Month: November 2022

Dix, Stefan published the artcileRadical C-H Trifluoromethoxylation of (Hetero)arenes with Bis(trifluoromethyl)peroxide, SDS of cas: 100-70-9, the main research area is trifluoromethoxylated hetero arene preparation; bis trifluoromethyl peroxide hetero arene radical CH trifluoromethoxylation photochem; (hetero)arenes; TEMPO; fluorine; photocatalysis; trifluoromethoxylation.

Herein, bis(trifluoromethyl)peroxide (BTMP, CF3OOCF3) as a practical and efficient trifluoromethoxylating reagent, which easily accessible from inexpensive bulk chems. was introduced. Using either visible light photoredox or TEMPO catalysis, trifluoromethoxylated arenes could be prepared in good yields under mild conditions directly from unactivated aromatics Moreover, TEMPO catalysis allowed for the one-step synthesis of valuable pyridine derivatives, which was previously prepared via multi-step approaches.

Chemistry – A European Journal published new progress about Photochemistry. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, SDS of cas: 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Zhang, Hao published the artcileA Strategy to Construct cis-Hydrocarbazole via Nickel/Lewis Acid Dual-Catalyzed Arylcyanation, COA of Formula: C7H6N2, the main research area is cis hydrocarbazole preparation diasteroselective; allylic aniline arylcyanation nickel Lewis acid catalyst.

A strategy for the synthesis of cis-hydrocarbazoles I [R1 = H, 6-Me, 7-F, etc.; R2 = Me, Et, Bn; R3 = H, Me; R4 = H, Me; R3R4 = O(CH2)2O] with a C3 quaternary carbon center was developed through Ni/Lewis acid dual-catalyzed arylcyanation of allylic anilines. A wide array of cis-hydrocarbazoles was accessed with high diastereoselectivities and atom economies in a good yield. The rich chem. of the installed nitrile group was demonstrated in the preparation of tryptamine- and tryptophol-derived cis-hydrocarbazoles.

Journal of Organic Chemistry published new progress about Carbazoles Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, COA of Formula: C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Lebedev, Yury published the artcileAsymmetric Hydroboration of Heteroaryl Ketones by Aluminum Catalysis, Recommanded Product: Picolinonitrile, the main research area is heterocyclic ketone enantioselective hydroboration aluminum catalyst; aluminum binol complex catalyst mechanism computational study.

A series of Me aluminum complexes bearing chiral biphenol-type ligands were found to be highly active catalysts in the asym. reduction of heterocyclic ketones (S/C = 100 – 500, ee up to 99%). The protocol is suitable for a wide range of substrates and has a high tolerance to functional groups. The formed 2-heterocyclic-alcs. are valuable building blocks in drug discovery or can be used as ligands in asym. catalysis. Isolation and comprehensive characterization of the reaction intermediates support a catalysis cycle proposed by DFT calculations

Journal of the American Chemical Society published new progress about Enantioselective synthesis. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Recommanded Product: Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Satyam, Killari published the artcileThe base-free Van Leusen reaction of cyclic imines on water: synthesis of N-fused imidazo 6,11-dihydro β-carboline derivatives, Category: nitriles-buliding-blocks, the main research area is dihydro imidazopyridoindole preparation green chem; dihydrocarboline tosylmethyl isocyanide Van Leusen reaction.

Construction of substituted 6,11-dihydro-5H-imidazo[1′,5′:1,2]pyrido[3,4-b]indole derivatives I (R = H, Et, Ph, etc.; R1 = H, 8-Br; R2 = H, 6-Ph, 5-Me, etc.) has been demonstrated on water under base-free conditions. The reaction of p-toluenesulfonylmethyl isocyanides 4-CH3C6H4SO2CH(R)NC and dihydro β-carboline imines II (R3 = H, 6-Br; R4 = H, 4-Ph, 3-Me, etc.) furnished the corresponding substituted 6,11-dihydro-5H-imidazo[1′,5′:1,2]pyrido[3,4-b]indole derivatives I in very good yields under ambient conditions. The use of deuterium oxide (D2O) as a solvent enabled the incorporation of deuterium isotopes in the imidazole ring.

Organic & Biomolecular Chemistry published new progress about Fused heterocyclic compounds Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 263389-54-4 belongs to class nitriles-buliding-blocks, name is a-Tosyl-(4-methoxybenzyl) isocyanide, and the molecular formula is C16H15NO3S, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Li, Quanzhe published the artcileOne-Pot Synthesis of Spirocyclopenta[a]indene Derivatives via a Cascade Ring Expansion and Intramolecular Friedel-Crafts-Type Cyclization, COA of Formula: C7H6N2, the main research area is spirocyclopentaindene derivative preparation; propargyl alc tethered alkylidenecyclobutane preparation cascade ring expansion cyclization.

A one-pot efficient synthetic approach for the rapid construction of spirocyclopenta[a]indene derivatives has been developed via an iodine-initiated cascade ring expansion and intramol. Friedel-Crafts-type cyclization from propargyl alc.-tethered alkylidenecyclobutanes under mild conditions with broad substrate scope. This cascade process can be elegantly conducted on a gram scale. A plausible reaction mechanism has been proposed on the basis of a series of deuterium labeling and control experiments

Journal of Organic Chemistry published new progress about Cyclization. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, COA of Formula: C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Tsutsumi, Hiroyuki published the artcileMolecular capture using the precipitate of creaming-down by (-)-epigallocatechin-3-O-gallate, Product Details of C6H4N2, the main research area is epigallocatechin gallate chloropyrimidine crystal structure hydrogen bond mol capture; (�-epigallocatechin-3-O-gallate; 2-chloropyrimidine; X-ray crystallographic analysis; creaming-down; quantitative 1H-NMR.

An aqueous solution of equimol. amounts of 2-chloropyrimidine and (-)-epigallocatechin 3-O-gallate (EGCg) afforded a colorless block crystal, which was determined to be a 2 : 2 complex of 2-chloropyrimidine and EGCg by X-ray crystallog. anal. The 2 : 2 complex was formed by the cooperative effect of three intermol. interactions, π-π and CH-π interactions, and intermol. hydrogen bonds. Upon formation of the 2 : 2 complex, a 2-chloropyrimidine mol. was captured by a hydrophobic space formed by the three aromatic rings of A, B, and B’ rings of two EGCg mols. The mol. capture abilities of various heterocyclic compounds using EGCg were evaluated by ratio of the heterocyclic compounds included in the precipitates of complex of EGCg to the heterocyclic compounds used. The amount of the heterocyclic compounds was measured by an integrated value of corresponding proton signals in the quant. 1H-NMR spectrum.

Chemical & Pharmaceutical Bulletin published new progress about Bond angle (hydrogen bond). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Product Details of C6H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Masaryk, Lukas published the artcileStability of a half-sandwich Os(II) complex with indomethacin-functionalized ligand in the presence of carboxypeptidase A, Product Details of C6H4N2, the main research area is osmium indomethacin functionalized half sandwich complex enzymic hydrolysis carboxypeptidase; thiadiazole pyridine osmium arene half sandwich indomethacin complex hydrolysis; antitumor agent osmium arene pyridylthiadiazole complex enzymic hydrolysis carboxypeptidase.

In the presence of carboxypeptidase, the hydrolytically stable complex [Os(η6-pcym)(L2)Cl]PF6 (2) partially released the bioactive substituent indomethacin, bound through the amide bond to the chelating 2-(1,3,4-thiadiazol-2-yl)pyridine-based moiety of L2. Stability in the presence of other relevant biomols. (GSH, NADH, GMP) and cancer cell viability were also studied.

Dalton Transactions published new progress about Antitumor agents (osmium complexes). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Product Details of C6H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Abe, Masahiro published the artcileNitrile Synthesis via Desulfonylative-Smiles Rearrangement, Formula: C6H4N2, the main research area is nitrile preparation; nitrophenyl sulfonyl benzamide desulfonylative Smiles rearrangement.

Herein, a simple nitrile ArCN [Ar = 2-BnC6H4, 4-MeOC6H4, 3-NCC6H4, etc.] synthesis from N-[(2-nitrophenyl)sulfonyl]benzamides via base-promoted intramol. nucleophilic aromatic substitution was designed. The process features redox-neutral conditions as well as no requirement of toxic cyanide species and transition metals. Our process showed broad scope and various functional group compatibility, affording a variety of (hetero)aromatic nitriles in good to excellent yields.

Journal of Organic Chemistry published new progress about Nitriles Role: SPN (Synthetic Preparation), PREP (Preparation). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Formula: C6H4N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Wu, Xiang published the artcileGold-catalyzed cyclization of 1-(2′-azidoaryl)propynols: synthesis of polysubstituted 4-quinolones, Name: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is quinolone preparation; azidoaryl propynol cyclization gold catalyst.

An unprecedented gold-catalyzed procedure for the synthesis of polysubstituted 4-quinolones I (R1 = C6H5, 4-NCC6H4, 4-FC6H4, etc.; R2 = H, 7-Me, 6-Br, etc.) from 1-(2′-azidoaryl)propynols II is described. The reaction underwent an intramol. nucleophilic attack of the azide group to the Au-activated triple bonds in a 6-endo-dig manner and subsequent gold-assisted expulsion of N2 to furnish an α-imino gold carbene intermediate, which triggers a 1,2-carbon migration and finally is converted to 2,3-disubstituted 4-quinolone.

Chemical Communications (Cambridge, United Kingdom) published new progress about Cyclization. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Name: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Wang, Xing published the artcileCu-Mediated C-H Thioetherification of Arenes at Room Temperature, HPLC of Formula: 1885-29-6, the main research area is arene ethylene sulfide thioetherification; aryl alkyl sulfide preparation hydrolysis cyclization; benzoxathiepinone preparation.

Cu-mediated C-H thioetherification of arenes with ethylene sulfide has been developed using a readily removable directing group. The reaction proceeded at room temperature, and a variety of sensitive functional groups including chloro, bromo, and vinyl were well tolerated. The thiolated products could be converted to the seven-membered benzoxathiepinones derivatives by a sequence of hydrolysis-lactonization reactions.

Organic Letters published new progress about Crystal structure. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, HPLC of Formula: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts