Month: November 2022

Ushijima, Sousuke published the artcileOne-pot conversion of aromatic bromides and aromatics into aromatic nitriles, Synthetic Route of 5653-62-3, the main research area is aryl bromide cyanation sequential lithiation DMF addition; arene cyanation sequential lithiation DMF addition; aromatic nitrile green preparation.

Various aromatic bromides and iodides were smoothly converted into the corresponding aromatic nitriles in good to moderate yields by sequential treatment with BuLi and DMF, followed by treatment with I2 in aqueous NH3. The same treatment of typical aromatics and heteroaromatics also provided the corresponding aromatic nitriles in good yields. The present reactions are novel 1-pot methods for the preparation of aromatic nitriles from aromatic bromides and aromatics, resp., through the formation of aryllithiums and their DMF adducts.

Synlett published new progress about Aromatic nitriles Role: SPN (Synthetic Preparation), PREP (Preparation). 5653-62-3 belongs to class nitriles-buliding-blocks, name is 2,3-Dimethoxybenzonitrile, and the molecular formula is C9H9NO2, Synthetic Route of 5653-62-3.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Mihai, Madalina T. published the artcilePara-Selective C-H Borylation of Common Arene Building Blocks Enabled by Ion-Pairing with a Bulky Countercation, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is para selective carbon hydrogen bond borylation aniline phenol benzylamine.

The selective functionalization of C-H bonds at the arene para position is highly challenging using transition metal catalysis. Ir-catalyzed borylation has emerged as a leading technique for arene functionalization, but there are only a handful of strategies for para-selective borylation, which operate on specific substrate classes and use bespoke ligands or catalysts. The authors describe a remarkably general protocol which results in para-selectivity on some of the most common arene building blocks (anilines, benzylamines, phenols, benzyl alcs.) and uses standard borylation ligands. The authors’ strategy hinges upon the facile conversion of the substrates into sulfate or sulfamate salts, wherein the anionic arene component is paired with a Bu4N cation. The authors hypothesize that the bulk of this cation disfavors meta-C-H borylation, thereby promoting the challenging para-selective reaction.

Journal of the American Chemical Society published new progress about Anilines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Recommanded Product: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Lesieur, Mathieu published the artcileDevelopment of a flow photochemical aerobic oxidation of benzylic C-H Bonds, Synthetic Route of 103589-67-9, the main research area is aryl ketone alc preparation; benzylic compound oxidation photocatalyst.

A continuous mesofluidic process has been developed for benzylic C-H oxidation with moderate to good yields using a photocatalyst (riboflavin tetraacetate, RFT) activated by a UV lamp and an iron additive [Fe(ClO4)2] via incorporation of singlet oxygen (1O2) for the direct formation of oxidized C=O or CH-OH compounds, e. g., I.

Organic Letters published new progress about Aryl ketones Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 103589-67-9 belongs to class nitriles-buliding-blocks, name is 3-Chloro-6,7-dihydro-5H-cyclopenta[c]pyridine-4-carbonitrile, and the molecular formula is C9H7ClN2, Synthetic Route of 103589-67-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Nechausov, S. S. published the artcileDual-curing propargyl/phthalonitrile monomers for composites by vacuum infusion process, Category: nitriles-buliding-blocks, the main research area is propargyl phthalonitrile monomer vacuum curing.

Four different bifunctional monomers were synthesized: two monomers containing N-propargylamine and phthalonitrile groups and two monomers containing O-propargyl ester and phthalonitrile groups. It was shown that only the latter one can be used to obtain composite materials by vacuum infusion (viscosity 40 mPa*s at 120°C). The N-propargylamine containing monomers demonstrated high viscosity of the melts and degradation with allene evolution while curing. Carbon fiber reinforced plastics (CFRP) were successfully obtained from 4-[3-(prop-2-yn-1-yloxy)phenoxy]benzene-1,2-dicarbonitrile by a vacuum infusion molding process. Mech. testing of the composites samples was performed. Influence of end-curing temperature on mech. properties and morphol. of composites was investigated. The curing temperature of 375°C critically affects the properties of the composite due to the high shrinkage. Composites cured at 375°C lost 18% of mech. properties at 300°C but cured at 330 only 10%. LOI for composites with a matrix of propargyl/phthalonitrile dual-curing polymers was equal to 75, which is higher than most materials obtained from thermosets.

IOP Conference Series: Materials Science and Engineering published new progress about Composites. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Asai, Kento published the artcilePalladium-Catalyzed Benzylic Silylation of Diarylmethyl Carbonates with Silylboranes under Base-Free Conditions, Safety of Phthalonitrile, the main research area is palladium catalyzed benzylic silylation diarylmethyl carbonate silylborane; benzylic silane nucleophile preparation reaction carbon electrophile.

A palladium-catalyzed benzylic silylation of diarylmethyl carbonates with silylboranes has been developed. The reaction proceeds smoothly even under external base-free conditions, and the corresponding benzylic silanes are formed in good to high yields. The obtained benzyl silane derivatives can work as the benzylic nucleophiles by the action of a suitable fluoride source and react with some carbon electrophiles to deliver the corresponding benzylic C-C cross-coupled products. Addnl., while still preliminary, the allylic silylation of the isoelectronic allylic carbonates is also achieved.

European Journal of Organic Chemistry published new progress about Carbonates Role: RCT (Reactant), RACT (Reactant or Reagent) (diarylmethyl). 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Safety of Phthalonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Kostyrko, E. O. published the artcileSynthesis and properties of new functionalized 2-benzazepines, Safety of 2-(2-(Bromomethyl)phenyl)acetonitrile, the main research area is aryl cyanomethylbenzyl aminoacetic acid ester cyclization sodium methylate; benzazepine functionalized preparation.

2-Aryl-4-hydroxy-2,3-dihydro-1H-2-benzazepine-5-carbonitriles were obtained by the cyclization of Me esters of N-aryl-N-(2-cyanomethylbenzyl)aminoacetic acids by the action of sodium methylate. The keto-enol tautomerism of these compounds and their reactions with hydrazines were studied.

Chemistry of Heterocyclic Compounds (New York, NY, United States) published new progress about Hydrazines Role: RCT (Reactant), RACT (Reactant or Reagent). 73217-11-5 belongs to class nitriles-buliding-blocks, name is 2-(2-(Bromomethyl)phenyl)acetonitrile, and the molecular formula is C9H8BrN, Safety of 2-(2-(Bromomethyl)phenyl)acetonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Qiu, Di published the artcileVisible Light-Driven, Photocatalyst-Free Arbuzov-Like Reaction via Arylazo Sulfones, Category: nitriles-buliding-blocks, the main research area is visible light Arbuzov reaction arylazo sulfone phosphite; heteroaryl aryl phosphonate preparation.

A visible light-induced formation of Aryl-Phosphorous bonds starting from arylazo sulfones and triaryl (or trialkyl)phosphites in the absence of any photoredox catalyst and any additives was developed. This reaction showed a broad substrate scope and afforded (hetero)aryl phosphonates in good yields and in up to the gram scale.

Advanced Synthesis & Catalysis published new progress about Azo compounds, aromatic Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Xiao, Yan published the artcileRhodium-Catalyzed Reaction of Azobenzenes and Nitrosoarenes toward Phenazines, SDS of cas: 1885-29-6, the main research area is azobenzene nitrosoarene rhodium annulation catalyst; phenazine preparation.

A rhodium-catalyzed annulative reaction between azobenzenes and nitrosoarenes has been developed, leading to a series of phenazines I (R1 = H, 2-Cl, 2-MeO, 2-Me, etc.; R2 = H, 2-Me, 2-t-Bu, 2-Br, etc.) in moderate to good yields. This procedure proceeds with sequential chelation-assisted addition of aryl C-H to nitrosoarenes and ring closure by electrophilic attack of azo group to aryl. During this transformation, the azo group served as not only a traceless directing group but also a building block in the final products.

Organic Letters published new progress about Aromatic compounds, nitroso Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, SDS of cas: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Geigle, Stefanie N. published the artcileDevelopment of DNA-Compatible Van Leusen Three-Component Imidazole Synthesis, Application In Synthesis of 263389-54-4, the main research area is DNA compatible three component imidazole synthesis.

DNA-encoded libraries (DELs) have generated recent interest due to their ability to provide new small mol. ligands for pharmaceutically important proteins. The chem. diversity of DELs determines their ability to provide potent, novel, and drug-like chem. matter, and DEL chem. diversity is limited by the scope of DNA-compatible chem. reactions. Herein, the one-pot three-component Van Leusen chem. is applied to DEL synthesis, providing the first reported DNA-compatible method to generate novel highly functionalized imidazoles.

Organic Letters published new progress about van Leusen three-component reaction. 263389-54-4 belongs to class nitriles-buliding-blocks, name is a-Tosyl-(4-methoxybenzyl) isocyanide, and the molecular formula is C16H15NO3S, Application In Synthesis of 263389-54-4.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Fu, Zhengjiang published the artcileConversions of aryl carboxylic acids into aryl nitriles using multiple types of Cu-mediated decarboxylative cyanation under aerobic conditions, Safety of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is aryl nitrile preparation green chem; malononitrile aryl carboxylic acid decarboxylative cyanation copper catalyst; azodimethylbutyronitrile aryl carboxylic acid decarboxylative cyanation copper catalyst.

Here, used malononitrile or AMBN as a cyanating agent to develop efficient and practical protocols for Cu-mediated decarboxylative cyanations, under aerobic conditions, of aryl carboxylic acids RC(O)OH (R = 2-nitrophenyl, 2,4,6-trimethoxyphenyl, 3-methyl-1-benzothiophen-2-yl, etc.) bearing nitro and methoxyl substituents at the ortho position as well as of heteroaromatic carboxylic acids. These protocols involved economical methods to synthesize value-added aryl nitriles RCN from simple and inexpensive raw materials. Further diversification of the 2-nitrobenzonitrile product was performed to highlight the practicality of the protocols.

Organic & Biomolecular Chemistry published new progress about Aromatic nitriles Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Safety of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts