Month: November 2022

Jiang, Chenhui published the artcileDirect Transformation of Nitrogen-Containing Methylheteroarenes to Heteroaryl Nitrile by Sodium Nitrite, Application of Picolinonitrile, the main research area is heteroaryl nitrile preparation; methylheteroarene acetyl chloride sodium nitrite cyanation.

The cyanation reaction of methylheteroarenes with acetyl chloride and sodium nitrite via the radical process in high yields is reported. According to the control experiments, the reaction mechanism underwent radical progress. It is very useful in the pharmacy industry due to its metal-free and easy treatment conditions.

Organic Letters published new progress about Benzoxazoles Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Application of Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Tyagi, Aparna published the artcileBroensted acid-catalyzed epoxide ring-opening using amine nucleophiles: A facile access to β-amino alcohols, Quality Control of 1885-29-6, the main research area is amino alc beta synthesis; styrene oxide epoxide ring opening aniline Broensted acid catalyst; ring opening reaction mechanism kinetics Hammett equation; Suzuki Miyaura Cross coupling reaction; aniline; metal-free; phenyl oxirane; β-amino alcohols.

A mild, efficient, and metal-free synthetic protocol for the synthesis of β-amino alcs. is reported. The reaction proceeds at room temperature with only 0.5 mol % catalyst loading and affords β-amino alc. derivatives in excellent yield. This protocol is well-tolerated by a wide range of styrene oxide and aniline derivatives A notably efficacious gram-scale synthesis is also reported with a high TON=842. Further, the Hammett correlation study was also performed to identify the rate-determining step.

Chemistry – An Asian Journal published new progress about Anilines Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Quality Control of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Long, Yang published the artcileNickel-Catalyzed Synthesis of an Aryl Nitrile via Aryl Exchange between an Aromatic Amide and a Simple Nitrile, Product Details of C8H4N2, the main research area is aromatic amide nitrile nickel catalyst cyanation; aryl nitrile preparation.

A nickel-catalyzed synthesis of an aryl nitrile via aryl exchange between an aromatic amide and a simple nitrile was developed. By using cheap, easy-to-handle, and low-toxic 4-cyanopyridine as the cyanating source, cyanation of various aromatic amides afforded an assortment of aryl nitriles including bioactive drugs and organic luminescent mols. in good yields. The reaction exhibited wide substrate scope, good functional group tolerance, and unique selectivity that were complementary to traditional methods. Moreover, two key nickel complexes formed by oxidative addition to each substrate are obtained and determined by X-ray crystallog., which gave strong support for the mechanism elucidations.

ACS Catalysis published new progress about Amino group. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Product Details of C8H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Long, Yang published the artcileNickel-Catalyzed Synthesis of an Aryl Nitrile via Aryl Exchange between an Aromatic Amide and a Simple Nitrile, Application of Picolinonitrile, the main research area is aromatic amide nitrile nickel catalyst cyanation; aryl nitrile preparation.

A nickel-catalyzed synthesis of an aryl nitrile via aryl exchange between an aromatic amide and a simple nitrile was developed. By using cheap, easy-to-handle, and low-toxic 4-cyanopyridine as the cyanating source, cyanation of various aromatic amides afforded an assortment of aryl nitriles including bioactive drugs and organic luminescent mols. in good yields. The reaction exhibited wide substrate scope, good functional group tolerance, and unique selectivity that were complementary to traditional methods. Moreover, two key nickel complexes formed by oxidative addition to each substrate are obtained and determined by X-ray crystallog., which gave strong support for the mechanism elucidations.

ACS Catalysis published new progress about Amino group. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Application of Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Guan, Dan published the artcileMetal-free Efficient Method for the Synthesis of N-(2-haloethyl)benzamides through the Ring-opening of 2-oxazolines, HPLC of Formula: 1885-29-6, the main research area is dihydrooxazolylphenyl amide preparation halosuccinimide ring opening halogenation; amido haloethyl benzamide preparation.

An efficient, metal-free C-H halogenated method for the synthesis of β-halogenated carboxamides using non-corrosive NXS (X=Cl, Br) as the halogenated source and ammonium thiocyanate (NH4SCN) as the additive was proposed and accomplished. Various substituted 2-oxazolines efficiently afforded the corresponding β-halogenated carboxamides via a ring-opening reaction in good yields. The characteristic features of this reaction include readily available materials, mild reaction conditions and functional groups tolerance.

ChemistrySelect published new progress about Amides, halo Role: SPN (Synthetic Preparation), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, HPLC of Formula: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Osinubi, Adejoke published the artcileSynthesis and in vitro anticancer activities of substituted N-(4′-nitrophenyl)-L-prolinamides, Related Products of nitriles-buliding-blocks, the main research area is substituted nitrophenyl prolinamide preparation in vitro anticancer human; aryl proline preparation amine amidation; para fluoronitrobenzene thionyl chloride proline DMF catalyst condensation; anti-cancer agents; biomolecules; carcinoma cell lines; cytotoxicity; pyrrolidine-2-carboxamides.

Synthesis of N-(4′-substituted phenyl)-L-prolinamides I [R1 = CN, NO2; R2 = H, OH; R3 = H, Me, cyclohexyl, etc.; R4 = Pr, cyclohexyl, SO2C6H5, etc.; R3R4 = 4-morpholinyl, 2-isoindolinyl] via amidation reaction of N-aryl-L-prolines II with amines in presence of SOCl2 was described. Intermediate compounds II were obtained by condensation of p-fluoronitrobenzene with L-proline under aqueous-alc. basic conditions. The cytotoxicities of I against four human carcinoma cell lines (SGC7901, HCT-116, HepG2 and A549) were evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay; with good tumor inhibitory activities (79.50 ± 1.24%-50.04 ± 1.45%) against HepG2. I [R1 = NO2; R2 = H; R3 = R4 = n-butyl] exhibited the best anti-tumor activity against A549 with percentage cell inhibition of 95.41 ± 0.67% at 100μM. Likewise, I [R1 = NO2; R2 = H; R3 = Me; R4 = Ph] (70.13 ± 3.41%) and I [R1 = NO2; R2 = H; R3 = H; R4 = 4-NO2C6H4] (83.36 ± 1.70%) displayed stronger antineoplastic potencies against A549 than the standard, 5-fluorouracil (64.29 ± 2.09%), whereas I [R1 = NO2; R2 = H; R3 = R4 = n-butyl] (93.33 ± 1.36%) and I [R1 = NO2; R2 = H; R3 = H; R4 = 4-NO2C6H4] (81.29 ± 2.32%) outperformed the reference (81.20 ± 0.08%) against HCT-116. SGC7901 Showed lower percentage cell viabilities with I [R1 = NO2; R2 = H; R3 = H; R4 = 4-NO2C6H4] (8.02 ± 1.54%) and I [R1 = NO2; R2 = H; R3 = R4 = cyclohexyl] (27.27 ± 2.38%). These results underscored the antiproliferative efficacies of L-prolinamides while exposing I [R1 = NO2; R2 = H; R3 = H, Me; R4 = Ph, 4-NO2C6H4] as promising broad-spectrum anti-cancer agents. Structure-activity relationship studies were also discussed.

Royal Society Open Science published new progress about Amidation. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Related Products of nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Wu, Xianqing published the artcilePd-Catalyzed Regiodivergent Synthesis of Diverse Oxindoles Enabled by the Versatile Heck Reaction of Carbamoyl Chlorides, Quality Control of 1885-29-6, the main research area is propenylphenyl carbamic chloride alkene palladium tandem heterocyclization Heck reaction; alkenyl oxindole regioselective diastereoselective preparation; alkene phenylvinyl phenylcarbamoyl chloride palladium tandem heterocyclization Heck reaction; alkenylphenyl oxindole regioselective diastereoselective preparation; alkenylalc phenylvinyl phenylcarbamoyl chloride palladium tandem heterocyclization Heck reaction; formylalkyl phenyloxindole regioselective diastereoselective preparation.

A miscellaneous oxindole synthesis bearing an all-carbon quaternary center, enabled by Pd-catalyzed intramol. cyclization followed by multiple intermol. Heck reactions of both easily accessible alkene-tethered carbamoyl chlorides and olefins was reoprted. This protocol obviates the use of prefunctionalized olefinic reagents, exhibited excellent functional group tolerance and features fascinating reactive versatility.

Organic Letters published new progress about Aldehydes Role: SPN (Synthetic Preparation), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Quality Control of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Wang, Guangzhu published the artcileNi-Catalyzed enantioselective reductive arylcyanation/cyclization of N-(2-iodo-aryl) acrylamide, HPLC of Formula: 1885-29-6, the main research area is iodophenyl acrylamide phenylmalononitrile nickel enantioselective reductive cyanation Heck cyclization; cyanomethyl oxoindole preparation.

A Ni/(S,S)-BDPP-catalyzed intramol. Heck cyclization of N-(2-iodo-aryl)acrylamides with 2-methyl-2-phenylmalononitrile was developed to give oxindoles with good enantioselectivities. By utilizing such an electrophilic cyanation reagent could tackle the deleterious effect of the coordinative cyanide ion in the asym. alkene arylcyanation.

Chemical Communications (Cambridge, United Kingdom) published new progress about Acrylamides Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, HPLC of Formula: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Louvel, Dan published the artcileMetal-Free Visible-Light Synthesis of Arylsulfonyl Fluorides: Scope and Mechanism, Quality Control of 1885-29-6, the main research area is arylsulfonyl fluoride preparation; diazonium salt DABSO fluorination photocatalyst visible light induced; arylsulfonyl fluorides; fluorine; mechanistic investigations; metal-free synthesis; organo-photoredox.

A series of arylsulfonyl fluorides I [R = H, 4-Me, 2-CN, etc.] was synthesized via organo-photoredox-induced nucleophilic fluorination of aryl diazonium salts with a SO2 source (DABSO). The reaction tolerated the presence of both electron-rich and -poor aryls and demonstrated a broad functional group tolerance. To shed the light on the reaction mechanism, several exptl. techniques were combined, including fluorescence, NMR and EPR spectroscopy as well as DFT calculations

Chemistry – A European Journal published new progress about Fluorination. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Quality Control of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Schrage, Briana R. published the artcileSubbiliazine: A Contracted Phthalocyanine Analog, Quality Control of 91-15-6, the main research area is pyrazolylimino isoindoline chelate preparation borylation fluoroborane; boron subphthalocyanine analog preparation crystal structure optimized geometry DFT; mol structure boron subphthalocyanine analog.

The direct borylation of two bis(pyrazolylimino)isoindoline chelates with BF3 and base under dry conditions gave two B adducts. These are ring-contracted analogs of biliazine and can be considered as subbiliazines, as they have bowl-shaped structures similar to subphthalocyanine. Addnl., a new iminooxoisoindoline BF2 complex was made from hydrolysis of the free base in the presence of BF3. The electronic structures of the free bases and subbiliazines were probed by d. functional theory (DFT) and time-dependent DFT (TDDFT) methods.

Organic Letters published new progress about Borylation. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Quality Control of 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts