Month: November 2022

Wang, Hui published the artcileSelective Coupling of 1,2-Bis-Boronic Esters at the more Substituted Site through Visible-Light Activation of Electron Donor-Acceptor Complexes, Product Details of C8H4N2, the main research area is photochem coupling regioselective diboronate aromatic nitrile preparation aryl ethylboronate; arylethyl boronate preparation diboronate coupling aromatic nitrile aryllithium directed; 1,2-Boron Shift; Alkyl Radicals; Boronate Complexes; Electron Donor-Acceptor Complexes; Photoactivation.

1,2-Bis-boronic esters are useful synthetic intermediates particularly as the two boronic esters can be selectively functionalized. Usually, the less hindered primary boronic ester reacts, but herein, we report a coupling reaction that enables the reversal of this selectivity. This is achieved through the formation of a boronate complex with an electron-rich aryllithium which, in the presence of an electron-deficient aryl nitrile, leads to the formation of an electron donor-acceptor complex. Following visible-light photoinduced electron transfer, a primary radical is generated which isomerizes to the more stable secondary radical before radical-radical coupling with the arene radical-anion, giving β-aryl primary boronic ester products. The reactions proceed under catalyst-free conditions. This method also allows stereodivergent coupling of cyclic cis-1,2-bis-boronic esters to provide trans-substituted products, complementing the selectivity observed in the Suzuki-Miyaura reaction.

Angewandte Chemie, International Edition published new progress about Boronic acids, esters Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Product Details of C8H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Yuan, Shuo published the artcile“”On-Water”” Palladium-Catalyzed Tandem Cyclization Reaction for the Synthesis of Biologically Relevant 4-Arylquinazolines, Synthetic Route of 1885-29-6, the main research area is aryl quinazoline preparation green chem; benzonitrile preparation arylboronic acid tandem heterocyclization palladium catalyst; cascade reactions; catalysis; on-water synthesis; palladium; quinazolines.

The quinazoline scaffold is prevalent in pharmaceutically relevant mols. that show diverse biol. activities. An efficient “”on-water”” palladium-catalyzed tandem cyclization reaction from com. available arylboronic acids RB(OH)2 (R = Ph, 3-nitrophenyl, naphthalen-1-yl, etc.) and benzonitriles (E)-2-CN-R1C6H4N=C(R2)N(Me)2 [R1 = H, 5-Me, 4,5-(OMe)2, etc.; R2 = H, Me] that enable the rapid access to 4-arylquinazoline scaffolds I [R3 = H, 7-Me, 6,7-(OMe)2, etc.] in good to excellent yields (45 examples, up to 98% yield) was reported. This protocol has shown good functional group tolerance and broad substrate scope. The reaction was also performed on a gram scale and successfully applied to the synthesis of the highly potent and selective PI3Kδ inhibitor II, showing the practicability and synthetic utility of the protocol. In this reaction, the quinazoline scaffold I is efficiently constructed with the simultaneous formation of one C-C bond and one C-N bond. Collectively, the protocol could serve as an alternative strategy to synthesize biol. important quinazoline scaffolds.

Chemistry – A European Journal published new progress about Bond formation catalysts (C-N, C-C). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Synthetic Route of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Reilly, Sean W. published the artcileLate-Stage Carbon Isotope Exchange of Aryl Nitriles through Ni-Catalyzed C-CN Bond Activation, Quality Control of 100-70-9, the main research area is aryl nitrile zinc cyanide C13 nickel carbon isotope exchange; C13 aryl nitrile preparation.

A facile one-pot strategy for 13CN and 14CN exchange with aryl, heteroaryl, and alkenyl nitriles using a Ni phosphine catalyst and BPh3 is described. This late-stage carbon isotope exchange (CIE) strategy employs labeled Zn(CN)2 to facilitate enrichment using the nonlabeled parent compound as the starting material, eliminating de novo synthesis for precursor development. A broad substrate scope encompassing multiple pharmaceuticals is disclosed, including the preparation of [14C] belzutifan to illustrate the exceptional functional group tolerance and utility of this labeling approach. Preliminary exptl. and computational studies suggest the Lewis acid BPh3 is not critical for the oxidative addition step and instead plays a role in facilitating CN exchange on Ni. This CIE method dramatically reduces the synthetic steps and radioactive waste involved in preparation of 14C labeled tracers for clin. development.

Journal of the American Chemical Society published new progress about Bond activation (C-CN). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Quality Control of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Xu, Chang published the artcileVisible-Light-Induced α-Amino C-H Bond Arylation Enabled by Electron Donor-Acceptor Complexes, Name: Phthalonitrile, the main research area is tertiary amine benzonitrile photochem regioselective arylation.

Enabled by electron donor-acceptor complexes, a novel visible-light-induced α-amino C-H bond arylation protocol, without a photoredox catalyst, was disclosed. The protocol does not require any transition metal, oxidant, or exclusion of oxygen or moisture. A direct irradiation of the mixture of tertiary amines and benzonitriles with visible light in N,N-diethylethanamide in the presence of Cs2CO3 afforded α-arylated amines in good to excellent yields.

Organic Letters published new progress about Arylation, regioselective. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Name: Phthalonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Moghaddam, Firouz Matloubi published the artcileA ligand and Palladium-free Avenue for Cyanation of Aryl Halides: The Art of Samarium Powder in C-C Coupling Reaction, Computed Properties of 100-70-9, the main research area is benzonitrile preparation green chem chemoselective; aryl halide sodium cyanide cyanation samarium powder catalyst.

This was the first study of samarium powder catalyzed cyanation reaction of aryl halides, bearing electron-withdrawing and electron-releasing substituents, in the presence of NaCN to afford corresponding benzonitriles ArCN [Ar = C6H5, 4-O2NC6H4, naphth-1-yl, etc.] in high yields. This protocol took the advantage of being done in the absence of additive, ligand and precious transition metals such as palladium.

ChemistrySelect published new progress about Aryl halides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Computed Properties of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Shit, Sudip published the artcileSynthesis of Spiro[furan-2,1′-isoindolin]-3′-ones from 2-(4-Hydroxybut-1-yn-1-yl)benzonitriles and Aryl Aldehydes under the Action of Triflic Acid, Quality Control of 1885-29-6, the main research area is spiro furanisoindolinone diastereoselective preparation; hydroxybutynyl benzonitrile aryl aldehyde Prins Ritter ring opening addition.

The synthesis of spiro[furan-2,1′-isoindolin]-3′-ones I [R1 = H, 5-Me, 6-Cl, 6-Br; R2 = H, Me, Et; Ar = Ph, 4-FC6H4, 2-BrC6H4, etc.] from 2-(4-hydroxybut-1-yn-1-yl)benzonitriles and aryl aldehydes was demonstrated. It involved the initial formation of dihydrofuranylideneisoindolinone via intramol. sequential Prins and Ritter reactions, followed by the ring opening of the furanyl moiety to generate N-acyliminium ions and alcs. for the final cyclization reaction, and the spiro-cyclic compounds were produced in moderate to good yields. It was a one-pot, three-component reaction in which one new quaternary carbon, two five-membered rings, one C-N bond, two C-O bonds and one C-C bond are formed. The reaction was carried out with a Bronsted acid from 0°C to room temperature within a short period of time.

Journal of Organic Chemistry published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Quality Control of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Goeker, Hakan published the artcileSynthesis and potent antifungal activity against Candida species of some novel 1H-benzimidazoles, COA of Formula: C7H5N3O2, the main research area is benzimidazole preparation nucleophilic substitution reduction aryl diamine benzaldehyde heterocyclization; fungal infection antifungal structure activity Candida.

A series of 47 novel N1-alkylated-2-aryl-5(6)-substituted-1H-benzimidazoles and their three novel indole analogs were synthesized and evaluated for in vitro antifungal activities against Candida species by the tube dilution method. The results showed that I and II, having pyridine at the position C-2, of benzimidazoles exhibited the greatest activity with MIC values of 6.25-3.12 μg/mL. Indole analogs III (R1 = H, R2 = Br; R1 = Pr, R2 = Br, CN) have no inhibitory activity.

Journal of Heterocyclic Chemistry published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 87331-46-2 belongs to class nitriles-buliding-blocks, name is 2-Amino-3-nitrobenzonitrile, and the molecular formula is C7H5N3O2, COA of Formula: C7H5N3O2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Rakshit, Amitava published the artcilePd(II)-Catalyzed Synthesis of Furo[2,3-b]pyridines from β-Ketodinitriles and Alkynes via Cyclization and N-H/C Annulation, Computed Properties of 1885-29-6, the main research area is furopyridine preparation; ketodinitrile alkyne annulation palladium catalyst.

A Pd(II)-catalyzed synthesis of furopyridines, e.g., I has been developed from β-ketodinitriles, e.g., 2-(1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)propanedinitrile and alkynes, e.g., diphenylacetylene via an unusual N-H/C annulation. The participation of both the nitrile groups and the concurrent construction of furan and pyridine rings through the formation of C-C, C=C, C-O, C-N, and C=N bonds are the important features. The synthetic applicability is further demonstrated through a series of postsynthetic alterations.

Organic Letters published new progress about C-C bond formation. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Computed Properties of 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Xin, Lin published the artcileResearch on the Pollutant Migration Law Based on Large-Scale Three-Dimensional Similar Simulation Experiments of Underground Coal Gasification, HPLC of Formula: 91-15-6, the main research area is pollutant migration coal seam simulation underground gasification.

The potential pollution risk of underground coal gasification (UCG) has become a key factor restricting the development of UCG industrialization. Therefore, studying the migration and diffusion behavior of harmful pollutants is of great significance for preventing UCG pollution. In this paper, a large-scale three-dimensional similar simulation exptl. device for UCG is used to simulate the gasification of Tianjin fat coal under actual working conditions. The rock layer around the simulated coal seam was sampled after the gasification was completed, the contaminants in the samples were examined by XRD, and the changes in the relative content of the contaminants at different sampling points were studied by FTIR. The results showed that benzene, phenols, aldehydes, aromatic hydrocarbons, and aromatic heterocyclic compounds remained after the gasification of Number 7 sampling point in Qianjiang, Tianjin, and that the main pollutants were aromatic hydrocarbons. The migration and enrichment of phenol and aldehyde pollutants were about the same on the east and west sides of the gasification center, while benzene pollutants were more easily migrated and enriched than aromatic heterocyclic compounds The migration distance of phenolic pollutants on the south side of the gasification area is smaller than that of other pollutants and their maximum vertical distance from the gasification reaction area to the south is about 0.7 m. The results can provide a scientific basis for pollutant risk identification and prevention and control in the later UCG field test.

ACS Omega published new progress about Aromatic hydrocarbons Role: PEP (Physical, Engineering or Chemical Process), POL (Pollutant), PROC (Process), OCCU (Occurrence). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, HPLC of Formula: 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Karges, Johannes published the artcileSynthesis of tetranuclear rhenium(I) tricarbonyl metallacycles, Recommanded Product: Picolinonitrile, the main research area is tetranuclear rhenium tricarbonyl metallacycle preparation structure conformation; crystal structure mol tetranuclear rhenium tricarbonyl metallacycle preparation.

Re(I) tricarbonyl complexes have received much attention due to their attractive photochem., electrochem., and biol. properties. Beyond simple mononuclear complexes, multinuclear assemblies offer greater structural diversity and properties. Despite previous reports on the preparation of di-, tri-, or tetranuclear Re(I) tricarbonyl assemblies, the synthesis of these supramol. structures remains challenging due to overall low yields or tedious purification protocols. Herein, the facile preparation and characterization of tetranuclear Re(I) tricarbonyl metallacycles with a square geometry is reported using a tetrazole-based ligand. The synthesis of the metallacycle was optimized using different metal precursors, solvents, temperatures, and reagent concentrations Finally, the scope of suitable tetrazole-based ligands was explored to produce several tetranuclear Re(I) tricarbonyl-based metallacycles.

Dalton Transactions published new progress about Conformation. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Recommanded Product: Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts