Month: November 2022

Kim, Youyoung published the artcileIr(III)-Catalysed electrooxidative intramolecular dehydrogenative C-H/N-H coupling for the synthesis of N-H indoles, Category: nitriles-buliding-blocks, the main research area is alkenyl arylamine iridium catalyst electrooxidation intramol dehydrogenation coupling; indole preparation.

An iridium(III)-catalyzed electrooxidative intramol. dehydrogenative C-H/N-H coupling of unprotected 2-alkenyl anilines was described. The developed method allowed the synthesis of a variety of 3-substituted N-H indole scaffolds under undivided electrolytic conditions. Mechanistic studies suggested that the reaction proceeds through the electro-oxidation induced reductive elimination pathway.

Chemical Communications (Cambridge, United Kingdom) published new progress about Aromatic amines Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Fukazawa, Yasuaki published the artcileA Mild Method for Electrochemical Reduction of Heterocyclic N-Oxides, Related Products of nitriles-buliding-blocks, the main research area is electrochem reduction heterocyclic amine oxide.

Deoxygenation of heteroaromatic N-oxides is commonly accomplished using chem. or enzymic methods. In this work, we report on an expedient protocol for electrochem. reduction of pyridine N-oxide derivatives under mild conditions. A diverse range of mono- and bis N-oxides were converted into the corresponding nitrogen bases in good yields. Importantly, the method is highly selective towards N-oxides and tolerates challenging halo and nitro substituents in the heteroaromatic ring. Thus, e.g., 2-phenylpyridine N-oxide �2-phenylpyridine (89% isolated) by carring out the reaction in an undivided electrochem. cell with two graphite electrodes in 1:1 MeCN/water mixture using LiBF4 as supporting electrolyte.

European Journal of Organic Chemistry published new progress about Chemoselectivity (of electroreduction of amine oxide function group in presence of halogen or nitro groups). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Related Products of nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Chen, Chen published the artcilePalladium-Catalyzed Carbamoyl-Carbamoylation/ Carboxylation/Thioesterification of Alkene-Tethered Carbamoyl Chlorides Using Mo(CO)6 as the Carbonyl Source, Safety of 2-Aminobenzonitrile(Flakes or Chunks), the main research area is aryl oxindole preparation; alkene tethered carbamoyl chloride carbamoylation palladium catalyst.

A palladium-catalyzed carbamoyl-carbamoylation/carboxylation/thioesterification of alkene-tethered carbamoyl chlorides such as I [R1 = H, 5-Cl, 7-Me, etc.; R2 = Bn, PMB; R3 = Me, n-Bu, Ph, etc.] using Mo(CO)6 as the carbonyl source was reported. The reactions were typically performed with good functional group compatibility and tolerated different nucleophiles (amines, alcs., phenols, thiols and water), which provided amidated/esterificated/thioesterificated/carboxylated oxindoles or lactams such as II [R4 = Ph, 2-tolyl, 1-naphthyl, etc.; R5 = H, Me] bearing an all-carbon quaternary stereocenter under CO gas-free conditions. Furthermore, natural product mutation and divergent late-stage derivatization were the important practical features.

Advanced Synthesis & Catalysis published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Safety of 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Kobayashi, Kazuhiro published the artcileA Convenient Synthesis of 2,3-Dihydro-3-methylidene-1H-isoindol-1-ones by Reaction of 2-Formylbenzonitriles with Dimethyloxosulfonium Methylide, Quality Control of 1013112-48-5, the main research area is formyl benzonitrile dimethyloxosulfonium methylide heterocyclization; dihydro methylidene isoindolone preparation.

A facile method for the synthesis of 2,3-dihydro-3-methylidene-1H-isoindol-1-one and its derivatives carrying substituent(s) at C(5) and/or C(6) has been developed. The reaction of 2-formylbenzonitrile with dimethyloxosulfonium methylide, generated by the treatment of trimethylsulfoxonium iodide with NaH in DMSO/THF at 0°, resulted in the formation of 2,3-dihydro-3-methylidene-1H-isoindol-1-one (I) in 77% yield. Similarly, six 2-formylbenzonitriles carrying substituent(s) at C(4) and/or C(5), also gave the corresponding expected products in comparable yields.

Helvetica Chimica Acta published new progress about Aryl aldehydes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (o-cyano). 1013112-48-5 belongs to class nitriles-buliding-blocks, name is 2-Formyl-4,5-dimethoxybenzonitrile, and the molecular formula is C10H9NO3, Quality Control of 1013112-48-5.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Kumar, Girijesh published the artcileSynthesis and photophysical properties of pyridyl conjugated triazole appended naphthalenediimide derivatives, Computed Properties of 100-70-9, the main research area is bis dipyridinyltriazolyl phenanthroline tetraone preparation reduction potential fluorescence.

A series of three substituted triazole appended naphthalenediimide (NDI)-derivatives, 2,7-bis(3,5-di(pyridin-X-yl)-4H-1,2,4-triazol-4-yl)benzo[lmn][3,8]phenanthroline-1,3,6,8(2H,7H)-tetraones (where X = 2, NDI-PyTz-1; 3, NDI-PyTz-2; and 4, NDI-PyTz-3), were designed, synthesized and well characterized using various anal. and spectroscopic techniques. All the three NDI-PyTz derivatives exhibited decent electronic properties as suggested by DFT, cyclic voltammetry and fluorescence studies. In particular, NDI-PyTz-1 demonstrated the generation of a stable anion radical [NDI-PyTz-1].-.

Photochemical & Photobiological Sciences published new progress about Aromatic nitriles Role: RCT (Reactant), RACT (Reactant or Reagent). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Computed Properties of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Cho, Il Young published the artcileNickelocene as an Air- and Moisture-Tolerant Precatalyst in the Regioselective Synthesis of Multisubstituted Pyridines, Computed Properties of 100-70-9, the main research area is pyridine derivative regioselective preparation; diyne nitrile cycloaddition nickelocene catalyst.

Herein, operationally simple nickel(0) catalysis to access substituted pyridines I [R = Me, Ph, 2-furyl, etc.; R1 = Me, Ph, trimethylsilyl, etc.; R2 = H, Me, Ph, etc.; Z = CH2, O, C(CO2Et)2, N-Ts] from various nitriles and 1,6-diynes without the aid of air-free techniques was reported. The Ni-Xantphos-based catalytic manifold was tolerant to air, moisture and heat while promoting the [2 + 2 + 2] cycloaddition reactions with high reaction yields and broad substrate scope. In addition, the steric effect but also the frontier MO interactions could played a critical role in determining the regiochem. outcome of nickel-catalyzed [2 + 2 + 2] cycloaddition for the synthesis of compounds I.

Journal of Organic Chemistry published new progress about Aromatic esters Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Computed Properties of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Wan, Yin-Bo published the artcileHighly Enantioselective Iridium-Catalyzed Hydrogenation of o-Amidophenyl Ketones Enabled by 1,2-Diphenylethylenediamine-Derived P,N,N-Ligands with Tertiary Amine Terminus, HPLC of Formula: 1885-29-6, the main research area is arylcarbonylaryl acetamide iridium catalyst enantioselective hydrogenation; hydroxymethylaryl acetamide preparation.

A readily available and highly modular class of chiral P,N,N-ligands based on a structurally flexible nonchiral phosphine-amine framework with an optically active 1,2-diphenylethylenediamine unit bearing a tertiary amine terminus as the chiral source were developed and successfully applied in the Ir-catalyzed asym. hydrogenation of o-amidophenyl ketones. These tridentate P,N,N-ligands exhibited excellent activity, enantioselectivity, and substrate tolerance, thus furnishing various optically active o-amidobenzhydrols in up to 99% yields and with >99% ee. The utility of this protocol was proven by synthetically diverse product transformation and highly enantioselective production of a rice plant growth regulator, (S)-inabenfide.

Organic Letters published new progress about Aralkyl alcohols Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, HPLC of Formula: 1885-29-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Shuai, Bin published the artcileNickel-Catalyzed Favorskii-Type Rearrangement of Cyclobutanone Oxime Esters to Cyclopropanecarbonitriles, Quality Control of 97009-67-1, the main research area is cyclopropanecarbonitrile preparation; cyclobutanone oxime ester Favorskii rearrangement nickel catalyst.

A nickel-catalyzed base-promoted rearrangement of cyclobutanone oxime esters I (R1 = H, 4-tert-butyphenyl, 6-methoxynaphthalen-2-yl, phenylselanyl, etc.; R2 = H, Me, Ph; R3 = H, 2-naphthyl, 4-tert-butylphenyl, Ph, etc.; R2R3 = 1-adamantyl, 4-phenylcyclohexyl, cycloheptyl, etc.) to cyclopropanecarbonitriles II was developed. The ring opening of cyclobutanone oxime esters I occurs at the sterically less hindered side. A base-promoted nickelacyclobutane intermediate, formed in situ, is assumed to be involved in the formation of the product.

Synlett published new progress about Cyclopropanes Role: SPN (Synthetic Preparation), PREP (Preparation) (carbonitriles). 97009-67-1 belongs to class nitriles-buliding-blocks, name is 1-(4-Fluorophenyl)cyclopropanecarbonitrile, and the molecular formula is C10H8FN, Quality Control of 97009-67-1.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Arita, Mao published the artcileThree Step Synthesis of Fully and Differently Arylated Pyridines, Synthetic Route of 100-70-9, the main research area is arylated pyridine synthesis cyclocondensation pyridylenamine unsaturated ketone.

Condensation of β-(2-pyridyl)enamine and α,β-unsaturated ketone in the presence of FeCl3 under air afforded highly substituted pyridines. In this transformation, FeCl3 acted as not only an acid catalyst but also an oxidant for the intermediate dihydropyridine. The substituents could be easily modified by altering the substrates to obtain tri- and tetraarylpyridines including bipyridines and terpyridine. Synthesis of differently substituted pentaarylpyridines was consequently achieved via only three steps from com. available reagents with simple exptl. manipulations. Thus, e.g., enamine I + benzylideneacetone â†?II (84%).

European Journal of Organic Chemistry published new progress about Aldol condensation (for preparation of α,β-unsaturated ketones). 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Synthetic Route of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Li, Yajuan published the artcileCatalytic Asymmetric Reductive Azaarylation of Olefins via Enantioselective Radical Coupling, Recommanded Product: Picolinonitrile, the main research area is azaarene enantioselective preparation; acrylophenone cyanopyridine irridium photocatalyst reductive azaarylation; pyridinyl chromanone enantioselective preparation; cyanopyridine flavone irridium photocatalyst reductive azaarylation.

Herein, chiral hydrogen-bonding/photosensitizer catalysis found a viable platform as it enabled the realization of the first enantioselective manifold. A variety of acyclic and cyclic enones as the reaction partners were compatible with the dual catalyst system, leading to a wide array of valuable enantioenriched azaarene variants I [Ar = Ph, 2-naphthyl, 2-furanyl, etc.; R = Me, i-Pr, Ph, etc.] and II [X = O, S; R1 = H, 5-Cl, 6-Me, etc.; R2 = Me, Ph, 2-FC6H4, etc.; R3 = 4-pyridyl, 2-methylpyridin-4-yl, 2,6-dimethylpyridin-4-yl, etc.] with high yields and ees. Regulating the types of chiral catalysts represented one of the important manners to success, in which several readily accessible Cinchona alkaloid-derived bifunctional catalysts were introduced in asym. photochem. reactions.

Journal of the American Chemical Society published new progress about Arylation catalysts. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Recommanded Product: Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts