Month: November 2022

Takahashi, Yusuke published the artcileA Practical Procedure for Regioselective Bromination of Anilines, Name: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is bromoaniline green preparation regioselective; aniline oxidative bromination copper catalyst.

A highly practical procedure for the preparation of bromoanilines ArNH2 [Ar = 2-O2N-4-BrC6H3, 2,4-di-BrC6H3, 2-Br-4-ClC6H3, etc.] by using copper-catalyzed oxidative bromination was developed. Treatment of free anilines with readily available NaBr and Na2S2O8 in the presence of a catalytic amount of CuSO4·5H2O enabled regioselective bromination.

Synthesis published new progress about Aryl bromides Role: SPN (Synthetic Preparation), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Name: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Seki, Masahiko published the artcileRegioselective C-H Azidation of Anilines and Application to Synthesis of Key Intermediate for Pharmaceutical, Synthetic Route of 1885-29-6, the main research area is aniline copper catalyst regioselective C H azidation; azidoaniline preparation.

A catalytic system for regioselective C-H azidation of inactive anilines were developed. In the presence of CuSO4·5H2O, simultaneous addition of NaN3 and Na2S2O8 to aqueous CH3CN solution of free anilines under weakly acidic conditions (pH 4.5) smoothly underwent C-H azidation to provide corresponding α-azidated products in high yields. Me α-azidoanthranilate obtained by this method were readily transformed via simple reduction followed by cyclization to Me 2-ethoxybenzimidazol-7-carboxylate, a key intermediate for antihypertensive Candesartan Cilexetil.

Journal of Organic Chemistry published new progress about Aryl azides Role: SPN (Synthetic Preparation), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Synthetic Route of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Yu, Caiyun published the artcileSynthesis of N-Arylindoles from 2-Alkenylanilines and Diazonaphthalen-2(1H)-ones through Simultaneous Indole Construction and Aryl Introduction, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is indolyl naphthalenol green preparation; alkenylaniline diazonaphthalenone tandem intramol cyclization oxidative aromatization catalyst ruthenium.

In this paper, an efficient synthesis of N-arylindoles I [R1 = H, 5-Me, 6-t-Bu, etc.; R2 = Me, Et, Ph, etc.; R3 = H, Me; R2R3 = (CH2)3, (CH2)4; R4 = H, 6-Me, 7-OEt, etc.] through the cascade reaction of 2-alkenylanilines with diazonaphthalen-2(1H)-ones was presented. Mechanistically, this reaction involved the generation of a Ru-carbene complex from diazonaphthalen-2(1H)-one, followed by carbene N-H bond insertion with 2-alkenylaniline, intramol. cyclization, and oxidative aromatization. In this reaction, the Ru(II) complex acted as a multifunctional catalyst to promote not only the carbene formation but also the intramol. cyclization and the dehydrogenative aromatization. Meanwhile, air acted as a green and cost-effective oxidant. To our knowledge, this was the first example in which N-arylindoles I were synthesized through simultaneous introduction of the N-aryl unit and construction of the indole scaffold. Notable advantages of this method included readily accessible and halide-free substrates, additive-free reaction conditions, good efficiency, excellent atom economy, and compatibility with diverse functional groups. In addition, the utility of the product thus obtained was showcased by its diverse structural transformations.

Journal of Organic Chemistry published new progress about Aromatization (oxidative). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zeynizadeh, Behzad published the artcileGreen and convenient protocols for the efficient reduction of nitriles and nitro compounds to corresponding amines with NaBH4 in water catalyzed by magnetically retrievable CuFe2O4 nanoparticles, Product Details of C8H4N2, the main research area is reusable copper ferrite magnetic nanoparticle preparation surface area recyclability; benzonitrile sodium borohydride copper ferrite nanocatalyst reduction green chem; benzylamine preparation; nitrobenzene sodium borohydride copper ferrite nanocatalyst reduction green chem; aniline preparation.

Firstly, CuFe2O4 nanoparticles were prepared by a simple operation. The structure of the mentioned nanoparticles was characterized by Fourier transform IR spectroscopy, X-ray diffraction, SEM, transmission electron microscopy, energy-dispersive X-ray spectroscopy, inductively coupled plasma-optical emission spectrometry, vibrating sample magnetometer and also Brunauer-Emmett-Teller and Barrett-Joyner-Halenda analyses. The prepared magnetically copper ferrite nanocomposite was successfully applied as a simple, cost-effective, practicable and recoverable catalyst on the green, highly efficient, fast, base-free and ligand-free reduction of nitriles and also on the affordable and eco-friendly reduction of nitro compounds with the broad substrate scope to the corresponding amines with NaBH4 in water at reflux in high to excellent yields.

Research on Chemical Intermediates published new progress about Aralkyl amines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Product Details of C8H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

de Oliveira Lima Filho, Edson published the artcileMechanochemical Thiocyanation of Aryl Compounds via C-H Functionalization, Quality Control of 1885-29-6, the main research area is aryl thiocyanate mechanochem synthesis ball milling thiocyanation arene; ball milling thiocyanation aniline phenol anisole thioanisole indole.

Aryl thiocyanate compounds are important building blocks for the synthesis of bioactive compounds and intermediates for several functional groups. Reported thiocyanation reactions via C-H functionalization have limited substrate scope and low RME. The ball-milling method reported here uses ammonium persulfate and ammonium thiocyanate as reagents and silica as a grinding auxiliary. It afforded aryl thiocyanates with moderate to excellent yields for a wide variety of aryl compounds (36 examples, 8-96% yield), such as anilines, phenols, anisoles, thioanisole, and indole, thus tolerating substrates with sensitive functional groups. New products such as benzo[d][1,3]oxathiol-2-ones were obtained with C-4 substituted phenols. Thus, to our knowledge, we report, for the first time, aryl thiocyanation reaction by ball-milling at room temperature and solvent-free conditions, with short reaction times and no workup. Anal. of several mass-based green metrics indicates that it is an efficient greener method.

ACS Omega published new progress about Anisoles Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Quality Control of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Li, Liping published the artcileExperimental and Computational Studies on Cp*CyRh(III)/KOPiv-Catalyzed Intramolecular Dehydrogenative Cross-Couplings for Building Eight-Membered Sultam/Lactam Frameworks, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is dibenzothiazocine dioxide dibenzoazocinone preparation stereoselective chemoselective regioselective rhodium catalyst; vinyl aryl amide Intramol dehydrogenative cross coupling; benzamide witting reaction vinyl aniline preparation.

Described herein is an unusual Cp*CyRh(III)-catalyzed intramol. site-specific aryl C-H annulation, a highly chemoselective protocol providing direct access to eight-membered sultams/lactams I (R1 = H, 9-Me, 7-Cl, etc; R2 = Me, Et, Ph, 4-Br-C6H4; R3 = H, 2-Me, 3-OMe, etc.)and II (X = CO, PO-Ph; Ar = Ph, 2-Me-C6H4, Naph, Py, etc.) with broad substrate/functional group tolerance. Exptl. and computational studies reveal that such a transformation involves a unique PivOH-assisted aryl C-H activation/alkene insertion/β-H elimination/hydrogen-transfer process involving the Rh(III)-hydride species as the active intermediate with the concomitant release of H2 as the major byproduct, thus enabling the developed Cp*CyRh(III) catalysis with redox-neutral and highly atom-economical features.

Organic Letters published new progress about Aromatic amides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Guo, Rui published the artcileDevelopment of Novel Phosphino-Oxazoline Ligands and Their Application in Asymmetric Alkynlylation of Benzylic Halides, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is chiral alkyne preparation enantioselective copper phosphino oxazoline; benzo fused cyclic bromide silyl benzyl coupling.

A new set of stereochem. diverse phosphino-oxazoline ligands derived from simple L-amino acids and 2-(diphenylphosphanyl)benzoic acid were developed. Those mono anionic tridentated N,N,P-ligands promote the Cu-catalyzed enantioselective radical coupling of terminal alkynes with a broad range of benzylic halides including benzo-fused cyclic α-halides and α-silyl benzyl halides in high yield and excellent enantioselectivity under mild reaction conditions. With multi distinct sites for structural modification, a diverse pool of chiral N,N,P-ligands is readily accessed, allowing for rapid optimization of the ligand structure for a specific substrate. Notably, the enantioselective alkynlylation of benzylic halides bonds in benzo-cyclic mols. has also been realized for the first time.

Chinese Journal of Chemistry published new progress about Alkynes, aryl Role: SPN (Synthetic Preparation), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Davies, Alex M. published the artcileValorization of Ethanol: Ruthenium-Catalyzed Guerbet and Sequential Functionalization Processes, SDS of cas: 91-15-6, the main research area is ethanol ruthenium catalyst tandem guerbet alkylation; alc preparation.

A ruthenium-catalyzed tandem Guerbet-alkylation strategy for the valorization of ethanol was reported. The products of ethanol upgrading (higher-order alcs.) undergo subsequent C-C bond forming reactions with four carbon pronucleophiles and one ylide. Studies into catalyst design led to the development of ClRu(5-Mebpi)(PPh3)2 (bpi = 1,3-bis(2′-pyridylimino)isoindolate) as a highly efficient catalyst for producing biofuels and value-added chems. from ethanol via Guerbet and tandem Guerbet reactions. This catalyst affords 65% higher-order alcs. in short reaction times (2 h), providing the highest TON (155,890) and TOF (12,690 h-1) for a homogeneous catalyst reported to date.

ACS Catalysis published new progress about Alkylation. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, SDS of cas: 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Kramm, Frederik published the artcileIron-Catalyzed Cycloisomerization and C-C Bond Activation to Access Non-canonical Tricyclic Cyclobutanes, COA of Formula: C10H8FN, the main research area is cyclopropyl enyne iron catalyst diastereoselective cycloisomerization; octahydrocyclobutacyclopenta pyrrole preparation; Cyclobutanes; Cycloisomerization; Cyclopropanes; Iron Catalysis; Rearrangement.

Cycloisomerizations are powerful skeletal rearrangements that allow the construction of complex mol. architectures in an atom-economic way. Here an unusual type of cyclopropyl enyne cycloisomerization that couples the process of a cycloisomerization with the activation of a C-C bond in cyclopropanes was presented . A set of substituted non-canonical tricyclic cyclobutanes were synthesized under mild conditions using [(Ph3P)2Fe(CO)(NO)]BF4 as catalyst in good to excellent yields with high levels of stereocontrol.

Angewandte Chemie, International Edition published new progress about Cyclobutanes Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation). 97009-67-1 belongs to class nitriles-buliding-blocks, name is 1-(4-Fluorophenyl)cyclopropanecarbonitrile, and the molecular formula is C10H8FN, COA of Formula: C10H8FN.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Abel-Snape, Xavier published the artcileSynthesis of Indenes and Benzofulvenes via a Palladium-Catalyzed Three-Component Reaction, Formula: C7H6N2, the main research area is indene benzofulvene preparation palladium catalyst three component reaction.

A palladium-catalyzed three-component domino reaction to access indene derivatives is reported. This reaction proceeds via the sequential formation of three bonds: the first two resulting from inter- and intramol. carbopalladation and the final bond arising from an attack by a terminating nucleophilic reagent. Modifying the starting tether on the iodoarene led to either indenes or benzofulvenes. Three termination variations were compatible with this sequence, which furnished products in moderate to good yields. The oxabicycle used in this work acts as an acetylene surrogate, which is revealed in a postcatalytic retro-Diels-Alder step. A diastereomerically enriched mixture of oxabicyclic derivatives allowed for preliminary results for the enantioselective synthesis of indenes.

ACS Catalysis published new progress about Boronic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Formula: C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts