Month: November 2022

Fereidoonnezhad, Masood published the artcileDesign, synthesis, molecular docking, biological evaluations and QSAR studies of novel dichloroacetate analogues as anticancer agent, COA of Formula: C7H6N2, the main research area is aryl dichloroacetamide preparation antitumor mol docking QSAR; dichloroacetate aryl preparation antitumor mol docking QSAR.

In this study, a series of novel N-aryl-2,2-dichloroacetamide ArNHC(O)CHCl2 (Ar = 9,10-dioxo-9,10-dihydroanthracen-1-yl (I), pyridin-2-yl, thiazol-2-yl, etc.) and aryl-2,2-dichloroacetate derivatives Ar1OC(O)CHCl2 (Ar1 = 2-hydroxyphenyl, 4-fluorophenyl, 3-methoxyphenyl, etc.) were designed and synthesized. Their cytotoxic activities against various human cancer cell lines including A549, HCA-7, MCF-7, MDA-MB-231, KB and SKOV3 were evaluated. These compounds showed satisfactory potencies with much higher anticancer activity than the parent compound DCA, against the studied cancer cell lines. Mol. docking studies were also done to find their binding site and types of their interactions with PDKs isoenzymes. Among the synthesized compounds, compound I can also induce A549 cells apoptosis. Therefore, compound I might have a potential value for further study in drug development. QSAR studies of this class of compounds were also explored using a collection of chemometrics methods.

Journal of Molecular Structure published new progress about Amides Role: PAC (Pharmacological Activity), PRP (Properties), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), PREP (Preparation), USES (Uses) (dichloro, aryl). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, COA of Formula: C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Baechle, Felix published the artcileGlycoconjugated Phthalocyanines as Photosensitizers for PDT – Overcoming Aggregation in Solution, Synthetic Route of 91-15-6, the main research area is glycoconjugated zinc phthalocyanine complex preparation CD spectra fluorescence; cytotoxicity activity glycoconjugated zinc phthalocyanine complex.

A series of new glycoconjugated zinc(II) phthalocyanines (Pcs) was synthesized and fully characterized. The major focus of the structural design for these new Pcs was upon the reduction of aggregate formation in solution Therefore, the aglycons of the Pc-linked sugars, the number and the position of the carbohydrate substituents on the Pc and the linker between sugar and Pc were varied. Specifically, di- and octasubstituted zinc(II) phthalocyanines with triazole and C-C linkages were synthesized and their aggregation behavior was investigated by UV/visible-, CD- and NMR spectroscopy. The C-glycosidically decorated Pcs described here are the first compound types of this kind. These C-glycosidically substituted Pcs not form any aggregation in solution and hence, are considered to be potential photosensitizers in photodynamic therapy. All Pcs synthesized in this study exhibited excellent photophys. properties for use as photosensitizers (λmax > 675 nm with εmax > 105 M-1 cm-1). Preliminary cytotoxicity studies of the Pcs presented here showed that all Pcs are photodynamically effective.

European Journal of Organic Chemistry published new progress about Circular dichroism. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Synthetic Route of 91-15-6.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Tlusty, M. published the artcileRegioselective formation of the quinazoline moiety on the upper rim of calix[4]arene as a route to inherently chiral systems, Synthetic Route of 100-70-9, the main research area is calixarene quinazoline conformation crystal structure pi interaction inclusion compound.

The meta- and para-substituted aminocalix[4]arenes immobilized in the cone conformation were acylated to yield the corresponding acyl amides. Subsequent cyclization with aryl or alkyl cyanides afforded the expected quinazolines only in the case of the para-substituted series, while only complex reaction mixtures were obtained for the meta-substituted analogs. This finding was used as a strategy for the preparation of novel inherently chiral calixarenes with strong fluorescence. The structure of the products was proved by the combination of NMR and single crystal X-ray analyses. The dynamic NMR study of quinazoline derivatives revealed the existence of two different atropisomers in solution at lower temperatures As evidenced by resolution with a chiral HPLC column and by the fluorescence titration experiments, novel quinazolines represent inherently chiral macrocycles of high potential for the design of chiral calixarene-based receptors.

New Journal of Chemistry published new progress about Cation-pi interaction. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Synthetic Route of 100-70-9.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Sharma, Swagat published the artcileDiscovery, synthesis and characterization of a series of (1-alkyl-3-methyl-1H-pyrazol-5-yl)-2-(5-aryl-2H-tetrazol-2-yl)acetamides as novel GIRK1/2 potassium channel activators, Category: nitriles-buliding-blocks, the main research area is pyrazolyl arylazolyl acetamide preparation GIRK channel activator SAR; Activator; G protein-regulated inwardly-rectifying potassium channel; GIRK; Tetrazole.

The study described the discovery and characterization of a series of 5-aryl-2H-tetrazol-3-yl acetamides as G protein-gated inwardly-rectifying potassium (GIRK) channels activators. Working from an initial hit discovered during a high-throughput screening campaign, a tetrazole scaffold was identified that shifts away from the previously reported urea-based scaffolds while remaining effective GIRK1/2 channel activators. In addition, the compounds were evaluated in Tier 1 DMPK assays and identified a (3-methyl-1H-pyrazol-1-yl)tetrahydrothiophene-1,1-dioxide head group that imparts interesting and unexpected microsomal stability compared to previously-reported pyrazole head groups.

Bioorganic & Medicinal Chemistry Letters published new progress about Drug discovery. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Category: nitriles-buliding-blocks.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Grigor’eva, A. I. published the artcileSynthesis and Antimonoamine Oxidase Activity of 2-(3-Iminoisoindol-1-ylidene)-2-arylacetonitriles, Recommanded Product: Phthalonitrile, the main research area is oxoisoindolylidene arylacetonitrile preparation; iminoisoindolylidene arylacetonitrile preparation diastereoselective hydrolysis antimonoamine oxidase activity; phthalonitrile arylacetonitrile cascade condensation.

A one-pot synthesis of 2-(3-iminoisoindol-1-ylidene)-2-arylacetonitriles (E)-I (Ar = Ph, 3-chlorophenyl, 4-methylphenyl, 4-methoxyphenyl, 1-naphthyl; X = NH) in yields of up to 95% by the cascade condensation of phthalonitrile with arylacetonitriles ArCH2CN in a superbasic NaOH/DMSO medium was proposed. A method for the synthesis of (E)-2-(3-oxoisoindol-1-ylidene)-2-arylacetonitriles I (X = O) by the hydrolysis of 2-(3-iminoisoindol-1-ylidene)-2-arylacetonitriles I (X = NH) in acetic acid was developed. The obtained (E)-2-(3-iminoisoindol-1-ylidene)-2-arylacetonitriles I (X = NH) were shown to be active inhibitors of human monoamine oxidase [IC50 (MAO-A) for I (Ar = 4-methylphenyl, X = NH) 3.26μM].

Russian Journal of Organic Chemistry published new progress about Condensation reaction, stereoselective. 91-15-6 belongs to class nitriles-buliding-blocks, name is Phthalonitrile, and the molecular formula is C8H4N2, Recommanded Product: Phthalonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Remya, Chandran published the artcileNeuroprotective derivatives of tacrine that target NMDA receptor and acetyl cholinesterase – Design, synthesis and biological evaluation, Product Details of C7H6N2, the main research area is aminotetrahydroacridine preparation NMDA receptor antagonist cholinesterase inhibition SAR docking; AChE, acetylcholinesterase; AChEIs, acetylcholinesterase inhibitors; AChT, acetylthiocholine; AD, Alzheimer’s disease; ADME, absorption, distribution, metabolism and excretion; Acetylcholinesterase; Alzheimer’s disease; BBB, blood brain barrier; Ca2+, calcium; ChE, Cholinesterases; DMEM, Dulbecco’s modified Eagle’s medium; DTNB, 5,5-dithiobis-(2-nitrobenzoic acid); ENM, elastic network modeling; ER, endoplasmic reticulum; FRET, fluorescence resonance energy transfer; G6PD, glucose-6-phosphate dehydrogenase; HBSS, Hank’s balanced salt solution; IP, intraperitoneal; LBD, Ligand binding domain; LC-MS, Liquid chromatography-mass spectrometry; LiCABEDS, Ligand Classifier of Adaptively Boosting Ensemble Decision Stumps; MAP2, microtubule associated protein 2; MD, Molecular dynamics; MTDLs; MTDLs, multi-target directed ligands; MWM, Morris water maze; NBM, neurobasal medium; NMA, normal mode analysis; NMDA receptor; NMDAR, N-methyl-D-aspartate receptor; Neuroprotection; OPLS, Optimized potential for liquid simulations; PBS, phosphate-buffered saline; PFA, paraformaldehyde; Polypharmacology; RMSD, root mean square deviation; SAR, structure-activity relationships; SD, standard deviation; SVM, support vector machine; Structure-based drug design; TBI, traumatic brain injury; TMD, transmembrane domain; Tacrine; h-NMDAR, human NMDAR; hAChE, human AChE; ppm, parts per million.

An novel high affinity multi-target directed ligands (MTDLs) against AChE and NMDAR, with reduced hepatotoxicity, performed in-silico structure-based modifications on tacrine, chem. synthesis of the derivatives and in-vitro validation of their activities. Nineteen such derivatives I [R = H, methylcarbamoyl, hydrazinecarbonyl, ethoxycarbonyl; R1 = 2-furanyl, 1-methylpyrazol-4-yl, 2-FC6H4, etc.] showed inhibition with IC50 values in the range of 18.53 ± 2.09 – 184.09 ± 19.23 nM against AChE and 0.27 ± 0.05 – 38.84 ± 9.64μM against NMDAR. Some of the selected compounds protected rat primary cortical neurons from glutamate induced excitotoxicity. Two of the tacrine derived MTDLs, I [R = H, R1 = 1-methylpyrazol-4-yl; R = H, R1 = 2-FC6H4] exhibited in-vivo efficacy in rats by protecting against behavioral impairment induced by administration of the excitotoxic agent, monosodium glutamate. Addnl., several of these synthesized compounds also exhibited promising inhibitory activitiy against butyrylcholinesterase. MTDL-201 I [R = H, R1 = 1-methylpyrazol-4-yl] was also devoid of hepatotoxicity in-vivo. Given the therapeutic potential of MTDLs in disease-modifying therapy, studies revealed several promising MTDLs among which I [R = H, R1 = 1-methylpyrazol-4-yl] appeared to be a potential candidate for immediate preclin. evaluations.

Computational and Structural Biotechnology Journal published new progress about Arylboronic acids Role: RCT (Reactant), RACT (Reactant or Reagent). 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Product Details of C7H6N2.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Diao, Peng-Cheng published the artcileDesign, synthesis and biological evaluation of novel indole-based oxalamide and aminoacetamide derivatives as tubulin polymerization inhibitors, Name: 2-Aminobenzonitrile(Flakes or Chunks), the main research area is indole based oxalamide preparation antiproliferative docking tubulin inhibitor human; antiproliferative docking tubulin inhibitor human indole based aminoacetamide preparation; Antiproliferative activity; Indoles; Synthesis; Tubulin polymerization.

A series of novel indole-based oxalamides I [R1 = H, Me, Cl; R2 = H, C(O)Me, C(O)C6H5, cyclopropanecarbonyl, furan-2-carbonyl; X = N, CH] and aminoacetamides II [R3 = H, Cl; R4 = C(O)C6H5, 4-MeC6H4C(O), 4-MeOC6H4C(O); R5 = H, 2-Me, 4-Me, 4-F, 4-MeO, 3,4,5-tri-MeO] were designed, synthesized, and evaluated for antiproliferative activities. Preliminary results revealed that compound II [R3 = Cl; R4 = C(O)C6H5; R5 = H] exhibited significant antiproliferative effect against PC-3, HeLa and HCT-116 cell lines. Flow cytometric anal. of the cell cycle demonstrated the compound II [R3 = Cl; R4 = C(O)C6H5; R5 = H] induced the cell cycle arrest at G2/M phase in HeLa cell lines. Immunocytochem. revealed loss of intact microtubule structure in cells treated with compound II [R3 = Cl; R4 = C(O)C6H5; R5 = H] and inhibition of tubulin polymerization Addnl., mol. docking anal. suggested that compound II [R3 = Cl; R4 = C(O)C6H5; R5 = H] formed stable interactions in the colchicine-binding site of tubulin. These preliminary results demonstrated that a new class of novel indole-based oxalamide and aminoacetamide derivatives described in the investigation could be developed as potential scaffolds to new anticancer agents.

Bioorganic & Medicinal Chemistry Letters published new progress about Antiproliferative agents. 1885-29-6 belongs to class nitriles-buliding-blocks, name is 2-Aminobenzonitrile(Flakes or Chunks), and the molecular formula is C7H6N2, Name: 2-Aminobenzonitrile(Flakes or Chunks).

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts

Huang, Zhuo-Bin published the artcileSelectively Oxidative Thiolysis of Nitriles into Primary Thioamides and Insecticidal Application, Name: Picolinonitrile, the main research area is aryl carbothioamide preparation green chem agrochem toxicity.

Primary thioamides were useful building blocks for drug and insecticide development, therefore an environmentally benign synthesis of primary thioamides was desired. An oxidative thiolysis for the selective transformation of nitriles into primary thioamides using elemental sulfur or thiuram in the presence of K2S2O8 in DMF/H2O was discussed. This practical method enables access to a wide range of synthetically and pharmaceutically useful primary thioamides. Advantages of this reaction include transition-metal-free and base-free reaction conditions, use of an environmentally benign solvent (DMF/H2O) system, the use of non-toxic elemental sulfur or thiuram as the sulfur sources, and good functional groups tolerances with excellent selectivity. Furthermore, the insecticide Fipronil was also converted to the corresponding thioamide and maintains excellent bioactivity against P. xylostella. The LC50 value of Fipronil thioamide was 1.25 mg/L.

Asian Journal of Organic Chemistry published new progress about Green chemistry. 100-70-9 belongs to class nitriles-buliding-blocks, name is Picolinonitrile, and the molecular formula is C6H4N2, Name: Picolinonitrile.

Referemce:
Nitrile – Wikipedia,
Nitriles – Chemistry LibreTexts