis of substituted 1-aminoisoquinolines, HPLC of Formula: 1013112-48-5, the main research area is cyanobenzaldehyde formylbenzonitrile cyclization isocyanoacetate copper catalyst; aminoisoquinoline isoquinolinamine preparation.

A Cu(acac)2-catalyzed cyclization reaction of 2-cyanobenzaldehydes with 2-isocyanoacetates was successfully developed providing an efficient strategy for the synthesis of substituted 1-aminoisoquinolines I (R1 = H, 6-Cl, 7-F, 8-MeO, etc.; R2 = CO2Et, CO2Me, CO2Bu-t). The reaction proceeded smoothly under mild conditions with high efficiency, and provides an alternative strategy for the synthesis of 1-aminoisoquinoline containing mols.

Chemical Communications (Cambridge, United Kingdom) published new progress about Aromatic nitriles Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1013112-48-5 belongs to class nitriles-buliding-blocks, name is 2-Formyl-4,5-dimethoxybenzonitrile, and the molecular formula is C10H9NO3, HPLC of Formula: 1013112-48-5.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Kurosawa, Miki B. published the artcileUnified synthesis of multiply arylated alkanes by catalytic deoxygenative transformation of diarylketones, HPLC of Formula: 42872-30-0, the main research area is diarylketone palladium catalyst reduction; diarylmethane preparation; oxomethyldiarene palladium catalyst reduction dimerization; tetraarylethane preparation; triarylmethane preparation.

A deoxygenative transformation of diarylketones leading to multiply arylated alkanes was developed. Diarylketones were reacted with diphenylphosphine oxide resulting in a phospha-Brook rearrangement, followed by palladium-catalyzed cross-couplings or a Friedel-Crafts type alkylation to afford the corresponding multiply arylated alkanes. A variety of diarylketones was converted to multiply arylated alkanes such as diarylmethanes, tetraarylethanes and triarylmethanes by reduction, dimerization and arylation in one pot. Furthermore, a one-pot conversion from arylcarboxylic acids to diarylmethanes and tetraarylethanes and a synthesis of tetraarylmethane and triphenylethane using sequential coupling reactions were also presented.

Chemical Science published new progress about Aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 42872-30-0 belongs to class nitriles-buliding-blocks, name is 2-(3-Benzoylphenyl)propanenitrile, and the molecular formula is C16H13NO, HPLC of Formula: 42872-30-0.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Xiao, Xiao published the artcileHHQ-4, a quinoline derivate, preferentially inhibits proliferation of glucose-deprived breast cancer cells as a GRP78 down-regulator, Related Products of nitriles-buliding-blocks, the main research area is breast cancer cell proliferation HHQ4 anticancer agent GRP78; Breast cancer cells; Glucose deprivation; Glucose-regulated protein 78; HHQ-4; Unfolded protein response.

As a central regulator for endoplasmic reticulum (ER) stress, glucose-regulated protein 78 (GRP78), controls the activation of ER-transmembrane signaling mechanisms by inducing unfolded protein response (UPR) in response to ER stress. Based on this premise, we investigated the mol. mechanisms of a synthetic quinolone derivative, 2-hexyl-3-methyl-4(1H)-quinolinone (HHQ-4), in regulating the GRP78 expression and UPR transcriptional program under glucose deprivation or 2-deoxy-D-glucose (2-DG)-stressed conditions. We found that HHQ-4 suppressed the transcriptional and translational expression of GRP78 gene in glucose-deprived breast cancer cells. Constitutive expression of GRP78 completely prevented breast cancer cells from HHQ-4-mediated proliferation inhibition during glucose starvation, stressing the important role of suppression of the GRP78 in HHQ-4-mediated cell proliferation inhibition. HHQ-4 was also found to exert inhibitory activity against breast cancer cell proliferation by suppressing three survival arms of the UPR, including PERK/eIF2a/ATF4, IRE1/XBP1, and ATF6, which orchestrate an intricate signaling network to modulate GRP78 gene transcription under glucose-deprived stress. Our findings show HHQ-4 could be a promising candidate, alone or in combination with 2-DG, for selectively inhibiting breast cancer cell proliferation by down-regulating the transcription and expression of GRP78 under stressful microenvironments.

Toxicology and Applied Pharmacology published new progress about Activating transcription factor 6α Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Related Products of nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Aleshkevich, V. V. published the artcileC/C composites developed from phthalonitrile based composites, Recommanded Product: Phthalonitrile, the main research area is carbon fabric phthalonitrile composite reinforced plastic porosity.

Carbonization of carbon fabric reinforced plastics (CFRPs) with phthalonitrile matrixes at 1000°C was investigated. Four different carbonization modes were tested. It was explored, that a mode with step heat rate is most beneficial. Two different phthalonitrile resins were investigated. Elemental anal. of final carbon-carbon composite (C/C) matrix was carried out and the results showed up to 88.5 mass% carbon presence. Final C/C d. reached 1.5991 after only one cycle of impregnation-carbonization. Final porosity of samples reached 9.2%. These results allow to consider phthalonitriles as a prospective carbon precursor for C/Cs manufacturing Mech. testing of the C/C samples was performed (Compressive strength P = 72.2MPa, E = 11.8 GPa). Tribol. data was received (coefficient of friction = 0.31, wear rate = 30μ/min). Thermal anal. was carried out (χ = 72.94 W/m*K, α = 85.8 cm2/s).

IOP Conference Series: Materials Science and Engineering published new progress about Carbonization. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Recommanded Product: Phthalonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Smith, Cameron J. published the artcile2-Arylbenzoxazoles as CETP inhibitors: Substitution of the benzoxazole moiety, Quality Control of 34133-58-9, the main research area is CETP inhibitor arylbenzoxazole preparation structure activity.

A series of 2-arylbenzoxazole inhibitors of the cholesterol ester transfer protein (CETP) is described. Structure-activity studies focused on variation of the substitution of the benzoxazole moiety. Substitution at the 5- and 7-positions of the benzoxazole moiety was beneficial for CETP inhibition. Compound 47 was the most potent inhibitor in this series and inhibited CETP with an IC50 of 28 nM.

Bioorganic & Medicinal Chemistry Letters published new progress about Structure-activity relationship. 34133-58-9 belongs to class nitriles-buliding-blocks, name is 4-Hydroxyisophthalonitrile, and the molecular formula is C8H4N2O, Quality Control of 34133-58-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Denekamp, Ilse M. published the artcileA simple synthesis of symmetric phthalocyanines and their respective perfluoro and transition-metal complexes, Product Details of C8H4N2, the main research area is phthalocyanine transition metal complex preparation.

The authors report a simple synthesis protocol for making phthalocyanines (Pcs) starting from phthalonitriles. This method is general and requires no specialized equipment. The complexes are isolated and characterized using x-ray diffraction, NMR, FTIR and Raman spectroscopy and high-resolution mass spectrometry. First, the authors study and present a 1-step synthesis route to a metal-free Pc (H2PcH16), as well as to the corresponding MPcH16 complexes of Mn, Fe, Co, Ni, Cu and Zn. Then, this route can also be used to make the fluorinated Pc analogs (MPcF16). Finally, the authors present a new and useful procedure for inserting a metal ion into a metal-free H2PcH16 ring, by direct metalation, yielding the corresponding MPcH16 complex. This last method is especially useful if you want to make different MPcH16 complexes.

Applied Organometallic Chemistry published new progress about Phthalocyanines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Product Details of C8H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Odani, Riko published the artcileCopper-Mediated C6-Selective Dehydrogenative Heteroarylation of 2-Pyridones with 1,3-Azoles, Safety of 4-(5-Oxazolyl)benzonitrile, the main research area is heteroarylpyridine preparation; pyridone azole heteroarylation copper; CH cleavage; arylation; copper; pyridones; synthetic methods.

A copper-mediated C6-selective dehydrogenative heteroarylation of 2-pyridones with 1,3-azoles has been developed. The reaction proceeded smoothly by two fold C-H cleavage even in the absence of noble-metal catalysts. The observed site selectivity was directed by a pyridyl substituent on the nitrogen atom of the pyridone ring. This directing group was readily removed after the coupling event, thus leading to 2-pyridone derivatives with a free N-H group. Moreover, in some cases, catalytic turnover of the Cu salt was also possible with the ideal terminal oxidant: mol. oxygen in air.

Angewandte Chemie, International Edition published new progress about Heteroarylation (dehydrogenative). 87150-13-8 belongs to class nitriles-buliding-blocks, name is 4-(5-Oxazolyl)benzonitrile, and the molecular formula is C10H6N2O, Safety of 4-(5-Oxazolyl)benzonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Plante, Jeffrey P. published the artcileShape-selective fluorescent sensing ensemble using a tweezer-type metalloreceptor, Application In Synthesis of 263389-54-4, the main research area is heteroaromatic shape selective fluorescent sensing bisimidazole pyridine derived metalloreceptor; tweezer type copper bisimidazole pyridine derived metalloreceptor fluorescent sensor.

A fluorescent sensing ensemble for pyridine-derived compounds is described. The receptor portion of the ensemble was prepared from a bisimidazole pyridine which coordinates copper to form a well-defined cavity. Small heteroaromatic guests such as adenine bind strongly in the cavity. The fluorescent response is provided by a dye which is coordinated to the receptor and quenched by the metal ion. The dye is released upon guest binding providing up to 25-fold fluorescence increases.

Organic Letters published new progress about Fluorescence. 263389-54-4 belongs to class nitriles-buliding-blocks, name is a-Tosyl-(4-methoxybenzyl) isocyanide, and the molecular formula is C16H15NO3S, Application In Synthesis of 263389-54-4.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Mills, L. Reginald published the artcileDesign of an Electron-Withdrawing Benzonitrile Ligand for Ni-Catalyzed Cross-Coupling Involving Tertiary Nucleophiles, Application In Synthesis of 91-15-6, the main research area is quaternary aryl nitrile synthesis; benzonitrile ligand nickel catalyzed cross coupling tertiary nucleophile; safety cyanide.

The design of new ligands for cross-coupling is essential for developing new catalytic reactions that access valuable products such as pharmaceuticals. In this report, we exploit the reactivity of nitrile-containing additives in Ni catalysis to design a benzonitrile-containing ligand for cross-coupling involving tertiary nucleophiles. Kinetic and Hammett studies are used to elucidate the role of the optimized ligand, which demonstrate that the benzonitrile moiety acts as an electron-acceptor to promote reductive elimination over β-hydride elimination and stabilize low-valent Ni. With these conditions, a protocol for decyanation-metalation and Ni-catalyzed arylation is conducted, enabling access to quaternary α-arylnitriles from disubstituted malononitriles. Safety: cyanide handling.

Journal of the American Chemical Society published new progress about Arylation. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Application In Synthesis of 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts